Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester (BioDeep_00000848400)
代谢物信息卡片
Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester
化学式: C16H17N3O3S (331.09905720000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-]
InChI: InChI=1S/C16H17N3O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21/h1-8H,9-11H2,(H3,17,18)
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代谢反应
0 个相关的代谢反应过程信息。
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Janet D Talbot, Gavriel David, Ellen F Barrett, John N Barrett. Calcium dependence of damage to mouse motor nerve terminals following oxygen/glucose deprivation.
Experimental neurology.
2012 Mar; 234(1):95-104. doi:
10.1016/j.expneurol.2011.12.020. [PMID: 22206924] - Venkatachalem Sathish, Philippe F Delmotte, Michael A Thompson, Christina M Pabelick, Gary C Sieck, Y S Prakash. Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.
PloS one.
2011; 6(8):e23662. doi:
10.1371/journal.pone.0023662. [PMID: 21858195] - Hui Dong, Ki-Nam Shim, Jenny M J Li, Christine Estrema, Tiffany A Ornelas, Flang Nguyen, Shanglei Liu, Sonia L Ramamoorthy, Samuel Ho, John M Carethers, Jimmy Y C Chow. Molecular mechanisms underlying Ca2+-mediated motility of human pancreatic duct cells.
American journal of physiology. Cell physiology.
2010 Dec; 299(6):C1493-503. doi:
10.1152/ajpcell.00242.2010. [PMID: 20861471] - Marina Granado e Sá, B B Baptista, L S Farah, V P Leite, F P Zanotto. Calcium transport and homeostasis in gill cells of a freshwater crab Dilocarcinus pagei.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2010 Mar; 180(3):313-21. doi:
10.1007/s00360-009-0427-4. [PMID: 20012436] - Kazuho Sakamoto, Yuki Owada, Yayoi Shikama, Ikuo Wada, Satoshi Waguri, Takahiro Iwamoto, Junko Kimura. Involvement of Na+/Ca2+ exchanger in migration and contraction of rat cultured tendon fibroblasts.
The Journal of physiology.
2009 Nov; 587(Pt 22):5345-59. doi:
10.1113/jphysiol.2009.172080. [PMID: 19770194] - Haifa Hong, Huiwen Chen, Wei Gao, Xiaoman Cai, Yanjuan Sun, Meng Yin, Jinfen Liu. Hypoxia-induced cytosolic calcium decrease is mediated primarily by the forward mode of Na(+)/Ca(2+) exchanger in smooth muscle cells of fetal ductus arteriosus.
Pediatric cardiology.
2009 Oct; 30(7):958-64. doi:
10.1007/s00246-009-9478-2. [PMID: 19495847] - Genaro Barrientos, Diptiman D Bose, Wei Feng, Isela Padilla, Isaac N Pessah. The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.
Molecular pharmacology.
2009 Sep; 76(3):560-8. doi:
10.1124/mol.109.057265. [PMID: 19509218] - Susan K Fellner, William J Arendshorst. Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange.
American journal of physiology. Renal physiology.
2008 Jan; 294(1):F212-9. doi:
10.1152/ajprenal.00244.2007. [PMID: 17977908] - J Santo-Domingo, L Vay, E Hernández-Sanmiguel, C D Lobatón, A Moreno, M Montero, J Alvarez. The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.
British journal of pharmacology.
2007 Jul; 151(5):647-54. doi:
10.1038/sj.bjp.0707260. [PMID: 17471180] - Takahiro Iwamoto, Satomi Kita. [Na+/Ca2+ exchanger (NCX1) and cardiovascular disease].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2007 Apr; 129(4):262-5. doi:
10.1254/fpj.129.262. [PMID: 17435337] - Satomi Kita, Ayako Furuta, Yukio Takano, Takahiro Iwamoto. The role of Na+/Ca2+ exchanger in endothelin-1-aggravated hypoxia/reoxygenation-induced injury in renal epithelial cells.
Annals of the New York Academy of Sciences.
2007 Mar; 1099(?):473-7. doi:
10.1196/annals.1387.041. [PMID: 17446489] - Tony D Gover, Thaís H V Moreira, Joseph P Y Kao, Daniel Weinreich. Calcium regulation in individual peripheral sensory nerve terminals of the rat.
The Journal of physiology.
2007 Jan; 578(Pt 2):481-90. doi:
10.1113/jphysiol.2006.119008. [PMID: 17095566] - Anders J Smith, Alfred E Chappell, Andre G Buret, Kim E Barrett, Hui Dong. 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2006 Dec; 20(14):2486-95. doi:
10.1096/fj.06-6391com. [PMID: 17142798] - Hui Dong, Yanfen Jiang, Chris R Triggle, Xiaofang Li, Jonathan Lytton. Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle.
American journal of physiology. Heart and circulatory physiology.
2006 Sep; 291(3):H1226-35. doi:
10.1152/ajpheart.00196.2006. [PMID: 16617138] - Birgit Mazurek, Nyamaa Amarjargal, Heidemarie Haupt, Johann Gross. High potassium concentrations protect inner and outer hair cells in the newborn rat culture from ischemia-induced damage.
Hearing research.
2006 May; 215(1-2):31-8. doi:
10.1016/j.heares.2006.02.010. [PMID: 16678987] - Takahiro Iwamoto. [Na+/Ca2+ exchanger(NCX1) and salt-sensitive hypertension].
Nihon rinsho. Japanese journal of clinical medicine.
2006 Jan; 64(1):167-76. doi:
. [PMID: 16408465] - Yasushi Sakai, Hiroki Kinoshita, Keiichirou Saitou, Ikuo Homma, Koji Nobe, Takahiro Iwamoto. Functional differences of Na+/Ca2+ exchanger expression in Ca2+ transport system of smooth muscle of guinea pig stomach.
Canadian journal of physiology and pharmacology.
2005 Aug; 83(8-9):791-7. doi:
10.1139/y05-079. [PMID: 16333381] - José R Romero, Alicia Rivera, Vasco Lança, Manuel D P Bicho, Paul R Conlin, Dennis A Ricupero. Na+/Ca2+ exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor beta1- and Des-Arg10-kallidin-stimulated myofibroblasts.
The Journal of biological chemistry.
2005 Apr; 280(15):14378-84. doi:
10.1074/jbc.m410052200. [PMID: 15703175] - Vladyslav Dreval, Peter Dieterich, Christian Stock, Albrecht Schwab. The role of Ca2+ transport across the plasma membrane for cell migration.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2005; 16(1-3):119-26. doi:
10.1159/000087738. [PMID: 16121040] - Luisa M Solís-Garrido, Antonio J Pintado, Eva Andrés-Mateos, María Figueroa, Carlos Matute, Carmen Montiel. Cross-talk between native plasmalemmal Na+/Ca2+ exchanger and inositol 1,4,5-trisphosphate-sensitive ca2+ internal store in Xenopus oocytes.
The Journal of biological chemistry.
2004 Dec; 279(50):52414-24. doi:
10.1074/jbc.m408872200. [PMID: 15375168] - Takahiro Iwamoto, Satomi Kita, Takeshi Katsuragi. Endothelin-1 aggravates hypoxia/reoxygenation-induced injury in renal epithelial cells through the activation of a Na+/Ca2+ exchanger.
Journal of cardiovascular pharmacology.
2004 Nov; 44 Suppl 1(?):S462-6. doi:
10.1097/01.fjc.0000166313.61129.3a. [PMID: 15838349] - Christian Rosker, Annarita Graziani, Michael Lukas, Petra Eder, Michael X Zhu, Christoph Romanin, Klaus Groschner. Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger.
The Journal of biological chemistry.
2004 Apr; 279(14):13696-704. doi:
10.1074/jbc.m308108200. [PMID: 14736881] - Takahiro Iwamoto, Satomi Kita. Development and application of Na+/Ca2+ exchange inhibitors.
Molecular and cellular biochemistry.
2004 Apr; 259(1-2):157-61. doi:
10.1023/b:mcbi.0000021367.42752.54. [PMID: 15124919] - M Martínez-Sánchez, F Striggow, U H Schröder, S Kahlert, K G Reymann, G Reiser. Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures.
Neuroscience.
2004; 128(4):729-40. doi:
10.1016/j.neuroscience.2004.06.074. [PMID: 15464281] - Masaya Ogata, Takahiro Iwamoto, Naoko Tazawa, Mitsunori Nishikawa, Junji Yamashita, Masanori Takaoka, Yasuo Matsumura. A novel and selective Na+/Ca2+ exchange inhibitor, SEA0400, improves ischemia/reperfusion-induced renal injury.
European journal of pharmacology.
2003 Oct; 478(2-3):187-98. doi:
10.1016/j.ejphar.2003.08.082. [PMID: 14575804] - Junji Yamashita, Satomi Kita, Takahiro Iwamoto, Masaya Ogata, Masanori Takaoka, Naoko Tazawa, Mitsunori Nishikawa, Koji Wakimoto, Munekazu Shigekawa, Issei Komuro, Yasuo Matsumura. Attenuation of ischemia/reperfusion-induced renal injury in mice deficient in Na+/Ca2+ exchanger.
The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):284-93. doi:
10.1124/jpet.102.039024. [PMID: 12490603] - Md Shah Amran, Nobuo Homma, Keitaro Hashimoto. Pharmacology of KB-R7943: a Na+-Ca2+ exchange inhibitor.
Cardiovascular drug reviews.
2003; 21(4):255-76. doi:
10.1111/j.1527-3466.2003.tb00121.x. [PMID: 14647531] - Aneta Czyz, Lech Kiedrowski. In depolarized and glucose-deprived neurons, Na+ influx reverses plasmalemmal K+-dependent and K+-independent Na+/Ca2+ exchangers and contributes to NMDA excitotoxicity.
Journal of neurochemistry.
2002 Dec; 83(6):1321-8. doi:
10.1046/j.1471-4159.2002.01227.x. [PMID: 12472886] - Takahiro Iwamoto, Satomi Kita, Munekazu Shigekawa. [Functional analysis of Na+/Ca2+ exchanger using novel drugs and genetically engineered mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2002 Nov; 120(1):91P-93P. doi:
NULL. [PMID: 12491791] - Hui Dong, Jeremy Dunn, Jonathan Lytton. Electrophysiological studies of the cloned rat cardiac NCX1.1 in transfected HEK cells: a focus on the stoichiometry.
Annals of the New York Academy of Sciences.
2002 Nov; 976(?):159-65. doi:
10.1111/j.1749-6632.2002.tb04737.x. [PMID: 12502557] - Akira Miyata, Douglas P Zipes, Stephen Hall, Michael Rubart. Kb-R7943 prevents acute, atrial fibrillation-induced shortening of atrial refractoriness in anesthetized dogs.
Circulation.
2002 Sep; 106(11):1410-9. doi:
10.1161/01.cir.0000028587.85711.f6. [PMID: 12221061] - Aneta Czyz, Gytis Baranauskas, Lech Kiedrowski. Instrumental role of Na+ in NMDA excitotoxicity in glucose-deprived and depolarized cerebellar granule cells.
Journal of neurochemistry.
2002 Apr; 81(2):379-89. doi:
10.1046/j.1471-4159.2002.00851.x. [PMID: 12064485] - N Zhong, V Beaumont, R S Zucker. Roles for mitochondrial and reverse mode Na+/Ca2+ exchange and the plasmalemma Ca2+ ATPase in post-tetanic potentiation at crayfish neuromuscular junctions.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2001 Dec; 21(24):9598-607. doi:
10.1523/jneurosci.21-24-09598.2001. [PMID: 11739570] - F Schweda, B K Krämer, A Kurtz. Differential roles of the sodium-calcium exchanger in renin secretion and renal vascular resistance.
Pflugers Archiv : European journal of physiology.
2001 Aug; 442(5):693-9. doi:
10.1007/s004240100591. [PMID: 11512025] - S Takano, J Kimura, T Ono. Inhibition of aggregation of rabbit and human platelets induced by adrenaline and 5-hydroxytryptamine by KB-R7943, a Na(+)/Ca(2+) exchange inhibitor.
British journal of pharmacology.
2001 Apr; 132(7):1383-8. doi:
10.1038/sj.bjp.0703928. [PMID: 11264230] - J Yamashita, M Ogata, M Takaoka, Y Matsumura. KB-R7943, a selective Na+/Ca2+ exchange inhibitor, protects against ischemic acute renal failure in mice by inhibiting renal endothelin-1 overproduction.
Journal of cardiovascular pharmacology.
2001 Mar; 37(3):271-9. doi:
10.1097/00005344-200103000-00005. [PMID: 11243417] - J Yamashita, M Itoh, T Kuro, Y Kobayashi, M Ogata, M Takaoka, Y Matsumura. Pre- or post-ischemic treatment with a novel Na+/Ca2+ exchange inhibitor, KB-R7943, shows renal protective effects in rats with ischemic acute renal failure.
The Journal of pharmacology and experimental therapeutics.
2001 Feb; 296(2):412-9. doi:
NULL. [PMID: 11160625] - F Schweda, H Seebauer, B K Krämer, A Kurtz. Functional role of sodium-calcium exchange in the regulation of renal vascular resistance.
American journal of physiology. Renal physiology.
2001 Jan; 280(1):F155-61. doi:
10.1152/ajprenal.2001.280.1.f155. [PMID: 11133525]