{[2-(2-{2-[bis(carboxymethyl)amino]-5-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)phenoxy}ethoxy)-4-methylphenyl](carboxymethyl)amino}acetic acid (BioDeep_00000846931)
代谢物信息卡片
{[2-(2-{2-[bis(carboxymethyl)amino]-5-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)phenoxy}ethoxy)-4-methylphenyl](carboxymethyl)amino}acetic acid
化学式: C36H30F2N2O13 (736.1715874)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=C(C=C1)N(CC(=O)O)CC(=O)O)OCCOC2=C(C=CC(=C2)C3=C4C=C(C(=O)C=C4OC5=CC(=C(C=C53)F)O)F)N(CC(=O)O)CC(=O)O
InChI: InChI=1S/C36H30F2N2O13/c1-18-2-4-24(39(14-32(43)44)15-33(45)46)30(8-18)51-6-7-52-31-9-19(3-5-25(31)40(16-34(47)48)17-35(49)50)36-20-10-22(37)26(41)12-28(20)53-29-13-27(42)23(38)11-21(29)36/h2-5,8-13,41H,6-7,14-17H2,1H3,(H,43,44)(H,45,46)(H,47,48)(H,49,50)
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gang Shen, Zongyuan Zhou, Yanlei Guo, Li Li, Jin Zeng, Jianbo Wang, Junning Zhao. Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca2+ antagonism and maintaining mitochondrial function.
Journal of ethnopharmacology.
2023 Sep; 319(Pt 2):117192. doi:
10.1016/j.jep.2023.117192. [PMID: 37734472] - Sujuan Li, Weili Wang, Lisha Lin, Lian Yang, Ying Cai, Xingzhi Yang, Taocui Zhang, Chuang Xiao, Hui Yan, Na Gao, Jinhua Zhao. Oligosaccharide Blocks PAR1 (Proteinase-Activated Receptor 1)-PAR4-Mediated Platelet Activation by Binding to Thrombin Exosite II and Impairs Thrombosis.
Arteriosclerosis, thrombosis, and vascular biology.
2023 02; 43(2):253-266. doi:
10.1161/atvbaha.122.318085. [PMID: 36519467] - Lina Qiu, Daqing Huang, Yongzhang Wang, Haiyong Qu. Staining the Cytoplasmic Ca2+ with Fluo-4/AM in Apple Pulp.
Journal of visualized experiments : JoVE.
2021 11; ?(177):. doi:
10.3791/62526. [PMID: 34806711] - Tomasz Radzik, Tomasz Boczek, Bozena Ferenc, Maciej Studzian, Lukasz Pulaski, Ludmila Zylinska. Calcium Dyshomeostasis Alters CCL5 Signaling in Differentiated PC12 Cells.
BioMed research international.
2019; 2019(?):9616248. doi:
10.1155/2019/9616248. [PMID: 31032369] - Viola Introini, Alex Crick, Teresa Tiffert, Jurij Kotar, Yen-Chun Lin, Pietro Cicuta, Virgilio L Lew. Evidence against a Role of Elevated Intracellular Ca2+ during Plasmodium falciparum Preinvasion.
Biophysical journal.
2018 04; 114(7):1695-1706. doi:
10.1016/j.bpj.2018.02.023. [PMID: 29642038] - Nathan A Smith, Benjamin T Kress, Yuan Lu, Devin Chandler-Militello, Abdellatif Benraiss, Maiken Nedergaard. Fluorescent Ca2+ indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.
Science signaling.
2018 01; 11(515):. doi:
10.1126/scisignal.aal2039. [PMID: 29382785] - Jorge M P Rodrigues, Cátia S Pereira, Natacha Fontes, Hernâni Gerós, Manuela Côrte-Real. Flow Cytometry and Fluorescence Microscopy as Tools for Structural and Functional Analysis of Vacuoles Isolated from Yeast and Plant Cells.
Methods in molecular biology (Clifton, N.J.).
2018; 1789(?):101-115. doi:
10.1007/978-1-4939-7856-4_8. [PMID: 29916074] - G Corkidi, F Montoya, P Hernández-Herrera, W A Ríos-Herrera, M F Müller, C L Treviño, A Darszon. Are there intracellular Ca2+ oscillations correlated with flagellar beating in human sperm? A three vs. two-dimensional analysis.
Molecular human reproduction.
2017 09; 23(9):583-593. doi:
10.1093/molehr/gax039. [PMID: 28911211] - Chunhong Song, Jieqiong Wang, Dongmei Gao, Yanhong Yu, Fang Li, Sheng Wei, Peng Sun, Meiyan Wang, Mingqi Qiao. Paeoniflorin, the Main Active Ingredient of Shuyu Capsule, Inhibits Cav1.2 and Regulates Calmodulin/Calmodulin-Dependent Protein Kinase II Signalling.
BioMed research international.
2017; 2017(?):8459287. doi:
10.1155/2017/8459287. [PMID: 29362718] - Aniello Schiano Moriello, Luciano De Petrocellis. Assay of TRPV1 Receptor Signaling.
Methods in molecular biology (Clifton, N.J.).
2016; 1412(?):65-76. doi:
10.1007/978-1-4939-3539-0_7. [PMID: 27245892] - Insa M A Wolf, Björn-Philipp Diercks, Ellen Gattkowski, Frederik Czarniak, Jan Kempski, René Werner, Daniel Schetelig, Hans-Willi Mittrücker, Valéa Schumacher, Manuel von Osten, Dimitri Lodygin, Alexander Flügel, Ralf Fliegert, Andreas H Guse. Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.
Science signaling.
2015 Oct; 8(398):ra102. doi:
10.1126/scisignal.aab0863. [PMID: 26462735] - Pavel Montes de Oca Balderas, Penélope Aguilera. A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes.
PloS one.
2015; 10(5):e0126314. doi:
10.1371/journal.pone.0126314. [PMID: 25954808] - Alice Assinger, Ivo Volf, Diethart Schmid. A novel, rapid method to quantify intraplatelet calcium dynamics by ratiometric flow cytometry.
PloS one.
2015; 10(4):e0122527. doi:
10.1371/journal.pone.0122527. [PMID: 25849642] - Katja Ihlefeld, Hans Vienken, Ralf Frederik Claas, Kira Blankenbach, Agnes Rudowski, Michael ter Braak, Alexander Koch, Paul P Van Veldhoven, Josef Pfeilschifter, Dagmar Meyer zu Heringdorf. Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts.
Journal of lipid research.
2015 Jan; 56(1):60-9. doi:
10.1194/jlr.m052761. [PMID: 25385827] - Yuliya V Kucherenko, Ingolf Bernhardt. Natural antioxidants improve red blood cell 'survival' in non-leukoreduced blood samples.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 35(5):2055-68. doi:
10.1159/000374012. [PMID: 25871329] - F Semeraro, C T Ammollo, N L Esmon, C T Esmon. Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells.
Journal of thrombosis and haemostasis : JTH.
2014 Oct; 12(10):1697-702. doi:
10.1111/jth.12677. [PMID: 25069624] - Giuseppe Ronzitti, Giovanna Bucci, Marco Emanuele, Damiana Leo, Tatyana D Sotnikova, Liudmila V Mus, Camille H Soubrane, Mark L Dallas, Agnes Thalhammer, Lorenzo A Cingolani, Sumiko Mochida, Raul R Gainetdinov, Gary J Stephens, Evelina Chieregatti. Exogenous α-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014 Aug; 34(32):10603-15. doi:
10.1523/jneurosci.0608-14.2014. [PMID: 25100594] - Jelle Caers, Katleen Peymen, Nick Suetens, Liesbet Temmerman, Tom Janssen, Liliane Schoofs, Isabel Beets. Characterization of G protein-coupled receptors by a fluorescence-based calcium mobilization assay.
Journal of visualized experiments : JoVE.
2014 Jul; ?(89):e51516. doi:
10.3791/51516. [PMID: 25146596] - Xiaomin Hou, Yu Liu, Longgang Niu, Lijuan Cui, Mingsheng Zhang. Enhancement of voltage-gated K+ channels and depression of voltage-gated Ca2+ channels are involved in quercetin-induced vasorelaxation in rat coronary artery.
Planta medica.
2014 Apr; 80(6):465-72. doi:
10.1055/s-0034-1368320. [PMID: 24710898] - Jorge Navarro-Dorado, Mauricio Garcia-Alonso, Cornelis van Breemen, Teresa Tejerina, Nicola Fameli. Calcium oscillations in human mesenteric vascular smooth muscle.
Biochemical and biophysical research communications.
2014 Feb; 445(1):84-8. doi:
10.1016/j.bbrc.2014.01.150. [PMID: 24508261] - Andreu Viader, Yo Sasaki, Sungsu Kim, Amy Strickland, Cayce S Workman, Kui Yang, Richard W Gross, Jeffrey Milbrandt. Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.
Neuron.
2013 Mar; 77(5):886-98. doi:
10.1016/j.neuron.2013.01.012. [PMID: 23473319] - Jue Wang, Lisa Wagner-Britz, Anna Bogdanova, Sandra Ruppenthal, Kathrina Wiesen, Elisabeth Kaiser, Qinghai Tian, Elmar Krause, Ingolf Bernhardt, Peter Lipp, Stephan E Philipp, Lars Kaestner. Morphologically homogeneous red blood cells present a heterogeneous response to hormonal stimulation.
PloS one.
2013; 8(6):e67697. doi:
10.1371/journal.pone.0067697. [PMID: 23840765] - Stéphane Diring, Dan Ohtan Wang, Chiwon Kim, Mio Kondo, Yong Chen, Susumu Kitagawa, Ken-ichiro Kamei, Shuhei Furukawa. Localized cell stimulation by nitric oxide using a photoactive porous coordination polymer platform.
Nature communications.
2013; 4(?):2684. doi:
10.1038/ncomms3684. [PMID: 24158008] - Yuleima Díaz, Franshelle Peña, Olga Carolina Aristimuño, Lorena Matteo, Marisela De Agrela, Maria Elena Chemello, Fabian Michelangeli, Marie Christine Ruiz. Dissecting the Ca²⁺ entry pathways induced by rotavirus infection and NSP4-EGFP expression in Cos-7 cells.
Virus research.
2012 Aug; 167(2):285-96. doi:
10.1016/j.virusres.2012.05.012. [PMID: 22634036] - Matthew T Conner, Alex C Conner, Charlotte E Bland, Luke H J Taylor, James E P Brown, H Rheinallt Parri, Roslyn M Bill. Rapid aquaporin translocation regulates cellular water flow: mechanism of hypotonicity-induced subcellular localization of aquaporin 1 water channel.
The Journal of biological chemistry.
2012 Mar; 287(14):11516-25. doi:
10.1074/jbc.m111.329219. [PMID: 22334691] - Koji Sumitomo, Arianna McAllister, Yukihiro Tamba, Yoshiaki Kashimura, Aya Tanaka, Youichi Shinozaki, Keiichi Torimitsu. Ca2+ ion transport through channels formed by α-hemolysin analyzed using a microwell array on a Si substrate.
Biosensors & bioelectronics.
2012 Jan; 31(1):445-50. doi:
10.1016/j.bios.2011.11.010. [PMID: 22152991] - Alak Manna, Piu Saha, Avijit Sarkar, Debanjan Mukhopadhyay, Ajay K Bauri, Deepak Kumar, Padma Das, Subrata Chattopadhyay, Mitali Chatterjee. Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line.
PloS one.
2012; 7(5):e36938. doi:
10.1371/journal.pone.0036938. [PMID: 22590637] - Laurence Desrues, Thomas Lefebvre, Céline Lecointre, Marie-Thérèse Schouft, Jérôme Leprince, Vincent Compère, Fabrice Morin, François Proust, Pierrick Gandolfo, Marie-Christine Tonon, Hélène Castel. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity.
PloS one.
2012; 7(5):e36319. doi:
10.1371/journal.pone.0036319. [PMID: 22563490] - Zhen Yao, Wan Namkung, Eun A Ko, Jinhong Park, Lukmanee Tradtrantip, A S Verkman. Fractionation of a herbal antidiarrheal medicine reveals eugenol as an inhibitor of Ca2+-Activated Cl- channel TMEM16A.
PloS one.
2012; 7(5):e38030. doi:
10.1371/journal.pone.0038030. [PMID: 22666439] - Eiji Shigetomi, Xiaoping Tong, Kelvin Y Kwan, David P Corey, Baljit S Khakh. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.
Nature neuroscience.
2011 Dec; 15(1):70-80. doi:
10.1038/nn.3000. [PMID: 22158513] - Julien Gibon, Pierre Richaud, Alexandre Bouron. Hyperforin changes the zinc-storage capacities of brain cells.
Neuropharmacology.
2011 Dec; 61(8):1321-6. doi:
10.1016/j.neuropharm.2011.08.002. [PMID: 21854792] - Kimiko Yamamoto, Kishio Furuya, Makiko Nakamura, Eiry Kobatake, Masahiro Sokabe, Joji Ando. Visualization of flow-induced ATP release and triggering of Ca2+ waves at caveolae in vascular endothelial cells.
Journal of cell science.
2011 Oct; 124(Pt 20):3477-83. doi:
10.1242/jcs.087221. [PMID: 22010198] - Md Sharoare Hossain, Anders Johannisson, Amanda Pimenta Siqueira, Margareta Wallgren, Heriberto Rodriguez-Martinez. Spermatozoa in the sperm-peak-fraction of the boar ejaculate show a lower flow of Ca(2+) under capacitation conditions post-thaw which might account for their higher membrane stability after cryopreservation.
Animal reproduction science.
2011 Oct; 128(1-4):37-44. doi:
10.1016/j.anireprosci.2011.08.006. [PMID: 21962836] - Markus Gyger, Daniel Rose, Roland Stange, Tobias Kiessling, Mareike Zink, Ben Fabry, Josef A Käs. Calcium imaging in the optical stretcher.
Optics express.
2011 Sep; 19(20):19212-22. doi:
10.1364/oe.19.019212. [PMID: 21996863] - Daniele Chaves-Moreira, Fernanda N Souza, Rosalvo T H Fogaça, Oldemir C Mangili, Waldemiro Gremski, Andrea Senff-Ribeiro, Olga M Chaim, Silvio S Veiga. The relationship between calcium and the metabolism of plasma membrane phospholipids in hemolysis induced by brown spider venom phospholipase-D toxin.
Journal of cellular biochemistry.
2011 Sep; 112(9):2529-40. doi:
10.1002/jcb.23177. [PMID: 21590705] - Sarah K Harten, Miguel A Esteban, Deepa Shukla, Margaret Ashcroft, Patrick H Maxwell. Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells.
Molecular cancer.
2011 Jul; 10(?):89. doi:
10.1186/1476-4598-10-89. [PMID: 21791076] - Kyung Ho Kim, Diptiman D Bose, Atefeh Ghogha, Joyce Riehl, Rui Zhang, Christopher D Barnhart, Pamela J Lein, Isaac N Pessah. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity.
Environmental health perspectives.
2011 Apr; 119(4):519-26. doi:
10.1289/ehp.1002728. [PMID: 21106467] - Hisayuki Ohata, Hideyuki Yamada, Kazutaka Momose. Lysophosphatidic acid induces shear stress-dependent Ca2+ influx in mouse aortic endothelial cells in situ.
Experimental physiology.
2011 Apr; 96(4):468-75. doi:
10.1113/expphysiol.2011.056416. [PMID: 21402880] - Robert J Gasperini, Xu Hou, Helena Parkington, Harry Coleman, David W Klaver, Adele J Vincent, Lisa C Foa, David H Small. TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons.
Molecular neurodegeneration.
2011 Mar; 6(1):19. doi:
10.1186/1750-1326-6-19. [PMID: 21375738] - Alina B Elperin, Shruti A Pore, Jordanah M Evans, Annabel L Naditz, Douglas B Light. Swelling-induced Ca²+ influx and K+ efflux in American alligator erythrocytes.
The Journal of membrane biology.
2011 Mar; 240(1):1-12. doi:
10.1007/s00232-010-9336-4. [PMID: 21153478] - Aiming Liu, Julin Yang, Frank J Gonzalez, Gary Q Cheng, Renke Dai. Biphasic regulation of intracellular calcium by gemfibrozil contributes to inhibiting L6 myoblast differentiation: implications for clinical myotoxicity.
Chemical research in toxicology.
2011 Feb; 24(2):229-37. doi:
10.1021/tx100312h. [PMID: 21175127] - Jacqueline Naylor, Eman Al-Shawaf, Lynn McKeown, Paul T Manna, Karen E Porter, David O'Regan, Katsuhiko Muraki, David J Beech. TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes.
The Journal of biological chemistry.
2011 Feb; 286(7):5078-86. doi:
10.1074/jbc.m110.196956. [PMID: 21127073] - Veronica Dominguez, Claudio Raimondi, Sangeeta Somanath, Marco Bugliani, Merewyn K Loder, Charlotte E Edling, Nullin Divecha, Gabriela da Silva-Xavier, Lorella Marselli, Shanta J Persaud, Mark D Turner, Guy A Rutter, Piero Marchetti, Marco Falasca, Tania Maffucci. Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells.
The Journal of biological chemistry.
2011 Feb; 286(6):4216-25. doi:
10.1074/jbc.m110.200295. [PMID: 21127054] - Ping Huang, Oladapo Yeku, Haihong Zong, Phyllis Tsang, Wenjuan Su, Xiao Yu, Shuzhi Teng, Mary Osisami, Yasunori Kanaho, Jeffrey E Pessin, Michael A Frohman. Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice.
Diabetes.
2011 Feb; 60(2):454-63. doi:
10.2337/db10-0614. [PMID: 21270258] - Tünde Molnár, László Héja, Zsuzsa Emri, Agnes Simon, Gabriella Nyitrai, Ildikó Pál, Julianna Kardos. Activation of astroglial calcium signaling by endogenous metabolites succinate and gamma-hydroxybutyrate in the nucleus accumbens.
Frontiers in neuroenergetics.
2011; 3(?):7. doi:
10.3389/fnene.2011.00007. [PMID: 22180742] - Zoltan Varga, Tamás Juhász, Csaba Matta, János Fodor, Éva Katona, Adam Bartok, Tamás Oláh, Attila Sebe, László Csernoch, Gyorgy Panyi, Róza Zákány. Switch of voltage-gated K+ channel expression in the plasma membrane of chondrogenic cells affects cytosolic Ca2+-oscillations and cartilage formation.
PloS one.
2011; 6(11):e27957. doi:
10.1371/journal.pone.0027957. [PMID: 22132179] - Sunil S Metkar, Baikun Wang, Elena Catalan, Gregor Anderluh, Robert J C Gilbert, Julian Pardo, Christopher J Froelich. Perforin rapidly induces plasma membrane phospholipid flip-flop.
PloS one.
2011; 6(9):e24286. doi:
10.1371/journal.pone.0024286. [PMID: 21931672] - Yuka Kambara, Kogiku Shiba, Manabu Yoshida, Chihiro Sato, Ken Kitajima, Chikako Shingyoji. Mechanism regulating Ca2+-dependent mechanosensory behaviour in sea urchin spermatozoa.
Cell structure and function.
2011; 36(1):69-82. doi:
10.1247/csf.10020. [PMID: 21358125] - Andoria Tjondrokoesoemo, Ki Ho Park, Christopher Ferrante, Shinji Komazaki, Sebastian Lesniak, Marco Brotto, Jae-Kyun Ko, Jingsong Zhou, Noah Weisleder, Jianjie Ma. Disrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.
PloS one.
2011; 6(9):e25740. doi:
10.1371/journal.pone.0025740. [PMID: 21984944] - Marco Diociaiuti, Maria Cristina Gaudiano, Fiorella Malchiodi-Albedi. The slowly aggregating salmon Calcitonin: a useful tool for the study of the amyloid oligomers structure and activity.
International journal of molecular sciences.
2011; 12(12):9277-95. doi:
10.3390/ijms12129277. [PMID: 22272133] - Krishana S Sankar, Brenda J Green, Alana R Crocker, Jocelyne E Verity, Svetlana M Altamentova, Jonathan V Rocheleau. Culturing pancreatic islets in microfluidic flow enhances morphology of the associated endothelial cells.
PloS one.
2011; 6(9):e24904. doi:
10.1371/journal.pone.0024904. [PMID: 21961048] - Kenichiro Kawai, Barrett J Larson, Hisako Ishise, Antoine Lyonel Carre, Soh Nishimoto, Michael Longaker, H Peter Lorenz. Calcium-based nanoparticles accelerate skin wound healing.
PloS one.
2011; 6(11):e27106. doi:
10.1371/journal.pone.0027106. [PMID: 22073267] - Sujuan Yan, Yamei Chen, Min Dong, Weizhong Song, Scott M Belcher, Hong-Sheng Wang. Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling.
PloS one.
2011; 6(9):e25455. doi:
10.1371/journal.pone.0025455. [PMID: 21980463] - N T Lieggi, A Edvardsson, P J O'Brien. Translation of novel anti-cancer cytotoxicity biomarkers detected with high content analysis from an in vitro predictive model to an in vivo cell model.
Toxicology in vitro : an international journal published in association with BIBRA.
2010 Dec; 24(8):2063-71. doi:
10.1016/j.tiv.2010.07.014. [PMID: 20670680] - Mario Bortolozzi, Marisa Brini, Nick Parkinson, Giulia Crispino, Pietro Scimemi, Romolo Daniele De Siati, Francesca Di Leva, Andrew Parker, Saida Ortolano, Edoardo Arslan, Steve D Brown, Ernesto Carafoli, Fabio Mammano. The novel PMCA2 pump mutation Tommy impairs cytosolic calcium clearance in hair cells and links to deafness in mice.
The Journal of biological chemistry.
2010 Nov; 285(48):37693-703. doi:
10.1074/jbc.m110.170092. [PMID: 20826782] - Ben T Atkinson, Reema Jasuja, Vivien M Chen, Prathima Nandivada, Bruce Furie, Barbara C Furie. Laser-induced endothelial cell activation supports fibrin formation.
Blood.
2010 Nov; 116(22):4675-83. doi:
10.1182/blood-2010-05-283986. [PMID: 20675401] - Arnold Sipos, Sarah Vargas, János Peti-Peterdi. Direct demonstration of tubular fluid flow sensing by macula densa cells.
American journal of physiology. Renal physiology.
2010 Nov; 299(5):F1087-93. doi:
10.1152/ajprenal.00469.2009. [PMID: 20719981] - Rupashree Sen, Piu Saha, Avijit Sarkar, Sudipto Ganguly, Mitali Chatterjee. Iron enhances generation of free radicals by Artemisinin causing a caspase-independent, apoptotic death in Leishmania donovani promastigotes.
Free radical research.
2010 Nov; 44(11):1289-95. doi:
10.3109/10715762.2010.498475. [PMID: 20815780] - Marie-Line Peyot, Emilie Pepin, Julien Lamontagne, Martin G Latour, Bader Zarrouki, Roxane Lussier, Marco Pineda, Thomas L Jetton, S R Murthy Madiraju, Erik Joly, Marc Prentki. Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.
Diabetes.
2010 Sep; 59(9):2178-87. doi:
10.2337/db09-1452. [PMID: 20547980] - Hee-Jeong Son, Young-Cheol Lim, Kwon-Soo Ha, Seong-Sik Kang, Il-Young Cheong, Sang-Jin Lee, Seung-Woo Park, Byeong-Moon Hwang. Propofol and aminophylline antagonize each other during the mobilization of intracellular calcium in human umbilical vein endothelial cells.
Journal of Korean medical science.
2010 Aug; 25(8):1222-7. doi:
10.3346/jkms.2010.25.8.1222. [PMID: 20676337] - Sriram Govindan, Emily J A Taylor, Colin W Taylor. Ca(2+) signalling by P2Y receptors in cultured rat aortic smooth muscle cells.
British journal of pharmacology.
2010 Aug; 160(8):1953-62. doi:
10.1111/j.1476-5381.2010.00763.x. [PMID: 20649593] - Amitava Dasgupta, Laura Kidd, Brian J Poindexter, Roger J Bick. Interference of hawthorn on serum digoxin measurements by immunoassays and pharmacodynamic interaction with digoxin.
Archives of pathology & laboratory medicine.
2010 Aug; 134(8):1188-92. doi:
10.5858/2009-0404-oa.1. [PMID: 20670141] - Kyung-Min Lim, Sujin Kim, Ji-Yoon Noh, Keunyoung Kim, Won-Hee Jang, Ok-Nam Bae, Seung-Min Chung, Jin-Ho Chung. Low-level mercury can enhance procoagulant activity of erythrocytes: a new contributing factor for mercury-related thrombotic disease.
Environmental health perspectives.
2010 Jul; 118(7):928-35. doi:
10.1289/ehp.0901473. [PMID: 20308036] - Pika Miklavc, Manfred Frick, Oliver H Wittekindt, Thomas Haller, Paul Dietl. Fusion-activated Ca(2+) entry: an 'active zone' of elevated Ca(2+) during the postfusion stage of lamellar body exocytosis in rat type II pneumocytes.
PloS one.
2010 Jun; 5(6):e10982. doi:
10.1371/journal.pone.0010982. [PMID: 20544027] - Sébastien Roger, Ludovic Gillet, Alberto Baroja-Mazo, Annmarie Surprenant, Pablo Pelegrin. C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation.
The Journal of biological chemistry.
2010 Jun; 285(23):17514-24. doi:
10.1074/jbc.m109.053082. [PMID: 20378545] - Julien Gibon, Peng Tu, Alexandre Bouron. Store-depletion and hyperforin activate distinct types of Ca(2+)-conducting channels in cortical neurons.
Cell calcium.
2010 Jun; 47(6):538-43. doi:
10.1016/j.ceca.2010.05.003. [PMID: 20621761] - Mark T W Handley, Lu-Yun Lian, Lee P Haynes, Robert D Burgoyne. Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder.
PloS one.
2010 May; 5(5):e10534. doi:
10.1371/journal.pone.0010534. [PMID: 20479890] - Stephan C Collins, Michael B Hoppa, Jonathan N Walker, Stefan Amisten, Fernando Abdulkader, Martin Bengtsson, Jane Fearnside, Reshma Ramracheya, Ayo A Toye, Quan Zhang, Anne Clark, Dominique Gauguier, Patrik Rorsman. Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.
Diabetes.
2010 May; 59(5):1192-201. doi:
10.2337/db09-0791. [PMID: 20150285] - Michelle A Berny, Imke C A Munnix, Jocelyn M Auger, Saskia E M Schols, Judith M E M Cosemans, Peter Panizzi, Paul E Bock, Steve P Watson, Owen J T McCarty, Johan W M Heemskerk. Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear.
PloS one.
2010 Apr; 5(4):e10415. doi:
10.1371/journal.pone.0010415. [PMID: 20454680] - Alessia Ligresti, Luciano De Petrocellis, Dolores Hernán Pérez de la Ossa, Rosario Aberturas, Luigia Cristino, Aniello Schiano Moriello, Andrea Finizio, M Esther Gil, Ana-Isabel Torres, Jesús Molpeceres, Vincenzo Di Marzo. Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter.
PloS one.
2010 Apr; 5(4):e10239. doi:
10.1371/journal.pone.0010239. [PMID: 20422025] - Yuqing Wang, Yingfang Zhu, Yu Ling, Haiyan Zhang, Peng Liu, Frantisek Baluska, Jozef Samaj, Jinxing Lin, Qinli Wang. Disruption of actin filaments induces mitochondrial Ca2+ release to the cytoplasm and [Ca2+]c changes in Arabidopsis root hairs.
BMC plant biology.
2010 Mar; 10(?):53. doi:
10.1186/1471-2229-10-53. [PMID: 20334630] - Shailja Singh, M Mahmood Alam, Ipsita Pal-Bhowmick, Joseph A Brzostowski, Chetan E Chitnis. Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites.
PLoS pathogens.
2010 Feb; 6(2):e1000746. doi:
10.1371/journal.ppat.1000746. [PMID: 20140184] - Annarita Graziani, Michael Poteser, Wolfgang-Moritz Heupel, Hannes Schleifer, Martin Krenn, Detlev Drenckhahn, Christoph Romanin, Werner Baumgartner, Klaus Groschner. Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction.
The Journal of biological chemistry.
2010 Feb; 285(6):4213-4223. doi:
10.1074/jbc.m109.060301. [PMID: 19996314] - Dong-Ha Oh, Sang Yeol Lee, Ray A Bressan, Dae-Jin Yun, Hans J Bohnert. Intracellular consequences of SOS1 deficiency during salt stress.
Journal of experimental botany.
2010 Feb; 61(4):1205-13. doi:
10.1093/jxb/erp391. [PMID: 20054031] - Natacha Fontes, Rui Silva, Céline Vignault, Fatma Lecourieux, Hernâni Gerós, Serge Delrot. Purification and functional characterization of protoplasts and intact vacuoles from grape cells.
BMC research notes.
2010 Jan; 3(?):19. doi:
10.1186/1756-0500-3-19. [PMID: 20181000] - Wenyan Chen, Jeremy B Bergsman, Xiaohua Wang, Gawain Gilkey, Carol-Renée Pierpoint, Erin A Daniel, Emmanuel M Awumey, Philippe Dauban, Robert H Dodd, Martial Ruat, Stephen M Smith. Presynaptic external calcium signaling involves the calcium-sensing receptor in neocortical nerve terminals.
PloS one.
2010 Jan; 5(1):e8563. doi:
10.1371/journal.pone.0008563. [PMID: 20052292] - Ciara M Walsh, Michael Chvanov, Lee P Haynes, Ole H Petersen, Alexei V Tepikin, Robert D Burgoyne. Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry.
The Biochemical journal.
2009 Dec; 425(1):159-68. doi:
10.1042/bj20090884. [PMID: 19843011] - Tania Maffucci, Claudio Raimondi, Shadi Abu-Hayyeh, Veronica Dominguez, Gianluca Sala, Ian Zachary, Marco Falasca. A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation.
PloS one.
2009 Dec; 4(12):e8285. doi:
10.1371/journal.pone.0008285. [PMID: 20011604] - Jingsheng Xia, Dejian Ren. The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent.
Reproductive biology and endocrinology : RB&E.
2009 Oct; 7(?):119. doi:
10.1186/1477-7827-7-119. [PMID: 19860887] - Akiyasu Kanamori, Maiko Naka, Masahide Fukuda, Makoto Nakamura, Akira Negi. Tafluprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2009 Oct; 247(10):1353-60. doi:
10.1007/s00417-009-1122-6. [PMID: 19551401] - Priscilla M C Dos Santos, Fabio P Freitas, Jeane Mendes, Ana Lucia Tararthuch, Ricardo Fernandez. Differential regulation of H+-ATPases in MDCK-C11 cells by aldosterone and vasopressin.
Canadian journal of physiology and pharmacology.
2009 Sep; 87(9):653-65. doi:
10.1139/y09-057. [PMID: 19794516] - B J King, D Hoefel, S P Lim, B S Robinson, P T Monis. Flow cytometric assessment of distinct physiological stages within Cryptosporidium parvum sporozoites post-excystation.
Parasitology.
2009 Aug; 136(9):953-66. doi:
10.1017/s0031182009006519. [PMID: 19549353] - Elvin Odgaard, Helle A Praetorius, Jens Leipziger. AVP-stimulated nucleotide secretion in perfused mouse medullary thick ascending limb and cortical collecting duct.
American journal of physiology. Renal physiology.
2009 Aug; 297(2):F341-9. doi:
10.1152/ajprenal.00190.2009. [PMID: 19515810] - Peng Tu, Gérard Brandolin, Alexandre Bouron. The anti-inflammatory agent flufenamic acid depresses store-operated channels by altering mitochondrial calcium homeostasis.
Neuropharmacology.
2009 May; 56(6-7):1010-6. doi:
10.1016/j.neuropharm.2009.02.004. [PMID: 19233217] - Zheng Chen, Zhengzheng Li, Gong Peng, Xiaoli Chen, Wenxuan Yin, Michael I Kotlikoff, Zeng-Qiang Yuan, Guangju Ji. Extracellular ATP-induced nuclear Ca2+ transient is mediated by inositol 1,4,5-trisphosphate receptors in mouse pancreatic beta-cells.
Biochemical and biophysical research communications.
2009 May; 382(2):381-4. doi:
10.1016/j.bbrc.2009.03.030. [PMID: 19285037] - Shaka S Scarlett, Jody A White, Peter F Blackmore, Karl H Schoenbach, Juergen F Kolb. Regulation of intracellular calcium concentration by nanosecond pulsed electric fields.
Biochimica et biophysica acta.
2009 May; 1788(5):1168-75. doi:
10.1016/j.bbamem.2009.02.006. [PMID: 19230822] - Eiji Shigetomi, Baljit S Khakh. Measuring near plasma membrane and global intracellular calcium dynamics in astrocytes.
Journal of visualized experiments : JoVE.
2009 Apr; ?(26):. doi:
10.3791/1142. [PMID: 19396060] - Wen Fu, Tom McCormick, Xiaoping Qi, Liping Luo, Lingyin Zhou, Xin Li, Bing-Cheng Wang, Heidi E Gibbons, Fadi W Abdul-Karim, George I Gorodeski. Activation of P2X(7)-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice.
BMC cancer.
2009 Apr; 9(?):114. doi:
10.1186/1471-2407-9-114. [PMID: 19379509] - Damien S K Samways, Amy B Harkins, Terrance M Egan. Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry.
Cell calcium.
2009 Apr; 45(4):319-25. doi:
10.1016/j.ceca.2008.12.002. [PMID: 19185346] - Ignasi Barba, Laia Chavarria, Marisol Ruiz-Meana, Maribel Mirabet, Esperanza Agulló, David Garcia-Dorado. Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia-reperfusion injury in cardiomyocytes.
The Journal of physiology.
2009 Mar; 587(Pt 6):1331-41. doi:
10.1113/jphysiol.2008.163311. [PMID: 19188253] - John Kuo, Omid R Hariri, Galyna Bondar, Julie Ogi, Paul Micevych. Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes.
Endocrinology.
2009 Mar; 150(3):1369-76. doi:
10.1210/en.2008-0994. [PMID: 18948402] - Akiyasu Kanamori, Maiko Naka, Masahide Fukuda, Makoto Nakamura, Akira Negi. Latanoprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo.
Experimental eye research.
2009 Mar; 88(3):535-41. doi:
10.1016/j.exer.2008.11.012. [PMID: 19084521] - Peng Tu, Christiane Kunert-Keil, Silke Lucke, Heinrich Brinkmeier, Alexandre Bouron. Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons.
Journal of neurochemistry.
2009 Jan; 108(1):126-38. doi:
10.1111/j.1471-4159.2008.05752.x. [PMID: 19094061] - Hyun J Kwon, Jae Hyung Koo, Frank Zufall, Trese Leinders-Zufall, Frank L Margolis. Ca extrusion by NCX is compromised in olfactory sensory neurons of OMP mice.
PloS one.
2009; 4(1):e4260. doi:
10.1371/journal.pone.0004260. [PMID: 19165324] - Naotoshi Nakamura, Toshiko Yamazawa, Yohei Okubo, Masamitsu Iino. Temporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells.
Molecular systems biology.
2009; 5(?):247. doi:
10.1038/msb.2009.6. [PMID: 19293827] - Elvin Odgaard, Helle A Praetorius, Jens Leipziger. AVP-stimulated nucleotide secretion in perfused mouse medullary thick ascending limb and cortical collecting duct.
The journal of medical investigation : JMI.
2009; 56 Suppl(?):262-3. doi:
10.2152/jmi.56.262. [PMID: 20224196] - Carl P Nelson, Stefan R Nahorski, R A John Challiss. Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons.
Journal of neurochemistry.
2008 Nov; 107(3):602-15. doi:
10.1111/j.1471-4159.2008.05587.x. [PMID: 18665913] - Muhammad N Ghayur, Anwarul H Gilani, Huma Rasheed, Abdullah Khan, Zafar Iqbal, Muhammad Ismail, Sheikh A Saeed, Luke J Janssen. Cardiovascular and airway relaxant activities of peony root extract.
Canadian journal of physiology and pharmacology.
2008 Nov; 86(11):793-803. doi:
10.1139/y08-084. [PMID: 19011675] - Thi Thuy Ha Nguyen, Soon Ock Cho, Ju Yeon Ban, Ju Yeon Kim, Hyun Soo Ju, Sang Bum Koh, Kyung-Sik Song, Yeon Hee Seong. Neuroprotective effect of Sanguisorbae radix against oxidative stress-induced brain damage: in vitro and in vivo.
Biological & pharmaceutical bulletin.
2008 Nov; 31(11):2028-35. doi:
10.1248/bpb.31.2028. [PMID: 18981568]