(S)-Azelastine (BioDeep_00000845043)
代谢物信息卡片
(S)-Azelastine
化学式: C22H24ClN3O (381.1607804)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl
InChI: InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3/t18-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wuyi Zha, Linyee Shum. Simultaneous determination of azelastine and its major metabolite desmethylazelastine in human plasma using high performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Oct; 906(?):69-74. doi:
10.1016/j.jchromb.2012.08.023. [PMID: 22954967] - Hartmut Derendorf, Ullrich Munzel, Ursula Petzold, Joachim Maus, Hermann Mascher, Robert Hermann, Jean Bousquet. Bioavailability and disposition of azelastine and fluticasone propionate when delivered by MP29-02, a novel aqueous nasal spray.
British journal of clinical pharmacology.
2012 Jul; 74(1):125-33. doi:
10.1111/j.1365-2125.2012.04222.x. [PMID: 22356350] - Roman Huber, Florian Conrad Stintzing, Daniel Briemle, Christiane Beckmann, Ulrich Meyer, Carsten Gründemann. In vitro antiallergic effects of aqueous fermented preparations from Citrus and Cydonia fruits.
Planta medica.
2012 Mar; 78(4):334-40. doi:
10.1055/s-0031-1280455. [PMID: 22193979] - Daniel Baumann, Claus Bachert, Petra Högger. Development of a novel model for comparative evaluation of intranasal pharmacokinetics and effects of anti-allergic nasal sprays.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2012 Jan; 80(1):156-63. doi:
10.1016/j.ejpb.2011.09.003. [PMID: 21945271] - Sarah V Gerhart, Diane M Eble, R Michael Burger, Stefan N Oline, Ana Vacaru, Kirsten C Sadler, Rebecca Jefferis, M Kathryn Iovine. The Cx43-like connexin protein Cx40.8 is differentially localized during fin ontogeny and fin regeneration.
PloS one.
2012; 7(2):e31364. doi:
10.1371/journal.pone.0031364. [PMID: 22347467] - Rituparna Maiti, Jyothirmai Jaida, Jalelur Rahman, Rajasri Gaddam, Anuradha Palani. Olopatadine hydrochloride and rupatadine fumarate in seasonal allergic rhinitis: A comparative study of efficacy and safety.
Journal of pharmacology & pharmacotherapeutics.
2011 Oct; 2(4):270-6. doi:
10.4103/0976-500x.85958. [PMID: 22025856] - Carsten Gründemann, Menelaos Papagiannopoulos, Evelyn Lamy, Volker Mersch-Sundermann, Roman Huber. Immunomodulatory properties of a lemon-quince preparation (Gencydo®) as an indicator of anti-allergic potency.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Jun; 18(8-9):760-8. doi:
10.1016/j.phymed.2010.11.016. [PMID: 21256726] - Naruo Shoji, Kazuhito Asano, Atsuko Furuta, Kojiro Hirano, Harumi Suzaki. Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro.
International archives of allergy and immunology.
2011; 155(1):38-51. doi:
10.1159/000318720. [PMID: 21109747] - Sj Wadsworth, Dd Sin, Dr Dorscheid. Clinical update on the use of biomarkers of airway inflammation in the management of asthma.
Journal of asthma and allergy.
2011; 4(?):77-86. doi:
10.2147/jaa.s15081. [PMID: 21792321] - Tsugunobu Andoh, Qun Zhang, Takumi Yamamoto, Manabu Tayama, Masao Hattori, Ken Tanaka, Yasushi Kuraishi. Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice.
Journal of pharmacological sciences.
2010; 114(3):292-7. doi:
10.1254/jphs.10180fp. [PMID: 20948166] - Samia Yazid, Egle Solito, Helen Christian, Simon McArthur, Nicolas Goulding, Roderick Flower. Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.
Biochemical pharmacology.
2009 Jun; 77(12):1814-26. doi:
10.1016/j.bcp.2009.03.010. [PMID: 19428336] - Naoko Inomata, Satoko Tatewaki, Zenro Ikezawa. Multiple H1-antihistamine-induced urticaria.
The Journal of dermatology.
2009 Apr; 36(4):224-7. doi:
10.1111/j.1346-8138.2009.00627.x. [PMID: 19348661] - Kazuhiko Hanashiro, Masanori Sunagawa, Toshiyuki Nakasone, Mariko Nakamura, Tadayoshi Kosugi. Inhibition of IgE-mediated phosphorylation of FcepsilonRIgamma protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: a novel action of antiallergic drugs.
International immunopharmacology.
2007 Jul; 7(7):994-1002. doi:
10.1016/j.intimp.2007.02.017. [PMID: 17499203] - Josiane Sabbadini Neves, Luciana Pontes Coelho, Renato Sérgio Balão Cordeiro, Marcia Paranho Veloso, Patricia Machado Rodrigues e Silva, Marcelo Henrique dos Santos, Marco Aurélio Martins. Antianaphylactic properties of 7-epiclusianone, a tetraprenylated benzophenone isolated from Garcinia brasiliensis.
Planta medica.
2007 Jun; 73(7):644-9. doi:
10.1055/s-2007-981534. [PMID: 17562491] - Ihab T Abdel-Raheem, Izumi Hide, Yuhki Yanase, Yukari Shigemoto-Mogami, Norio Sakai, Yasuhito Shirai, Naoaki Saito, Farid M Hamada, Nagh A El-Mahdy, Alaa El-Din E Elsisy, Samya S Sokar, Yoshihiro Nakata. Protein kinase C-alpha mediates TNF release process in RBL-2H3 mast cells.
British journal of pharmacology.
2005 Jun; 145(4):415-23. doi:
10.1038/sj.bjp.0706207. [PMID: 15806111] - Sung-Hwan Park, Eun-Kyung Park, Dong-Hyun Kim. Passive cutaneous anaphylaxis-inhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliata.
Planta medica.
2005 Jan; 71(1):24-7. doi:
10.1055/s-2005-837746. [PMID: 15678369] - Neung-Kee Lee, Seung-Hoon Choi, Sung-Hwan Park, Eun-Kyung Park, Dong-Hyun Kim. Antiallergic activity of hesperidin is activated by intestinal microflora.
Pharmacology.
2004 Aug; 71(4):174-80. doi:
10.1159/000078083. [PMID: 15240993] - Toshiaki Makino, Takahiro Inagaki, Ken-Ichi Komatsu, Yoshihiro Kano. Pharmacokinetic interactions between Japanese traditional medicine (kampo) and modern medicine (III). Effect of Sho-seiryu-to on the pharmacokinetics of azelastine hydrochloride in rats.
Biological & pharmaceutical bulletin.
2004 May; 27(5):670-3. doi:
10.1248/bpb.27.670. [PMID: 15133242] - Fadia F Mahmoud, David D Haines, Habib T Abul, Adnan T Abal, Babatunde O Onadeko, John A Wise. In vitro effects of astaxanthin combined with ginkgolide B on T lymphocyte activation in peripheral blood mononuclear cells from asthmatic subjects.
Journal of pharmacological sciences.
2004 Feb; 94(2):129-36. doi:
10.1254/jphs.94.129. [PMID: 14978350] - Ute Heinemann, Gottfried Blaschke, Norbert Knebel. Simultaneous enantioselective separation of azelastine and three of its metabolites for the investigation of the enantiomeric metabolism in rats. I. Liquid chromatography-ionspray tandem mass spectrometry and electrokinetic capillary chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Aug; 793(2):389-404. doi:
10.1016/s1570-0232(03)00357-x. [PMID: 12906914] - C Blondin, B Cholley, N Haeffner-Cavaillon, P Goldschmidt. [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].
Journal francais d'ophtalmologie.
2003 Apr; 26(4):328-36. doi:
. [PMID: 12843888] - Kazuhiko Hanashiro, Yoshihiro Tokeshi, Toshiyuki Nakasone, Masanori Sunagawa, Mariko Nakamura, Tadayoshi Kosugi. Azelastine and suplatast shorten the distribution half-life of IgE in rats.
Mediators of inflammation.
2002 Feb; 11(1):61-4. doi:
10.1080/09629350210310. [PMID: 11926596] - S Li, M Blaschke, J F Heubach, E Wettwer, U Ravens. Effects of azelastine on contractility, action potentials and L-type Ca(2+) current in guinea pig cardiac preparations.
European journal of pharmacology.
2001 Apr; 418(1-2):7-14. doi:
10.1016/s0014-2999(01)00923-2. [PMID: 11334859] - T Niitsuma, S Morita, T Hayashi, M Homma, K Oka. Effects of absorbed components of saiboku-to on the release of leukotrienes from polymorphonuclear leukocytes of patients with bronchial asthma.
Methods and findings in experimental and clinical pharmacology.
2001 Mar; 23(2):99-104. doi:
10.1358/mf.2001.23.2.627938. [PMID: 11484418]