2-[[(2R)-3-hexadecoxy-2-hydroxypropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium (BioDeep_00000846018)

   


代谢物信息卡片


2-[[(2R)-3-hexadecoxy-2-hydroxypropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium

化学式: C24H53NO6P+ (482.36103080000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCOCC(COP(=O)(O)OCC[N+](C)(C)C)O
InChI: InChI=1S/C24H52NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-29-22-24(26)23-31-32(27,28)30-21-19-25(2,3)4/h24,26H,5-23H2,1-4H3/p+1/t24-/m1/s1

描述信息

D007155 - Immunologic Factors

同义名列表

1 个代谢物同义名

2-[[(2R)-3-hexadecoxy-2-hydroxypropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Xue Gao, Yijie Liu, Yuancheng Li, Hao Fan, Rong Wu, Rukang Zhang, Brandon Faubert, Yu-Ying He, Marc B Bissonnette, Siyuan Xia, Dong Chen, Hui Mao, Titus J Boggon, Jing Chen. Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation. Molecular cell. 2022 06; 82(11):1992-2005.e9. doi: 10.1016/j.molcel.2022.03.026. [PMID: 35417664]
  • Kun Shi, Qiong Wang, Yao Su, Xingcui Xuan, Yaqiong Liu, Weiwei Chen, Yuanmin Qian, Gendie E Lash. Identification and functional analyses of differentially expressed metabolites in early stage endometrial carcinoma. Cancer science. 2018 Apr; 109(4):1032-1043. doi: 10.1111/cas.13532. [PMID: 29436067]
  • Fabian Dorninger, Ann B Moser, Jianqiu Kou, Christoph Wiesinger, Sonja Forss-Petter, Andreas Gleiss, Margareta Hinterberger, Susanne Jungwirth, Peter Fischer, Johannes Berger. Alterations in the Plasma Levels of Specific Choline Phospholipids in Alzheimer's Disease Mimic Accelerated Aging. Journal of Alzheimer's disease : JAD. 2018; 62(2):841-854. doi: 10.3233/jad-171036. [PMID: 29480199]
  • Isabel Sanz-Vicente, Andrés Domínguez, Carlos Ferrández, Javier Galbán. Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF. Analytical biochemistry. 2017 Feb; 519(?):30-37. doi: 10.1016/j.ab.2016.12.005. [PMID: 27956151]
  • Akira Sato, Keitaro Oe, Hikaru Yamanaka, Izumi Yokoyama, Keiichi Ebina. C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo. European journal of pharmacology. 2014 Dec; 745(?):46-51. doi: 10.1016/j.ejphar.2014.10.020. [PMID: 25455842]
  • Marilita M Moschos, Irini P Chatziralli, George Stamatakis, Vasiliki D Papakonstantinou, Constantinos A Demopoulos. In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. Cutaneous and ocular toxicology. 2014 Sep; 33(3):235-41. doi: 10.3109/15569527.2013.835818. [PMID: 24147947]
  • Michał Flasiński, Katarzyna Hąc-Wydro, Paweł Wydro, Patrycja Dynarowicz-Łątka. Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level. Journal of the Royal Society, Interface. 2014 Jun; 11(95):20131103. doi: 10.1098/rsif.2013.1103. [PMID: 24694892]
  • Toshihiko Tsutsumi, Junichi Morishige, Kenji Fukuzawa, Akira Tokumura. Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. Prostaglandins & other lipid mediators. 2007 Feb; 83(1-2):33-41. doi: 10.1016/j.prostaglandins.2006.09.007. [PMID: 17259070]
  • Koji Nakagawa, Shuji Yamano, Masaharu Kamada, Masahiko Maegawa, Akira Tokumura, Minoru Irahara, Hidekazu Saito. Sperm-immobilizing antibodies suppress an increase in the plasma membrane fluidity of human spermatozoa. Fertility and sterility. 2004 Oct; 82 Suppl 3(?):1054-8. doi: 10.1016/j.fertnstert.2004.03.034. [PMID: 15474073]
  • Paraskevi G Thanou, Demokritos C Tsoukatos. Non-enzymatic platelet-activating factor formation by acetylated proteins. FEBS letters. 2004 Aug; 573(1-3):11-4. doi: 10.1016/j.febslet.2004.07.037. [PMID: 15327967]
  • Shuji Yamano, Jun Yamazaki, Minoru Irahara, Akira Tokumura, Koji Nakagawa, Hidekazu Saito. Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid. Fertility and sterility. 2004 Mar; 81(3):605-10. doi: 10.1016/j.fertnstert.2003.07.036. [PMID: 15037409]
  • Cynthia Brewer, Fanny Bonin, Paula Bullock, Marie-Christine Nault, Jennifer Morin, Sophie Imbeault, T Y Shen, D J Franks, Steffany A L Bennett. Platelet activating factor-induced apoptosis is inhibited by ectopic expression of the platelet activating factor G-protein coupled receptor. Journal of neurochemistry. 2002 Sep; 82(6):1502-11. doi: 10.1046/j.1471-4159.2002.01094.x. [PMID: 12354298]
  • G K Marathe, A R Silva, H C de Castro Faria Neto, L W Tjoelker, S M Prescott, G A Zimmerman, T M McIntyre. Lysophosphatidylcholine and lyso-PAF display PAF-like activity derived from contaminating phospholipids. Journal of lipid research. 2001 Sep; 42(9):1430-7. doi: 10.1016/s0022-2275(20)30275-3. [PMID: 11518762]
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  • F Dupuis, S Levasseur, F Jean-Louis, C Dulery, V Praloran, Y Denizot, L Michel. Production, metabolism and effect of platelet-activating factor on the growth of the human K562 erythroid cell line. Biochimica et biophysica acta. 1997 Dec; 1359(3):241-9. doi: 10.1016/s0167-4889(97)00106-7. [PMID: 9434130]
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  • S O Oh, B O Ibe, C Johnson, J Kurantsin-Mills, J U Raj. Platelet-activating factor in plasma of patients with sickle cell disease in steady state. The Journal of laboratory and clinical medicine. 1997 Aug; 130(2):191-6. doi: 10.1016/s0022-2143(97)90095-0. [PMID: 9280146]
  • R E Jones. Synthesis of ether lipids and phosphatidylethanolamine by ejaculated human spermatozoa. Archives of andrology. 1997 May; 38(3):181-9. doi: 10.3109/01485019708994876. [PMID: 9140614]
  • Y Denizot, F Rougier, F Dupuis, F Trimoreau, C Dulery, M Laskar, V Praloran. Presence and metabolism of lyso platelet-activating factor in human bone marrow. Journal of lipid mediators and cell signalling. 1997 May; 16(1):53-62. doi: 10.1016/s0929-7855(96)00567-6. [PMID: 9101422]
  • S I Svetlov, K M Howard, M Miwa, B D Flickinger, M S Olson. Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation. Archives of biochemistry and biophysics. 1996 Mar; 327(1):113-22. doi: 10.1006/abbi.1996.0099. [PMID: 8615681]
  • M Trapali, M Mavri-Vavayanni, A Siafaka-Kapadai. PAF-acetylhydrolase activity and PAF levels in pancreas and plasma of well-fed, diabetic and fasted rat. Life sciences. 1996; 59(10):849-57. doi: 10.1016/0024-3205(96)00375-x. [PMID: 8761318]
  • T M Davis, T Q Binh, N van Phuong, M Sturm, A St John, J R Dyer, T K Anh. The metabolism of platelet-activating factor in severe and cerebral malaria. The Journal of infection. 1995 Nov; 31(3):181-8. doi: 10.1016/s0163-4453(95)80024-7. [PMID: 8586836]
  • F Bussolino, M Arese, G Montrucchio, L Barra, L Primo, R Benelli, F Sanavio, M Aglietta, D Ghigo, M R Rola-Pleszczynski. Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis. The Journal of clinical investigation. 1995 Aug; 96(2):940-52. doi: 10.1172/jci118142. [PMID: 7543496]
  • J Morris, V Burke, T A Mori, R Vandongen, L J Beilin. Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study. Clinical and experimental pharmacology & physiology. 1995 Jun; 22(6-7):414-7. doi: 10.1111/j.1440-1681.1995.tb02032.x. [PMID: 8582091]
  • M L Blank, V Fitzgerald, Z L Smith, F Snyder. Generation of the precursor (lyso-PAF) of platelet-activating factor via a CoA-dependent transacylase. Biochemical and biophysical research communications. 1995 May; 210(3):1052-8. doi: 10.1006/bbrc.1995.1763. [PMID: 7763233]
  • R Schaloske, C Sordano, S Bozzaro, D Malchow. Stimulation of calcium influx by platelet activating factor in Dictyostelium. Journal of cell science. 1995 Apr; 108 ( Pt 4)(?):1597-603. doi: 10.1242/jcs.108.4.1597. [PMID: 7615678]
  • M L Blank, Z L Smith, V Fitzgerald, F Snyder. The CoA-independent transacylase in PAF biosynthesis: tissue distribution and molecular species selectivity. Biochimica et biophysica acta. 1995 Feb; 1254(3):295-301. doi: 10.1016/0005-2760(94)00189-6. [PMID: 7857969]
  • K Karasawa, H Kato, M Setaka, S Nojima. Accumulation of platelet-activating factor acetylhydrolase in the peritoneal cavity of guinea pig after endotoxin shock. Journal of biochemistry. 1994 Aug; 116(2):368-73. doi: 10.1093/oxfordjournals.jbchem.a124533. [PMID: 7822256]
  • R M Graham, C J Stephens, W Silvester, L L Leong, M J Sturm, R R Taylor. Plasma degradation of platelet-activating factor in severely ill patients with clinical sepsis. Critical care medicine. 1994 Feb; 22(2):204-12. doi: 10.1097/00003246-199402000-00009. [PMID: 8306677]
  • F Bussolino, F Silvagno, G Garbarino, C Costamagna, F Sanavio, M Arese, R Soldi, M Aglietta, G Pescarmona, G Camussi. Human endothelial cells are targets for platelet-activating factor (PAF). Activation of alpha and beta protein kinase C isozymes in endothelial cells stimulated by PAF. The Journal of biological chemistry. 1994 Jan; 269(4):2877-86. doi: 10.1016/s0021-9258(17)42024-2. [PMID: 7507929]
  • D C Tsoukatos, A D Tselepis, M E Lekka. Studies on the subcellular distribution of 1-O-alkyl-2-acetyl-sn-glycero phosphocholine (PAF) and on the enzymic activities involved in its biosynthesis within the ciliate Tetrahymena pyriformis. Biochimica et biophysica acta. 1993 Nov; 1170(3):258-64. doi: 10.1016/0005-2760(93)90008-w. [PMID: 8218344]
  • M Noris, D Macconi, V Nanni, M Salmona, M Todeschini, G Remuzzi. Defective glomerular [3H]lysoPAF metabolism in the autologous phase of rabbit nephrotoxic nephritis. Kidney international. 1993 Oct; 44(4):747-54. doi: 10.1038/ki.1993.309. [PMID: 8258952]
  • Y Ihara, R A Frenkel, J M Johnston. Hormonal regulation of platelet-activating factor-acetyltransferase activity in rat tissues. Archives of biochemistry and biophysics. 1993 Aug; 304(2):503-7. doi: 10.1006/abbi.1993.1382. [PMID: 8346925]
  • N Lepage, P Miron, R Hemmings, K D Roberts, J Langlais. Distribution of lysophospholipids and metabolism of platelet-activating factor in human follicular and peritoneal fluids. Journal of reproduction and fertility. 1993 Jul; 98(2):349-56. doi: 10.1530/jrf.0.0980349. [PMID: 8410799]
  • L J Beilin, K D Croft, C A Michael, J Ritchie, L Schmidt, R Vandongen, B N Walters. Neutrophil platelet-activating factor in normal and hypertensive pregnancy and in pregnancy-induced hypertension. Clinical science (London, England : 1979). 1993 Jul; 85(1):63-70. doi: 10.1042/cs0850063. [PMID: 8149697]
  • K Jarvi, K D Roberts, J Langlais, C Gagnon. Effect of platelet-activating factor, lyso-platelet-activating factor, and lysophosphatidylcholine on sperm motion: importance of albumin for motility stimulation. Fertility and sterility. 1993 Jun; 59(6):1266-75. doi: 10.1016/s0015-0282(16)55988-3. [PMID: 8495776]
  • M E Venable, S C Olson, M L Nieto, R L Wykle. Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. The Journal of biological chemistry. 1993 Apr; 268(11):7965-75. doi: 10.1016/s0021-9258(18)53052-0. [PMID: 8463317]
  • E Rotllan, G Escolar, A Ordinas, E Bastida. [Effect of PAF (platelet-activating factor) on hemostasis. Studies on endothelial cells and platelets]. Sangre. 1993 Apr; 38(2):115-9. doi: NULL. [PMID: 8390724]
  • J Fu, H P Yu, P S Li. [Bioassay of Lyso-PAF platelet activating factor and it's role in bronchial asthma]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. 1993 Feb; 16(1):30-2, 63. doi: NULL. [PMID: 8403058]
  • T Nakamura, K Ishihara, M Kuriyama, K Ito, Y Matsumura. Platelet-activating factor in Japanese cedar pollinosis. Journal of lipid mediators. 1992 Jun; 5(2):193-5. doi: NULL. [PMID: 1525363]
  • F Joly, M Breton, C Wolf, E Ninio, O Colard. Heterogeneity of arachidonate and paf-acether precursor pools in mast cells. Biochimica et biophysica acta. 1992 May; 1125(3):305-12. doi: 10.1016/0005-2760(92)90060-9. [PMID: 1596519]
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  • Y Denizot, S Chaussade, N Nathan, J F Colombel, M J Bossant, N Cherouki, J Benveniste, D Couturier. PAF-acether and acetylhydrolase in stool of patients with Crohn's disease. Digestive diseases and sciences. 1992 Mar; 37(3):432-7. doi: 10.1007/bf01307739. [PMID: 1735366]
  • C J Stephens, R M Graham, O P Yadava, L L Leong, M J Sturm, R R Taylor. Plasma platelet activating factor degradation and serum lipids after coronary bypass surgery. Cardiovascular research. 1992 Jan; 26(1):25-31. doi: 10.1093/cvr/26.1.25. [PMID: 1516109]
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  • T Nakamura, M Kuriyama, K Ishihara, Y Matsumura, T Miyamoto. Platelet-activating factor (PAF) in allergic diseases: inhibitory effects of anti-allergic drugs, ketotifen and three kampo medicines on PAF production. Lipids. 1991 Dec; 26(12):1297-300. doi: 10.1007/bf02536552. [PMID: 1726443]
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