6-[4-(Methylthio)phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline (BioDeep_00000845414)

   


代谢物信息卡片


Pyrrolo(2,1-a)isoquinoline, 1,2,3,5,6,10b-hexahydro-6-(4-(methylthio)phenyl)-, (6R,10bS)-

化学式: C19H21NS (295.13946260000006)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CSC1=CC=C(C=C1)C2CN3CCCC3C4=CC=CC=C24
InChI: InChI=1S/C19H21NS/c1-21-15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists

同义名列表

3 个代谢物同义名

6-[4-(Methylthio)phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline; Pyrrolo(2,1-a)isoquinoline, 1,2,3,5,6,10b-hexahydro-6-(4-(methylthio)phenyl)-, (6R,10bS)-; (6S,10bR)-6-[4-(methylthio)phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Michael Strupp-Levitsky, Jeffrey M Miller, Harry Rubin-Falcone, Francesca Zanderigo, Matthew S Milak, Gregory Sullivan, R Todd Ogden, Maria A Oquendo, Christine DeLorenzo, Norman Simpson, Ramin V Parsey, J John Mann. Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults. Psychiatry research. Neuroimaging. 2016 Sep; 255(?):81-6. doi: 10.1016/j.pscychresns.2016.08.002. [PMID: 27567324]
  • Ursula F Bailer, Guido K Frank, Julie C Price, Carolyn C Meltzer, Carl Becker, Chester A Mathis, Angela Wagner, Nicole C Barbarich-Marsteller, Cinnamon S Bloss, Karen Putnam, Nicholas J Schork, Anthony Gamst, Walter H Kaye. Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa. Psychiatry research. 2013 Feb; 211(2):160-8. doi: 10.1016/j.pscychresns.2012.06.010. [PMID: 23154100]
  • Swen Hesse, Peter Brust, Peter Mäding, Georg-Alexander Becker, Marianne Patt, Anita Seese, Dietlind Sorger, Jörg Zessin, Philipp M Meyer, Donald Lobsien, Sven Laudi, Bernd Habermann, Frank Füchtner, Julia Luthardt, Anke Bresch, Jörg Steinbach, Osama Sabri. Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans. European journal of nuclear medicine and molecular imaging. 2012 Jun; 39(6):1001-11. doi: 10.1007/s00259-012-2078-z. [PMID: 22349718]
  • Kazuhiko Nakamura, Yoshimoto Sekine, Yasuomi Ouchi, Masatsugu Tsujii, Etsuji Yoshikawa, Masami Futatsubashi, Kenji J Tsuchiya, Genichi Sugihara, Yasuhide Iwata, Katsuaki Suzuki, Hideo Matsuzaki, Shiro Suda, Toshiro Sugiyama, Nori Takei, Norio Mori. Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. Archives of general psychiatry. 2010 Jan; 67(1):59-68. doi: 10.1001/archgenpsychiatry.2009.137. [PMID: 20048223]
  • Jeffrey M Miller, Erin L Kinnally, R Todd Ogden, Maria A Oquendo, J John Mann, Ramin V Parsey. Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder. Synapse (New York, N.Y.). 2009 Jul; 63(7):565-73. doi: 10.1002/syn.20637. [PMID: 19288578]
  • Ursula F Bailer, Guido K Frank, Shannan E Henry, Julie C Price, Carolyn C Meltzer, Carl Becker, Scott K Ziolko, Chester A Mathis, Angela Wagner, Nicole C Barbarich-Marsteller, Karen Putnam, Walter H Kaye. Serotonin transporter binding after recovery from eating disorders. Psychopharmacology. 2007 Dec; 195(3):315-24. doi: 10.1007/s00213-007-0896-7. [PMID: 17690869]
  • Ralph Buchert, Frank Thiele, Rainer Thomasius, Florian Wilke, Kay Petersen, Winfried Brenner, Janos Mester, Lothar Spies, Malte Clausen. Ecstasy-induced reduction of the availability of the brain serotonin transporter as revealed by [11C](+)McN5652-PET and the multi-linear reference tissue model: loss of transporters or artifact of tracer kinetic modelling?. Journal of psychopharmacology (Oxford, England). 2007 Aug; 21(6):628-34. doi: 10.1177/0269881106071975. [PMID: 17092972]
  • Una D McCann, Zsolt Szabo, Melin Vranesic, Esen Seckin, Gary Wand, Anna Duval, Robert F Dannals, George A Ricaurte. Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine. Molecular imaging and biology. 2007 May; 9(3):151-7. doi: 10.1007/s11307-007-0082-7. [PMID: 17473958]
  • Maria A Oquendo, Ramin S Hastings, Yung-Yu Huang, Norman Simpson, R Todd Ogden, Xian-Zhang Hu, David Goldman, Victoria Arango, Ronald L Van Heertum, J John Mann, Ramin V Parsey. Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Archives of general psychiatry. 2007 Feb; 64(2):201-8. doi: 10.1001/archpsyc.64.2.201. [PMID: 17283287]
  • René Hummerich, Oliver Schulze, Thomas Rädler, Pal Mikecz, Matthias Reimold, Winfried Brenner, Malte Clausen, Patrick Schloss, Ralph Buchert. Inhibition of serotonin transport by (+)McN5652 is noncompetitive. Nuclear medicine and biology. 2006 Apr; 33(3):317-23. doi: 10.1016/j.nucmedbio.2005.12.009. [PMID: 16631080]
  • Ralph Buchert, Rainer Thomasius, Kay Petersen, Florian Wilke, Jost Obrocki, Bruno Nebeling, Lutz Wartberg, Pavlina Zapletalova, Malte Clausen. Reversibility of ecstasy-induced reduction in serotonin transporter availability in polydrug ecstasy users. European journal of nuclear medicine and molecular imaging. 2006 Feb; 33(2):188-99. doi: 10.1007/s00259-005-1850-8. [PMID: 16133393]
  • Ralph Buchert, Oliver Schulze, Florian Wilke, Georg Berding, Rainer Thomasius, Kay Petersen, Winfried Brenner, Malte Clausen. Is correction for age necessary in SPECT or PET of the central serotonin transporter in young, healthy adults?. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2006 Jan; 47(1):38-42. doi: NULL. [PMID: 16391185]
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  • Yoshimoto Sekine, Yasuomi Ouchi, Nori Takei, Etsuji Yoshikawa, Kazuhiko Nakamura, Masami Futatsubashi, Hiroyuki Okada, Yoshio Minabe, Katsuaki Suzuki, Yasuhide Iwata, Kenji J Tsuchiya, Hideo Tsukada, Masaomi Iyo, Norio Mori. Brain serotonin transporter density and aggression in abstinent methamphetamine abusers. Archives of general psychiatry. 2006 Jan; 63(1):90-100. doi: 10.1001/archpsyc.63.1.90. [PMID: 16389202]
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  • Betina Elfving, Ove Wiborg. Binding of S-citalopram and paroxetine discriminates between species. Synapse (New York, N.Y.). 2005 Mar; 55(4):280-2. doi: 10.1002/syn.20116. [PMID: 15668984]
  • Shigeyuki Yamamoto, Yasuomi Ouchi, Hirotaka Onoe, Etsuji Yoshikawa, Hideo Tsukada, Hidetoshi Takahashi, Masao Iwase, Kouzi Yamaguti, Hirohiko Kuratsune, Yasuyoshi Watanabe. Reduction of serotonin transporters of patients with chronic fatigue syndrome. Neuroreport. 2004 Dec; 15(17):2571-4. doi: 10.1097/00001756-200412030-00002. [PMID: 15570154]
  • Martin Reivich, Jay D Amsterdam, David J Brunswick, Chyng Yann Shiue. PET brain imaging with [11C](+)McN5652 shows increased serotonin transporter availability in major depression. Journal of affective disorders. 2004 Oct; 82(2):321-7. doi: 10.1016/j.jad.2003.12.014. [PMID: 15488265]
  • Hank F Kung, Suzanne Newman, Seok-Rye Choi, Shunichi Oya, Catherine Hou, Zhi-Ping Zhuang, Paul D Acton, Karl Plössl, Jeffrey Winkler, Mei-Ping Kung. 2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent. Journal of medicinal chemistry. 2004 Oct; 47(21):5258-64. doi: 10.1021/jm049917p. [PMID: 15456270]
  • Ralph Buchert, Rainer Thomasius, Florian Wilke, Kay Petersen, Bruno Nebeling, Jost Obrocki, Oliver Schulze, Ulrich Schmidt, Malte Clausen. A voxel-based PET investigation of the long-term effects of 'Ecstasy' consumption on brain serotonin transporters. The American journal of psychiatry. 2004 Jul; 161(7):1181-9. doi: 10.1176/appi.ajp.161.7.1181. [PMID: 15229049]
  • Ralph Buchert, József Varga, Janos Mester. Limitations of bi-linear regression analysis for the determination of receptor occupancy with positron emission tomography. Nuclear medicine communications. 2004 May; 25(5):451-9. doi: 10.1097/00006231-200405000-00005. [PMID: 15100503]
  • W Gordon Frankle, Yiyun Huang, Dah-Ren Hwang, Peter S Talbot, Mark Slifstein, Ronald Van Heertum, Anissa Abi-Dargham, Marc Laruelle. Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2004 Apr; 45(4):682-94. doi: NULL. [PMID: 15073266]
  • Zsolt Szabo, Taofeek Owonikoko, Mark Peyrot, Jozsef Varga, William B Mathews, Hayden T Ravert, Robert F Dannals, Gary Wand. Positron emission tomography imaging of the serotonin transporter in subjects with a history of alcoholism. Biological psychiatry. 2004 Apr; 55(7):766-71. doi: 10.1016/j.biopsych.2003.11.023. [PMID: 15039007]
  • H Blair Simpson, Ilise Lombardo, Mark Slifstein, Henry Yiyun Huang, Dah Ren Hwang, Anissa Abi-Dargham, Michael R Liebowitz, Marc Laruelle. Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652. Biological psychiatry. 2003 Dec; 54(12):1414-21. doi: 10.1016/s0006-3223(03)00544-4. [PMID: 14675806]
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  • Bruce E Maryanoff, David F McComsey, Rina K Dukor, Laurence A Nafie, Teresa B Freedman, Xiaolin Cao, Victor W Day. Structural studies on McN-5652-X, a high-affinity ligand for the serotonin transporter in mammalian brain. Bioorganic & medicinal chemistry. 2003 May; 11(11):2463-70. doi: 10.1016/s0968-0896(03)00151-2. [PMID: 12735993]
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  • Peter Brust, Jörg Zessin, Hiroto Kuwabara, Beate Pawelke, Marion Kretzschmar, Rainer Hinz, Jörgen Bergman, Olli Eskola, Olof Solin, Jörg Steinbach, Bernd Johannsen. Positron emission tomography imaging of the serotonin transporter in the pig brain using [11C](+)-McN5652 and S-([18F]fluoromethyl)-(+)-McN5652. Synapse (New York, N.Y.). 2003 Feb; 47(2):143-51. doi: 10.1002/syn.10163. [PMID: 12454952]
  • Päivi Marjamäki, Jörg Zessin, Olli Eskola, Tove Grönroos, Merja Haaparanta, Jörgen Bergman, Pertti Lehikoinen, Sarita Forsback, Peter Brust, Jörg Steinbach, Olof Solin. S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse (New York, N.Y.). 2003 Jan; 47(1):45-53. doi: 10.1002/syn.10150. [PMID: 12422372]
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