(R)-ranolazine (BioDeep_00000845231)
代谢物信息卡片
(R)-ranolazine
化学式: C24H33N3O4 (427.2470938000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
InChI: InChI=1S/C24H33N3O4/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3/h4-10,20,28H,11-17H2,1-3H3,(H,25,29)/t20-/m1/s1
数据库引用编号
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Saumya Das, Takeshi Aiba, Michael Rosenberg, Katherine Hessler, Chunyang Xiao, Pablo A Quintero, Filomena G Ottaviano, Ashley C Knight, Evan L Graham, Pontus Boström, Michael R Morissette, Federica del Monte, Michael J Begley, Lewis C Cantley, Patrick T Ellinor, Gordon F Tomaselli, Anthony Rosenzweig. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.
Circulation.
2012 Oct; 126(18):2208-19. doi:
10.1161/circulationaha.112.115592. [PMID: 23019294] - Marco Panfili, Massimo Iafrate, Filippo Marzot, Silvia Secco, Giovanni De Rosa, Francesca Groppa, Roberto Padrini. Ranolazine-induced severe bladder hypotonia.
The Annals of pharmacotherapy.
2012 Sep; 46(9):e24. doi:
10.1345/aph.1r172. [PMID: 22828972] - Marc P Bonaca, Benjamin M Scirica, Marc S Sabatine, Petr Jarolim, Sabina A Murphy, Janna S Chamberlin, Daniel W Rhodes, Paula C Southwick, Eugene Braunwald, David A Morrow. Prospective evaluation of pregnancy-associated plasma protein-a and outcomes in patients with acute coronary syndromes.
Journal of the American College of Cardiology.
2012 Jul; 60(4):332-8. doi:
10.1016/j.jacc.2012.04.023. [PMID: 22813612] - Qin-You Tan, Rong-Hua Zhu, Huan-de Li, Ping-Fei Fang, Miao Yan, Qi-Zhi Zhang, Wen-Xing Peng. Development and validation of a sensitive U-HPLC-MS/MS method with electrospray ionization for quantitation of ranolazine in human plasma: application to a clinical pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Jul; 901(?):119-24. doi:
10.1016/j.jchromb.2012.06.011. [PMID: 22749688] - Hugues Abriel. Cardiac sodium channel Na(v)1.5 mechanosensitivity is inhibited by ranolazine.
Circulation.
2012 Jun; 125(22):2681-3. doi:
10.1161/circulationaha.112.110908. [PMID: 22565937] - Arthur Beyder, Peter R Strege, Santiago Reyes, Cheryl E Bernard, Andre Terzic, Jonathan Makielski, Michael J Ackerman, Gianrico Farrugia. Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.
Circulation.
2012 Jun; 125(22):2698-706. doi:
10.1161/circulationaha.112.094714. [PMID: 22565935] - Chun-Yu Deng, Su-Juan Kuang, Fang Rao, Hui Yang, Xian-Hong Fang, Zhi-Xin Shan, Xiao-Hong Li, Zhi-Ling Zhou, Qiu-Xiong Lin, Min Yang, Shu-Lin Wu, Xi-Yong Yu, Shu-Guang Lin. Effect of ranolazine on rat intrarenal arteries in vitro.
European journal of pharmacology.
2012 May; 683(1-3):211-6. doi:
10.1016/j.ejphar.2012.03.010. [PMID: 22449375] - Yuan Wang, Xiaoyan Chen, Zuoming Sun, Yong Yang, Ying Zhang, Wanhui Liu, Dafang Zhong. Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Mar; 889-890(?):10-6. doi:
10.1016/j.jchromb.2012.01.003. [PMID: 22377406] - Catherine E Morris, Pierre-Alexandre Boucher, Béla Joós. Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists?.
Frontiers in pharmacology.
2012; 3(?):19. doi:
10.3389/fphar.2012.00019. [PMID: 22375118] - Yong-Hu Fang, Lin Piao, Zhigang Hong, Peter T Toth, Glenn Marsboom, Peter Bache-Wiig, Jalees Rehman, Stephen L Archer. Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle.
Journal of molecular medicine (Berlin, Germany).
2012 Jan; 90(1):31-43. doi:
10.1007/s00109-011-0804-9. [PMID: 21874543] - Hitesh Patni, Michael Gitman, Azzour Hazzan, Kenar D Jhaveri. Ranolazine, tacrolimus, and diltiazem might be a hazardous combination in a transplant patient.
Renal failure.
2012; 34(2):251-3. doi:
10.3109/0886022x.2011.647210. [PMID: 22263871] - Chen Dai, Wei Xiao, Yan Liang, Lin Xie, Guangji Wang, Gang Ding, Zhaoqing Meng, Juan Zhang, Tianye Guan, An Kang, Xiao Zheng, Tong Xie, Chunzhu Li, Qijin Zhao, Wenjun Liu, Li Zhao, Jia Xu. Validated liquid chromatography mass spectrometry method for quantitative determination of strictosamide in dog plasma and its application to pharmacokinetic study.
Biomedical chromatography : BMC.
2011 Dec; 25(12):1338-42. doi:
10.1002/bmc.1606. [PMID: 21387351] - Tuomo Nieminen, Caio A M Tavares, José R M Pegler, Luiz Belardinelli, Richard L Verrier. Ranolazine injection into coronary or femoral arteries exerts marked, transient regional vasodilation without systemic hypotension in an intact porcine model.
Circulation. Cardiovascular interventions.
2011 Oct; 4(5):481-7. doi:
10.1161/circinterventions.111.962852. [PMID: 21953372] - Andrew C Zygmunt, Vladislav V Nesterenko, Sridharan Rajamani, Dan Hu, Hector Barajas-Martinez, Luiz Belardinelli, Charles Antzelevitch. Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: I. Experimental analysis of the use-dependent block.
American journal of physiology. Heart and circulatory physiology.
2011 Oct; 301(4):H1606-14. doi:
10.1152/ajpheart.00242.2011. [PMID: 21821778] - Said Abdalla, Xuebin Fu, Sherif S Elzahwy, Kristin Klaetschke, Thomas Streichert, Ursula Quitterer. Up-regulation of the cardiac lipid metabolism at the onset of heart failure.
Cardiovascular & hematological agents in medicinal chemistry.
2011 Jul; 9(3):190-206. doi:
10.2174/187152511797037583. [PMID: 21711241] - Gong Zhao, Erin Walsh, John C Shryock, Eric Messina, Yuzhi Wu, Dewan Zeng, Xiaobin Xu, Manuel Ochoa, Stephen P Baker, Thomas H Hintze, Luiz Belardinelli. Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs.
Journal of cardiovascular pharmacology.
2011 Jun; 57(6):639-47. doi:
10.1097/fjc.0b013e31821458e8. [PMID: 21633249] - Yun Ning, Wei Zhen, Zhuo Fu, Jenny Jiang, Dongmin Liu, Luiz Belardinelli, Arvinder K Dhalla. Ranolazine increases β-cell survival and improves glucose homeostasis in low-dose streptozotocin-induced diabetes in mice.
The Journal of pharmacology and experimental therapeutics.
2011 Apr; 337(1):50-8. doi:
10.1124/jpet.110.176396. [PMID: 21228065] - Sebastian Obrzut, Jay Tiongson, Neema Jamshidi, Huy Minh Phan, Carl Hoh, Ulrika Birgersdotter-Green. Assessment of metabolic phenotypes in patients with non-ischemic dilated cardiomyopathy undergoing cardiac resynchronization therapy.
Journal of cardiovascular translational research.
2010 Dec; 3(6):643-51. doi:
10.1007/s12265-010-9223-5. [PMID: 20842468] - Ann C Hylton, Tanya O Ezekiel. Rhabdomyolysis in a patient receiving ranolazine and simvastatin.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2010 Nov; 67(21):1829-31. doi:
10.2146/ajhp090299. [PMID: 20966146] - Dwayne A Pierce, Amber M Reeves-Daniel. Ranolazine-tacrolimus interaction.
The Annals of pharmacotherapy.
2010 Nov; 44(11):1844-9. doi:
10.1345/aph.1p297. [PMID: 20876828] - Chang-jun Li, Yan-ling Yu, Qing-min Yang, Ying Li, Yu-hong Zhang, Jing-yi Wang. [Optimization of the formulation of ranolazine hydrochloride sustained-release tablet and its pharmacokinetics in dogs].
Yao xue xue bao = Acta pharmaceutica Sinica.
2010 Sep; 45(9):1170-6. doi:
NULL. [PMID: 21351575] - Jeffrey W Chisholm, Allison B Goldfine, Arvinder K Dhalla, Eugene Braunwald, David A Morrow, Ewa Karwatowska-Prokopczuk, Luiz Belardinelli. Effect of ranolazine on A1C and glucose levels in hyperglycemic patients with non-ST elevation acute coronary syndrome.
Diabetes care.
2010 Jun; 33(6):1163-8. doi:
10.2337/dc09-2334. [PMID: 20357382] - Syamantak Majumder, M Ilayaraja, Himabindu Reddy Seerapu, Swaraj Sinha, Jamila H Siamwala, Suvro Chatterjee. Chick embryo partial ischemia model: a new approach to study ischemia ex vivo.
PloS one.
2010 May; 5(5):e10524. doi:
10.1371/journal.pone.0010524. [PMID: 20479865] - David A Morrow, Benjamin M Scirica, Marc S Sabatine, James A de Lemos, Sabina A Murphy, Petr Jarolim, Pierre Theroux, Christophe Bode, Eugene Braunwald. B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary-Thrombolysis In Myocardial Infarction 36) trial.
Journal of the American College of Cardiology.
2010 Mar; 55(12):1189-1196. doi:
10.1016/j.jacc.2009.09.068. [PMID: 20298924] - Arvinder K Dhalla, Wei-Qun Wang, Joan Dow, John C Shryock, Luiz Belardinelli, Anil Bhandari, Robert A Kloner. Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion.
American journal of physiology. Heart and circulatory physiology.
2009 Nov; 297(5):H1923-9. doi:
10.1152/ajpheart.00173.2009. [PMID: 19767532] - Lionel H Opie, Juhani Knuuti. The adrenergic-fatty acid load in heart failure.
Journal of the American College of Cardiology.
2009 Oct; 54(18):1637-46. doi:
10.1016/j.jacc.2009.07.024. [PMID: 19850204] - Lin Wu, Sridharan Rajamani, Hong Li, Craig T January, John C Shryock, Luiz Belardinelli. Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.
American journal of physiology. Heart and circulatory physiology.
2009 Sep; 297(3):H1048-57. doi:
10.1152/ajpheart.00467.2009. [PMID: 19592609] - Smriti H Deshmukh, Snehal R Patel, Elsa Pinassi, Catalin Mindrescu, Eileen V Hermance, Michael N Infantino, John T Coppola, Cezar S Staniloae. Ranolazine improves endothelial function in patients with stable coronary artery disease.
Coronary artery disease.
2009 Aug; 20(5):343-7. doi:
10.1097/mca.0b013e32832a198b. [PMID: 19444092] - Kapil Kumar, Bruce D Nearing, Marcelo Carvas, Bruno C G Nascimento, Mariana Acar, Luiz Belardinelli, Richard L Verrier. Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart.
Journal of cardiovascular electrophysiology.
2009 Jul; 20(7):796-802. doi:
10.1111/j.1540-8167.2009.01437.x. [PMID: 19298570] - Christopher P Cannon, Salman Waheed. Evaluating medical, percutaneous coronary intervention, and coronary artery bypass surgery options for chronic angina: an update of the revised guidelines.
Reviews in cardiovascular medicine.
2009; 10 Suppl 1(?):S21-9. doi:
10.3909/ricm10s10004. [PMID: 19898284] - Uttam Bhaumik, Animesh Ghosh, Amlan Kanti Sarkar, Anirbandeep Bose, P Senthamil Selvan, Pinaki Sengupta, Uday Sankar Chakraborty, Debotri Ghosh, Tapan Kumar Pal. Determination of ranolazine in human plasma by LC-MS/MS and its application in bioequivalence study.
Journal of pharmaceutical and biomedical analysis.
2008 Dec; 48(5):1404-10. doi:
10.1016/j.jpba.2008.09.033. [PMID: 18986788] - Kapil Kumar, Bruce D Nearing, Carlo R Bartoli, Kevin F Kwaku, Luiz Belardinelli, Richard L Verrier. Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart.
Journal of cardiovascular electrophysiology.
2008 Oct; 19(10):1073-9. doi:
10.1111/j.1540-8167.2008.01204.x. [PMID: 18479333] - Limei Zhao, Hao Li, Yao Jiang, Riyang Piao, Pengfei Li, Jingkai Gu. Determination of ranolazine in human plasma by liquid chromatographic-tandem mass spectrometric assay.
Journal of chromatographic science.
2008 Sep; 46(8):697-700. doi:
10.1093/chromsci/46.8.697. [PMID: 18796225] - Sridharan Rajamani, John C Shryock, Luiz Belardinelli. Rapid kinetic interactions of ranolazine with HERG K+ current.
Journal of cardiovascular pharmacology.
2008 Jun; 51(6):581-9. doi:
10.1097/fjc.0b013e3181799690. [PMID: 18520952] - Ging Kuo Wang, Joanna Calderon, Sho-Ya Wang. State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine.
Molecular pharmacology.
2008 Mar; 73(3):940-8. doi:
10.1124/mol.107.041541. [PMID: 18079277] - Stephen I Rifkin. Multiple drug interactions in a renal transplant patient leading to simvastatin-induced rhabdomyolysis: a case report.
Medscape journal of medicine.
2008; 10(11):264. doi:
NULL. [PMID: 19099014] - Antonio C P Chagas, Paulo M M Dourado, Tatiana de Fátima Gonçalves Galvão. Modulation of cardiac metabolism during myocardial ischemia.
Current pharmaceutical design.
2008; 14(25):2563-71. doi:
10.2174/138161208786071236. [PMID: 18991673] - Lei Tian, Juanjuan Jiang, Yiling Huang, Lu Hua, Hong Liu, Yishi Li. Sensitive quantification of ranolazine in human plasma by liquid chromatography--tandem mass spectrometry with positive electrospray ionization.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Feb; 846(1-2):346-50. doi:
10.1016/j.jchromb.2006.08.010. [PMID: 16959552] - Kristin Zerumsky, Brian F McBride. Ranolazine in the management of chronic stable angina.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2006 Dec; 63(23):2331-8. doi:
10.2146/ajhp060042. [PMID: 17106005] - Gong Zhao, Eric Messina, Xiaobin Xu, Manuel Ochoa, Sobrina Serpillon, John Shryock, Luiz Belardinelli, Thomas H Hintze. Ranolazine, a novel anti-anginal agent, does not alter isosorbide dinitrate- or sildenafil-induced changes in blood pressure in conscious dogs.
European journal of pharmacology.
2006 Jul; 541(3):171-6. doi:
10.1016/j.ejphar.2006.05.016. [PMID: 16777088] - Sandra Fredj, Kevin J Sampson, Huajun Liu, Robert S Kass. Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action.
British journal of pharmacology.
2006 May; 148(1):16-24. doi:
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Methods and findings in experimental and clinical pharmacology.
2006 Mar; 28(2):121-42. doi:
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American journal of cardiovascular drugs : drugs, devices, and other interventions.
2006; 6(5):357-9. doi:
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Drugs.
2006; 66(5):693-710. doi:
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Rapid communications in mass spectrometry : RCM.
2006; 20(4):523-8. doi:
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Clinical pharmacokinetics.
2006; 45(5):469-91. doi:
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Journal of cardiovascular pharmacology and therapeutics.
2005 Dec; 10(4):217-23. doi:
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Clinical pharmacology and therapeutics.
2005 Sep; 78(3):288-97. doi:
10.1016/j.clpt.2005.05.004. [PMID: 16153399] - Hisham Abdallah, Markus Jerling. Effect of hepatic impairment on the multiple-dose pharmacokinetics of ranolazine sustained-release tablets.
Journal of clinical pharmacology.
2005 Jul; 45(7):802-9. doi:
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Journal of clinical pharmacology.
2005 Apr; 45(4):422-33. doi:
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Journal of cardiovascular pharmacology and therapeutics.
2004 Sep; 9 Suppl 1(?):S65-83. doi:
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Circulation.
2004 Aug; 110(8):904-10. doi:
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Journal of the American College of Cardiology.
2004 Apr; 43(8):1375-82. doi:
10.1016/j.jacc.2003.11.045. [PMID: 15093870] - M F McCarty. A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets.
Medical hypotheses.
2004; 62(1):62-71. doi:
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European journal of drug metabolism and pharmacokinetics.
2003 Apr; 28(2):119-23. doi:
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European journal of pharmacology.
2001 Apr; 418(1-2):105-10. doi:
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