N-Demethyldiltiazem (BioDeep_00000845049)
代谢物信息卡片
N-Demethyldiltiazem
化学式: C21H24N2O4S (400.1457)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCNC)C3=CC=C(C=C3)OC
InChI: InChI=1S/C21H24N2O4S/c1-14(24)27-19-20(15-8-10-16(26-3)11-9-15)28-18-7-5-4-6-17(18)23(21(19)25)13-12-22-2/h4-11,19-20,22H,12-13H2,1-3H3/t19-,20+/m1/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Cho-Ming Loi, Dennis A Smith, Deepak Dalvie. Which metabolites circulate?.
Drug metabolism and disposition: the biological fate of chemicals.
2013 May; 41(5):933-51. doi:
10.1124/dmd.112.050278. [PMID: 23454828] - M A Bregante, J J Aramayona, L J Fraile, M A Garcia, C Solans. Diltiazem blood pharmacokinetics in the pregnant and non-pregnant rabbit: maternal and foetal tissue levels.
Xenobiotica; the fate of foreign compounds in biological systems.
2000 Aug; 30(8):831-41. doi:
10.1080/00498250050119871. [PMID: 11037114] - W Homsy, M Lefebvre, G Caillé, P du Souich. Metabolism of diltiazem in hepatic and extrahepatic tissues of rabbits: in vitro studies.
Pharmaceutical research.
1995 Apr; 12(4):609-14. doi:
10.1023/a:1016226601988. [PMID: 7597000] - D R Rutledge, A H Abadi, L M Lopez. Liquid chromatographic determination of celiprolol, diltiazem, desmethyldiltiazem and deacetyldiltiazem in plasma using a short alkyl chain silanol deactivated column.
Journal of pharmaceutical and biomedical analysis.
1994 Jan; 12(1):135-40. doi:
10.1016/0731-7085(94)80022-7. [PMID: 8161601] - D R Rutledge, A H Abadi, L M Lopez, C A Beaudreau. High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column.
Journal of chromatography.
1993 May; 615(1):111-6. doi:
10.1016/0378-4347(93)80296-g. [PMID: 8340449] - B A Finegan, M D Hussain, Y K Tam. Pharmacokinetics of diltiazem in patients undergoing coronary artery bypass grafting.
Therapeutic drug monitoring.
1992 Dec; 14(6):485-92. doi:
10.1097/00007691-199212000-00009. [PMID: 1485371] - C Maskasame, S Lankford, S A Bai. The effects of chronic oral diltiazem and cimetidine dosing on the pharmacokinetics and negative dromotropic action of intravenous and oral diltiazem in the dog.
Biopharmaceutics & drug disposition.
1992 Oct; 13(7):521-37. doi:
10.1002/bdd.2510130706. [PMID: 1489943] - J L Bonnefous, R Boulieu, C Lahet. Stability of diltiazem and its metabolites in human blood samples.
Journal of pharmaceutical sciences.
1992 Apr; 81(4):341-4. doi:
10.1002/jps.2600810409. [PMID: 1501069] - S C Sutton, K Engle, R A Deeken, K E Plute, R D Shaffer. Performance of diltiazem tablet and multiparticulate osmotic formulations in the dog.
Pharmaceutical research.
1990 Aug; 7(8):874-8. doi:
10.1023/a:1015925302374. [PMID: 2235885] - S C Tsao, T H Dickinson, D R Abernethy. Metabolite inhibition of parent drug biotransformation. Studies of diltiazem.
Drug metabolism and disposition: the biological fate of chemicals.
1990 Mar; 18(2):180-2. doi:
. [PMID: 1971570] - P Du Souich, N Lery, L Lery, F Varin, S Boucher, M Vezina, D Pilon, J Spenard, G Caillé. Influence of food on the bioavailability of diltiazem and two of its metabolites following the administration of conventional tablets and slow-release capsules.
Biopharmaceutics & drug disposition.
1990 Mar; 11(2):137-47. doi:
10.1002/bdd.2510110206. [PMID: 2328299] - F F Ververs, H G Schaefer, J F Lefevre, L M Lopez, H Derendorf. Simultaneous assay of propranolol, diltiazem and metabolites of diltiazem in human plasma by liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
1990; 8(6):535-9. doi:
10.1016/0731-7085(90)80064-v. [PMID: 2093390] - S Kurosawa, N Kurosawa, E Owada, H Soeda, K Ito. Pharmacokinetics of diltiazem in patients with liver cirrhosis.
International journal of clinical pharmacology research.
1990; 10(6):311-8. doi:
NULL. [PMID: 2099357] - R A Boyd, S K Chin, O Don-Pedro, D Verotta, L B Sheiner, R L Williams, K M Giacomini. The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose.
Clinical pharmacology and therapeutics.
1989 Oct; 46(4):408-19. doi:
10.1038/clpt.1989.159. [PMID: 2791444] - P Höglund, L G Nilsson. Pharmacokinetics of diltiazem and its metabolites after repeated multiple-dose treatments in healthy volunteers.
Therapeutic drug monitoring.
1989 Sep; 11(5):543-50. doi:
NULL. [PMID: 2815229] - P Höglund, L G Nilsson. Pharmacokinetics of diltiazem and its metabolites after single and multiple dosing in healthy volunteers.
Therapeutic drug monitoring.
1989 Sep; 11(5):558-66. doi:
NULL. [PMID: 2815231] - P Höglund, L G Nilsson. Pharmacokinetics of diltiazem and its metabolites after repeated single dosing in healthy volunteers.
Therapeutic drug monitoring.
1989 Sep; 11(5):551-7. doi:
NULL. [PMID: 2815230] - P Höglund, L G Nilsson. Physiological disposition of intravenously administered 14C-labeled diltiazem in healthy volunteers.
Therapeutic drug monitoring.
1988; 10(4):401-9. doi:
10.1097/00007691-198804000-00006. [PMID: 3201524] - S C Montamat, D R Abernethy. N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives.
British journal of clinical pharmacology.
1987 Aug; 24(2):185-9. doi:
10.1111/j.1365-2125.1987.tb03160.x. [PMID: 3620292] - S C Montamat, D R Abernethy, J R Mitchell. High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma.
Journal of chromatography.
1987 Mar; 415(1):203-7. doi:
10.1016/s0378-4347(00)83211-9. [PMID: 3584358]
