LL-dityrosine (BioDeep_00000848605)

   


代谢物信息卡片


LL-dityrosine

化学式: C18H20N2O6 (360.13213)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)C2=C(C=CC(=C2)CC(C(=O)O)N)O)O
InChI: InChI=1S/C18H20N2O6/c19-13(17(23)24)7-9-1-3-15(21)11(5-9)12-6-10(2-4-16(12)22)8-14(20)18(25)26/h1-6,13-14,21-22H,7-8,19-20H2,(H,23,24)(H,25,26)/t13-,14-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

LL-dityrosine



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Xue Tang, Fanhang Zeng, Jun Wang, Yipin Lyu, Renqiang Yu, Naiyan Lu, Zhou Zhou, Ailing Chen. Dietary Dityrosine Induces Oxidative Stress and Mitochondrial-Lipid Imbalance in Mouse Liver via MiR-144-3p-mediated Downregulation of Nrf2. Molecular nutrition & food research. 2023 Mar; ?(?):e2200674. doi: 10.1002/mnfr.202200674. [PMID: 36987812]
  • Jun Wang, Xue Tang, Yipin Lu, Yingying Zheng, Fanhang Zeng, Wentao Shi, Peng Zhou. Lycopene Regulates Dietary Dityrosine-Induced Mitochondrial-Lipid Homeostasis by Increasing Mitochondrial Complex Activity. Molecular nutrition & food research. 2022 01; 66(1):e2100724. doi: 10.1002/mnfr.202100724. [PMID: 34780105]
  • Dan Liu, Xiangyu Cao, Yuchi Kong, Teng Mu, Jianli Liu. Inhibitory mechanism of sinensetin on α-glucosidase and non-enzymatic glycation: Insights from spectroscopy and molecular docking analyses. International journal of biological macromolecules. 2021 Jan; 166(?):259-267. doi: 10.1016/j.ijbiomac.2020.10.174. [PMID: 33115652]
  • Geetika Garg, Abhishek Kumar Singh, Sandeep Singh, Avnish Kumar Verma, Syed Ibrahim Rizvi. Whey protein concentrate protects against age-dependent alteration in redox biomarkers. Biologia futura. 2020 Sep; 71(3):273-281. doi: 10.1007/s42977-020-00033-5. [PMID: 34554512]
  • Stefanie Wiedmer, Thomas Kurth, Ulrike Buder, Sinja Bleischwitz, Rolf Entzeroth, Michael Kurth. Correlative light and electron microscopy of wall formation in Eimeria nieschulzi. Parasitology research. 2020 Aug; 119(8):2667-2678. doi: 10.1007/s00436-020-06765-6. [PMID: 32627078]
  • Ai Yamada, Yoshiko Sato, Tokushi Horike, Masamitsu Miyanaga, Da-Hong Wang. Effects of a Forest Walk on Urinary Dityrosine and Hexanoyl-Lysine in Young People: A Pilot Study. International journal of environmental research and public health. 2020 07; 17(14):. doi: 10.3390/ijerph17144990. [PMID: 32664406]
  • Ramin Bahmani, Mahsa Modareszadeh, Mohammad Reza Bihamta. Genotypic variation for cadmium tolerance in common bean (Phaseolus vulgaris L.). Ecotoxicology and environmental safety. 2020 Mar; 190(?):110178. doi: 10.1016/j.ecoenv.2020.110178. [PMID: 31927193]
  • Muraly Puttabyatappa, Margaret Banker, Lixia Zeng, Jaclyn M Goodrich, Steven E Domino, Dana C Dolinoy, John D Meeker, Subramaniam Pennathur, Peter X K Song, Vasantha Padmanabhan. Maternal Exposure to Environmental Disruptors and Sexually Dimorphic Changes in Maternal and Neonatal Oxidative Stress. The Journal of clinical endocrinology and metabolism. 2020 02; 105(2):. doi: 10.1210/clinem/dgz063. [PMID: 31613966]
  • Antonio Mancini, Carmine Bruno, Edoardo Vergani, Francesco Guidi, Flavia Angelini, Elisabetta Meucci, Andrea Silvestrini. Evaluation of oxidative stress effects on different macromolecules in adult growth hormone deficiency. PloS one. 2020; 15(7):e0236357. doi: 10.1371/journal.pone.0236357. [PMID: 32687509]
  • Aušra Mongirdienė, Jolanta Laukaitienė, Vilius Skipskis, Artūras Kašauskas. The Effect of Oxidant Hypochlorous Acid on Platelet Aggregation and Dityrosine Concentration in Chronic Heart Failure Patients and Healthy Controls. Medicina (Kaunas, Lithuania). 2019 May; 55(5):. doi: 10.3390/medicina55050198. [PMID: 31126140]
  • Xiaolin Dong, Teodor Svantesson, Sabrina B Sholts, Cecilia Wallin, Jüri Jarvet, Astrid Gräslund, Sebastian K T S Wärmländer. Copper ions induce dityrosine-linked dimers in human but not in murine islet amyloid polypeptide (IAPP/amylin). Biochemical and biophysical research communications. 2019 03; 510(4):520-524. doi: 10.1016/j.bbrc.2019.01.120. [PMID: 30737030]
  • Maria-Pilar Martinez-Moral, Kurunthachalam Kannan. How stable is oxidative stress level? An observational study of intra- and inter-individual variability in urinary oxidative stress biomarkers of DNA, proteins, and lipids in healthy individuals. Environment international. 2019 02; 123(?):382-389. doi: 10.1016/j.envint.2018.12.009. [PMID: 30572170]
  • Hui Zhang, Yuhui Yang, Biao Yan, Xue Tang, Xiangrong Cheng, Guowei Le, Yonghui Shi. [Dityrosine administration induces myocardium injury and inflammatory response in mice]. Wei sheng yan jiu = Journal of hygiene research. 2018 May; 47(3):345-351. doi: . [PMID: 30081997]
  • Georg Degendorfer, Christine Y Chuang, Michele Mariotti, Astrid Hammer, Gerald Hoefler, Per Hägglund, Ernst Malle, Steven G Wise, Michael J Davies. Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function. Free radical biology & medicine. 2018 02; 115(?):219-231. doi: 10.1016/j.freeradbiomed.2017.11.019. [PMID: 29191462]
  • Attia Anwar, Provvidenza Maria Abruzzo, Sabah Pasha, Kashif Rajpoot, Alessandra Bolotta, Alessandro Ghezzo, Marina Marini, Annio Posar, Paola Visconti, Paul J Thornalley, Naila Rabbani. Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis. Molecular autism. 2018; 9(?):3. doi: 10.1186/s13229-017-0183-3. [PMID: 29479405]
  • Leo D Bemena, Omar Mukama, Aaron M Neiman, Zijie Li, Xiao-Dong Gao, Hideki Nakanishi. In vitro reconstitution of the yeast spore wall dityrosine layer discloses the mechanism of its assembly. The Journal of biological chemistry. 2017 09; 292(38):15880-15891. doi: 10.1074/jbc.m117.786202. [PMID: 28794156]
  • Yuhui Yang, Hui Zhang, Biao Yan, Tianyu Zhang, Ying Gao, Yonghui Shi, Guowei Le. Health Effects of Dietary Oxidized Tyrosine and Dityrosine Administration in Mice with Nutrimetabolomic Strategies. Journal of agricultural and food chemistry. 2017 Aug; 65(32):6957-6971. doi: 10.1021/acs.jafc.7b02003. [PMID: 28742334]
  • Yin-Yi Ding, Zhu-Qing Li, Xiang-Rong Cheng, Yu-Mei Ran, Sha-Ji Wu, Yonghui Shi, Guowei Le. Dityrosine administration induces dysfunction of insulin secretion accompanied by diminished thyroid hormones T3 function in pancreas of mice. Amino acids. 2017 08; 49(8):1401-1414. doi: 10.1007/s00726-017-2442-1. [PMID: 28624907]
  • Daiane Grigolo Bardemaker Rodrigues, Daniella de Moura Coelho, Ângela Sitta, Carlos Eduardo Diaz Jacques, Tatiane Hauschild, Vanusa Manfredini, Abdellatif Bakkali, Eduard A Struys, Cornelis Jakobs, Moacir Wajner, Carmen Regla Vargas. Experimental evidence of oxidative stress in patients with l-2-hydroxyglutaric aciduria and that l-carnitine attenuates in vitro DNA damage caused by d-2-hydroxyglutaric and l-2-hydroxyglutaric acids. Toxicology in vitro : an international journal published in association with BIBRA. 2017 Aug; 42(?):47-53. doi: 10.1016/j.tiv.2017.04.006. [PMID: 28396261]
  • Zhuqing Leslie Li, Yonghui Shi, Yinyi Ding, Yumei Ran, Guowei Le. Dietary oxidized tyrosine (O-Tyr) stimulates TGF-β1-induced extracellular matrix production via the JNK/p38 signaling pathway in rat kidneys. Amino acids. 2017 Feb; 49(2):241-260. doi: 10.1007/s00726-016-2353-6. [PMID: 27770286]
  • Xinxin Hu, Wei Song, Wei Li, Changying Guo, Zehua Yu, Rutao Liu. Effects of γ-Irradiation on the Molecular Structures and Functions of Human Serum Albumin. Journal of biochemical and molecular toxicology. 2016 Nov; 30(11):525-532. doi: 10.1002/jbt.21818. [PMID: 27140235]
  • Yumei Ran, Biao Yan, Zhuqing Li, Yinyi Ding, Yonghui Shi, Guowei Le. Dityrosine administration induces novel object recognition deficits in young adulthood mice. Physiology & behavior. 2016 10; 164(Pt A):292-9. doi: 10.1016/j.physbeh.2016.06.019. [PMID: 27317839]
  • Zhigang Ke, Qing Huang. Haem-assisted dityrosine-cross-linking of fibrinogen under non-thermal plasma exposure: one important mechanism of facilitated blood coagulation. Scientific reports. 2016 05; 6(?):26982. doi: 10.1038/srep26982. [PMID: 27229173]
  • Subramaniam Pennathur, Anuradha Vivekanandan-Giri, Morgan L Locy, Tejaswini Kulkarni, Degui Zhi, Lixia Zeng, Jaeman Byun, Joao A de Andrade, Victor J Thannickal. Oxidative Modifications of Protein Tyrosyl Residues Are Increased in Plasma of Human Subjects with Interstitial Lung Disease. American journal of respiratory and critical care medicine. 2016 Apr; 193(8):861-8. doi: 10.1164/rccm.201505-0992oc. [PMID: 26575972]
  • Adam P Gunn, Bruce X Wong, Timothy Johanssen, James C Griffith, Colin L Masters, Ashley I Bush, Kevin J Barnham, James A Duce, Robert A Cherny. Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons. The Journal of biological chemistry. 2016 Mar; 291(12):6134-45. doi: 10.1074/jbc.m115.655183. [PMID: 26697885]
  • Christopher J Kampf, Fobang Liu, Kathrin Reinmuth-Selzle, Thomas Berkemeier, Hannah Meusel, Manabu Shiraiwa, Ulrich Pöschl. Protein Cross-Linking and Oligomerization through Dityrosine Formation upon Exposure to Ozone. Environmental science & technology. 2015 Sep; 49(18):10859-66. doi: 10.1021/acs.est.5b02902. [PMID: 26287571]
  • Liliana Gutiérrez, José R García, María de Jesús Rincón, Guillermo M Ceballos, Ivonne M Olivares. [Effect of a hypocaloric diet in the oxidative stress in obese subjects without prescription of exercise and antioxidants]. Medicina clinica. 2015 Jul; 145(1):1-6. doi: 10.1016/j.medcli.2013.12.015. [PMID: 24629690]
  • Bruna Donida, Desirèe P Marchetti, Giovana B Biancini, Marion Deon, Paula R Manini, Helen T da Rosa, Dinara J Moura, Jenifer Saffi, Fernanda Bender, Maira G Burin, Adriana S Coitinho, Roberto Giugliani, Carmen Regla Vargas. Oxidative stress and inflammation in mucopolysaccharidosis type IVA patients treated with enzyme replacement therapy. Biochimica et biophysica acta. 2015 May; 1852(5):1012-9. doi: 10.1016/j.bbadis.2015.02.004. [PMID: 25701642]
  • Gui-Rong Wu, Maureen Cheserek, Yong-Hui Shi, Li-Ye Shen, Jing Yu, Guo-Wei Le. Elevated plasma dityrosine in patients with hyperlipidemia compared to healthy individuals. Annals of nutrition & metabolism. 2015; 66(1):44-50. doi: 10.1159/000365731. [PMID: 25531053]
  • Graziano Colombo, Marco Clerici, Daniela Giustarini, Nicola Portinaro, Salvatore Badalamenti, Ranieri Rossi, Aldo Milzani, Isabella Dalle-Donne. A central role for intermolecular dityrosine cross-linking of fibrinogen in high molecular weight advanced oxidation protein product (AOPP) formation. Biochimica et biophysica acta. 2015 Jan; 1850(1):1-12. doi: 10.1016/j.bbagen.2014.09.024. [PMID: 25280629]
  • Izabela Sadowska-Bartosz, Sabina Galiniak, Grzegorz Bartosz. Kinetics of glycoxidation of bovine serum albumin by glucose, fructose and ribose and its prevention by food components. Molecules (Basel, Switzerland). 2014 Nov; 19(11):18828-49. doi: 10.3390/molecules191118828. [PMID: 25407721]
  • Naofumi Tamaki, Rita Cristina Orihuela-Campos, Yuji Inagaki, Makoto Fukui, Toshihiko Nagata, Hiro-O Ito. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model. Free radical biology & medicine. 2014 Oct; 75(?):222-9. doi: 10.1016/j.freeradbiomed.2014.07.034. [PMID: 25091897]
  • Hilmi Orhan, Altan Sahin, Gonul Sahin, Ulku Aypar, Nico P E Vermeulen. Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2013 Feb; 18(1):73-81. doi: 10.3109/1354750x.2012.737026. [PMID: 23136842]
  • Coney Pei-Chen Lin, Carey Kim, Steven O Smith, Aaron M Neiman. A highly redundant gene network controls assembly of the outer spore wall in S. cerevisiae. PLoS genetics. 2013; 9(8):e1003700. doi: 10.1371/journal.pgen.1003700. [PMID: 23966878]
  • Dora Il'yasova, Peter Scarbrough, Ivan Spasojevic. Urinary biomarkers of oxidative status. Clinica chimica acta; international journal of clinical chemistry. 2012 Oct; 413(19-20):1446-53. doi: 10.1016/j.cca.2012.06.012. [PMID: 22683781]
  • O A Azizova, A V Aseychev, E M Beckman, S N Moskvina, O I Skotnikova, N V Smolina, Yu A Gryzunov, G E Dobretsov. Studies of oxidant-induced changes in albumin transport function with a fluorescent probe k-35. Effect of hypochlorite. Bulletin of experimental biology and medicine. 2012 Apr; 152(6):712-6. doi: 10.1007/s10517-012-1613-z. [PMID: 22803171]
  • Andrew Churg, Caroline V Marshall, Don D Sin, Sarah Bolton, Steven Zhou, Katherine Thain, Elaine B Cadogan, Justine Maltby, Matthew G Soars, Philip R Mallinder, Joanne L Wright. Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine. 2012 Jan; 185(1):34-43. doi: 10.1164/rccm.201103-0468oc. [PMID: 21997333]
  • Carlos Campos, Rodrigo Guzmán, Encarnación López-Fernández, Angela Casado. Evaluation of urinary biomarkers of oxidative/nitrosative stress in children with Down syndrome. Life sciences. 2011 Oct; 89(17-18):655-61. doi: 10.1016/j.lfs.2011.08.006. [PMID: 21871905]
  • Guangjie Cheng, Hong Li, Zehong Cao, Xiaoyun Qiu, Sally McCormick, Victor J Thannickal, William M Nauseef. Vascular peroxidase-1 is rapidly secreted, circulates in plasma, and supports dityrosine cross-linking reactions. Free radical biology & medicine. 2011 Oct; 51(7):1445-53. doi: 10.1016/j.freeradbiomed.2011.07.002. [PMID: 21798344]
  • Jing Sun, Akihiko Sugiyama, Aino Masuda, Tairin Ochi, Takashi Takeuchi. Expressions of protein oxidation markers, dityrosine and advanced oxidation protein products in acetaminophen-induced liver injury in rats. The Journal of veterinary medical science. 2011 Sep; 73(9):1185-90. doi: 10.1292/jvms.11-0088. [PMID: 21525711]
  • Kelly Mai, Nicholas C Smith, Zhi-Ping Feng, Marilyn Katrib, Jan Slapeta, Iveta Slapetova, Michael G Wallach, Catherine Luxford, Michael J Davies, Xuecheng Zhang, Raymond S Norton, Sabina I Belli. Peroxidase catalysed cross-linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima. International journal for parasitology. 2011 Sep; 41(11):1157-64. doi: 10.1016/j.ijpara.2011.07.001. [PMID: 21819990]
  • Akihiko Sugiyama, Yuka Fujita, Toshihiro Kobayashi, Mizuyuki Ryu, Yasushi Suzuki, Aino Masuda, Tairin Ochi, Takashi Takeuchi. Effect of protein malnutrition on the skin epidermis of hairless mice. The Journal of veterinary medical science. 2011 Jun; 73(6):831-5. doi: 10.1292/jvms.10-0399. [PMID: 21289473]
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  • Yumi Kimoto, Akihiko Sugiyama, Masaaki Nishinohara, Atsushi Asano, Aino Masuda, Tairin Ochi, Takashi Takeuchi. Expressions of protein oxidation markers, dityrosine and advanced oxidation protein products in Cisplatin-induced nephrotoxicity in rats. The Journal of veterinary medical science. 2011 Mar; 73(3):403-7. doi: 10.1292/jvms.10-0371. [PMID: 21048391]
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