[(2R)-2-hexadecanoyloxy-3-[hydroxy-[(2R,3R,5S,6R)-2,4,6-trihydroxy-3,5-diphosphonooxycyclohexyl]oxyphosphoryl]oxypropyl] hexadecanoate (BioDeep_00000845710)
代谢物信息卡片
化学式: C41H81O19P3 (970.4584666)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)OP(=O)(O)O)O)OP(=O)(O)O)O)OC(=O)CCCCCCCCCCCCCCC
InChI: InChI=1S/C41H81O19P3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(42)55-31-33(57-35(43)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)32-56-63(53,54)60-41-37(45)39(58-61(47,48)49)36(44)40(38(41)46)59-62(50,51)52/h33,36-41,44-46H,3-32H2,1-2H3,(H,53,54)(H2,47,48,49)(H2,50,51,52)/t33-,36?,37-,38-,39-,40+,41?/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Pilar Rivero-Ríos, Lois S Weisman. A signaling lipid drives synapse formation.
Science (New York, N.Y.).
2023 10; 382(6667):155-156. doi:
10.1126/science.adk5037
. [PMID: 37824634] - Filiz Sila Rizalar, Max T Lucht, Astrid Petzoldt, Shuhan Kong, Jiachen Sun, James H Vines, Narasimha Swamy Telugu, Sebastian Diecke, Thomas Kaas, Torsten Bullmann, Christopher Schmied, Delia Löwe, Jason S King, Wonhwa Cho, Stefan Hallermann, Dmytro Puchkov, Stephan J Sigrist, Volker Haucke. Phosphatidylinositol 3,5-bisphosphate facilitates axonal vesicle transport and presynapse assembly.
Science (New York, N.Y.).
2023 10; 382(6667):223-230. doi:
10.1126/science.adg1075
. [PMID: 37824668] - Claire C Weckerly, Gerald R V Hammond. Molding a PI(3,5)P2 biosensor.
The Journal of cell biology.
2023 09; 222(9):. doi:
10.1083/jcb.202308004
. [PMID: 37578524] - Chi Zhang, Yilin Feng, Adam Balutowski, Gregory E Miner, David A Rivera-Kohr, Michael R Hrabak, Katherine D Sullivan, Annie Guo, Jorge D Calderin, Rutilio A Fratti. The interdependent transport of yeast vacuole Ca2+ and H+ and the role of phosphatidylinositol 3,5-bisphosphate.
The Journal of biological chemistry.
2022 12; 298(12):102672. doi:
10.1016/j.jbc.2022.102672
. [PMID: 36334632] - Xavier Leray, Jacob K Hilton, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell. Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance.
eLife.
2022 06; 11(?):. doi:
10.7554/elife.74136
. [PMID: 35670560] - Xu Chen, Yuhong Zhang, Xiang Ren, Qi Su, Yan Liu, Xing Dang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Yaya Wang, Zhantao Bai, Edward T H Yeh, Hongmei Wu, Yitao Qi. The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
The Journal of biological chemistry.
2021 10; 297(4):101183. doi:
10.1016/j.jbc.2021.101183
. [PMID: 34509475] - Zachary N Wilson, Dalton Buysse, Matt West, Daniel Ahrens, Greg Odorizzi. Vacuolar H+-ATPase dysfunction rescues intralumenal vesicle cargo sorting in yeast lacking PI(3,5)P2 or Doa4.
Journal of cell science.
2021 08; 134(15):. doi:
10.1242/jcs.258459
. [PMID: 34342352] - Cansu Karabiyik, Mariella Vicinanza, Sung Min Son, David C Rubinsztein. Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
Developmental cell.
2021 07; 56(13):1961-1975.e5. doi:
10.1016/j.devcel.2021.05.010
. [PMID: 34107300] - Katharina Fitzian, Anne Brückner, Laura Brohée, Reinhard Zech, Claudia Antoni, Stephan Kiontke, Raphael Gasper, Anna Livia Linard Matos, Stephanie Beel, Sabine Wilhelm, Volker Gerke, Christian Ungermann, Mark Nellist, Stefan Raunser, Constantinos Demetriades, Andrea Oeckinghaus, Daniel Kümmel. TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Molecular cell.
2021 07; 81(13):2705-2721.e8. doi:
10.1016/j.molcel.2021.04.019
. [PMID: 33974911] - Marta Guerrero-Valero, Federica Grandi, Silvia Cipriani, Valeria Alberizzi, Roberta Di Guardo, Gaetan Chicanne, Linda Sawade, Francesca Bianchi, Ubaldo Del Carro, Ivan De Curtis, Davide Pareyson, Yesim Parman, Angelo Schenone, Volker Haucke, Bernard Payrastre, Alessandra Bolino. Dysregulation of myelin synthesis and actomyosin function underlies aberrant myelin in CMT4B1 neuropathy.
Proceedings of the National Academy of Sciences of the United States of America.
2021 03; 118(10):. doi:
10.1073/pnas.2009469118
. [PMID: 33653949] - Joshua A Lees, PeiQi Li, Nikit Kumar, Lois S Weisman, Karin M Reinisch. Insights into Lysosomal PI(3,5)P2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex.
Molecular cell.
2020 11; 80(4):736-743.e4. doi:
10.1016/j.molcel.2020.10.003
. [PMID: 33098764] - Gregory E Miner, Katherine D Sullivan, Chi Zhang, David Rivera-Kohr, Annie Guo, Logan R Hurst, Ez C Ellis, Matthew L Starr, Brandon C Jones, Rutilio A Fratti. Phosphatidylinositol 3,5-bisphosphate regulates Ca2+ transport during yeast vacuolar fusion through the Ca2+ ATPase Pmc1.
Traffic (Copenhagen, Denmark).
2020 07; 21(7):503-517. doi:
10.1111/tra.12736
. [PMID: 32388897] - Lorena Fernandez-Mosquera, King Faisal Yambire, Renata Couto, Leonardo Pereyra, Kamil Pabis, Amy H Ponsford, Cátia V Diogo, Massimiliano Stagi, Ira Milosevic, Nuno Raimundo. Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
Autophagy.
2019 09; 15(9):1572-1591. doi:
10.1080/15548627.2019.1586256
. [PMID: 30917721] - Deepak Kumar Choudhary, Priyanka Bhakt, Rupinder Kaur. Essential Role for the Phosphatidylinositol 3,5-Bisphosphate Synthesis Complex in Caspofungin Tolerance and Virulence in Candida glabrata.
Antimicrobial agents and chemotherapy.
2019 08; 63(8):. doi:
10.1128/aac.00886-19
. [PMID: 31138567] - Christopher J Penny, Kristin Vassileva, Archana Jha, Yu Yuan, Xavier Chee, Elizabeth Yates, Michela Mazzon, Bethan S Kilpatrick, Shmuel Muallem, Mark Marsh, Taufiq Rahman, Sandip Patel. Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers.
Biochimica et biophysica acta. Molecular cell research.
2019 07; 1866(7):1151-1161. doi:
10.1016/j.bbamcr.2018.10.022
. [PMID: 30408544] - Subhrajit Banerjee, Kaitlyn Clapp, Maureen Tarsio, Patricia M Kane. Interaction of the late endo-lysosomal lipid PI(3,5)P2 with the Vph1 isoform of yeast V-ATPase increases its activity and cellular stress tolerance.
The Journal of biological chemistry.
2019 06; 294(23):9161-9171. doi:
10.1074/jbc.ra119.008552
. [PMID: 31023825] - Gregory E Miner, Katherine D Sullivan, Annie Guo, Brandon C Jones, Logan R Hurst, Ez C Ellis, Matthew L Starr, Rutilio A Fratti. Phosphatidylinositol 3,5-bisphosphate regulates the transition between trans-SNARE complex formation and vacuole membrane fusion.
Molecular biology of the cell.
2019 01; 30(2):201-208. doi:
10.1091/mbc.e18-08-0505
. [PMID: 30427760] - Tomoko Hirano, Hiroki Konno, Seiji Takeda, Liam Dolan, Mariko Kato, Takashi Aoyama, Takumi Higaki, Hisako Takigawa-Imamura, Masa H Sato. PtdIns(3,5)P2 mediates root hair shank hardening in Arabidopsis.
Nature plants.
2018 11; 4(11):888-897. doi:
10.1038/s41477-018-0277-8
. [PMID: 30390081] - Michael Fine, Philip Schmiege, Xiaochun Li. Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nature communications.
2018 10; 9(1):4192. doi:
10.1038/s41467-018-06493-7
. [PMID: 30305615] - Sonja A Kirsch, Andreas Kugemann, Armando Carpaneto, Rainer A Böckmann, Petra Dietrich. Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2.
Cellular and molecular life sciences : CMLS.
2018 Oct; 75(20):3803-3815. doi:
10.1007/s00018-018-2829-5
. [PMID: 29705952] - Carla Brillada, Jiameng Zheng, Falco Krüger, Eliezer Rovira-Diaz, Jana Christin Askani, Karin Schumacher, Marcela Rojas-Pierce. Phosphoinositides control the localization of HOPS subunit VPS41, which together with VPS33 mediates vacuole fusion in plants.
Proceedings of the National Academy of Sciences of the United States of America.
2018 08; 115(35):E8305-E8314. doi:
10.1073/pnas.1807763115
. [PMID: 30104351] - Wei-Tong Zhang, En Li, Yan-Kui Guo, Shi-Xia Yu, Zhi-Yuan Wan, Ting Ma, Sha Li, Tomoko Hirano, Masa H Sato, Yan Zhang. Arabidopsis VAC14 Is Critical for Pollen Development through Mediating Vacuolar Organization.
Plant physiology.
2018 08; 177(4):1529-1538. doi:
10.1104/pp.18.00495
. [PMID: 29884680] - Yevgeniya A Mironova, Jing-Ping Lin, Ashley L Kalinski, Lucas D Huffman, Guy M Lenk, Leif A Havton, Miriam H Meisler, Roman J Giger. Protective role of the lipid phosphatase Fig4 in the adult nervous system.
Human molecular genetics.
2018 07; 27(14):2443-2453. doi:
10.1093/hmg/ddy145
. [PMID: 29688489] - Zachary N Wilson, Amber L Scott, Robin D Dowell, Greg Odorizzi. PI(3,5)P2 controls vacuole potassium transport to support cellular osmoregulation.
Molecular biology of the cell.
2018 07; 29(13):1718-1731. doi:
10.1091/mbc.e18-01-0015
. [PMID: 29791245] - Huynh Minh Hung, Tran Dieu Hang, Minh Tho Nguyen. Molecular details of spontaneous insertion and interaction of HCV non-structure 3 protease protein domain with PIP2-containing membrane.
Proteins.
2018 04; 86(4):423-433. doi:
10.1002/prot.25458
. [PMID: 29341226] - Navin Gopaldass, Bruno Fauvet, Hilal Lashuel, Aurélien Roux, Andreas Mayer. Membrane scission driven by the PROPPIN Atg18.
The EMBO journal.
2017 11; 36(22):3274-3291. doi:
10.15252/embj.201796859
. [PMID: 29030482] - Joachim Scholz-Starke. How may PI(3,5)P2 impact on vacuolar acidification?.
Channels (Austin, Tex.).
2017 11; 11(6):497-498. doi:
10.1080/19336950.2017.1354584
. [PMID: 28699817] - Marscha Hirschi, Mark A Herzik, Jinhong Wie, Yang Suo, William F Borschel, Dejian Ren, Gabriel C Lander, Seok-Yong Lee. Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.
Nature.
2017 10; 550(7676):411-414. doi:
10.1038/nature24055
. [PMID: 29019979] - Subhrajit Banerjee, Patricia M Kane. Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast.
Molecular biology of the cell.
2017 Sep; 28(19):2518-2530. doi:
10.1091/mbc.e17-05-0316
. [PMID: 28720663] - Benoit J Gentil, Erin O'Ferrall, Colin Chalk, Luis F Santana, Heather D Durham, Rami Massie. A New Mutation in FIG4 Causes a Severe Form of CMT4J Involving TRPV4 in the Pathogenic Cascade.
Journal of neuropathology and experimental neurology.
2017 Sep; 76(9):789-799. doi:
10.1093/jnen/nlx062
. [PMID: 28859335] - Natsuko Jin, Yui Jin, Lois S Weisman. Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome.
The Journal of cell biology.
2017 07; 216(7):2075-2090. doi:
10.1083/jcb.201611144
. [PMID: 28637746] - Armando Carpaneto, Anna Boccaccio, Laura Lagostena, Eleonora Di Zanni, Joachim Scholz-Starke. The signaling lipid phosphatidylinositol-3,5-bisphosphate targets plant CLC-a anion/H+ exchange activity.
EMBO reports.
2017 07; 18(7):1100-1107. doi:
10.15252/embr.201643814
. [PMID: 28536248] - Tomoko Hirano, Kelly Stecker, Teun Munnik, Haoxing Xu, Masa H Sato. Visualization of Phosphatidylinositol 3,5-Bisphosphate Dynamics by a Tandem ML1N-Based Fluorescent Protein Probe in Arabidopsis.
Plant & cell physiology.
2017 Jul; 58(7):1185-1195. doi:
10.1093/pcp/pcx011
. [PMID: 28158631] - Roeland Vanhauwaert, Sabine Kuenen, Roy Masius, Adekunle Bademosi, Julia Manetsberger, Nils Schoovaerts, Laura Bounti, Serguei Gontcharenko, Jef Swerts, Sven Vilain, Marina Picillo, Paolo Barone, Shashini T Munshi, Femke Ms de Vrij, Steven A Kushner, Natalia V Gounko, Wim Mandemakers, Vincenzo Bonifati, Frederic A Meunier, Sandra-Fausia Soukup, Patrik Verstreken. The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.
The EMBO journal.
2017 05; 36(10):1392-1411. doi:
10.15252/embj.201695773
. [PMID: 28331029] - Michael J Lang, Bethany S Strunk, Nadia Azad, Jason L Petersen, Lois S Weisman. An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels.
Molecular biology of the cell.
2017 Apr; 28(7):858-864. doi:
10.1091/mbc.e16-06-0390
. [PMID: 28148651] - Tomoko Hirano, Teun Munnik, Masa H Sato. Inhibition of phosphatidylinositol 3,5-bisphosphate production has pleiotropic effects on various membrane trafficking routes in Arabidopsis.
Plant & cell physiology.
2017 01; 58(1):120-129. doi:
10.1093/pcp/pcw164
. [PMID: 27803131] - Seong M Kim, Saurabh G Roy, Bin Chen, Tiffany M Nguyen, Ryan J McMonigle, Alison N McCracken, Yanling Zhang, Satoshi Kofuji, Jue Hou, Elizabeth Selwan, Brendan T Finicle, Tricia T Nguyen, Archna Ravi, Manuel U Ramirez, Tim Wiher, Garret G Guenther, Mari Kono, Atsuo T Sasaki, Lois S Weisman, Eric O Potma, Bruce J Tromberg, Robert A Edwards, Stephen Hanessian, Aimee L Edinger. Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
The Journal of clinical investigation.
2016 11; 126(11):4088-4102. doi:
10.1172/jci87148
. [PMID: 27669461] - Karen E Anderson, Veronique Juvin, Jonathan Clark, Len R Stephens, Phillip T Hawkins. Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells.
Advances in biological regulation.
2016 09; 62(?):18-24. doi:
10.1016/j.jbior.2015.11.002
. [PMID: 26639089] - Lauren M Compton, Ognian C Ikonomov, Diego Sbrissa, Puneet Garg, Assia Shisheva. Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.
American journal of physiology. Cell physiology.
2016 09; 311(3):C366-77. doi:
10.1152/ajpcell.00104.2016
. [PMID: 27335171] - Lee Dolat, Elias T Spiliotis. Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion.
The Journal of cell biology.
2016 08; 214(5):517-27. doi:
10.1083/jcb.201603030
. [PMID: 27551056] - Yevgeniya A Mironova, Guy M Lenk, Jing-Ping Lin, Seung Joon Lee, Jeffery L Twiss, Ilaria Vaccari, Alessandra Bolino, Leif A Havton, Sang H Min, Charles S Abrams, Peter Shrager, Miriam H Meisler, Roman J Giger. PI(3,5)P2 biosynthesis regulates oligodendrocyte differentiation by intrinsic and extrinsic mechanisms.
eLife.
2016 03; 5(?):. doi:
10.7554/elife.13023
. [PMID: 27008179] - Natsuko Jin, Michael J Lang, Lois S Weisman. Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time.
Biochemical Society transactions.
2016 Feb; 44(1):177-84. doi:
10.1042/bst20150174
. [PMID: 26862203] - Guy M Lenk, Christen M Frei, Ashley C Miller, Rachel C Wallen, Yevgeniya A Mironova, Roman J Giger, Miriam H Meisler. Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.
Human molecular genetics.
2016 Jan; 25(2):340-7. doi:
10.1093/hmg/ddv480
. [PMID: 26604144] - Heather Currinn, Benjamin Guscott, Zita Balklava, Alice Rothnie, Thomas Wassmer. APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex.
Cellular and molecular life sciences : CMLS.
2016 Jan; 73(2):393-408. doi:
10.1007/s00018-015-1993-0
. [PMID: 26216398] - Tomoko Hirano, Teun Munnik, Masa H Sato. Phosphatidylinositol 3-Phosphate 5-Kinase, FAB1/PIKfyve Kinase Mediates Endosome Maturation to Establish Endosome-Cortical Microtubule Interaction in Arabidopsis.
Plant physiology.
2015 Nov; 169(3):1961-74. doi:
10.1104/pp.15.01368
. [PMID: 26353760] - Tine Holemans, Danny Mollerup Sørensen, Sarah van Veen, Shaun Martin, Diane Hermans, Gerdi Christine Kemmer, Chris Van den Haute, Veerle Baekelandt, Thomas Günther Pomorski, Patrizia Agostinis, Frank Wuytack, Michael Palmgren, Jan Eggermont, Peter Vangheluwe. A lipid switch unlocks Parkinson's disease-associated ATP13A2.
Proceedings of the National Academy of Sciences of the United States of America.
2015 Jul; 112(29):9040-5. doi:
10.1073/pnas.1508220112
. [PMID: 26134396] - David R Slochower, Yu-Hsiu Wang, Ravi Radhakrishnan, Paul A Janmey. Physical chemistry and membrane properties of two phosphatidylinositol bisphosphate isomers.
Physical chemistry chemical physics : PCCP.
2015 May; 17(19):12608-15. doi:
10.1039/c5cp00862j
. [PMID: 25901568] - Cheuk Y Ho, Christopher H Choy, Christina A Wattson, Danielle E Johnson, Roberto J Botelho. The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.
The Journal of biological chemistry.
2015 Apr; 290(15):9919-28. doi:
10.1074/jbc.m114.613984
. [PMID: 25713145] - Xiaobing Li, Shin-Ichiroh Saitoh, Takuma Shibata, Natsuko Tanimura, Ryutaro Fukui, Kensuke Miyake. Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes.
International immunology.
2015 Feb; 27(2):83-94. doi:
10.1093/intimm/dxu086
. [PMID: 25239130] - Gerald R V Hammond, Shunsuke Takasuga, Takehiko Sasaki, Tamas Balla. The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells.
PloS one.
2015; 10(10):e0139957. doi:
10.1371/journal.pone.0139957
. [PMID: 26460749] - Xinghua Feng, Jian Xiong, Yungang Lu, Xuefeng Xia, Michael X Zhu. Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1.
Cell calcium.
2014 Dec; 56(6):446-56. doi:
10.1016/j.ceca.2014.09.004
. [PMID: 25266962] - Amber J McCartney, Sergey N Zolov, Emily J Kauffman, Yanling Zhang, Bethany S Strunk, Lois S Weisman, Michael A Sutton. Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression.
Proceedings of the National Academy of Sciences of the United States of America.
2014 Nov; 111(45):E4896-905. doi:
10.1073/pnas.1411117111
. [PMID: 25355904] - Edgar Dawkins, Robert Gasperini, Yanling Hu, Hao Cui, Adele J Vincent, Marta Bolós, Kaylene M Young, Lisa Foa, David H Small. The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons.
Journal of neuroscience research.
2014 Nov; 92(11):1478-89. doi:
10.1002/jnr.23422
. [PMID: 24916405] - Anna Boccaccio, Joachim Scholz-Starke, Shin Hamamoto, Nina Larisch, Margherita Festa, Paul Vijay Kanth Gutla, Alex Costa, Petra Dietrich, Nobuyuki Uozumi, Armando Carpaneto. The phosphoinositide PI(3,5)P₂ mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells.
Cellular and molecular life sciences : CMLS.
2014 Nov; 71(21):4275-83. doi:
10.1007/s00018-014-1623-2
. [PMID: 24770793] - Chunlei Cang, Biruk Bekele, Dejian Ren. The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
Nature chemical biology.
2014 Jun; 10(6):463-9. doi:
10.1038/nchembio.1522
. [PMID: 24776928] - Samantha J Pitt, Andy K M Lam, Katja Rietdorf, Antony Galione, Rebecca Sitsapesan. Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+.
Science signaling.
2014 May; 7(326):ra46. doi:
10.1126/scisignal.2004854
. [PMID: 24847115] - Sheena Claire Li, Theodore T Diakov, Tao Xu, Maureen Tarsio, Wandi Zhu, Sergio Couoh-Cardel, Lois S Weisman, Patricia M Kane. The signaling lipid PI(3,5)P₂ stabilizes V₁-V(o) sector interactions and activates the V-ATPase.
Molecular biology of the cell.
2014 Apr; 25(8):1251-62. doi:
10.1091/mbc.e13-10-0563
. [PMID: 24523285] - Natsuko Jin, Kai Mao, Yui Jin, Gela Tevzadze, Emily J Kauffman, Sujin Park, Dave Bridges, Robbie Loewith, Alan R Saltiel, Daniel J Klionsky, Lois S Weisman. Roles for PI(3,5)P2 in nutrient sensing through TORC1.
Molecular biology of the cell.
2014 Apr; 25(7):1171-85. doi:
10.1091/mbc.e14-01-0021
. [PMID: 24478451] - Guy M Lenk, Miriam H Meisler. Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.
Methods in enzymology.
2014; 534(?):245-60. doi:
10.1016/b978-0-12-397926-1.00014-7
. [PMID: 24359958] - Amber J McCartney, Yanling Zhang, Lois S Weisman. Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.
BioEssays : news and reviews in molecular, cellular and developmental biology.
2014 Jan; 36(1):52-64. doi:
10.1002/bies.201300012
. [PMID: 24323921] - Xinran Li, Xiang Wang, Xiaoli Zhang, Mingkun Zhao, Wai Lok Tsang, Yanling Zhang, Richard Gar Wai Yau, Lois S Weisman, Haoxing Xu. Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.
Proceedings of the National Academy of Sciences of the United States of America.
2013 Dec; 110(52):21165-70. doi:
10.1073/pnas.1311864110
. [PMID: 24324172] - Robert H Michell. Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease.
The FEBS journal.
2013 Dec; 280(24):6281-94. doi:
10.1111/febs.12452
. [PMID: 23902363] - Yang Liu, Yu-Chiang Lai, Elaine V Hill, Donatienne Tyteca, Sarah Carpentier, Ada Ingvaldsen, Didier Vertommen, Louise Lantier, Marc Foretz, Franck Dequiedt, Pierre J Courtoy, Christophe Erneux, Benoît Viollet, Peter R Shepherd, Jeremy M Tavaré, Jørgen Jensen, Mark H Rider. Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.
The Biochemical journal.
2013 Oct; 455(2):195-206. doi:
10.1042/bj20130644
. [PMID: 23905686] - David Oxley, Nicholas Ktistakis, Theodora Farmaki. Differential isolation and identification of PI(3)P and PI(3,5)P2 binding proteins from Arabidopsis thaliana using an agarose-phosphatidylinositol-phosphate affinity chromatography.
Journal of proteomics.
2013 Oct; 91(?):580-94. doi:
10.1016/j.jprot.2013.08.020
. [PMID: 24007659] - Isabelle Guillas, Aurélia Vernay, Jean-Jacques Vitagliano, Robert A Arkowitz. Phosphatidylinositol 4,5-bisphosphate is required for invasive growth in Saccharomyces cerevisiae.
Journal of cell science.
2013 Aug; 126(Pt 16):3602-14. doi:
10.1242/jcs.122606
. [PMID: 23781030] - Bong-Kwan Han, Scott D Emr. The phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-dependent Tup1 conversion (PIPTC) regulates metabolic reprogramming from glycolysis to gluconeogenesis.
The Journal of biological chemistry.
2013 Jul; 288(28):20633-45. doi:
10.1074/jbc.m113.452813
. [PMID: 23733183] - Gwangbae Bak, Eun-Jung Lee, Yuree Lee, Mariko Kato, Shoji Segami, Heven Sze, Masayoshi Maeshima, Jae-Ung Hwang, Youngsook Lee. Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate.
The Plant cell.
2013 Jun; 25(6):2202-16. doi:
10.1105/tpc.113.110411
. [PMID: 23757398] - Tamadher A Alghamdi, Cheuk Y Ho, Amra Mrakovic, Danielle Taylor, Daniel Mao, Roberto J Botelho. Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function.
The Journal of biological chemistry.
2013 Mar; 288(13):9363-72. doi:
10.1074/jbc.m113.453712
. [PMID: 23389034] - H Sun, L Jiang, X Luo, W Jin, Q He, J An, K Lui, J Shi, R Rong, W Su, C Lucchesi, Y Liu, M S Sheikh, Y Huang. Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer.
Oncogene.
2013 Jan; 32(2):234-41. doi:
10.1038/onc.2012.34
. [PMID: 22349814] - William's Elong Edimo, Jean-Marie Vanderwinden, Christophe Erneux. SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts.
Advances in biological regulation.
2013 Jan; 53(1):28-37. doi:
10.1016/j.jbior.2012.09.003
. [PMID: 23040614] - Kuan-Yi Lu, Sheng-Ce Tao, Tzu-Ching Yang, Yu-Hsuan Ho, Chia-Hsien Lee, Chen-Ching Lin, Hsueh-Fen Juan, Hsuan-Cheng Huang, Chin-Yu Yang, Ming-Shuo Chen, Yu-Yi Lin, Jin-Ying Lu, Heng Zhu, Chien-Sheng Chen. Profiling lipid-protein interactions using nonquenched fluorescent liposomal nanovesicles and proteome microarrays.
Molecular & cellular proteomics : MCP.
2012 Nov; 11(11):1177-90. doi:
10.1074/mcp.m112.017426
. [PMID: 22843995] - Sergey N Zolov, Dave Bridges, Yanling Zhang, Wei-Wei Lee, Ellen Riehle, Rakesh Verma, Guy M Lenk, Kimber Converso-Baran, Thomas Weide, Roger L Albin, Alan R Saltiel, Miriam H Meisler, Mark W Russell, Lois S Weisman. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Oct; 109(43):17472-7. doi:
10.1073/pnas.1203106109
. [PMID: 23047693] - Martin Zieger, Andreas Mayer. Yeast vacuoles fragment in an asymmetrical two-phase process with distinct protein requirements.
Molecular biology of the cell.
2012 Sep; 23(17):3438-49. doi:
10.1091/mbc.e12-05-0347
. [PMID: 22787281] - Diego Sbrissa, Ognian C Ikonomov, Catherine Filios, Khortnal Delvecchio, Assia Shisheva. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
American journal of physiology. Cell physiology.
2012 Aug; 303(4):C436-46. doi:
10.1152/ajpcell.00105.2012
. [PMID: 22621786] - Christian Grimm, Sami Hassan, Christian Wahl-Schott, Martin Biel. Role of TRPML and two-pore channels in endolysosomal cation homeostasis.
The Journal of pharmacology and experimental therapeutics.
2012 Aug; 342(2):236-44. doi:
10.1124/jpet.112.192880
. [PMID: 22518024] - Dave Bridges, Jing-Tyan Ma, Sujin Park, Ken Inoki, Lois S Weisman, Alan R Saltiel. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.
Molecular biology of the cell.
2012 Aug; 23(15):2955-62. doi:
10.1091/mbc.e11-12-1034
. [PMID: 22696681] - Peter A C van Gisbergen, Ming Li, Shu-Zon Wu, Magdalena Bezanilla. Class II formin targeting to the cell cortex by binding PI(3,5)P(2) is essential for polarized growth.
The Journal of cell biology.
2012 Jul; 198(2):235-50. doi:
10.1083/jcb.201112085
. [PMID: 22801781] - Xiaoli Zhang, Xinran Li, Haoxing Xu. Phosphoinositide isoforms determine compartment-specific ion channel activity.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Jul; 109(28):11384-9. doi:
10.1073/pnas.1202194109
. [PMID: 22733759] - Elizabeth M Davies, David A Sheffield, Priyanka Tibarewal, Clare G Fedele, Christina A Mitchell, Nicholas R Leslie. The PTEN and Myotubularin phosphoinositide 3-phosphatases: linking lipid signalling to human disease.
Sub-cellular biochemistry.
2012; 58(?):281-336. doi:
10.1007/978-94-007-3012-0_8
. [PMID: 22403079] - Guiscard Seebohm, Sebastian Neumann, Carsten Theiss, Tanja Novkovic, Elaine V Hill, Jeremy M Tavaré, Florian Lang, Michael Hollmann, Denise Manahan-Vaughan, Nathalie Strutz-Seebohm. Identification of a novel signaling pathway and its relevance for GluA1 recycling.
PloS one.
2012; 7(3):e33889. doi:
10.1371/journal.pone.0033889
. [PMID: 22470488] - Cheuk Y Ho, Tamadher A Alghamdi, Roberto J Botelho. Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.
Traffic (Copenhagen, Denmark).
2012 Jan; 13(1):1-8. doi:
10.1111/j.1600-0854.2011.01246.x
. [PMID: 21736686] - Debora Karali, David Oxley, John Runions, Nicholas Ktistakis, Theodora Farmaki. The Arabidopsis thaliana immunophilin ROF1 directly interacts with PI(3)P and PI(3,5)P2 and affects germination under osmotic stress.
PloS one.
2012; 7(11):e48241. doi:
10.1371/journal.pone.0048241
. [PMID: 23133621] - Bong-Kwan Han, Scott D Emr. Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1.
Genes & development.
2011 May; 25(9):984-95. doi:
10.1101/gad.1998611
. [PMID: 21536737] - Ognian C Ikonomov, Diego Sbrissa, Khortnal Delvecchio, Yufen Xie, Jian-Ping Jin, Daniel Rappolee, Assia Shisheva. The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
The Journal of biological chemistry.
2011 Apr; 286(15):13404-13. doi:
10.1074/jbc.m111.222364
. [PMID: 21349843] - Philipp Berger, Kristian Tersar, Kurt Ballmer-Hofer, Ueli Suter. The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling.
Journal of cellular and molecular medicine.
2011 Feb; 15(2):307-15. doi:
10.1111/j.1582-4934.2009.00967.x
. [PMID: 19912440] - Chad D Touchberry, Ian K Bales, Jessica K Stone, Travis J Rohrberg, Nikhil K Parelkar, Tien Nguyen, Oscar Fuentes, Xia Liu, Cheng-Kui Qu, Jon J Andresen, Héctor H Valdivia, Marco Brotto, Michael J Wacker. Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor.
The Journal of biological chemistry.
2010 Dec; 285(51):40312-21. doi:
10.1074/jbc.m110.179689
. [PMID: 20947503] - Eleonora Zakharian, Chike Cao, Tibor Rohacs. Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Sep; 30(37):12526-34. doi:
10.1523/jneurosci.3189-10.2010
. [PMID: 20844147] - Cole J Ferguson, Guy M Lenk, Miriam H Meisler. Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
Human molecular genetics.
2009 Dec; 18(24):4868-78. doi:
10.1093/hmg/ddp460
. [PMID: 19793721] - Fuminori Tsuruta, Eric M Green, Matthieu Rousset, Ricardo E Dolmetsch. PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death.
The Journal of cell biology.
2009 Oct; 187(2):279-94. doi:
10.1083/jcb.200903028
. [PMID: 19841139] - Yohei Katoh, Brigitte Ritter, Thomas Gaffry, Francois Blondeau, Stefan Höning, Peter S McPherson. The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology.
The Journal of biological chemistry.
2009 Oct; 284(40):27646-54. doi:
10.1074/jbc.m109.034884
. [PMID: 19651769] - Natsuko Jin, Clement Y Chow, Li Liu, Sergey N Zolov, Roderick Bronson, Muriel Davisson, Jason L Petersen, Yanling Zhang, Sujin Park, Jason E Duex, Daniel Goldowitz, Miriam H Meisler, Lois S Weisman. VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
The EMBO journal.
2008 Dec; 27(24):3221-34. doi:
10.1038/emboj.2008.248
. [PMID: 19037259] - Nahoko Nagasaki, Rie Tomioka, Masayoshi Maeshima. A hydrophilic cation-binding protein of Arabidopsis thaliana, AtPCaP1, is localized to plasma membrane via N-myristoylation and interacts with calmodulin and the phosphatidylinositol phosphates PtdIns(3,4,5)P(3) and PtdIns(3,5)P(2).
The FEBS journal.
2008 May; 275(9):2267-82. doi:
10.1111/j.1742-4658.2008.06379.x
. [PMID: 18397324] - Jem A Efe, Roberto J Botelho, Scott D Emr. Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate.
Molecular biology of the cell.
2007 Nov; 18(11):4232-44. doi:
10.1091/mbc.e07-04-0301
. [PMID: 17699591] - Yanling Zhang, Sergey N Zolov, Clement Y Chow, Shalom G Slutsky, Simon C Richardson, Robert C Piper, Baoli Yang, Johnathan J Nau, Randal J Westrick, Sean J Morrison, Miriam H Meisler, Lois S Weisman. Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.
Proceedings of the National Academy of Sciences of the United States of America.
2007 Oct; 104(44):17518-23. doi:
10.1073/pnas.0702275104
. [PMID: 17956977] - Lars C Huber, Astrid Jüngel, Jörg H W Distler, Falk Moritz, Renate E Gay, Beat A Michel, David S Pisetsky, Steffen Gay, Oliver Distler. The role of membrane lipids in the induction of macrophage apoptosis by microparticles.
Apoptosis : an international journal on programmed cell death.
2007 Feb; 12(2):363-74. doi:
10.1007/s10495-006-0622-7
. [PMID: 17191114] - Stephen K Dove, Zoë E Johnson. Our FABulous VACation: a decade of phosphatidylinositol 3,5-bisphosphate.
Biochemical Society symposium.
2007; ?(74):129-39. doi:
10.1042/bss0740129
. [PMID: 17233586] - Anne M Kong, Kristy A Horan, Absorn Sriratana, Charles G Bailey, Luke J Collyer, Harshal H Nandurkar, Assia Shisheva, Meredith J Layton, John E J Rasko, Tony Rowe, Christina A Mitchell. Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.
Molecular and cellular biology.
2006 Aug; 26(16):6065-81. doi:
10.1128/mcb.00203-06
. [PMID: 16880518] - Jez G Carlton, Miriam V Bujny, Brian J Peter, Viola M J Oorschot, Anna Rutherford, Rebecca S Arkell, Judith Klumperman, Harvey T McMahon, Peter J Cullen. Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.
Journal of cell science.
2005 Oct; 118(Pt 19):4527-39. doi:
10.1242/jcs.02568
. [PMID: 16179610] - George Leondaritis, Arno Tiedtke, Dia Galanopoulou. D-3 phosphoinositides of the ciliate Tetrahymena: characterization and study of their regulatory role in lysosomal enzyme secretion.
Biochimica et biophysica acta.
2005 Sep; 1745(3):330-41. doi:
10.1016/j.bbamcr.2005.06.011
. [PMID: 16081170]