(R)-betaxolol (BioDeep_00000846618)

   


代谢物信息卡片


(R)-betaxolol

化学式: C18H29NO3 (307.2147324)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O
InChI: InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

(R)-betaxolol



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Gabriella Inczedy-Farkas, Viktoria Remenyi, Aniko Gal, Zsofia Varga, Petra Balla, Agnes Udvardy-Meszaros, Benjamin Bereznai, Maria Judit Molnar. Psychiatric symptoms of patients with primary mitochondrial DNA disorders. Behavioral and brain functions : BBF. 2012 Feb; 8(?):9. doi: 10.1186/1744-9081-8-9. [PMID: 22329956]
  • Seung Don Baek, Sun-Joo Jang, So-Eun Park, Tae Jin Ok, Jaechan Leem, Ho-Su Lee, So Jung Park, Tae Hee Kim. Fatal rhabdomyolysis in a patient with liver cirrhosis after switching from simvastatin to fluvastatin. Journal of Korean medical science. 2011 Dec; 26(12):1634-7. doi: 10.3346/jkms.2011.26.12.1634. [PMID: 22148003]
  • E Pujos, C Cren-Olivé, O Paisse, M M Flament-Waton, M F Grenier-Loustalot. Comparison of the analysis of beta-blockers by different techniques. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(31):4007-14. doi: 10.1016/j.jchromb.2009.10.014. [PMID: 19879818]
  • Bonpei Takase, Yasuchika Takeishi, Tadakazu Hirai, Jong-Dae Lee, Hiroyasu Uzui, Shoichi Senda, Kunihisa Miwa, Yuji Hiraoka, Toru Kinugawa, Ryohei Hosokawa, Masatoshi Fujita. Comparative effects of amlodipine monotherapy and combination therapy with betaxolol on cardiac autonomic nervous activity and health-related quality of life in patients with poorly controlled hypertension. Circulation journal : official journal of the Japanese Circulation Society. 2008 May; 72(5):764-9. doi: 10.1253/circj.72.764. [PMID: 18441457]
  • Jolanta Małyszko, Justyna Tymcio. Thrombin activatable fibrinolysis inhibitor and other hemostatic parameters in patients with essential arterial hypertension. Polskie Archiwum Medycyny Wewnetrznej. 2008 Jan; 118(1-2):36-41. doi: . [PMID: 18405171]
  • Tran Quoc Trung, Pham Hai Long, Ahmed M Al-Abd, Hyo Jeong Ku, Ho Yoon Lee, Sung Joo Hwang, Kyeong Ho Kim. Determination of bevantolol in human plasma by high performance liquid chromatography using solid phase extraction technique. Archives of pharmacal research. 2007 Jul; 30(7):890-7. doi: 10.1007/bf02978842. [PMID: 17703743]
  • Claudio Babiloni, Rosanna Squitti, Claudio Del Percio, Emanuele Cassetta, Maria Carla Ventriglia, Florinda Ferreri, Mario Tombini, Giovanni Frisoni, Giuliano Binetti, Mariella Gurzi, Serenella Salinari, Filippo Zappasodi, Paolo M Rossini. Free copper and resting temporal EEG rhythms correlate across healthy, mild cognitive impairment, and Alzheimer's disease subjects. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2007 Jun; 118(6):1244-60. doi: 10.1016/j.clinph.2007.03.016. [PMID: 17462944]
  • Pascal Bilbault, Sophie Pynn, Cyrille Mathien, Jean P Mazzucotelli, Francis Schneider, A Jaeger. Near-fatal betaxolol self-poisoning treated with percutaneous extracorporeal life support. European journal of emergency medicine : official journal of the European Society for Emergency Medicine. 2007 Apr; 14(2):120-2. doi: 10.1097/mej.0b013e328013f87c. [PMID: 17496693]
  • Cécile Miège, Maxime Favier, Corinne Brosse, Jean-Pierre Canler, Marina Coquery. Occurrence of betablockers in effluents of wastewater treatment plants from the Lyon area (France) and risk assessment for the downstream rivers. Talanta. 2006 Nov; 70(4):739-44. doi: 10.1016/j.talanta.2006.07.002. [PMID: 18970833]
  • Hans R Figulla, Maria Krzeminska-Pakula, Krzystof Wrabec, Jiri Chochola, Claudia Kalmbach, P Fridl. Betaxolol is equivalent to carvedilol in patients with heart failure NYHA II or III: result of a randomized multicenter trial (BETACAR Trial). International journal of cardiology. 2006 Nov; 113(2):153-60. doi: 10.1016/j.ijcard.2005.06.067. [PMID: 16157399]
  • Kwou-Yeung Wu, Hwei-Zu Wang, Show-Jen Hong. Effects of antiglaucoma drugs on cellular proliferation in cultured human corneal keratocytes. The Kaohsiung journal of medical sciences. 2006 Mar; 22(3):120-5. doi: 10.1016/s1607-551x(09)70231-1. [PMID: 16602276]
  • D V Dupliakov, V L Glukhova, Z I Vozhdaeva, G A Golovina. [Cardioselective beta-adrenoblockers in patients with stable angina pectoris. Comparison of efficacy and safety]. Terapevticheskii arkhiv. 2006; 78(9):43-8. doi: . [PMID: 17076224]
  • Gábor Holló, Jess T Whitson, Robert Faulkner, Bette McCue, Michael Curtis, Helga Wieland, James Chastain, Mark Sanders, Louis DeSantis, Johan Przydryga, David C Dahlin. Concentrations of betaxolol in ocular tissues of patients with glaucoma and normal monkeys after 1 month of topical ocular administration. Investigative ophthalmology & visual science. 2006 Jan; 47(1):235-40. doi: 10.1167/iovs.05-0945. [PMID: 16384968]
  • Trudy Rodgers, David Leahy, Malcolm Rowland. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. Journal of pharmaceutical sciences. 2005 Jun; 94(6):1237-48. doi: 10.1002/jps.20323. [PMID: 15858851]
  • S Ma, D A Morilak. Norepinephrine release in medial amygdala facilitates activation of the hypothalamic-pituitary-adrenal axis in response to acute immobilisation stress. Journal of neuroendocrinology. 2005 Jan; 17(1):22-8. doi: 10.1111/j.1365-2826.2005.01279.x. [PMID: 15720472]
  • Hans H Maurer, Oliver Tenberken, Carsten Kratzsch, Armin A Weber, Frank T Peters. Screening for library-assisted identification and fully validated quantification of 22 beta-blockers in blood plasma by liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization. Journal of chromatography. A. 2004 Nov; 1058(1-2):169-81. doi: . [PMID: 15595665]
  • M D Hernando, M Petrovic, A R Fernández-Alba, D Barceló. Analysis by liquid chromatography-electrospray ionization tandem mass spectrometry and acute toxicity evaluation for beta-blockers and lipid-regulating agents in wastewater samples. Journal of chromatography. A. 2004 Aug; 1046(1-2):133-40. doi: . [PMID: 15387181]
  • Matthew W Hruska, Reginald F Frye. Simplified method for determination of rosiglitazone in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Apr; 803(2):317-20. doi: 10.1016/j.jchromb.2004.01.010. [PMID: 15063342]
  • Magali Delamoye, Charlotte Duverneuil, François Paraire, Philippe de Mazancourt, Jean-Claude Alvarez. Simultaneous determination of thirteen beta-blockers and one metabolite by gradient high-performance liquid chromatography with photodiode-array UV detection. Forensic science international. 2004 Apr; 141(1):23-31. doi: 10.1016/j.forsciint.2003.12.008. [PMID: 15066710]
  • Andrzej Gebka, Barbara Iwaszkiewicz-Bilikiewicz, Krystyna Raczyńska, Magdalena Homziuk, Cezary Ciechanowski. [Serum lipid profile in non-exudative AMD patients treated with locally administrated beta-blockers]. Klinika oczna. 2004; 106(3 Suppl):407-8. doi: NULL. [PMID: 15636216]
  • Catherine Blondin, Pascale Hamard, Béatrice Cholley, Nicole Haeffner-Cavaillon, Christophe Baudouin. In vitro effects of preserved or preservative-free antiglaucoma medications on human complement system. Current eye research. 2003 Oct; 27(4):253-9. doi: 10.1076/ceyr.27.4.253.16603. [PMID: 14562177]
  • A N Korzh. [Clinical and metabolic effects of betaxolol (lokren) in treatment of patients with chronic cardiac insufficiency]. Likars'ka sprava. 2003 Jul; ?(5-6):90-2. doi: . [PMID: 14618815]
  • Eric A Stone, Gary L Grunewald, Yan Lin, Rashedul Ahsan, Helen Rosengarten, H Kenneth Kramer, David Quartermain. Role of epinephrine stimulation of CNS alpha1-adrenoceptors in motor activity in mice. Synapse (New York, N.Y.). 2003 Jul; 49(1):67-76. doi: 10.1002/syn.10212. [PMID: 12710017]
  • Kiyoshi Ishii, Hiroshi Matsuo, Yasuhiro Fukaya, Sumiyoshi Tanaka, Hideyuki Sakaki, Mitsunori Waki, Makoto Araie. Iganidipine, a new water-soluble Ca2+ antagonist: ocular and periocular penetration after instillation. Investigative ophthalmology & visual science. 2003 Mar; 44(3):1169-77. doi: 10.1167/iovs.02-0482. [PMID: 12601046]
  • Kenichi Watanabe, Wen Juan, Gurusamy Narasimman, Meilei Ma, Mikio Inoue, Yuki Saito, Mir I I Wahed, Mikio Nakazawa, Go Hasegawa, Makoto Naito, Hitoshi Tachikawa, Naohito Tanabe, Makoto Kodama, Yoshifusa Aizawa, Tadashi Yamamoto, Kenichi Yamaguchi, Toshihiro Takahashi. Betaxolol improves the survival rate and changes natriuretic peptide expression in rats with heart failure. Journal of cardiovascular pharmacology. 2003 Jan; 41 Suppl 1(?):S99-103. doi: . [PMID: 12693380]
  • Michał Nowicki, Joanna Miszczak-Kuban. Nonselective Beta-adrenergic blockade augments fasting hyperkalemia in hemodialysis patients. Nephron. 2002 Jun; 91(2):222-7. doi: 10.1159/000058396. [PMID: 12053057]
  • Ikuyo Maruyama, Tadao Maeda, Shigekuni Okisaka, Atsushi Mizukawa, Mitsuru Nakazawa, Hiroshi Ohguro. Autoantibody against neuron-specific enolase found in glaucoma patients causes retinal dysfunction in vivo. Japanese journal of ophthalmology. 2002 Jan; 46(1):1-12. doi: 10.1016/s0021-5155(01)00453-1. [PMID: 11853707]
  • E Vainio-Jylhä, M L Vuori, K Pyykkö, R Huupponen. Plasma concentration of topically applied betaxolol in elderly glaucoma patients. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2001 Jun; 17(3):207-13. doi: 10.1089/108076801750295245. [PMID: 11436941]
  • K H Kim, H J Kim, J H Kim, S D Shin. Determination of terbutaline enantiomers in human urine by coupled achiral-chiral high-performance liquid chromatography with fluorescence detection. Journal of chromatography. B, Biomedical sciences and applications. 2001 Feb; 751(1):69-77. doi: 10.1016/s0378-4347(00)00449-7. [PMID: 11232857]