Butaclamol free base (BioDeep_00000845553)

   


代谢物信息卡片


Butaclamol free base

化学式: C25H31NO (361.2405516)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O
InChI: InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m1/s1

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist

同义名列表

1 个代谢物同义名

Butaclamol free base



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Raluca-Ioana Stefan-van Staden, Nontete Suzan Nhlapo, Jacobus Frederick van Staden, Hassan Y Aboul-Enein. Enantioanalysis of (-)butaclamol using vancomycin and teicoplanin as chiral selectors. Combinatorial chemistry & high throughput screening. 2010 Sep; 13(8):690-3. doi: 10.2174/138620710791920301. [PMID: 20426737]
  • Stéphane Bastianetto, Marc Danik, Françoise Mennicken, Sylvain Williams, Rémi Quirion. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC neuroscience. 2006 Mar; 7(?):28. doi: 10.1186/1471-2202-7-28. [PMID: 16573831]
  • Brian F O'Dowd, Xiaodong Ji, Mohammad Alijaniaram, Ryan D Rajaram, Michael M C Kong, Asim Rashid, Tuan Nguyen, Susan R George. Dopamine receptor oligomerization visualized in living cells. The Journal of biological chemistry. 2005 Nov; 280(44):37225-35. doi: 10.1074/jbc.m504562200. [PMID: 16115864]
  • Hassan Y Aboul-Enein, Mohamed M Hefnawy. Chiral analysis of butaclamol enantiomers in human plasma by HPLC using a macrocyclic antibiotic (vancomycin) chiral stationary phase and solid phase extraction. Chirality. 2004 Mar; 16(3):147-52. doi: 10.1002/chir.20001. [PMID: 14770410]
  • M Tiberi, M G Caron. High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. The Journal of biological chemistry. 1994 Nov; 269(45):27925-31. doi: NULL. [PMID: 7525564]
  • C M Hollis, J D Turner, P G Strange. Binding of [3H]SCH23390 to a non-dopaminergic site in bovine kidney. Biochemical pharmacology. 1992 May; 43(9):1947-55. doi: 10.1016/0006-2952(92)90637-x. [PMID: 1375829]
  • K M Dewar, T A Reader. Specific [3H]SCH23390 binding to dopamine D1 receptors in cerebral cortex and neostriatum: role of disulfide and sulfhydryl groups. Journal of neurochemistry. 1989 Feb; 52(2):472-82. doi: 10.1111/j.1471-4159.1989.tb09145.x. [PMID: 2463335]
  • J Logan, A P Wolf, C Y Shiue, J S Fowler. Kinetic modeling of receptor-ligand binding applied to positron emission tomographic studies with neuroleptic tracers. Journal of neurochemistry. 1987 Jan; 48(1):73-83. doi: 10.1111/j.1471-4159.1987.tb13129.x. [PMID: 2432176]
  • A D Baines, R Drangova. Neural not tubular dopamine increases glomerular filtration rate in perfused rat kidneys. The American journal of physiology. 1986 Apr; 250(4 Pt 2):F674-9. doi: 10.1152/ajprenal.1986.250.4.f674. [PMID: 2421588]
  • P Onali, M C Olianas, G L Gessa. Characterization of dopamine receptors mediating inhibition of adenylate cyclase activity in rat striatum. Molecular pharmacology. 1985 Aug; 28(2):138-45. doi: NULL. [PMID: 2410769]
  • C D Arnett, C Y Shiue, A P Wolf, J S Fowler, J Logan, M Watanabe. Comparison of three 18F-labeled butyrophenone neuroleptic drugs in the baboon using positron emission tomography. Journal of neurochemistry. 1985 Mar; 44(3):835-44. doi: 10.1111/j.1471-4159.1985.tb12891.x. [PMID: 2579198]
  • M Schmidt, J L Imbs, E M Giesen-Crouse, J Schwartz. Effects of SK&F 82526 and SK&F 83742 on the renal vascular dopamine receptor. Journal de pharmacologie. 1985 Jan; 16(1):15-22. doi: NULL. [PMID: 2582206]
  • J O Willoughby, H J Pederick, P M Jervois, M F Menadue. Sustained oestrogen-induced hyperprolactinaemia results from a pituitary defect. The Journal of endocrinology. 1983 Dec; 99(3):477-83. doi: 10.1677/joe.0.0990477. [PMID: 6196429]
  • M Schmidt, J L Imbs, E M Giesen, J Schwartz. Blockade of dopamine receptors in the renal vasculature by isomers of flupenthixol and sulpiride. Journal of cardiovascular pharmacology. 1983 Jan; 5(1):86-9. doi: 10.1097/00005344-198301000-00013. [PMID: 6186865]
  • M Schmidt, J L Imbs, E M Giesen, J Schwartz. Vasodilator effects of dopaminomimetics in the perfused rat kidney. European journal of pharmacology. 1982 Oct; 84(1-2):61-70. doi: 10.1016/0014-2999(82)90157-1. [PMID: 6183130]
  • C Y Cheung, A C Neill, R I Weiner. Stimulation of prolactin secretion by neuroleptics in rats with medial basal hypothalamic lesions. Neuroendocrinology. 1981 Jun; 32(6):370-4. doi: 10.1159/000123188. [PMID: 6165920]
  • N Faure, M J Cronin, J A Martial, R I Weiner. Decreased responsiveness of GH3 cells to the dopaminergic inhibition of prolactin. Endocrinology. 1980 Oct; 107(4):1022-6. doi: 10.1210/endo-107-4-1022. [PMID: 6157521]
  • M Schmidt, J L Imbs. Pharmacological characterization of renal vascular dopamine receptors. Journal of cardiovascular pharmacology. 1980 Sep; 2(5):595-605. doi: 10.1097/00005344-198009000-00009. [PMID: 6157952]
  • J O Willoughby, P Brazeau, J B Martin. Pulsatile growth hormone and prolactin: effects of (+) butaclamol, a dopamine receptor blocking agent. Endocrinology. 1977 Oct; 101(4):1298-303. doi: 10.1210/endo-101-4-1298. [PMID: 908278]
  • S V Drouva, R V Gallo. Further evidence for inhibition of episodic luteinizing hormone release in ovariectomized rats by stimulation of dopamine receptors. Endocrinology. 1977 Mar; 100(3):792-8. doi: 10.1210/endo-100-3-792. [PMID: 95702]