2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide (BioDeep_00000845116)

   


代谢物信息卡片


2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide

化学式: C23H22Cl2N2O3S (476.07281220000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl
InChI: InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)

描述信息

同义名列表

1 个代谢物同义名

2-[(chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide



数据库引用编号

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代谢反应

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文献列表

  • Jun Sang, Chen-Kai Liu, Jue Liu, Guan-Cong Luo, Wei-Ji Zheng, Ya Bai, De-Yun Jiang, Jiang-Ni Pu, Su An, Tian-Rui Xu. Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells. Biochemical pharmacology. 2024 May; 223(?):116194. doi: 10.1016/j.bcp.2024.116194. [PMID: 38583812]
  • Furong Ma, Yulong Li, Maohua Cai, Wenyan Yang, Zumei Wu, Jinyun Dong, Jiang-Jiang Qin. ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation. European journal of medicinal chemistry. 2024 Apr; 270(?):116387. doi: 10.1016/j.ejmech.2024.116387. [PMID: 38593589]
  • Zifeng Tang, Jie Li, Lijie Peng, Fang Xu, Yi Tan, Xiaoqiang He, Chengjun Zhu, Zhi-Min Zhang, Zhang Zhang, Pinghua Sun, Ke Ding, Zhengqiu Li. Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy. Journal of medicinal chemistry. 2024 Feb; 67(3):1872-1887. doi: 10.1021/acs.jmedchem.3c01608. [PMID: 38265413]
  • Tingting Chen, Jiafu Leng, Jun Tan, Yongjun Zhao, Shanshan Xie, Shifang Zhao, Xiangyu Yan, Liqiao Zhu, Jun Luo, Lingyi Kong, Yong Yin. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. Journal of medicinal chemistry. 2023 07; 66(14):10036-10059. doi: 10.1021/acs.jmedchem.3c00967. [PMID: 37452764]
  • Liquan Zhu, Shiqi Hu, Xiaoqiao Yan, Qian Zeng, Bei Zhang, Linye Jiang, Shao Q Yao, Jingyan Ge. Ugi reaction-assisted assembly of covalent PROTACs against glutathione peroxidase 4. Bioorganic chemistry. 2023 05; 134(?):106461. doi: 10.1016/j.bioorg.2023.106461. [PMID: 36924654]
  • Congjun Xu, Zhanghong Xiao, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, Yuanfeng He, Yuqi Gao, Chunshun Zhao. Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. Journal of medicinal chemistry. 2021 09; 64(18):13312-13326. doi: 10.1021/acs.jmedchem.1c00569. [PMID: 34506134]