(8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene (BioDeep_00000846583)
代谢物信息卡片
(8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
化学式: C21H36 (288.2816856)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1CCC2C1(CCC3C2CCC4C3(CCCC4)C)C
InChI: InChI=1S/C21H36/c1-4-15-9-11-18-17-10-8-16-7-5-6-13-20(16,2)19(17)12-14-21(15,18)3/h15-19H,4-14H2,1-3H3/t15-,16?,17-,18-,19-,20-,21+/m0/s1
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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2011 Sep; 50(9):605-11. doi:
10.2165/11587310-000000000-00000. [PMID: 21827215] - Christoph Wyen, Heidy Hendra, Marco Siccardi, Martin Platten, Hans Jaeger, Thomas Harrer, Stefan Esser, Johannes R Bogner, Norbert H Brockmeyer, Bernhard Bieniek, Juergen Rockstroh, Christian Hoffmann, Albrecht Stoehr, Claudia Michalik, Verena Dlugay, Alexander Jetter, Heribert Knechten, Hartwig Klinker, Adriane Skaletz-Rorowski, Gerd Fätkenheuer, Deirdre Egan, David J Back, Andrew Owen. Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens.
The Journal of antimicrobial chemotherapy.
2011 Sep; 66(9):2092-8. doi:
10.1093/jac/dkr272. [PMID: 21715435] - Yipeng Sui, Jinxian Xu, Jennifer Rios-Pilier, Changcheng Zhou. Deficiency of PXR decreases atherosclerosis in apoE-deficient mice.
Journal of lipid research.
2011 Sep; 52(9):1652-9. doi:
10.1194/jlr.m017376. [PMID: 21685500] - Keita Terui, Takeshi Saito, Tomoro Hishiki, Yoshiharu Sato, Tetsuya Mitsunaga, Hideo Yoshida. Hepatic expression of multidrug resistance protein 2 in biliary atresia.
Comparative hepatology.
2011 Aug; 10(?):6. doi:
10.1186/1476-5926-10-6. [PMID: 21813008] - Liang Li, Chuan-Jiang Li, Lei Zheng, Yan-Jun Zhang, Hai-Xia Jiang, Bo Si-Tu, Zhong-Hai Li. Tacrolimus dosing in Chinese renal transplant recipients: a population-based pharmacogenetics study.
European journal of clinical pharmacology.
2011 Aug; 67(8):787-95. doi:
10.1007/s00228-011-1010-y. [PMID: 21331500] - Jeff L Staudinger, Chenshu Xu, Arunima Biswas, Sridhar Mani. Post-translational modification of pregnane x receptor.
Pharmacological research.
2011 Jul; 64(1):4-10. doi:
10.1016/j.phrs.2011.02.011. [PMID: 21397695] - Guodong Li, Grace L Guo. Role of Class II nuclear receptors in liver carcinogenesis.
Anti-cancer agents in medicinal chemistry.
2011 Jul; 11(6):529-42. doi:
10.2174/187152011796011064. [PMID: 21554208] - Katharine Howe, Faizah Sanat, Alfred E Thumser, Tanya Coleman, Nick Plant. The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes.
Xenobiotica; the fate of foreign compounds in biological systems.
2011 Jul; 41(7):519-29. doi:
10.3109/00498254.2011.569773. [PMID: 21476904] - E N Pivovarova, M I Dushkin, M L Perepechaeva, V F Kobzev, V A Trufakin, A L Markel'. [All signs of metabolic syndrome in the hypertensive ISIAH rats are associated with increased activity of transcription factors PPAR, LXR, PXR, and CAR in the liver].
Biomeditsinskaia khimiia.
2011 Jul; 57(4):435-45. doi:
10.18097/pbmc20115704435. [PMID: 22066269] - P V Luoma. Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.
Current molecular medicine.
2011 Jul; 11(5):391-400. doi:
10.2174/156652411795976556. [PMID: 21568932] - Chunna Yu, Xiaojuan Chai, Lushan Yu, Shuqing Chen, Su Zeng. Identification of novel pregnane X receptor activators from traditional Chinese medicines.
Journal of ethnopharmacology.
2011 Jun; 136(1):137-43. doi:
10.1016/j.jep.2011.04.022. [PMID: 21524698] - Yuying Xu, Yin Zhang, Fan Zhou, Yifan Zheng, Xinqiang Zhu. [Human pregnane X receptor-mediated transcriptional regulation of CYP3A4 by extracts of 7 traditional Chinese medicines].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 Jun; 36(11):1524-7. doi:
10.4268/cjcmm20111126. [PMID: 22779192] - Jie Cheng, Xiaochao Ma, Frank J Gonzalez. Pregnane X receptor- and CYP3A4-humanized mouse models and their applications.
British journal of pharmacology.
2011 Jun; 163(3):461-8. doi:
10.1111/j.1476-5381.2010.01129.x. [PMID: 21091656] - Alessandro Schipani, Christoph Wyen, Tabitha Mahungu, Heidy Hendra, Deirdre Egan, Marco Siccardi, Gerry Davies, Saye Khoo, Gerd Fätkenheuer, Michael Youle, Jürgen Rockstroh, Norbert H Brockmeyer, Margaret A Johnson, Andrew Owen, David J Back. Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individuals.
The Journal of antimicrobial chemotherapy.
2011 Jun; 66(6):1332-9. doi:
10.1093/jac/dkr087. [PMID: 21441248] - Jorge Rioja, Eva Bandrés, David Rosell Costa, Anibal Rincón, Ines López, Juan Javier Zudaire Bergera, Jesús García Foncillas, María Jesús Gil, Angel Panizo, Luis Plaza, Luis Angel Rioja, José María Berián Polo. Association of steroid and xenobiotic receptor (SXR) and multidrug resistance 1 (MDR1) gene expression with survival among patients with invasive bladder carcinoma.
BJU international.
2011 Jun; 107(11):1833-8. doi:
10.1111/j.1464-410x.2010.09653.x. [PMID: 20840328] - Xiangdong Zhu, Guisheng Wu, Jianying Xiang, Huairong Luo, Shide Luo, Hongmei Zhu, Yifen Wang. New pregnane saponins from Ecdysanthera rosea and their cytotoxicity.
Fitoterapia.
2011 Jun; 82(4):632-6. doi:
10.1016/j.fitote.2011.01.022. [PMID: 21296131] - Sandeep Khurana, Jean-Pierre Raufman, Thomas L Pallone. Bile acids regulate cardiovascular function.
Clinical and translational science.
2011 Jun; 4(3):210-8. doi:
10.1111/j.1752-8062.2011.00272.x. [PMID: 21707953] - M F Yueh, P L Mellon, R H Tukey. Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor.
Molecular pharmacology.
2011 Jun; 79(6):1053-60. doi:
10.1124/mol.110.070649. [PMID: 21415305] - Jinhan He, Shigeru Nishida, Meishu Xu, Makoto Makishima, Wen Xie. PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts.
Gastroenterology.
2011 Jun; 140(7):2095-106. doi:
10.1053/j.gastro.2011.02.055. [PMID: 21354151] - Francina Fonseca, Rafael de la Torre, Laura Díaz, Antonio Pastor, Elisabet Cuyàs, Nieves Pizarro, Olha Khymenets, Magí Farré, Marta Torrens. Contribution of cytochrome P450 and ABCB1 genetic variability on methadone pharmacokinetics, dose requirements, and response.
PloS one.
2011 May; 6(5):e19527. doi:
10.1371/journal.pone.0019527. [PMID: 21589866] - Jian-Rong Wang, Qiang Shen, Li Fang, Shu-Ying Peng, Yi-Ming Yang, Jia Li, Hai-Li Liu, Yue-Wei Guo. Structural and stereochemical studies of five new pregnane steroids from the stem bark of Toona ciliata var. pubescens.
Steroids.
2011 May; 76(6):571-6. doi:
10.1016/j.steroids.2011.02.007. [PMID: 21349279] - Romi Ghose, Tao Guo, Jesus G Vallejo, Adarsh Gandhi. Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
2011 May; 39(5):874-81. doi:
10.1124/dmd.110.037382. [PMID: 21303924] - Anne S Mortensen, Robert J Letcher, Maria V Cangialosi, Shaogang Chu, Augustine Arukwe. Tissue bioaccumulation patterns, xenobiotic biotransformation and steroid hormone levels in Atlantic salmon (Salmo salar) fed a diet containing perfluoroactane sulfonic or perfluorooctane carboxylic acids.
Chemosphere.
2011 May; 83(8):1035-44. doi:
10.1016/j.chemosphere.2011.01.067. [PMID: 21354591] - Linda C Mota, Christina Barfield, Juan P Hernandez, William S Baldwin. Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes suggests that hPXR is less sensitive than mouse PXR to nonylphenol treatment.
Toxicology and applied pharmacology.
2011 May; 252(3):259-67. doi:
10.1016/j.taap.2011.02.017. [PMID: 21376070] - Víctor P García, Jaime Bermejo, Sara Rubio, José Quintana, Francisco Estévez. Pregnane steroidal glycosides and their cytostatic activities.
Glycobiology.
2011 May; 21(5):619-24. doi:
10.1093/glycob/cwq203. [PMID: 21147757] - J G Hengstler, H Foth, T Gebel, P-J Kramer, W Lilienblum, H Schweinfurth, W Völkel, K-M Wollin, U Gundert-Remy. Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A.
Critical reviews in toxicology.
2011 Apr; 41(4):263-91. doi:
10.3109/10408444.2011.558487. [PMID: 21438738] - Joseph J Raybon, Devin Pray, Daniel G Morgan, Mary Zoeckler, Ming Zheng, Michael Sinz, Sean Kim. Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid and xenobiotic X receptor humanized mice.
The Journal of pharmacology and experimental therapeutics.
2011 Apr; 337(1):75-82. doi:
10.1124/jpet.110.176677. [PMID: 21205914] - Tadeja Režen. The impact of cholesterol and its metabolites on drug metabolism.
Expert opinion on drug metabolism & toxicology.
2011 Apr; 7(4):387-98. doi:
10.1517/17425255.2011.558083. [PMID: 21320036] - Ya-He Liu, Sui-Lin Mo, Hui-Chang Bi, Bing-Fang Hu, Chun Guang Li, Yi-Tao Wang, Ling Huang, Min Huang, Wei Duan, Jun-Ping Liu, Ming Qian Wei, Shu-Feng Zhou. Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study.
Xenobiotica; the fate of foreign compounds in biological systems.
2011 Apr; 41(4):259-80. doi:
10.3109/00498254.2010.537395. [PMID: 21117944] - Maryam Modarai, Andy Suter, Andreas Kortenkamp, Michael Heinrich. The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations.
The Journal of pharmacy and pharmacology.
2011 Mar; 63(3):429-38. doi:
10.1111/j.2042-7158.2010.01235.x. [PMID: 21749392] - Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.
Toxicology.
2011 Feb; 280(3):77-87. doi:
10.1016/j.tox.2010.11.008. [PMID: 21115097] - Yu-Kun Jennifer Zhang, Grace L Guo, Curtis D Klaassen. Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters.
PloS one.
2011 Feb; 6(2):e16683. doi:
10.1371/journal.pone.0016683. [PMID: 21346810] - Youping Deng, Sharon A Meyer, Xin Guan, Barbara Lynn Escalon, Junmei Ai, Mitchell S Wilbanks, Ruth Welti, Natàlia Garcia-Reyero, Edward J Perkins. Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds.
PloS one.
2011 Feb; 6(2):e14662. doi:
10.1371/journal.pone.0014662. [PMID: 21346803] - Ian Bailey, G Gordon Gibson, Kathryn Plant, Mark Graham, Nick Plant. A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile.
PloS one.
2011 Feb; 6(2):e16703. doi:
10.1371/journal.pone.0016703. [PMID: 21311750] - Xiaoyan Pang, Jie Cheng, Kristopher W Krausz, De-an Guo, Frank J Gonzalez. Pregnane X receptor-mediated induction of Cyp3a by black cohosh.
Xenobiotica; the fate of foreign compounds in biological systems.
2011 Feb; 41(2):112-23. doi:
10.3109/00498254.2010.527021. [PMID: 20979450] - Mateja Hafner, Tadeja Rezen, Damjana Rozman. Regulation of hepatic cytochromes p450 by lipids and cholesterol.
Current drug metabolism.
2011 Feb; 12(2):173-85. doi:
10.2174/138920011795016890. [PMID: 21395540] - Julius Brtko, Zdenek Dvorak. Role of retinoids, rexinoids and thyroid hormone in the expression of cytochrome p450 enzymes.
Current drug metabolism.
2011 Feb; 12(2):71-88. doi:
10.2174/138920011795016881. [PMID: 21401514] - Katalin Monostory, Zdenek Dvorak. Steroid regulation of drug-metabolizing cytochromes P450.
Current drug metabolism.
2011 Feb; 12(2):154-72. doi:
10.2174/138920011795016854. [PMID: 21395541] - Walid Faraj, Hana Ajouz, Deborah Mukherji, Gerald Kealy, Ali Shamseddine, Mohamed Khalife. Inflammatory pseudo-tumor of the liver: a rare pathological entity.
World journal of surgical oncology.
2011 Jan; 9(?):5. doi:
10.1186/1477-7819-9-5. [PMID: 21255461]