(S)-Methyl 2-(4-(((R)-2-amino-3-mercaptopropyl)amino)-2-(naphthalen-1-yl)benzamido)-4-methylpentanoate (BioDeep_00000845157)
代谢物信息卡片
化学式: C27H33N3O3S (479.22425080000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)OC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC3=CC=CC=C32
InChI: InChI=1S/C27H33N3O3S/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31)/t19-,25+/m1/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tomomi Furihata, Shinya Kawamatsu, Ryo Ito, Kosuke Saito, Shota Suzuki, Satoshi Kishida, Yoshiro Saito, Atsuko Kamiichi, Kan Chiba. Hydrocortisone enhances the barrier properties of HBMEC/ciβ, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects.
Fluids and barriers of the CNS.
2015; 12(?):7. doi:
10.1186/s12987-015-0003-0. [PMID: 25763180] - A Khwaja, C C Sharpe, M Noor, B M Hendry. The role of geranylgeranylated proteins in human mesangial cell proliferation.
Kidney international.
2006 Oct; 70(7):1296-304. doi:
10.1038/sj.ki.5001713. [PMID: 16929252] - Toshiyuki Kusama, Mutsuko Mukai, Masaharu Tatsuta, Hiroyuki Nakamura, Masahiro Inoue. Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.
International journal of oncology.
2006 Jul; 29(1):217-23. doi:
. [PMID: 16773203] - Ekem T Efuet, Khandan Keyomarsi. Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.
Cancer research.
2006 Jan; 66(2):1040-51. doi:
10.1158/0008-5472.can-05-3416. [PMID: 16424040] - Rosemary Masterson, Kristen Kelynack, Tim Hewitson, Gavin Becker. Effect of inhibition of farnesylation and geranylgeranylation on renal fibrogenesis in vitro.
Nephron. Experimental nephrology.
2006; 102(1):e19-29. doi:
10.1159/000088403. [PMID: 16179803] - Changbin Chen, Martin B Dickman. cAMP blocks MAPK activation and sclerotial development via Rap-1 in a PKA-independent manner in Sclerotinia sclerotiorum.
Molecular microbiology.
2005 Jan; 55(1):299-311. doi:
10.1111/j.1365-2958.2004.04390.x. [PMID: 15612936] - I Tamura, J Rosenbloom, E Macarak, B Chaqour. Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.
American journal of physiology. Cell physiology.
2001 Nov; 281(5):C1524-32. doi:
10.1152/ajpcell.2001.281.5.c1524. [PMID: 11600415] - M Vitale, T Di Matola, G Rossi, C Laezza, G Fenzi, M Bifulco. Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism.
Endocrinology.
1999 Feb; 140(2):698-704. doi:
10.1210/endo.140.2.6494. [PMID: 9927296] - J Adnane, F A Bizouarn, Y Qian, A D Hamilton, S M Sebti. p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.
Molecular and cellular biology.
1998 Dec; 18(12):6962-70. doi:
10.1128/mcb.18.12.6962. [PMID: 9819384] - W W Stark, M A Blaskovich, B A Johnson, Y Qian, A Vasudevan, B Pitt, A D Hamilton, S M Sebti, P Davies. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
The American journal of physiology.
1998 07; 275(1):L55-63. doi:
10.1152/ajplung.1998.275.1.l55. [PMID: 9688935]