alpha-D-galactosyl-(1->3)-D-galactose (BioDeep_00000847290)
Metabolite Card
alpha-D-galactosyl-(1->3)-D-galactose
Formula: C12H22O11 (342.1162)
Chinese Names:
Spectrum Hits:
Top Source () 0%
Molecular Structure
SMILES: C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)CO)O)O)O)O)O
InChI: InChI=1S/C12H22O11/c13-1-3-5(15)7(17)8(18)12(22-3)23-10-6(16)4(2-14)21-11(20)9(10)19/h3-20H,1-2H2/t3-,4-,5+,6+,7+,8-,9-,10+,11?,12-/m1/s1
Cross Reference
Classification Terms
Related Pathways
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PlantCyc(0)
Biological Process
0 related biological process reactions.
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
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0 organism taxonomy source information
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
Literature Reference
- Beatrice Aiuto, Simona Cirrincione, Maria Gabriella Giuffrida, Laura Cavallarin, Chiara Portesi, Andrea Mario Rossi, Giorgio Borreani, Giovanni Rolla, Massimo Geuna, Stefania Nicola, Anna Quinternetto, Lucrezia Alessi, Elena Saracco, Luisa Brussino, Cristina Lamberti. Title Not Available.
Molecular nutrition & food research.
2024 May; 68(10):e2300796. doi:
10.1002/mnfr.202300796. [PMID: 38704747] - Tatenda Murangi, Prema Prakash, Bernardo Pereira Moreira, Wisdom Basera, Maresa Botha, Stephen Cunningham, Heidi Facey-Thomas, Ali Halajian, Lokesh Joshi, Jordache Ramjith, Franco H Falcone, William Horsnell, Michael E Levin. Ascaris lumbricoides and ticks associated with sensitization to galactose α1,3-galactose and elicitation of the alpha-gal syndrome.
The Journal of allergy and clinical immunology.
2022 02; 149(2):698-707.e3. doi:
10.1016/j.jaci.2021.07.018. [PMID: 34333031] - Elie Dolgin. Pig kidney transplant obscures value of engineered animals.
Science (New York, N.Y.).
2021 Nov; 374(6568):668-669. doi:
10.1126/science.acx9536. [PMID: 34735240] - Eun Jin Lee, Haneulnari Lee, Eun Mi Park, Hee Jung Kang, Sang Joon Kim, Chung-Gyu Park. Immunoglobulin M and Immunoglobulin G Subclass Distribution of Anti-galactose-Alpha-1,3-Galactose and Anti-N-Glycolylneuraminic Acid Antibodies in Healthy Korean Adults.
Transplantation proceedings.
2021 Jun; 53(5):1762-1770. doi:
10.1016/j.transproceed.2021.01.011. [PMID: 33581850] - Julien Serrier, Kathy Khoy, Yann Ollivier, Radj Gervais, Gabriel Le Moel, Marion Lafosse, Alison Johnson, Brigitte Le Mauff, Delphine Mariotte. Recurrent anaphylaxis to a gelatin-based colloid plasma substitute and to cetuximab following sensitisation to galactose-alpha-1,3-galactose.
British journal of anaesthesia.
2021 06; 126(6):e200-e202. doi:
10.1016/j.bja.2021.02.013. [PMID: 33810867] - Jeffrey M Wilson, Behnam Keshavarz, Hayley R James, Maya K C Retterer, Alexander J Schuyler, Alice Knoedler, Lisa J Workman, Lucy Ng'ang'a, Martha E Chico, Eva Rönmark, Peter W Heymann, Matthew S Perzanowski, Thomas A E Platts-Mills, Philip J Cooper. α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgG4.
The Journal of allergy and clinical immunology.
2021 04; 147(4):1393-1401.e7. doi:
10.1016/j.jaci.2020.12.650. [PMID: 33539899] - José Miguel Urra, Elisa Ferreras-Colino, Marinela Contreras, Carmen M Cabrera, Isabel G Fernández de Mera, Margarita Villar, Alejandro Cabezas-Cruz, Christian Gortázar, José de la Fuente. The antibody response to the glycan α-Gal correlates with COVID-19 disease symptoms.
Journal of medical virology.
2021 04; 93(4):2065-2075. doi:
10.1002/jmv.26575. [PMID: 33009829] - Nathan E Richards, Robert D Richards. Alpha-Gal Allergy as a Cause of Intestinal Symptoms in a Gastroenterology Community Practice.
Southern medical journal.
2021 Mar; 114(3):169-173. doi:
10.14423/smj.0000000000001223. [PMID: 33655311] - Cedar L Mitchell, Feng-Chang Lin, Meagan Vaughn, Charles S Apperson, Steven R Meshnick, Scott P Commins. Association between lone star tick bites and increased alpha-gal sensitization: evidence from a prospective cohort of outdoor workers.
Parasites & vectors.
2020 Sep; 13(1):470. doi:
10.1186/s13071-020-04343-4. [PMID: 32928302] - Jens Magnus Bernth Jensen, Nick Stub Laursen, Rasmus Kjeldsen Jensen, Gregers Rom Andersen, Jens Christian Jensenius, Uffe B Skov Sørensen, Steffen Thiel. Complement activation by human IgG antibodies to galactose-α-1,3-galactose.
Immunology.
2020 09; 161(1):66-79. doi:
10.1111/imm.13229. [PMID: 32583419] - Maja Krstić Ristivojević, Jeanette Grundström, Danijela Apostolović, Mirjana Radomirović, Vesna Jovanović, Vlad Radoi, M B Gea Kiewiet, Vladana Vukojević, Tanja Ćirković Veličković, Marianne van Hage. Alpha-Gal on the Protein Surface Hampers Transcytosis through the Caco-2 Monolayer.
International journal of molecular sciences.
2020 Aug; 21(16):. doi:
10.3390/ijms21165742. [PMID: 32796496] - Jens Magnus Bernth Jensen, Mikkel Steen Petersen, Svend Ellerman-Eriksen, Bjarne Kuno Møller, Jens Christian Jensenius, Uffe B Skov Sørensen, Steffen Thiel. Abundant human anti-Galα3Gal antibodies display broad pathogen reactivity.
Scientific reports.
2020 03; 10(1):4611. doi:
10.1038/s41598-020-61632-9. [PMID: 32165720] - C Abreu, B Bartolomé, L Cunha, H Falcão. Galactose-α-1,3-galactose allergy: a rare syndrome and an atypical presentation.
European annals of allergy and clinical immunology.
2018 07; 50(4):190-192. doi:
10.23822/eurannaci.1764-1489.49. [PMID: 29479927] - Da Woon Sim, Jong Sun Lee, Kyung Hee Park, Kyoung Yong Jeong, Young-Min Ye, Jae-Hyun Lee, Jung-Won Park. Accurate assessment of alpha-gal syndrome using cetuximab and bovine thyroglobulin-specific IgE.
Molecular nutrition & food research.
2017 10; 61(10):. doi:
10.1002/mnfr.201601046. [PMID: 28497612] - Andreas J Bircher, Kathrin Scherer Hofmeier, Susanne Link, Ingmar Heijnen. Food allergy to the carbohydrate galactose-alpha-1,3-galactose (alpha-gal): four case reports and a review.
European journal of dermatology : EJD.
2017 Feb; 27(1):3-9. doi:
10.1684/ejd.2016.2908. [PMID: 27873733] - Ivar Tjernberg, Carl Hamsten, Danijela Apostolovic, Marianne van Hage. IgE reactivity to α-Gal in relation to Lyme borreliosis.
PloS one.
2017; 12(9):e0185723. doi:
10.1371/journal.pone.0185723. [PMID: 28953957] - Jared Weiss, Juneko Grilley Olson, Allison Mary Deal, Bhishamjit Chera, Mark Weissler, Barbara A Murphy, David Neil Hayes, Jill Gilbert. Using the galactose-α-1,3-galactose enzyme-linked immunosorbent assay to predict anaphylaxis in response to cetuximab.
Cancer.
2016 06; 122(11):1697-701. doi:
10.1002/cncr.29978. [PMID: 26989991] - David K C Cooper, Burcin Ekser, Jagdeece Ramsoondar, Carol Phelps, David Ayares. The role of genetically engineered pigs in xenotransplantation research.
The Journal of pathology.
2016 Jan; 238(2):288-99. doi:
10.1002/path.4635. [PMID: 26365762] - Robert Ramm, Thorsten Hartmann, Igor Tudorache, Axel Haverich, Andres Hilfiker. No evidence for αGal epitope transfer from media containing FCS onto human endothelial cells in culture.
Xenotransplantation.
2015 Sep; 22(5):345-55. doi:
10.1111/xen.12183. [PMID: 26301779] - Agnes M Azimzadeh, Sean S Kelishadi, Mohamed B Ezzelarab, Avneesh K Singh, Tiffany Stoddard, Hayato Iwase, Tianshu Zhang, Lars Burdorf, Evelyn Sievert, Chris Avon, Xiangfei Cheng, David Ayares, Keith A Horvath, Philip C Corcoran, Muhammad M Mohiuddin, Rolf N Barth, David K C Cooper, Richard N Pierson. Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein.
Xenotransplantation.
2015 Jul; 22(4):310-6. doi:
10.1111/xen.12176. [PMID: 26174749] - Marcus Maurer, Martin K Church, Martin Metz, Maria Starkhammar, Carl Hamsten, Marianne van Hage. Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria.
International archives of allergy and immunology.
2015; 167(4):250-2. doi:
10.1159/000440653. [PMID: 26426899] - Barbara K Ballmer-Weber. Food allergy in adolescence and adulthood.
Chemical immunology and allergy.
2015; 101(?):51-8. doi:
10.1159/000371669. [PMID: 26022864] - A Uyttebroek, V Sabato, C H Bridts, L S De Clerck, D G Ebo. Anaphylaxis to succinylated gelatin in a patient with a meat allergy: galactose-α(1, 3)-galactose (α-gal) as antigenic determinant.
Journal of clinical anesthesia.
2014 Nov; 26(7):574-6. doi:
10.1016/j.jclinane.2014.04.014. [PMID: 25439422] - Scott P Commins, Hayley R James, Whitney Stevens, Shawna L Pochan, Michael H Land, Carol King, Susan Mozzicato, Thomas A E Platts-Mills. Delayed clinical and ex vivo response to mammalian meat in patients with IgE to galactose-alpha-1,3-galactose.
The Journal of allergy and clinical immunology.
2014 Jul; 134(1):108-15. doi:
10.1016/j.jaci.2014.01.024. [PMID: 24656556] - David Cohen, Yuko Miyagawa, Ruhina Mehra, Whayoung Lee, Kumiko Isse, Cassandra Long, David L Ayares, David K C Cooper, Hidetaka Hara. Distribution of non-gal antigens in pig cornea: relevance to corneal xenotransplantation.
Cornea.
2014 Apr; 33(4):390-7. doi:
10.1097/ico.0000000000000069. [PMID: 24488129] - Christopher G A McGregor, Heide Kogelberg, Michal Vlasin, Guerard W Byrne. Gal-knockout bioprostheses exhibit less immune stimulation compared to standard biological heart valves.
The Journal of heart valve disease.
2013 May; 22(3):383-90. doi:
NULL. [PMID: 24151765] - C Hamsten, M Starkhammar, T A T Tran, M Johansson, U Bengtsson, G Ahlén, M Sällberg, H Grönlund, M van Hage. Identification of galactose-α-1,3-galactose in the gastrointestinal tract of the tick Ixodes ricinus; possible relationship with red meat allergy.
Allergy.
2013 Apr; 68(4):549-52. doi:
10.1111/all.12128. [PMID: 23414348] - Stephen Cunningham, Emily Starr, Iain Shaw, John Glavin, Marian Kane, Lokesh Joshi. Development of a convenient competitive ELISA for the detection of the free and protein-bound nonhuman galactosyl-α-(1,3)-galactose epitope based on highly specific chicken single-chain antibody variable-region fragments.
Analytical chemistry.
2013 Jan; 85(2):949-55. doi:
10.1021/ac302587q. [PMID: 23215249] - M Morisset, C Richard, C Astier, S Jacquenet, A Croizier, E Beaudouin, V Cordebar, F Morel-Codreanu, N Petit, D A Moneret-Vautrin, G Kanny. Anaphylaxis to pork kidney is related to IgE antibodies specific for galactose-alpha-1,3-galactose.
Allergy.
2012 May; 67(5):699-704. doi:
10.1111/j.1398-9995.2012.02799.x. [PMID: 22494361] - Gisella L Puga Yung, Yunsen Li, Lubor Borsig, Anne-Laure Millard, Maria B Karpova, Dapeng Zhou, Jörg D Seebach. Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1,3galactosyltransferase knock-out pigs.
Xenotransplantation.
2012 May; 19(3):196-206. doi:
10.1111/j.1399-3089.2012.00705.x. [PMID: 22702471] - Christopher G A McGregor, Davide Ricci, Naoto Miyagi, Paul G Stalboerger, Zeji Du, Elise A Oehler, Henry D Tazelaar, Guerard W Byrne. Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts.
Transplantation.
2012 Apr; 93(7):686-92. doi:
10.1097/tp.0b013e3182472850. [PMID: 22391577] - Scott P Commins, Libby A Kelly, Eva Rönmark, Hayley R James, Shawna L Pochan, Edward J Peters, Bo Lundbäck, Lucy W Nganga, Philip J Cooper, Janelle M Hoskins, Saju S Eapen, Luis A Matos, Dane C McBride, Peter W Heymann, Judith A Woodfolk, Matthew S Perzanowski, Thomas A E Platts-Mills. Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.
American journal of respiratory and critical care medicine.
2012 Apr; 185(7):723-30. doi:
10.1164/rccm.201111-2017oc. [PMID: 22281828] - Beatrice Lyimo, Natsumi Funakuma, Yuji Minami, Fumio Yagi. Characterization of a new α-galactosyl-binding lectin from the mushroom Clavaria purpurea.
Bioscience, biotechnology, and biochemistry.
2012; 76(2):336-42. doi:
10.1271/bbb.110732. [PMID: 22313779] - Libby A Kelly, Elizabeth A Erwin, Thomas A E Platts-Mills. The indoor air and asthma: the role of cat allergens.
Current opinion in pulmonary medicine.
2012 Jan; 18(1):29-34. doi:
10.1097/mcp.0b013e32834db10d. [PMID: 22081090] - Jens Magnus Bernth-Jensen, Bjarne Kuno Møller, Jens Christian Jensenius, Steffen Thiel. Biological variation of anti-αGal-antibodies studied by a novel Time-Resolved ImmunoFluorometric Assay.
Journal of immunological methods.
2011 Oct; 373(1-2):26-35. doi:
10.1016/j.jim.2011.07.017. [PMID: 21835180] - Hidetaka Hara, Naoko Koike, Cassandra Long, Jordan Piluek, Danny S Roh, Nirmala SundarRaj, James L Funderburgh, Yoshiaki Mizuguchi, Kumiko Isse, Carol J Phelps, Suyapa F Ball, David L Ayares, David K C Cooper. Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs.
Investigative ophthalmology & visual science.
2011 Jul; 52(8):5278-86. doi:
10.1167/iovs.10-6947. [PMID: 21596821] - Scott P Commins, Hayley R James, Libby A Kelly, Shawna L Pochan, Lisa J Workman, Matthew S Perzanowski, Katherine M Kocan, John V Fahy, Lucy W Nganga, Eva Ronmark, Philip J Cooper, Thomas A E Platts-Mills. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.
The Journal of allergy and clinical immunology.
2011 May; 127(5):1286-93.e6. doi:
10.1016/j.jaci.2011.02.019. [PMID: 21453959] - Elwira Lisowska, Maria Duk. Diversity of natural anti-α-galactosyl antibodies in human serum.
Advances in experimental medicine and biology.
2011; 705(?):571-83. doi:
10.1007/978-1-4419-7877-6_30. [PMID: 21618130] - Akira Shimizu, Kazuhiko Yamada. Histopathology of xenografts in pig to non-human primate discordant xenotransplantation.
Clinical transplantation.
2010 Jul; 24 Suppl 22(?):11-5. doi:
10.1111/j.1399-0012.2010.01270.x. [PMID: 20590687] - Caroline M W van Stijn, Marloes van den Broek, Lonneke Vervelde, Richard A Alvarez, Richard D Cummings, Boris Tefsen, Irma van Die. Vaccination-induced IgG response to Galalpha1-3GalNAc glycan epitopes in lambs protected against Haemonchus contortus challenge infection.
International journal for parasitology.
2010 Feb; 40(2):215-22. doi:
10.1016/j.ijpara.2009.07.009. [PMID: 19695255] - Scott P Commins, Thomas A E Platts-Mills. Allergenicity of carbohydrates and their role in anaphylactic events.
Current allergy and asthma reports.
2010 Jan; 10(1):29-33. doi:
10.1007/s11882-009-0079-1. [PMID: 20425511] - Scott H Sicherer, Donald Y M Leung. Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009.
The Journal of allergy and clinical immunology.
2010 Jan; 125(1):85-97. doi:
10.1016/j.jaci.2009.11.031. [PMID: 20109740] - Hui Xu, Hua Wan, Wenqi Zuo, Wendell Sun, Rick T Owens, John R Harper, David L Ayares, David J McQuillan. A porcine-derived acellular dermal scaffold that supports soft tissue regeneration: removal of terminal galactose-alpha-(1,3)-galactose and retention of matrix structure.
Tissue engineering. Part A.
2009 Jul; 15(7):1807-19. doi:
10.1089/ten.tea.2008.0384. [PMID: 19196142] - Karla J Posekany, John E Wiley, Gregory A Gagnon. A novel method to display [gal alpha1, 3 gal] antigens on human leukemic cells for preparation of anti-leukemia vaccines.
Anticancer research.
2009 Jun; 29(6):2387-92. doi:
NULL. [PMID: 19528506] - Scott P Commins, Shama M Satinover, Jacob Hosen, Jonathan Mozena, Larry Borish, Barrett D Lewis, Judith A Woodfolk, Thomas A E Platts-Mills. Delayed anaphylaxis, angioedema, or urticaria after consumption of red meat in patients with IgE antibodies specific for galactose-alpha-1,3-galactose.
The Journal of allergy and clinical immunology.
2009 Feb; 123(2):426-33. doi:
10.1016/j.jaci.2008.10.052. [PMID: 19070355] - Sharon I Gundersen, Melanie S Kennedy, Andre F Palmer. Immune recognition of exposed xenoantigens on the surface of PEGylated bovine red blood cells.
Biotechnology and bioengineering.
2008 Oct; 101(2):337-44. doi:
10.1002/bit.21908. [PMID: 18454498] - Dale Christiansen, Julie Milland, Effie Mouhtouris, Hilary Vaughan, Daniel G Pellicci, Malcolm J McConville, Dale I Godfrey, Mauro S Sandrin. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.
PLoS biology.
2008 Jul; 6(7):e172. doi:
10.1371/journal.pbio.0060172. [PMID: 18630988] - Min Zhu, Wei Zhang, Fang Liu, Lu Wang, Bin Liu, Dong Chen, Xue-Hai Zhu, Wei-Jie Zhang, Thomas E Ichim, Zhi-Shui Chen, Ping Zhou, Shi Chen, Gang Chen. Resistance to anti-xenogeneic response by combining alpha-Gal silencing with HO-1 upregulation.
Transplant immunology.
2008 Jul; 19(3-4):202-8. doi:
10.1016/j.trim.2008.06.002. [PMID: 18598766] - Christine H Chung, Beloo Mirakhur, Emily Chan, Quynh-Thu Le, Jordan Berlin, Michael Morse, Barbara A Murphy, Shama M Satinover, Jacob Hosen, David Mauro, Robbert J Slebos, Qinwei Zhou, Diane Gold, Tina Hatley, Daniel J Hicklin, Thomas A E Platts-Mills. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose.
The New England journal of medicine.
2008 Mar; 358(11):1109-17. doi:
10.1056/nejmoa074943. [PMID: 18337601] - Mette Diswall, Jonas Angström, Henk-Jan Schuurman, Frank J M F Dor, Lennart Rydberg, Michael E Breimer. Studies on glycolipid antigens in small intestine and pancreas from alpha1,3-galactosyltransferase knockout miniature swine.
Transplantation.
2007 Nov; 84(10):1348-56. doi:
10.1097/01.tp.0000287599.46165.15. [PMID: 18049121] - Julie Milland, Elizabeth Yuriev, Pei-Xiang Xing, Ian F C McKenzie, Paul A Ramsland, Mauro S Sandrin. Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies.
Immunology and cell biology.
2007 Nov; 85(8):623-32. doi:
10.1038/sj.icb.7100111. [PMID: 17724458] - Hyeon Ii Lee, Mee Kum Kim, Joo Youn Oh, Jung Hwa Ko, Hyun Ju Lee, Won Ryang Wee, Jin Hak Lee. Gal alpha(1-3)Gal expression of the cornea in vitro, in vivo and in xenotransplantation.
Xenotransplantation.
2007 Nov; 14(6):612-8. doi:
10.1111/j.1399-3089.2007.00433.x. [PMID: 17991149] - Polina Obukhova, Robert Rieben, Nicolai Bovin. Normal human serum contains high levels of anti-Gal alpha 1-4GlcNAc antibodies.
Xenotransplantation.
2007 Nov; 14(6):627-35. doi:
10.1111/j.1399-3089.2007.00436.x. [PMID: 17991151] - Marit Saethre, Bettina C Baumann, Michael Fung, Jörg D Seebach, Tom Eirik Mollnes. Characterization of natural human anti-non-gal antibodies and their effect on activation of porcine gal-deficient endothelial cells.
Transplantation.
2007 Jul; 84(2):244-50. doi:
10.1097/01.tp.0000268815.90675.d5. [PMID: 17667817] - Antoine Dürrbach, Emma Baple, Andrew F Preece, Bernard Charpentier, Kenth Gustafsson. Virus recognition by specific natural antibodies and complement results in MHC I cross-presentation.
European journal of immunology.
2007 May; 37(5):1254-65. doi:
10.1002/eji.200636129. [PMID: 17407191] - NULL. Satellite Symposium on Xenotransplantation.
Xenotransplantation.
2007 Mar; 14(2):174-89. doi:
NULL. [PMID: 17455376] - Bettina C Baumann, Georg Stussi, Katja Huggel, Robert Rieben, Jörg D Seebach. Reactivity of human natural antibodies to endothelial cells from Galalpha(1,3)Gal-deficient pigs.
Transplantation.
2007 Jan; 83(2):193-201. doi:
10.1097/01.tp.0000250478.00567.e5. [PMID: 17264816] - Miguel Pérez Fontán, Rafael Máñez, Ana Rodríguez-Carmona, Javier Peteiro, Verónica Martínez, Teresa García-Falcón, Nieves Domenech. Serum levels of anti-alphaGalactosyl antibodies predict survival and peritoneal dialysis-related enteric peritonitis rates in patients undergoing renal replacement therapy.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2006 Dec; 48(6):972-82. doi:
10.1053/j.ajkd.2006.08.027. [PMID: 17162152] - Maria Duk, Elwira Lisowska. Presence of natural anti-Galalpha1-4GalNAcbeta1-3Gal (anti-NOR) antibodies in animal sera.
Glycoconjugate journal.
2006 Nov; 23(7-8):585-90. doi:
10.1007/s10719-006-8188-8. [PMID: 17006649] - Tomás M Díaz-Román, Rafael Mañez, Eduardo López-Pelaez, Alberto Centeno, Isabel Moscoso, Sonia Pértegaz, Nieves Doménech. Human DAF on pig cells protects against human and non-human primate sera cytotoxicity mediated by exogenous or endogenous complement, as determined by flow cytometry.
Transplant immunology.
2006 Aug; 16(2):125-30. doi:
10.1016/j.trim.2006.03.008. [PMID: 16860716] - James M G Larkin, Peter J Norsworthy, Roger P A'Hern, Tim G Eisen, Martin E Gore, Colin D Porter. Anti-alphaGal-dependent complement-mediated cytotoxicity in metastatic melanoma.
Melanoma research.
2006 Apr; 16(2):157-63. doi:
10.1097/01.cmr.0000200490.62723.b0. [PMID: 16567971] - Yuanxin Xu, Yong-Guang Yang, Hideki Ohdan, David Ryan, David Harper, Cecelia Wu, Huw S Kruger-Grey, Aron D Thall, Michel Awwad, Megan Sykes. Characterization of anti-Gal antibody-producing cells of baboons and humans.
Transplantation.
2006 Mar; 81(6):940-8. doi:
10.1097/01.tp.0000203300.87272.a3. [PMID: 16570021] - Philip J O'Connell. Thrombotic microangiopathy: the next big hurdle for xenotransplantation.
Journal of the American Society of Nephrology : JASN.
2005 Sep; 16(9):2529-30. doi:
10.1681/asn.2005070735. [PMID: 16093447] - Paul B Yu, William Parker, Jayakar V Nayak, Jeffrey L Platt. Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies.
Transplantation.
2005 Jul; 80(1):102-9. doi:
10.1097/01.tp.0000162976.07023.6d. [PMID: 16003240] - Maarten-Paul van de Kerkhove, Menno R Germans, Tanja Deurholt, Ruurdtje Hoekstra, David H Joziasse, Albert C W A van Wijk, Thomas M van Gulik, Robert A F M Chamuleau, Anja Roos. Evidence for Galalpha(1-3)Gal expression on primary porcine hepatocytes: implications for bioartificial liver systems.
Journal of hepatology.
2005 Apr; 42(4):541-7. doi:
10.1016/j.jhep.2004.11.041. [PMID: 15763340] - Luyang Yu, Hongsheng Miao, Lihe Guo. Effect of RNA interference on Gal alpha 1,3 Gal expression in PIEC cells.
DNA and cell biology.
2005 Apr; 24(4):235-43. doi:
10.1089/dna.2005.24.235. [PMID: 15812240] - Muriel Aubert, Christian Crotte, Liliane Benkoel, Laurence Panicot-Dubois, Jean-Paul Bernard, Dominique Lombardo, Marie-Odile Sadoulet, Eric Mas. Relationship between alphaGal epitope expression and decrease of tumorigenicity in pancreatic adenocarcinoma model.
Molecular carcinogenesis.
2005 Apr; 42(4):202-12. doi:
10.1002/mc.20082. [PMID: 15761838] - Luyang Yu, Hongsheng Miao, Lihe Guo. Effect of RNA interference on Gal alpha 1,3 Gal expression in PIEC cells.
DNA and cell biology.
2005 Mar; 24(3):180-8. doi:
10.1089/dna.2005.24.180. [PMID: 15767784] - E P Smorodin, O A Kurtenkov, I N Shevchuk, R H Tanner. The isolation and characterization of human natural alphaGal-specific IgG antibodies applicable to the detection of alphaGal-glycosphingolipids.
Journal of immunoassay & immunochemistry.
2005; 26(2):145-56. doi:
10.1081/ias-200051999. [PMID: 15794123] - Kazuhiko Yamada, Koji Yazawa, Akira Shimizu, Takehiro Iwanaga, Yosuke Hisashi, Matthew Nuhn, Patricia O'Malley, Shuji Nobori, Parsia A Vagefi, Clive Patience, Jay Fishman, David K C Cooper, Robert J Hawley, Julia Greenstein, Henk-Jan Schuurman, Michel Awwad, Megan Sykes, David H Sachs. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Nature medicine.
2005 Jan; 11(1):32-4. doi:
10.1038/nm1172. [PMID: 15619627] - T M Díaz, R Mañez, I Moscoso, D López, I Santamarina, E Lopez, A Centeno, N Domenéch. The serum level of xenoantibodies, and hDAF or alphaGAL expression on pig cells, modulate in vitro the protection given by hDAF to primate complement-mediated damage.
Transplantation proceedings.
2005 Jan; 37(1):510-1. doi:
10.1016/j.transproceed.2005.02.020. [PMID: 15808692] - Tuan T Lam, Ricardo Paniagua, Giridhar Shivaram, Henk-Jan Schuurman, Dominique C Borie, Randall E Morris. Anti-non-Gal porcine endothelial cell antibodies in acute humoral xenograft rejection of hDAF-transgenic porcine hearts in cynomolgus monkeys.
Xenotransplantation.
2004 Nov; 11(6):531-5. doi:
10.1111/j.1399-3089.2004.00175.x. [PMID: 15479463] - Tim Key, Henk-Jan Schuurman, Craig J Taylor. Does exposure to swine leukocyte antigens after pig-to-nonhuman primate xenotransplantation provoke antibodies that cross-react with human leukocyte antigens?.
Xenotransplantation.
2004 Sep; 11(5):452-6. doi:
10.1111/j.1399-3089.2004.00167.x. [PMID: 15303982] - Rafael Mañez, Nieves Domenech, Alberto Centeno, Eduardo Lopez-Pelaez, Fabian Crespo, Alberto Juffe, Rudolf O Duthaler, Andreas G Katopodis. Failure to deplete anti-Galalpha1-3Gal antibodies after pig-to-baboon organ xenotransplantation by immunoaffinity columns containing multiple Galalpha1-3Gal oligosaccharides.
Xenotransplantation.
2004 Sep; 11(5):408-15. doi:
10.1111/j.1399-3089.2004.00152.x. [PMID: 15303977] - Frank J M F Dor, Yau-Lin Tseng, Jane Cheng, Kathleen Moran, Todd M Sanderson, Courtney J Lancos, Akira Shimizu, Kazuhiko Yamada, Michel Awwad, David H Sachs, Robert J Hawley, Henk-Jan Schuurman, David K C Cooper. alpha1,3-Galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies.
Transplantation.
2004 Jul; 78(1):15-20. doi:
10.1097/01.tp.0000130487.68051.eb. [PMID: 15257033] - Saema Magre, Yasuhiro Takeuchi, Gillian Langford, Andrew Richards, Clive Patience, Robin Weiss. Reduced sensitivity to human serum inactivation of enveloped viruses produced by pig cells transgenic for human CD55 or deficient for the galactosyl-alpha(1-3) galactosyl epitope.
Journal of virology.
2004 Jun; 78(11):5812-9. doi:
10.1128/jvi.78.11.5812-5819.2004. [PMID: 15140979] - Gary Quinn, James C Wood, David J J Ryan, Kristen M Suling, Kathleen M Moran, Donna L Kolber-Simonds, Julia L Greenstein, Henk-Jan Schuurman, Robert J Hawley, Clive Patience. Porcine endogenous retrovirus transmission characteristics of galactose alpha1-3 galactose-deficient pig cells.
Journal of virology.
2004 Jun; 78(11):5805-11. doi:
10.1128/jvi.78.11.5805-5811.2004. [PMID: 15140978] - Christoph Knosalla, Johannes Müller, Kathleen Moran, Gerd Wallukat, Roland Hetzer, David K C Cooper. Non-specific removal of antibodies in patients with idiopathic dilated cardiomyopathy: implications for xenotransplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2004 May; 23(5):623-6. doi:
10.1016/s1053-2498(03)00229-8. [PMID: 15135381] - Joseph R Leventhal, JingDong Sun, Jenny Zhang, Uri Galili, Anita Chong, Marshall Baker, Dixon B Kaufman, James R Wright. Evidence that tilapia islets do not express alpha-(1,3)gal: implications for islet xenotransplantation.
Xenotransplantation.
2004 May; 11(3):276-83. doi:
10.1111/j.1399-3089.2004.00133.x. [PMID: 15099208] - Hiroshi Komoda, Shuji Miyagawa, Tomoko Kubo, Etsuko Kitano, Hajime Kitamura, Takeshi Omori, Toshinori Ito, Hikaru Matsuda, Ryota Shirakura. A study of the xenoantigenicity of adult pig islets cells.
Xenotransplantation.
2004 May; 11(3):237-46. doi:
10.1111/j.1399-3089.2004.00121.x. [PMID: 15099203] - L Wennberg, Z Song, W Bennet, J O Sandberg, B Sundberg, A Thall, O Korsgren. Importance of the Gal alpha1-3 Gal antigen in discordant islet xenotransplantation: immunosuppression, which inhibits porcine islet xenograft rejection in ordinary mice, is equally effective in Gal-knockout mice.
Transplantation.
2004 Apr; 77(8):1275-80. doi:
10.1097/01.tp.0000119162.11743.af. [PMID: 15114098] - Bruce E Loveland, Julie Milland, Peter Kyriakou, Bruce R Thorley, Dale Christiansen, Marc B Lanteri, Mark Regensburg, Maureen Duffield, Andrew J French, Lindsay Williams, Louise Baker, Malcolm R Brandon, Pei-Xiang Xing, Del Kahn, Ian F C McKenzie. Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons.
Xenotransplantation.
2004 Mar; 11(2):171-83. doi:
10.1046/j.1399-3089.2003.00103.x. [PMID: 14962279] - Yanjun Jia, Huiming Ren, Xin Gao, Shouping Ji, Jun Yang, Zepeng Liu, Subo Li, Yangpei Zhang. Expression of human alpha-galactosidase and alpha1,2-fucosyltransferase genes modifies the cell surface Galalpha1,3Gal antigen and confers resistance to human serum-mediated cytolysis.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.
2004 Mar; 19(1):31-7. doi:
NULL. [PMID: 15104222] - Joel Kaye, Jessamyn Bagley, Denise Malkowski, John Iacomini. The role of complement receptors in production of antibodies specific for Galalpha1,3Gal.
Transplantation.
2004 Jan; 77(2):314-6. doi:
10.1097/01.tp.0000101008.13282.fd. [PMID: 14743001] - Daniela Cavallone, Nadia Malagolini, Angela Monti, Xue-Ru Wu, Franca Serafini-Cessi. Variation of high mannose chains of Tamm-Horsfall glycoprotein confers differential binding to type 1-fimbriated Escherichia coli.
The Journal of biological chemistry.
2004 Jan; 279(1):216-22. doi:
10.1074/jbc.m308821200. [PMID: 14570881] - Jan M Eckermann, Leo H Buhler, Alex Zhu, Frank J M F Dor, Michel Awwad, David K C Cooper. Initial investigation of the potential of modified porcine erythrocytes for transfusion in primates.
Xenotransplantation.
2004 Jan; 11(1):18-26. doi:
10.1111/j.1399-3089.2004.00087.x. [PMID: 14962289] - Irene Leonardsson, Halina Miller-Podraza, Susann Teneberg, Michael E Breimer. Isolation and partial characterization of Gal alpha-containing polyglycosylceramides from porcine tissues.
Xenotransplantation.
2004 Jan; 11(1):97-100. doi:
10.1111/j.1399-3089.2004.00076.x. [PMID: 14962298] - Sunao Hayashi, Seiji Ogawa, Yasuhiro Takashima, Haruki Otsuka. The neutralization of pseudorabies virus by anti-alpha-galactocyl natural antibody in normal serum.
Virus research.
2004 Jan; 99(1):1-7. doi:
10.1016/j.virusres.2003.09.008. [PMID: 14687940] - F J M F Dor, J Cheng, A Alt, D K C Cooper, H-J Schuurman. Gal alpha 1,3Gal expression on porcine pancreatic islets, testis, spleen, and thymus.
Xenotransplantation.
2004 Jan; 11(1):101-6. doi:
10.1111/j.1399-3089.2004.00078.x. [PMID: 14962299] - D Harper, B Gollackner, Y Xu, D Calderhead, D Ryan, W Li, J Cheng, C Wu, K Moran, D Latinne, H Bazin, M E White-Scharf, D K C Cooper, M Awwad, J Chang. In vitro and in vivo investigation of a novel monoclonal antibody to plasma cells (W5 mAb).
Xenotransplantation.
2004 Jan; 11(1):78-90. doi:
10.1111/j.1399-3089.2004.00086.x. [PMID: 14962296] - R M Baertschiger, F J M F Dor, D Prabharasuth, K Kuwaki, D K C Cooper. Absence of humoral and cellular alloreactivity in baboons sensitized to pig antigens.
Xenotransplantation.
2004 Jan; 11(1):27-32. doi:
10.1111/j.1399-3089.2004.00075.x. [PMID: 14962290] - Tae-Wook Chung, Kyoung-Sook Kim, Cheorl-Ho Kim. Reduction of the Gal-alpha1,3-Gal epitope of mouse endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene.
Molecules and cells.
2003 Dec; 16(3):368-76. doi:
. [PMID: 14744028] - Bernd Gollackner, Christoph Knosalla, Stuart Houser, Shamila Mauiyyedi, Leo Buhler, Tatsuo Kawai, Mike Duggan, David H Sachs, Michel Awwad, David K C Cooper. Pig kidney transplantation in baboons treated intravenously with a bovine serum albumin-Galalpha1-3Gal conjugate.
Xenotransplantation.
2003 Nov; 10(6):606-14. doi:
10.1034/j.1399-3089.2003.00065.x. [PMID: 14708529] - Anja Roos, Robert Rieben, Maria C Faber-Krol, Mohamed R Daha. IgM-enriched human introvenous immunoglobulin strongly inhibits complement-dependent porcine cell cytotoxicity mediated by human xenoreactive antibodies.
Xenotransplantation.
2003 Nov; 10(6):596-605. doi:
10.1034/j.1399-3089.2003.00063.x. [PMID: 14708528] - Jonathan G Schoenecker, Rachel K Johnson, Ryan C Fields, Aaron P Lesher, Taymon Domzalski, Kamran Baig, Jeffrey H Lawson, William Parker. Relative purity of thrombin-based hemostatic agents used in surgery.
Journal of the American College of Surgeons.
2003 Oct; 197(4):580-90. doi:
10.1016/s1072-7515(03)00670-7. [PMID: 14522327] - Jing-Lian Yan, Lu-Yang Yu, Li-Hua Zhu, Li-He Guo. Expression of human alpha-galactosidase leads to reduction of major xenoepitope Galalpha(1,3) Gal in NIH 3T3 cell.
Acta pharmacologica Sinica.
2003 Oct; 24(10):985-90. doi:
NULL. [PMID: 14531939] - Carsten Schröder, Guosheng S Wu, Edward Price, Joyce E Johnson, Richard N Pierson, Agnes M Azimzadeh. Hyperacute rejection of mouse lung by human blood: characterization of the model and the role of complement.
Transplantation.
2003 Sep; 76(5):755-60. doi:
10.1097/01.tp.0000069836.91593.09. [PMID: 14501848] - Brian C Grubbs, Barbara A Benson, Agustin P Dalmasso. Characteristics of CD59 up-regulation induced in porcine endothelial cells by alphaGal ligation and its association with protection from complement.
Xenotransplantation.
2003 Sep; 10(5):387-97. doi:
10.1034/j.1399-3089.2003.02088.x. [PMID: 12950982] - Christine L Lau, Edward Cantu, Gonzalo V Gonzalez-Stawinski, Zoie E Holzknecht, Timothy C Nichols, Katherine E Posther, Cory A Rayborn, Jeffrey L Platt, William Parker, R Duane Davis. The role of antibodies and von Willebrand factor in discordant pulmonary xenotransplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2003 Sep; 3(9):1065-75. doi:
10.1034/j.1600-6143.2003.00190.x. [PMID: 12919085]
