5,10-Methylenetetrahydrofolate(2-) (BioDeep_00000848311)
代谢物信息卡片
5,10-Methylenetetrahydrofolate(2-)
化学式: C20H21N7O6-2 (455.15532460000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2CN(CN2C3=C(N1)N=C(NC3=O)N)C4=CC=C(C=C4)C(=O)NC(CCC(=O)[O-])C(=O)[O-]
InChI: InChI=1S/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/p-2/t12?,13-/m0/s1
相关代谢途径
Reactome(7)
BioCyc(0)
PlantCyc(0)
代谢反应
425 个相关的代谢反应过程信息。
Reactome(107)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + Q0VCN9 ⟶ FOLR2:FOLA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
6x(PCCA:PCCB) + ATP + Btn ⟶ 6x(Btn-PCCA:PCCB) + AMP + PPi - Metabolism of water-soluble vitamins and cofactors:
6x(PCCA:PCCB) + ATP + Btn ⟶ 6x(Btn-PCCA:PCCB) + AMP + PPi - Metabolism of folate and pterines:
A0A5F4C041 + FOLA ⟶ FOLR2:FOLA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + folr ⟶ FOLR2:FOLA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + H+ + TPNH ⟶ DHF + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + FOLR2_HUMAN ⟶ FOLR2:FOLA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + Folr2 ⟶ FOLR2:FOLA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
dihydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 ⟶ Tetrahydrobiopterin + p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 - Metabolism of water-soluble vitamins and cofactors:
L-Cys + MOCS3:Zn2+ (red.) ⟶ L-Ala + MOCS3-S-S(1-):Zn2+ - Metabolism of folate and pterines:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
D4A4S5 + FOLA ⟶ FOLR2:FOLA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
A0A5G2QLX9 + FOLA ⟶ FOLR2:FOLA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + Homologues of FOLR2 ⟶ FOLR2:FOLA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Metabolism of vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of water-soluble vitamins and cofactors:
H2O + Oxygen + PXL ⟶ H2O2 + PDXate - Metabolism of folate and pterines:
FOLA + H+ + TPNH ⟶ DHF + TPN - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Glyoxylate metabolism and glycine degradation:
L-Ala + glyoxylate ⟶ Gly + PYR - Glycine degradation:
GCSH:SAMDLL + THF ⟶ 5,10-methylene-THF + GCSH:DHLL + ammonia
BioCyc(0)
WikiPathways(0)
Plant Reactome(318)
- Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
glycolate ⟶ glyoxylate - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - PCO cycle:
Gly + NAD + THF ⟶ 5,10-methylene-THF + NADH + ammonia + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + L-Glu + a tetrahydrofolate polyglutamate ⟶ ADP + Pi + a tetrahydrofolate polyglutamate - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
9-mercaptodethiobiotin ⟶ Btn - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + L-Glu + a tetrahydrofolate polyglutamate ⟶ ADP + Pi + a tetrahydrofolate polyglutamate - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + L-Glu + a tetrahydrofolate polyglutamate ⟶ ADP + Pi + a tetrahydrofolate polyglutamate - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + L-Glu + a tetrahydrofolate polyglutamate ⟶ ADP + Pi + a tetrahydrofolate polyglutamate - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Folate polyglutamylation I:
ATP + HCOOH + THF ⟶ 10-formyl-THF + ADP + Pi
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Helena Taflin, Elisabeth Odin, Göran Carlsson, Roger Tell, Bengt Gustavsson, Yvonne Wettergren. Plasma deoxyuridine as a surrogate marker for toxicity and early clinical response in patients with metastatic colorectal cancer after 5-FU-based therapy in combination with arfolitixorin.
Cancer chemotherapy and pharmacology.
2021 01; 87(1):31-41. doi:
10.1007/s00280-020-04173-2. [PMID: 33099678] - Aamod S Dekhne, Changwen Ning, Md Junayed Nayeen, Khushbu Shah, Hasini Kalpage, Josephine Frühauf, Adrianne Wallace-Povirk, Carrie O'Connor, Zhanjun Hou, Seongho Kim, Maik Hüttemann, Aleem Gangjee, Larry H Matherly. Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Molecular pharmacology.
2020 01; 97(1):9-22. doi:
10.1124/mol.119.117937. [PMID: 31707355] - Mehmet Serdar Kutuk, Asli Subasioglu, Semih Uludag, Nazife Tascioglu, Mahmut Tuncay Ozgun, Munis Dundar. The effect of parental 5,10-methylenetetrahydrofolate reductase 677C/T and 1298A/C gene polymorphisms on response to single-dose methotrexate in tubal ectopic pregnancy.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2017 May; 30(10):1232-1237. doi:
10.1080/14767058.2016.1209652. [PMID: 27379466] - Natario L Couser, Julie McClure, Michael W Evans, Nathan R Haines, Susan K Burden, Joseph Muenzer. Homocysteinemia due to MTHFR deficiency in a young adult presenting with bilateral lens subluxations.
Ophthalmic genetics.
2017 Jan; 38(1):91-94. doi:
10.3109/13816810.2016.1143017. [PMID: 27046515] - José F Cascalheira, Mónica Gonçalves, Madalena Barroso, Rita Castro, Manuela Palmeira, André Serpa, Ana C Dias-Cabral, Fernanda C Domingues, Sofia Almeida. Association of the transcobalamin II gene 776C → G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A → C polymorphism genotype.
Annals of clinical biochemistry.
2015 Jul; 52(Pt 4):448-55. doi:
10.1177/0004563214561770. [PMID: 25395544] - Azita Hekmatdoost, Farhad Vahid, Zahra Yari, Mohammadreza Sadeghi, Hassan Eini-Zinab, Niknam Lakpour, Soheila Arefi. Methyltetrahydrofolate vs Folic Acid Supplementation in Idiopathic Recurrent Miscarriage with Respect to Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms: A Randomized Controlled Trial.
PloS one.
2015; 10(12):e0143569. doi:
10.1371/journal.pone.0143569. [PMID: 26630680] - Yvonne Wettergren, Helena Taflin, Elisabeth Odin, Karl Kodeda, Kristoffer Derwinger. A pharmacokinetic and pharmacodynamic investigation of Modufolin® compared to Isovorin® after single dose intravenous administration to patients with colon cancer: a randomized study.
Cancer chemotherapy and pharmacology.
2015 Jan; 75(1):37-47. doi:
10.1007/s00280-014-2611-9. [PMID: 25342290] - Bridget Wilcken. Leukoencephalopathies associated with disorders of cobalamin and folate metabolism.
Seminars in neurology.
2012 Feb; 32(1):68-74. doi:
10.1055/s-0032-1306389. [PMID: 22422209] - Grazyna Kurzawińska, Agnieszka Seremak-Mrozikiewicz, Krzysztof Drews, Magdalena Barlik, Przemysław M Mrozikiewicz. [Genetic conditioned changes in activity of 5,10-methylenetetrahydrofolate reductase (MTHFR) and recurrent miscarriages].
Ginekologia polska.
2009 Oct; 80(10):762-7. doi:
. [PMID: 19943541] - José F Cascalheira, Sara S João, Sandra S Pinhanços, Rita Castro, Manuela Palmeira, Sofia Almeida, Maria C Faria, Fernanda C Domingues. Serum homocysteine: interplay with other circulating and genetic factors in association to Alzheimer's type dementia.
Clinical biochemistry.
2009 Jun; 42(9):783-90. doi:
10.1016/j.clinbiochem.2009.02.006. [PMID: 19232336] - Yvonne Lamers, Jerry Williamson, Maria Ralat, Eoin P Quinlivan, Lesa R Gilbert, Christine Keeling, Robert D Stevens, Christopher B Newgard, Per M Ueland, Klaus Meyer, Ase Fredriksen, Peter W Stacpoole, Jesse F Gregory. Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.
The Journal of nutrition.
2009 Mar; 139(3):452-60. doi:
10.3945/jn.108.099184. [PMID: 19158217] - V T Ramaekers, J Weis, J M Sequeira, E V Quadros, N Blau. Mitochondrial complex I encephalomyopathy and cerebral 5-methyltetrahydrofolate deficiency.
Neuropediatrics.
2007 Aug; 38(4):184-7. doi:
10.1055/s-2007-991150. [PMID: 18058625] - H Ashktorab, R Begum, A Akhgar, D T Smoot, M Elbedawi, M Daremipouran, A Zhao, B Momen, F M Giardiello. Folate status and risk of colorectal polyps in African Americans.
Digestive diseases and sciences.
2007 Jun; 52(6):1462-70. doi:
10.1007/s10620-006-9236-8. [PMID: 17372834] - Ken D Stark, Robert J Pawlosky, Robert J Sokol, John H Hannigan, Norman Salem. Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma.
The American journal of clinical nutrition.
2007 Mar; 85(3):796-802. doi:
10.1093/ajcn/85.3.796. [PMID: 17344502] - L Flicker, R N Martins, J Thomas, J Acres, K Taddei, P Norman, K Jamrozik, O P Almeida. Homocysteine, Alzheimer genes and proteins, and measures of cognition and depression in older men.
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