N-Acetyl-S-(3-hydroxypropyl)cysteine (BioDeep_00000846655)
代谢物信息卡片
N-Acetyl-S-(3-hydroxypropyl)cysteine
化学式: C8H15NO4S (221.072175)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC(CSCCCO)C(=O)O
InChI: InChI=1S/C8H15NO4S/c1-6(11)9-7(8(12)13)5-14-4-2-3-10/h7,10H,2-5H2,1H3,(H,9,11)(H,12,13)/t7-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Banrida Wahlang, Tyler C Gripshover, Hong Gao, Tatiana Krivokhizhina, Rachel J Keith, Israel D Sithu, Shesh N Rai, Aruni Bhatnagar, Craig J McClain, Sanjay Srivastava, Mathew C Cave. Associations Between Residential Exposure to Volatile Organic Compounds and Liver Injury Markers.
Toxicological sciences : an official journal of the Society of Toxicology.
2021 12; 185(1):50-63. doi:
10.1093/toxsci/kfab119. [PMID: 34668566] - Nicholas S Race, Katharine D Andrews, Elizabeth A Lungwitz, Sasha M Vega Alvarez, Timothy R Warner, Glen Acosta, Jiayue Cao, Kun-Han Lu, Zhongming Liu, Amy D Dietrich, Sreeparna Majumdar, Anantha Shekhar, William A Truitt, Riyi Shi. Psychosocial impairment following mild blast-induced traumatic brain injury in rats.
Behavioural brain research.
2021 08; 412(?):113405. doi:
10.1016/j.bbr.2021.113405. [PMID: 34097900] - Yahdiana Harahap, Arry Yanuar, Cyril Muhammad, Madeline Melhan, Denni Joko Purwanto. Quantification of 3-Hydroxypropyl Mercapturic Acid in the Urine of Patients with Breast Cancer to Monitor Cyclophosphamide Toxicity.
Therapeutic drug monitoring.
2020 08; 42(4):548-553. doi:
10.1097/ftd.0000000000000737. [PMID: 32079909] - Meike Ruenz, Katharina Goerke, Tamara Bakuradze, Klaus Abraham, Alfonso Lampen, Gerhard Eisenbrand, Elke Richling. Sustained Human Background Exposure to Acrolein Evidenced by Monitoring Urinary Exposure Biomarkers.
Molecular nutrition & food research.
2019 12; 63(24):e1900849. doi:
10.1002/mnfr.201900849. [PMID: 31752044] - Menglan Chen, Steven G Carmella, Chistopher Sipe, Joni Jensen, Xianghua Luo, Chap T Le, Sharon E Murphy, Neal L Benowitz, F Joseph McClernon, Ryan Vandrey, Sharon S Allen, Rachel Denlinger-Apte, Paul M Cinciripini, Andrew A Strasser, Mustafa al'Absi, Jason D Robinson, Eric C Donny, Dorothy Hatsukami, Stephen S Hecht. Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein.
PloS one.
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10.1371/journal.pone.0210104. [PMID: 30608961] - Lynne Dawkins, Sharon Cox, Maciej Goniewicz, Hayden McRobbie, Catherine Kimber, Mira Doig, Leon Kośmider. 'Real-world' compensatory behaviour with low nicotine concentration e-liquid: subjective effects and nicotine, acrolein and formaldehyde exposure.
Addiction (Abingdon, England).
2018 10; 113(10):1874-1882. doi:
10.1111/add.14271. [PMID: 29882257] - Dorothy K Hatsukami, Xianghua Luo, Joni A Jensen, Mustafa al'Absi, Sharon S Allen, Steven G Carmella, Menglan Chen, Paul M Cinciripini, Rachel Denlinger-Apte, David J Drobes, Joseph S Koopmeiners, Tonya Lane, Chap T Le, Scott Leischow, Kai Luo, F Joseph McClernon, Sharon E Murphy, Viviana Paiano, Jason D Robinson, Herbert Severson, Christopher Sipe, Andrew A Strasser, Lori G Strayer, Mei Kuen Tang, Ryan Vandrey, Stephen S Hecht, Neal L Benowitz, Eric C Donny. Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial.
JAMA.
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Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
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Journal of chromatography. A.
2017 Sep; 1517(?):79-85. doi:
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Environmental research.
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10.1016/j.envres.2016.03.015. [PMID: 26991531] - Kyohei Higashi, Kazuei Igarashi, Toshihiko Toida. Recent Progress in Analytical Methods for Determination of Urinary 3-Hydroxypropylmercapturic Acid, a Major Metabolite of Acrolein.
Biological & pharmaceutical bulletin.
2016; 39(6):915-9. doi:
10.1248/bpb.b15-01022. [PMID: 27251493] - Jonghyuck Park, Lingxing Zheng, Glen Acosta, Sasha Vega-Alvarez, Zhe Chen, Breanne Muratori, Peng Cao, Riyi Shi. Acrolein contributes to TRPA1 up-regulation in peripheral and central sensory hypersensitivity following spinal cord injury.
Journal of neurochemistry.
2015 Dec; 135(5):987-97. doi:
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Environmental health perspectives.
2015 Dec; 123(12):1302-8. doi:
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Cancer prevention research (Philadelphia, Pa.).
2015 Sep; 8(9):873-8. doi:
10.1158/1940-6207.capr-15-0058. [PMID: 26333731] - Stephen S Hecht, Steven G Carmella, Delshanee Kotandeniya, Makenzie E Pillsbury, Menglan Chen, Benjamin W S Ransom, Rachel Isaksson Vogel, Elizabeth Thompson, Sharon E Murphy, Dorothy K Hatsukami. Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
2015 Jun; 17(6):704-9. doi:
10.1093/ntr/ntu218. [PMID: 25335945] - Madoka Yoshida, Kyohei Higashi, Kyoshiro Kuni, Mutsumi Mizoi, Ryotaro Saiki, Mizuho Nakamura, Masaaki Waragai, Kenichi Uemura, Toshihiko Toida, Keiko Kashiwagi, Kazuei Igarashi. Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.
Clinica chimica acta; international journal of clinical chemistry.
2015 Feb; 441(?):115-21. doi:
10.1016/j.cca.2014.12.023. [PMID: 25542982] - Stephen S Hecht, Woon-Puay Koh, Renwei Wang, Menglan Chen, Steven G Carmella, Sharon E Murphy, Jian-Min Yuan. Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home.
PloS one.
2015; 10(3):e0120023. doi:
10.1371/journal.pone.0120023. [PMID: 25807518] - Sungshim L Park, Steven G Carmella, Menglan Chen, Yesha Patel, Daniel O Stram, Christopher A Haiman, Loic Le Marchand, Stephen S Hecht. Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
PloS one.
2015; 10(6):e0124841. doi:
10.1371/journal.pone.0124841. [PMID: 26053186] - Melissa Tully, Lingxing Zheng, Glen Acosta, Ran Tian, Riyi Shi. Acute systemic accumulation of acrolein in mice by inhalation at a concentration similar to that in cigarette smoke.
Neuroscience bulletin.
2014 Dec; 30(6):1017-1024. doi:
10.1007/s12264-014-1480-x. [PMID: 25446876] - Natasha DeJarnett, Daniel J Conklin, Daniel W Riggs, John A Myers, Timothy E O'Toole, Ihab Hamzeh, Stephen Wagner, Atul Chugh, Kenneth S Ramos, Sanjay Srivastava, Deirdre Higdon, David J Tollerud, Andrew DeFilippis, Carrie Becher, Brad Wyatt, James McCracken, Wes Abplanalp, Shesh N Rai, Tiffany Ciszewski, Zhengzhi Xie, Ray Yeager, Sumanth D Prabhu, Aruni Bhatnagar. Acrolein exposure is associated with increased cardiovascular disease risk.
Journal of the American Heart Association.
2014 Aug; 3(4):. doi:
10.1161/jaha.114.000934. [PMID: 25099132] - Nada O F Kassem, Reem M Daffa, Sandy Liles, Sheila R Jackson, Noura O Kassem, Maram A Younis, Setoo Mehta, Menglan Chen, Peyton Jacob, Steve G Carmella, Dale A Chatfield, Neal L Benowitz, Georg E Matt, Stephen S Hecht, Melbourne F Hovell. Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.
2014 Jul; 16(7):961-75. doi:
10.1093/ntr/ntu016. [PMID: 24590387] - Steven G Carmella, Menglan Chen, Adam Zarth, Stephen S Hecht. High throughput liquid chromatography-tandem mass spectrometry assay for mercapturic acids of acrolein and crotonaldehyde in cigarette smokers' urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Sep; 935(?):36-40. doi:
10.1016/j.jchromb.2013.07.004. [PMID: 23934173] - Madoka Yoshida, Takahiro Mikami, Kyohei Higashi, Ryotaro Saiki, Mutsumi Mizoi, Kazumasa Fukuda, Takao Nakamura, Itsuko Ishii, Kazuhiro Nishimura, Toshihiko Toida, Hideyuki Tomitori, Keiko Kashiwagi, Kazuei Igarashi. Inverse correlation between stroke and urinary 3-hydroxypropyl mercapturic acid, an acrolein-glutathione metabolite.
Clinica chimica acta; international journal of clinical chemistry.
2012 Apr; 413(7-8):753-9. doi:
10.1016/j.cca.2012.01.020. [PMID: 22293277] - Emmanuel Minet, Francis Cheung, Graham Errington, Katharina Sterz, Gerhard Scherer. Urinary excretion of the acrylonitrile metabolite 2-cyanoethylmercapturic acid is correlated with a variety of biomarkers of tobacco smoke exposure and consumption.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2011 Feb; 16(1):89-96. doi:
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Se pu = Chinese journal of chromatography.
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Chemical research in toxicology.
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Toxicology.
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Rapid communications in mass spectrometry : RCM.
2008 Sep; 22(17):2629-38. doi:
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