(E)-Desmethyldoxepin (BioDeep_00000845103)

   


代谢物信息卡片


(E)-Desmethyldoxepin

化学式: C18H19NO (265.1467)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNCCC=C1C2=CC=CC=C2COC3=CC=CC=C31
InChI: InChI=1S/C18H19NO/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18/h2-5,7-11,19H,6,12-13H2,1H3/b16-10+

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
The (E)-isomer of desmethyldoxepin.

同义名列表

1 个代谢物同义名

(E)-Desmethyldoxepin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Binjie Zheng, Lulu Chen, Tiandong Zheng, Liping Hou, Xinyi Huang, Chao Li, Xintong Wang, Qing Fang, Jie Chen, Zhi Tang, Zhenyu Li, Dongsheng Ouyang. A novel solid phase extraction sample preparation method for sensitively determining doxepin and N-nordoxepin in human plasma and its application in a bioequivalence study in healthy Chinese volunteers. Analytical methods : advancing methods and applications. 2022 06; 14(22):2168-2178. doi: 10.1039/d2ay00129b. [PMID: 35608048]
  • Tigran Margaryan, Mariam Sargsyan, Arpine Gevorgyan, Hasmik Zakaryan, Armine Aleksanyan, Armen Harutyunyan, Yeghig Armoudjian, Astghik Mikayelyan. High-throughput protein precipitation method with 96-well plate for determination of doxepin and nordoxepin in human plasma using LC-MS/MS. Biomedical chromatography : BMC. 2020 Aug; 34(8):e4844. doi: 10.1002/bmc.4844. [PMID: 32250456]
  • Maike Scherf-Clavel, Jasper Zebner, Leif Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Nortriptyline serum concentration as a predictor for cardiac risk in amitriptyline-treated patients. European journal of clinical pharmacology. 2020 Jan; 76(1):73-80. doi: 10.1007/s00228-019-02766-2. [PMID: 31641787]
  • Maike Scherf-Clavel, Lydia Samanski, Leif G Hommers, Jürgen Deckert, Andreas Menke, Stefan Unterecker. Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2. International clinical psychopharmacology. 2019 03; 34(2):93-100. doi: 10.1097/yic.0000000000000250. [PMID: 30557209]
  • Robert Schomburg, Daniela Remane, Klaus Fassbender, Hans H Maurer, Jörg Spiegel. Doxepin concentrations in plasma and cerebrospinal fluid. Journal of neural transmission (Vienna, Austria : 1996). 2011 Apr; 118(4):641-5. doi: 10.1007/s00702-011-0613-x. [PMID: 21350940]
  • Mei Zhang, Grant A Moore, Murray L Barclay, Evan J Begg. Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Oct; 877(27):3025-30. doi: 10.1016/j.jchromb.2009.07.021. [PMID: 19646935]
  • Antonia Gronewold, Andrea Dettling, Hans T Haffner, Gisela Skopp. Doxepin and nordoxepin concentrations in body fluids and tissues in doxepin associated deaths. Forensic science international. 2009 Sep; 190(1-3):74-9. doi: 10.1016/j.forsciint.2009.05.015. [PMID: 19524381]
  • Suryanarayana Sista, John Chi-Keung Lai, Okponanabofa Eradiri, Kenneth S Albert. Pharmacokinetics of a novel diltiazem HCl extended-release tablet formulation for evening administration. Journal of clinical pharmacology. 2003 Oct; 43(10):1149-57. doi: 10.1177/0091270003257214. [PMID: 14517197]
  • M Meyer-Barner, I Meineke, K H Schreeb, C H Gleiter. Pharmacokinetics of doxepin and desmethyldoxepin: an evaluation with the population approach. European journal of clinical pharmacology. 2002 Jul; 58(4):253-7. doi: 10.1007/s00228-002-0448-3. [PMID: 12136371]
  • Heinz-Werner Hagedorn, Heribert Meiser, Heidrun Zankl, Rüdiger Schulz. The isomeric metabolites of doxepin in equine serum and urine. Journal of pharmaceutical and biomedical analysis. 2002 Jun; 29(1-2):317-23. doi: 10.1016/s0731-7085(02)00069-9. [PMID: 12062692]
  • D Badenhorst, F C Sutherland, A D de Jager, T Scanes, H K Hundt, K J Swart, A F Hundt. Determination of doxepin and desmethyldoxepin in human plasma using liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 2000 May; 742(1):91-8. doi: 10.1016/s0378-4347(00)00136-5. [PMID: 10892587]
  • L A Drake, L Cohen, R Gillies, J G Flood, A T Riordan, S B Phillips, M J Stiller. Pharmacokinetics of doxepin in subjects with pruritic atopic dermatitis. Journal of the American Academy of Dermatology. 1999 Aug; 41(2 Pt 1):209-14. doi: 10.1016/s0190-9622(99)70051-4. [PMID: 10426891]
  • O R Frey, P Scheidt, A I von Brenndorff. Adverse effects in a newborn infant breast-fed by a mother treated with doxepin. The Annals of pharmacotherapy. 1999 Jun; 33(6):690-3. doi: 10.1345/aph.18210. [PMID: 10410181]
  • J H Yan, J W Hubbard, G McKay, K K Midha. Stereoselective in vivo and in vitro studies on the metabolism of doxepin and N-desmethyldoxepin. Xenobiotica; the fate of foreign compounds in biological systems. 1997 Dec; 27(12):1245-57. doi: 10.1080/004982597239831. [PMID: 9460230]
  • J Yan, J W Hubbard, G McKay, K K Midha. Stereoselective and simultaneous measurement of cis- and trans-isomers of doxepin and N-desmethyldoxepin in plasma or urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 1997 Mar; 691(1):131-8. doi: 10.1016/s0378-4347(96)00451-3. [PMID: 9140766]
  • M Adamczyk, J R Fishpaugh, C Harrington. Quantitative determination of E- and Z-doxepin and E- and Z-desmethyldoxepin by high-performance liquid chromatography. Therapeutic drug monitoring. 1995 Aug; 17(4):371-6. doi: 10.1097/00007691-199508000-00010. [PMID: 7482692]
  • K K Midha, J W Hubbard, G McKay, E M Hawes, E D Korchinski, T Gurnsey, J K Cooper, R Schwede. Stereoselective pharmacokinetics of doxepin isomers. European journal of clinical pharmacology. 1992; 42(5):539-44. doi: 10.1007/bf00314865. [PMID: 1607001]
  • H Ghabrial, C Prakash, U G Tacke, I A Blair, G R Wilkinson. Geometric isomerization of doxepin during its N-demethylation in humans. Drug metabolism and disposition: the biological fate of chemicals. 1991 May; 19(3):596-9. doi: NULL. [PMID: 1680624]
  • P D Hrdina, D Bakish, S Swenson, Y D Lapierre. Cis- and trans-isomers of doxepin and desmethyldoxepin in the plasma of depressed patients treated with doxepin. Therapeutic drug monitoring. 1990 Mar; 12(2):129-33. doi: 10.1097/00007691-199003000-00003. [PMID: 2315969]
  • C Dilger, Z Salama, H Jaeger. High-performance liquid chromatographic determination of trans-doxepin and desmethyldoxepin. Arzneimittel-Forschung. 1988 Oct; 38(10):1525-8. doi: NULL. [PMID: 3196396]
  • T Emm, L J Lesko, M B Perkal. Simultaneous determination of doxepin and nordoxepin in serum using high-performance liquid chromatography. Journal of chromatography. 1987 Aug; 419(?):445-51. doi: 10.1016/0378-4347(87)80314-6. [PMID: 3667805]
  • D L Sutherland, A J Remillard, K R Haight, M A Brown, L Old. The influence of cimetidine versus ranitidine on doxepin pharmacokinetics. European journal of clinical pharmacology. 1987; 32(2):159-64. doi: 10.1007/bf00542189. [PMID: 3582480]
  • F S Messiha. Determination of carbamazepine by HPLC electrochemical detection and application for estimation of imipramine desipramine, doxepin and nordoxepin. Alcohol (Fayetteville, N.Y.). 1986 Mar; 3(2):135-8. doi: 10.1016/0741-8329(86)90023-6. [PMID: 3718666]
  • D R Abernethy, E L Todd. Doxepin-cimetidine interaction: increased doxepin bioavailability during cimetidine treatment. Journal of clinical psychopharmacology. 1986 Feb; 6(1):8-12. doi: NULL. [PMID: 3950073]
  • J Kemp, K F Ilett, J Booth, L P Hackett. Excretion of doxepin and N-desmethyldoxepin in human milk. British journal of clinical pharmacology. 1985 Nov; 20(5):497-9. doi: 10.1111/j.1365-2125.1985.tb05106.x. [PMID: 4074620]
  • M Scheinin, R Virtanen, E Iisalo. Effect of single and repeated doses of activated charcoal on the pharmacokinetics of doxepin. International journal of clinical pharmacology, therapy, and toxicology. 1985 Jan; 23(1):38-42. doi: . [PMID: 3988390]
  • R D Faulkner, H O Senekjian, C S Lee. Hemodialysis of doxepin and desmethyldoxepin in uremic patients. Artificial organs. 1984 May; 8(2):151-5. doi: 10.1111/j.1525-1594.1984.tb04264.x. [PMID: 6732542]
  • R D Faulkner, W M Pitts, C S Lee, W A Lewis, W E Fann. Multiple-dose doxepin kinetics in depressed patients. Clinical pharmacology and therapeutics. 1983 Oct; 34(4):509-15. doi: 10.1038/clpt.1983.206. [PMID: 6617074]
  • R D Faulkner, C Lee. Comparative assays for doxepin and desmethyldoxepin using high-performance liquid chromatography and high-performance thin-layer chromatography. Journal of pharmaceutical sciences. 1983 Oct; 72(10):1165-7. doi: 10.1002/jps.2600721014. [PMID: 6644564]
  • T P Davis, S K Veggeberg, S R Hameroff, K L Watts. Sensitive and quantitative determination of plasma doxepin and desmethyldoxepin in chronic pain patients by gas chromatography and mass spectrometry. Journal of chromatography. 1983 Apr; 273(2):436-41. doi: 10.1016/s0378-4347(00)80967-6. [PMID: 6863457]
  • S R Hameroff, R C Cork, K Scherer, B R Crago, C Neuman, J R Womble, T P Davis. Doxepin effects on chronic pain, depression and plasma opioids. The Journal of clinical psychiatry. 1982 Aug; 43(8 Pt 2):22-7. doi: . [PMID: 6284720]
  • R Virtanen, E Iisalo, K Irjala. Protein binding of doxepin and desmethyldoxepin. Acta pharmacologica et toxicologica. 1982 Aug; 51(2):159-64. doi: 10.1111/j.1600-0773.1982.tb01008.x. [PMID: 7113722]
  • P M Kabra, N A Mar, L J Marton. Simultaneous liquid chromatographic analysis of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and nordoxepin. Clinica chimica acta; international journal of clinical chemistry. 1981 Apr; 111(2-3):123-32. doi: 10.1016/0009-8981(81)90179-0. [PMID: 7226545]
  • M G Bogaert, M T Rosseel, R Deberdt, C Vranckx. Plasma levels of the cis- and trans-isomers of doxepin and desmethyldoxepin after administration of doxepin to patients. Arzneimittel-Forschung. 1981; 31(1):113-5. doi: NULL. [PMID: 7194087]
  • R Virtanen, M Scheinin, E Iisalo. Single dose pharmacokinetics of doxepin in healthy volunteers. Acta pharmacologica et toxicologica. 1980 Nov; 47(5):371-6. doi: 10.1111/j.1600-0773.1980.tb01575.x. [PMID: 7293791]
  • R Virtanen, J S Salonen, M Scheinin, E Iisalo, V Mattila. Radioimmunoassay for doxepin and desmethyldoxepin. Acta pharmacologica et toxicologica. 1980 Oct; 47(4):274-8. doi: 10.1111/j.1600-0773.1980.tb03654.x. [PMID: 7468227]
  • T R Norman, G D Burrows, G N Bianchi, K P Maguire, J M Wurm. Doxepin plasma levels and anxiolytic response. International pharmacopsychiatry. 1980; 15(4):247-52. doi: 10.1159/000468444. [PMID: 7021450]