2-(3,4-dichlorophenyl)-N-methyl-N-[(1S,2S)-2-(1-pyrrolidinyl)cyclohexyl]acetamide (BioDeep_00000846150)
代谢物信息卡片
2-(3,4-dichlorophenyl)-N-methyl-N-[(1S,2S)-2-(1-pyrrolidinyl)cyclohexyl]acetamide
化学式: C19H26Cl2N2O (368.1422086)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C1CCCCC1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
InChI: InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m0/s1
描述信息
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代谢反应
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- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Qin Zheng, Qi Wu, Hong Yang, Qiuhong Chen, Xiaohui Li, Jingyi Guo. A κ-OR Agonist Protects the Endothelial Function Impaired by Hyperuricemia Through Regulating the Akt/eNOS Signal Pathway.
Probiotics and antimicrobial proteins.
2022 08; 14(4):751-759. doi:
10.1007/s12602-022-09945-1. [PMID: 35536506] - Kanako Miyano, Yuki Yoshida, Shigeto Hirayama, Hideki Takahashi, Haruka Ono, Yoshiyuki Meguro, Sei Manabe, Akane Komatsu, Miki Nonaka, Takaaki Mizuguchi, Hideaki Fujii, Yoshikazu Higami, Minoru Narita, Yasuhito Uezono. Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway.
Cells.
2021 10; 10(10):. doi:
10.3390/cells10102651. [PMID: 34685631] - Laura L Erwin, Mark R Nilges, Ian B Denys, Jane C Sutphen, Ashton J Friend, Daniel R Kapusta, Peter J Winsauer. Interactive effects of (±)-trans-U50488 and its stereoisomers with cannabinoids.
Pharmacology, biochemistry, and behavior.
2021 08; 207(?):173218. doi:
10.1016/j.pbb.2021.173218. [PMID: 34118232] - Amelia Dunn, Kyle Windisch, Ariel Ben-Ezra, Phillip Pikus, Michelle Morochnik, Jose Erazo, Brian Reed, Mary Jeanne Kreek. Modulation of cocaine-related behaviors by low doses of the potent KOR agonist nalfurafine in male C57BL6 mice.
Psychopharmacology.
2020 Aug; 237(8):2405-2418. doi:
10.1007/s00213-020-05543-7. [PMID: 32435819] - Li-Jie Liu, Jian-Jun Yu, Xiao-Lin Xu. Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway.
Acta pharmacologica Sinica.
2018 Jan; 39(1):97-106. doi:
10.1038/aps.2017.51. [PMID: 28770825] - M Morgan, A Heffernan, F Benhabib, S Wagner, A K Hewavitharana, P N Shaw, P J Cabot. The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.
Peptides.
2017 03; 89(?):9-16. doi:
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ACS chemical neuroscience.
2016 12; 7(12):1737-1745. doi:
10.1021/acschemneuro.6b00249. [PMID: 27700049] - Juan Li, Xiaojie Liang, Yaguang Zhou, Shumiao Zhang, Fan Yang, Haitao Guo, Rong Fan, Na Feng, Min Jia, Yueming Wang, Mingchao Liu, Jianming Pei. Role of dynorphin in hypoxic pulmonary hypertension.
European journal of pharmacology.
2016 Nov; 791(?):78-84. doi:
10.1016/j.ejphar.2016.08.019. [PMID: 27568355] - Géza Berecki, Leonid Motin, David J Adams. Mechanism of direct Cav2.2 channel block by the κ-opioid receptor agonist U50488H.
Neuropharmacology.
2016 10; 109(?):49-58. doi:
10.1016/j.neuropharm.2016.05.019. [PMID: 27245500] - Fei Tian, Xu-Yang Zheng, Juan Li, Shu-Miao Zhang, Na Feng, Hai-Tao Guo, Min Jia, Yue-Min Wang, Rong Fan, Jian-Ming Pei. κ-Opioid Receptor Stimulation Improves Endothelial Function via Akt-stimulated NO Production in Hyperlipidemic Rats.
Scientific reports.
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Cell reports.
2016 Mar; 14(12):2774-83. doi:
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BMC endocrine disorders.
2015 Feb; 15(?):7. doi:
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Journal of cellular biochemistry.
2015 Feb; 116(2):252-9. doi:
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European journal of pharmacology.
2014 Aug; 737(?):177-84. doi:
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Cytokine.
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Inflammation.
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Cytokine.
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2010 Dec; 40(4):301-9. doi:
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American journal of physiology. Heart and circulatory physiology.
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Heart and vessels.
2007 Sep; 22(5):335-44. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Jul; 293(1):R162-8. doi:
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Experimental physiology.
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European journal of pharmacology.
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The Journal of pharmacology and experimental therapeutics.
2005 Feb; 312(2):678-85. doi:
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Developmental and comparative immunology.
2004 Jul; 28(9):949-58. doi:
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Japanese journal of pharmacology.
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The Journal of pharmacology and experimental therapeutics.
1993 Oct; 267(1):197-204. doi:
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The Journal of pharmacology and experimental therapeutics.
1993 Sep; 266(3):1385-9. doi:
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The Journal of pharmacology and experimental therapeutics.
1993 Sep; 266(3):1602-6. doi:
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Journal of neuroendocrinology.
1993 Jun; 5(3):307-14. doi:
10.1111/j.1365-2826.1993.tb00487.x. [PMID: 8100468] - A J Douglas, G Clarke, S J MacMillan, P M Bull, I Neumann, S A Way, D M Wright, B G McGrory, J A Russell. Effects of the kappa-opioid agonist U50,488 on parturition in rats.
British journal of pharmacology.
1993 May; 109(1):251-8. doi:
10.1111/j.1476-5381.1993.tb13561.x. [PMID: 8388299] - H N Bhargava, G A Matwyshyn, A K Rattan, K L Koo, G A Tejwani. The effect of U-50,488H tolerance-dependence and abstinence on the levels of dynorphin (1-13) in brain regions, spinal cord, pituitary gland and peripheral tissues of the rat.
Brain research.
1993 Jan; 600(1):151-5. doi:
10.1016/0006-8993(93)90413-h. [PMID: 8093675] - A Petit, N Gallo-Payet, D Bellabarba, J G Lehoux, S Bélisle. The modulation of placental lactogen release by opioids: a role for extracellular calcium.
Molecular and cellular endocrinology.
1993 Jan; 90(2):165-70. doi:
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Life sciences.
1993; 53(10):795-801. doi:
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Experimental brain research.
1993; 94(2):237-46. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
1993; 47(8):337-44. doi:
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Molecular pharmacology.
1992 Dec; 42(6):1083-9. doi:
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Physiology & behavior.
1992 Dec; 52(6):1179-85. doi:
10.1016/0031-9384(92)90479-l. [PMID: 1336603] - P G Green, J D Levine. Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat.
Neuroscience.
1992 Jul; 49(1):129-33. doi:
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The American journal of physiology.
1992 Mar; 262(3 Pt 1):G461-9. doi:
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Neuropharmacology.
1992 Feb; 31(2):143-8. doi:
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The Journal of pharmacology and experimental therapeutics.
1992 Jan; 260(1):327-33. doi:
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Neuropeptides.
1991 Oct; 20(2):95-102. doi:
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Anesthesia and analgesia.
1991 Oct; 73(4):427-33. doi:
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The Journal of endocrinology.
1991 Jun; 129(3):411-6. doi:
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The Journal of pharmacy and pharmacology.
1991 Mar; 43(3):212-6. doi:
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The Journal of pharmacology and experimental therapeutics.
1991 Jan; 256(1):211-21. doi:
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European journal of pharmacology.
1990 Dec; 191(3):437-46. doi:
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The Journal of pharmacology and experimental therapeutics.
1990 Dec; 255(3):1287-95. doi:
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Diabetes.
1990 Oct; 39(10):1289-97. doi:
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Neuroendocrinology.
1990 Aug; 52(2):200-5. doi:
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Journal of medicinal chemistry.
1990 Apr; 33(4):1171-6. doi:
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Hormone research.
1990; 34(3-4):129-32. doi:
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Neuroscience.
1990; 37(3):635-45. doi:
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The Journal of pharmacology and experimental therapeutics.
1990 Jan; 252(1):225-34. doi:
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British journal of pharmacology.
1990 Jan; 99(1):181-5. doi:
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Brain research.
1989 Nov; 502(1):143-8. doi:
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