Methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone (BioDeep_00000845115)
代谢物信息卡片
化学式: C22H35ClN4O7 (502.219415)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C(C(=O)CCl)NC(=O)C1CCCN1C(=O)C(C)NC(=O)C(C)NC(=O)CCC(=O)OC
InChI: InChI=1S/C22H35ClN4O7/c1-12(2)19(16(28)11-23)26-21(32)15-7-6-10-27(15)22(33)14(4)25-20(31)13(3)24-17(29)8-9-18(30)34-5/h12-15,19H,6-11H2,1-5H3,(H,24,29)(H,25,31)(H,26,32)/t13-,14-,15-,19-/m0/s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
D009676 - Noxae > D000477 - Alkylating Agents > D000590 - Amino Acid Chloromethyl Ketones
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Louis M Pelus, Huimin Bian, Andrew G King, Seiji Fukuda. Neutrophil-derived MMP-9 mediates synergistic mobilization of hematopoietic stem and progenitor cells by the combination of G-CSF and the chemokines GRObeta/CXCL2 and GRObetaT/CXCL2delta4.
Blood.
2004 Jan; 103(1):110-9. doi:
10.1182/blood-2003-04-1115. [PMID: 12958067] - Takeshi Kawamura, Noriko Okada, Hidechika Okada. Elastase from activated human neutrophils activates procarboxypeptidase R.
Microbiology and immunology.
2002; 46(3):225-30. doi:
10.1111/j.1348-0421.2002.tb02690.x. [PMID: 12008933] - D S Fletcher, D G Osinga, K Keenan, R J Bonney, J B Doherty, P E Finke, S K Shah, P Davies. An inhibitor of leukocyte elastase prevents immune complex-mediated hemorrhage in the rat lung.
The Journal of pharmacology and experimental therapeutics.
1995 Jul; 274(1):548-54. doi:
NULL. [PMID: 7616444] - I Daudi, P W Gudewicz, T M Saba, E Cho, P Vincent. Proteolysis of gelatin-bound fibronectin by activated leukocytes: a role for leukocyte elastase.
Journal of leukocyte biology.
1991 Oct; 50(4):331-40. doi:
10.1002/jlb.50.4.331. [PMID: 1655937] - P S Hiemstra, J A Kramps, T M de Vreede, F C Breedveld, M R Daha. Inhibition of polymorphonuclear leukocyte-mediated endothelial cell detachment by antileukoprotease: a comparison with other proteinase inhibitors.
Immunobiology.
1991 Mar; 182(2):117-26. doi:
10.1016/s0171-2985(11)80195-6. [PMID: 1885205] - B O Anderson, J M Brown, D D Bensard, M A Grosso, A Banerjee, A Patt, G J Whitman, A H Harken. Reversible lung neutrophil accumulation can cause lung injury by elastase-mediated mechanisms.
Surgery.
1990 Aug; 108(2):262-7; discussion 267. doi:
NULL. [PMID: 2166356] - J Tumen, B Meyrick, L Berry, K L Brigham. Antiproteinases protect cultured lung endothelial cells from endotoxin injury.
Journal of applied physiology (Bethesda, Md. : 1985).
1988 Aug; 65(2):835-43. doi:
10.1152/jappl.1988.65.2.835. [PMID: 2844719] - L A Smedly, M G Tonnesen, R A Sandhaus, C Haslett, L A Guthrie, R B Johnston, P M Henson, G S Worthen. Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.
The Journal of clinical investigation.
1986 Apr; 77(4):1233-43. doi:
10.1172/jci112426. [PMID: 3485659] - D Polacek, R E Byrne, G M Fless, A M Scanu. In vitro proteolysis of human plasma low density lipoproteins by an elastase released from human blood polymorphonuclear cells.
The Journal of biological chemistry.
1986 Feb; 261(5):2057-63. doi:
NULL. [PMID: 3632977]