1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) (BioDeep_00000847468)

   


代谢物信息卡片


1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

化学式: C41H82O22P4 (1050.4247992)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)O)OC(=O)CCCCCCCCCCCCCCC
InChI: InChI=1S/C41H82O22P4/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)57-31-33(59-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-58-67(55,56)63-38-36(44)39(60-64(46,47)48)41(62-66(52,53)54)40(37(38)45)61-65(49,50)51/h33,36-41,44-45H,3-32H2,1-2H3,(H,55,56)(H2,46,47,48)(H2,49,50,51)(H2,52,53,54)/t33-,36+,37+,38-,39+,40-,41-/m1/s1

描述信息

A 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate in which the phosphatidyl acyl groups at positions 1 and 2 are both specified as hexadecanoyl (palmitoyl).

同义名列表

1 个代谢物同义名

1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Alessandra Luchini, Achebe N O Nzulumike, Tania K Lind, Tommy Nylander, Robert Barker, Lise Arleth, Kell Mortensen, Marité Cárdenas. Towards biomimics of cell membranes: Structural effect of phosphatidylinositol triphosphate (PIP3) on a lipid bilayer. Colloids and surfaces. B, Biointerfaces. 2019 Jan; 173(?):202-209. doi: 10.1016/j.colsurfb.2018.09.031. [PMID: 30292933]
  • Anastasiia Stratiievska, Sara Nelson, Eric N Senning, Jonathan D Lautz, Stephen Ep Smith, Sharona E Gordon. Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor. eLife. 2018 12; 7(?):. doi: 10.7554/elife.38869. [PMID: 30560783]
  • Constance Agamasu, Ruba H Ghanam, Jamil S Saad. Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt. The Journal of biological chemistry. 2015 Nov; 290(45):27403-27413. doi: 10.1074/jbc.m115.673939. [PMID: 26391397]
  • Xinxin Wang, Scott E Boyken, Jiancheng Hu, Xiaolu Xu, Ryan P Rimer, Madeline A Shea, Andrey S Shaw, Amy H Andreotti, Yina H Huang. Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production. Science signaling. 2014 Aug; 7(337):ra74. doi: 10.1126/scisignal.2005147. [PMID: 25097034]
  • Alessandra Reversi, Eva Loeser, Devaraj Subramanian, Carsten Schultz, Stefano De Renzis. Plasma membrane phosphoinositide balance regulates cell shape during Drosophila embryo morphogenesis. The Journal of cell biology. 2014 May; 205(3):395-408. doi: 10.1083/jcb.201309079. [PMID: 24798734]
  • Tim Ting Chiu, Yi Sun, Alexandra Koshkina, Amira Klip. Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance. The Journal of biological chemistry. 2013 Jun; 288(24):17520-31. doi: 10.1074/jbc.m113.467647. [PMID: 23640896]
  • Thang Manh Khuong, Ron L P Habets, Sabine Kuenen, Agata Witkowska, Jaroslaw Kasprowicz, Jef Swerts, Reinhard Jahn, Geert van den Bogaart, Patrik Verstreken. Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release. Neuron. 2013 Mar; 77(6):1097-108. doi: 10.1016/j.neuron.2013.01.025. [PMID: 23522045]
  • Craig N Lumb, Mark S P Sansom. Defining the membrane-associated state of the PTEN tumor suppressor protein. Biophysical journal. 2013 Feb; 104(3):613-21. doi: 10.1016/j.bpj.2012.12.002. [PMID: 23442912]
  • Xiao Wang, Lingdi Wang, Lu Zhu, Yi Pan, Fei Xiao, Weizhong Liu, Zhenzhen Wang, Feifan Guo, Yong Liu, Walter G Thomas, Yan Chen. PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Diabetes. 2013 Feb; 62(2):444-56. doi: 10.2337/db12-0244. [PMID: 23086038]
  • H Sun, L Jiang, X Luo, W Jin, Q He, J An, K Lui, J Shi, R Rong, W Su, C Lucchesi, Y Liu, M S Sheikh, Y Huang. Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer. Oncogene. 2013 Jan; 32(2):234-41. doi: 10.1038/onc.2012.34. [PMID: 22349814]
  • William's Elong Edimo, Jean-Marie Vanderwinden, Christophe Erneux. SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts. Advances in biological regulation. 2013 Jan; 53(1):28-37. doi: 10.1016/j.jbior.2012.09.003. [PMID: 23040614]
  • Amit Gupta, Chinmoy Sankar Dey. PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance. Molecular biology of the cell. 2012 Oct; 23(19):3882-98. doi: 10.1091/mbc.e12-05-0337. [PMID: 22875989]
  • Olof Idevall-Hagren, Eamonn J Dickson, Bertil Hille, Derek K Toomre, Pietro De Camilli. Optogenetic control of phosphoinositide metabolism. Proceedings of the National Academy of Sciences of the United States of America. 2012 Aug; 109(35):E2316-23. doi: 10.1073/pnas.1211305109. [PMID: 22847441]
  • Stephanie J Harris, Richard V Parry, John G Foster, Matthew D Blunt, Amu Wang, Federica Marelli-Berg, John Westwick, Stephen G Ward. Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility. Journal of immunology (Baltimore, Md. : 1950). 2011 Apr; 186(8):4936-45. doi: 10.4049/jimmunol.1002350. [PMID: 21402888]
  • Yulia Artemenko, Kristen F Swaney, Peter N Devreotes. Assessment of development and chemotaxis in Dictyostelium discoideum mutants. Methods in molecular biology (Clifton, N.J.). 2011; 769(?):287-309. doi: 10.1007/978-1-61779-207-6_20. [PMID: 21748684]
  • Michal Bohdanowicz, Gabriela Cosío, Jonathan M Backer, Sergio Grinstein. Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes. The Journal of cell biology. 2010 Nov; 191(5):999-1012. doi: 10.1083/jcb.201004005. [PMID: 21115805]
  • Il-Sun Kwon, Kyung-Hoon Lee, Joung Woo Choi, Jee-Yin Ahn. PI(3,4,5)P3 regulates the interaction between Akt and B23 in the nucleus. BMB reports. 2010 Feb; 43(2):127-32. doi: 10.5483/bmbrep.2010.43.2.127. [PMID: 20193132]
  • Weijiu Liu, ChingChun Hsin, Fusheng Tang. A molecular mathematical model of glucose mobilization and uptake. Mathematical biosciences. 2009 Oct; 221(2):121-9. doi: 10.1016/j.mbs.2009.07.005. [PMID: 19651146]
  • Yong Zhang, Sun Hyung Kwon, Walter K Vogel, Theresa M Filtz. PI(3,4,5)P3 potentiates phospholipase C-beta activity. Journal of receptor and signal transduction research. 2009; 29(1):52-62. doi: 10.1080/10799890902729449. [PMID: 19519170]
  • Kewei Ma, Samuel M Cheung, Aaron J Marshall, Vincent Duronio. PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity. Cellular signalling. 2008 Apr; 20(4):684-94. doi: 10.1016/j.cellsig.2007.12.004. [PMID: 18249092]
  • Kai S Erdmann, Yuxin Mao, Heather J McCrea, Roberto Zoncu, Sangyoon Lee, Summer Paradise, Jan Modregger, Daniel Biemesderfer, Derek Toomre, Pietro De Camilli. A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Developmental cell. 2007 Sep; 13(3):377-90. doi: 10.1016/j.devcel.2007.08.004. [PMID: 17765681]
  • Alexander Staruschenko, Oleh Pochynyuk, Alain Vandewalle, Vladislav Bugaj, James D Stockand. Acute regulation of the epithelial Na+ channel by phosphatidylinositide 3-OH kinase signaling in native collecting duct principal cells. Journal of the American Society of Nephrology : JASN. 2007 Jun; 18(6):1652-61. doi: 10.1681/asn.2007010020. [PMID: 17442787]
  • Oliver Hoeller, Robert R Kay. Chemotaxis in the absence of PIP3 gradients. Current biology : CB. 2007 May; 17(9):813-7. doi: 10.1016/j.cub.2007.04.004. [PMID: 17462897]
  • WenYan Niu, Manabu Ishiki, Philip J Bilan, Zhi Yao. Glucose transporter 4 can be inserted in the membrane without exposing its catalytic site for photolabeling from the medium. Science in China. Series C, Life sciences. 2007 Apr; 50(2):147-54. doi: 10.1007/s11427-007-0026-0. [PMID: 17447020]
  • R Michael Sharrard, Norman J Maitland. Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines. Cellular signalling. 2007 Jan; 19(1):129-38. doi: 10.1016/j.cellsig.2006.05.029. [PMID: 16842970]
  • Elita Avota, Harry Harms, Sibylle Schneider-Schaulies. Measles virus induces expression of SIP110, a constitutively membrane clustered lipid phosphatase, which inhibits T cell proliferation. Cellular microbiology. 2006 Nov; 8(11):1826-39. doi: 10.1111/j.1462-5822.2006.00752.x. [PMID: 16824039]
  • Maude Tessier, James R Woodgett. Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3. The Journal of biological chemistry. 2006 Aug; 281(33):23978-89. doi: 10.1074/jbc.m604333200. [PMID: 16790420]
  • Francisca Vazquez, Peter Devreotes. Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. Cell cycle (Georgetown, Tex.). 2006 Jul; 5(14):1523-7. doi: 10.4161/cc.5.14.3005. [PMID: 16861931]
  • John F Andersen, José M C Ribeiro. A secreted salivary inositol polyphosphate 5-phosphatase from a blood-feeding insect: allosteric activation by soluble phosphoinositides and phosphatidylserine. Biochemistry. 2006 May; 45(17):5450-7. doi: 10.1021/bi052444j. [PMID: 16634626]
  • Linnia H Mayeenuddin, William E McIntire, James C Garrison. Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers. The Journal of biological chemistry. 2006 Jan; 281(4):1913-20. doi: 10.1074/jbc.m506034200. [PMID: 16301321]
  • Markku Lehto, Riikka Hynynen, Katja Karjalainen, Esa Kuismanen, Kati Hyvärinen, Vesa M Olkkonen. Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants. Experimental cell research. 2005 Nov; 310(2):445-62. doi: 10.1016/j.yexcr.2005.08.003. [PMID: 16143324]
  • Clare M Wain, John Westwick, Stephen G Ward. Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes. Cellular signalling. 2005 Oct; 17(10):1194-202. doi: 10.1016/j.cellsig.2004.12.009. [PMID: 16038794]
  • Shaun W Lee, Dustin L Higashi, Aurelie Snyder, Alexey J Merz, Laura Potter, Magdalene So. PilT is required for PI(3,4,5)P3-mediated crosstalk between Neisseria gonorrhoeae and epithelial cells. Cellular microbiology. 2005 Sep; 7(9):1271-84. doi: 10.1111/j.1462-5822.2005.00551.x. [PMID: 16098215]
  • Damian B van Rossum, Randen L Patterson, Sumit Sharma, Roxanne K Barrow, Michael Kornberg, Donald L Gill, Solomon H Snyder. Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature. 2005 Mar; 434(7029):99-104. doi: 10.1038/nature03340. [PMID: 15744307]
  • Venizelos Papayannopoulos, Carl Co, Kenneth E Prehoda, Scott Snapper, Jack Taunton, Wendell A Lim. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Molecular cell. 2005 Jan; 17(2):181-91. doi: 10.1016/j.molcel.2004.11.054. [PMID: 15664188]
  • Khaled Ali, Antonio Bilancio, Matthew Thomas, Wayne Pearce, Alasdair M Gilfillan, Christine Tkaczyk, Nicolas Kuehn, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, Carol Sawyer, Klaus Okkenhaug, Peter Finan, Bart Vanhaesebroeck. Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature. 2004 Oct; 431(7011):1007-11. doi: 10.1038/nature02991. [PMID: 15496927]
  • Alexias Safi, Marie Vandromme, Sabine Caussanel, Laure Valdacci, Dominique Baas, Marc Vidal, Gilbert Brun, Laurent Schaeffer, Evelyne Goillot. Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation. Molecular and cellular biology. 2004 Feb; 24(3):1245-55. doi: 10.1128/mcb.24.3.1245-1255.2004. [PMID: 14729969]
  • Annemarie Gagnon, Yulia Artemenko, Thet Crapper, Alexander Sorisky. Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes. Journal of cellular physiology. 2003 Nov; 197(2):243-50. doi: 10.1002/jcp.10367. [PMID: 14502564]
  • Masaru Ishii, Atsushi Inanobe, Yoshihisa Kurachi. PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 2002 Apr; 99(7):4325-30. doi: 10.1073/pnas.072073399. [PMID: 11904384]
  • R H Insall, O D Weiner. PIP3, PIP2, and cell movement--similar messages, different meanings?. Developmental cell. 2001 Dec; 1(6):743-7. doi: 10.1016/s1534-5807(01)00086-7. [PMID: 11740936]
  • T Wada, T Sasaoka, M Funaki, H Hori, S Murakami, M Ishiki, T Haruta, T Asano, W Ogawa, H Ishihara, M Kobayashi. Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. Molecular and cellular biology. 2001 Mar; 21(5):1633-46. doi: 10.1128/mcb.21.5.1633-1646.2001. [PMID: 11238900]
  • L Dowal, J Elliott, S Popov, T M Wilkie, S Scarlata. Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1. Biochemistry. 2001 Jan; 40(2):414-21. doi: 10.1021/bi001923+. [PMID: 11148035]
  • S Dowler, R A Currie , D G Campbell , M Deak, G Kular, C P Downes, D R Alessi. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. The Biochemical journal. 2000 Oct; 351(Pt 1):19-31. doi: 10.1042/0264-6021:3510019. [PMID: 11001876]
  • A L Hsu, T T Ching, G Sen, D S Wang, S Bondada, K S Authi, C S Chen. Novel function of phosphoinositide 3-kinase in T cell Ca2+ signaling. A phosphatidylinositol 3,4,5-trisphosphate-mediated Ca2+ entry mechanism. The Journal of biological chemistry. 2000 May; 275(21):16242-50. doi: 10.1074/jbc.m002077200. [PMID: 10748064]
  • A Gagnon, C S Chen, A Sorisky. Activation of protein kinase B and induction of adipogenesis by insulin in 3T3-L1 preadipocytes: contribution of phosphoinositide-3,4,5-trisphosphate versus phosphoinositide-3,4-bisphosphate. Diabetes. 1999 Apr; 48(4):691-8. doi: 10.2337/diabetes.48.4.691. [PMID: 10102683]
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