Temiverine hydrochloride hydrate (BioDeep_00000845575)
代谢物信息卡片
Temiverine hydrochloride hydrate
化学式: C24H38ClNO4 (439.24892180000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CC#CC(C)(C)OC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O.O.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M Nakazawa, E Kitayama, T Adachi, M Yoshida, S Ishibashi, K Yoshikawa, T Kajihara, K Iwakura, N Sumi. [Toxicokinetics of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence, in mice and rats during 13-week dietary administration].
The Journal of toxicological sciences.
1997 Apr; 22 Suppl 1(?):177-85. doi:
10.2131/jts.22.supplementi_177. [PMID: 9170607] - R C Hatch, K S Regan, S Ishibashi, M Nakazawa, K Iwakura, N Sumi. Seventy-eight-week dietary carcinogenicity study of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence, in mice.
The Journal of toxicological sciences.
1997 Apr; 22 Suppl 1(?):275-87. doi:
10.2131/jts.22.supplementi_275. [PMID: 9170615] - R C Hatch, K S Regan, S Ishibashi, M Nakazawa, K Iwakura, N Sumi. Two-year dietary carcinogenicity study of (+/-)-4-diethylamino-1, 1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence, in rats.
The Journal of toxicological sciences.
1997 Apr; 22 Suppl 1(?):289-306. doi:
10.2131/jts.22.supplementi_289. [PMID: 9170616] - K Okasaki, S Baba, H Ikeda, Y Chihaya, S Satake, R Nagata, S Ishibashi, K Iwakura, N Sumi. [A 26-week oral repeated dose toxicity study of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence, in rats followed by a 9-week recovery test].
The Journal of toxicological sciences.
1997 Apr; 22 Suppl 1(?):59-92. doi:
10.2131/jts.22.supplementi_59. [PMID: 9170603] - M Yoshida, A Kawaminami, T Tawaratani, S Ishibashi, M Nakazawa, E Kitayama, T Oka, T Adachi, K Iwakura, N Sumi. [A 12-month oral repeated dose toxicity study of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence, in dogs followed by a 2-month recovery test].
The Journal of toxicological sciences.
1997 Apr; 22 Suppl 1(?):147-75. doi:
10.2131/jts.22.supplementi_147. [PMID: 9170606] - Y Nishiguchi, T Adachi, M Nakazawa, T Tawaratani, H Uchimoto, M Yoshida, S Ishibashi, E Kitayama, K Iwakura, N Sumi. [A 13-week oral repeated dose toxicity study of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence, in rats followed by a 5-week recovery test].
The Journal of toxicological sciences.
1997 Apr; 22 Suppl 1(?):27-57. doi:
10.2131/jts.22.supplementi_27. [PMID: 9170602] - S Furukawa, H Kouyama, M Kikumori, Y Taniguchi, T Nishimori, S Ishibashi, K Iwakura, N Sumi. [Oral single-dose and 13-week repeat-dose toxicity studies of RCC-36, the active metabolite of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate(NS-21), a novel drug for urinary frequency and incontinence, in rats].
The Journal of toxicological sciences.
1997 Apr; 22 Suppl 1(?):93-124. doi:
10.2131/jts.22.supplementi_93. [PMID: 9170604] - A Nakamura, T Hirota, K Sugihara, A Morino. Pharmacokinetics of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate. 3rd communication: plasma concentrations of the unchanged drug and its deethylated metabolite in rats, dogs and monkeys.
Arzneimittel-Forschung.
1997 Feb; 47(2):169-74. doi:
NULL. [PMID: 9079236] - A Nakamura, T Hirota, K Sugihara, S Watanabe, K Tougou, A Morino, Y Ezumi, M Takaichi. Pharmacokinetics of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate. 2nd communication: tissue levels and enzyme activity in rats after repeated administration, and placental and milk transfer after single administration.
Arzneimittel-Forschung.
1997 Feb; 47(2):160-8. doi:
NULL. [PMID: 9079235] - A Nakamura, K Sugihara, T Hirota, A Morino, Y Ezumi, M Takaichi. Pharmacokinetics of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate. 1st communication: absorption, distribution and excretion after single administration of 14C-labeled compound to rats and dogs.
Arzneimittel-Forschung.
1997 Feb; 47(2):151-9. doi:
NULL. [PMID: 9079234] - T Hirota, A Nakamura, K Sugihara, A Morino. Pharmacokinetics of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate. 4th communication: metabolism in rats and dogs.
Arzneimittel-Forschung.
1997 Feb; 47(2):175-81. doi:
NULL. [PMID: 9079237]