Butamben picrate (BioDeep_00000844931)
代谢物信息卡片
化学式: C28H33N5O11 (615.2176)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCOC(=O)C1=CC=C(C=C1)N.CCCCOC(=O)C1=CC=C(C=C1)N.C1=C(C=C(C(=C1[N+](=O)[O-])O)[N+](=O)[O-])[N+](=O)[O-]
InChI: 1-2,10H
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hery Mitsutake, Gustavo H Rodrigues da Silva, Eneida de Paula, Márcia C Breitkreitz. When it is too much: Identifying butamben excess on the surface of pharmaceutical preformulation samples by Raman mapping.
Journal of pharmaceutical and biomedical analysis.
2023 Oct; 235(?):115644. doi:
10.1016/j.jpba.2023.115644. [PMID: 37633164] - Gustavo H Rodrigues da Silva, Julia Borges Paes Lemes, Gabriela Geronimo, Fernando Freitas de Lima, Ludmilla David de Moura, Ariany Carvalho Dos Santos, Nathalia Santos Carvalho, Kauê Franco Malange, Márcia C Breitkreitz, Carlos A Parada, Eneida de Paula. Lipid nanoparticles loaded with butamben and designed to improve anesthesia at inflamed tissues.
Biomaterials science.
2021 May; 9(9):3378-3389. doi:
10.1039/d1bm00077b. [PMID: 33949447] - Markéta Paloncýová, Russell H DeVane, Bruce P Murch, Karel Berka, Michal Otyepka. Rationalization of reduced penetration of drugs through ceramide gel phase membrane.
Langmuir : the ACS journal of surfaces and colloids.
2014 Nov; 30(46):13942-8. doi:
10.1021/la503289v. [PMID: 25354090] - Y Kuroda, H Nasu, Y Fujiwara, T Nakagawa. Orientations and locations of local anesthetics benzocaine and butamben in phospholipid membranes as studied by 2H NMR spectroscopy.
The Journal of membrane biology.
2000 Sep; 177(2):117-28. doi:
10.1007/s002320001105. [PMID: 11003686] - R J Van den Berg, Z Wang, R J Grouls, H H Korsten. The local anesthetic, n-butyl-p-aminobenzoate, reduces rat sensory neuron excitability by differential actions on fast and slow Na+ current components.
European journal of pharmacology.
1996 Nov; 316(1):87-95. doi:
10.1016/s0014-2999(96)00638-3. [PMID: 8982655] - K Yamasaki, T Maruyama, U Kragh-Hansen, M Otagiri. Characterization of site I on human serum albumin: concept about the structure of a drug binding site.
Biochimica et biophysica acta.
1996 Jul; 1295(2):147-57. doi:
10.1016/0167-4838(96)00013-1. [PMID: 8695640] - R J Grouls, E Machielsen, H H Korsten, L J Hellebrekers, D D Breimer, E W Ackerman. Capillary gas chromatographic method for the determination of n-butyl-p-aminobenzoate and lidocaine in plasma samples.
Journal of chromatography. B, Biomedical applications.
1995 Nov; 673(1):51-7. doi:
10.1016/0378-4347(95)00237-d. [PMID: 8925074] - R J Van den Berg, P F Van Soest, Z Wang, R J Grouls, H H Korsten. The local anesthetic n-butyl-p-aminobenzoate selectively affects inactivation of fast sodium currents in cultured rat sensory neurons.
Anesthesiology.
1995 Jun; 82(6):1463-73. doi:
10.1097/00000542-199506000-00018. [PMID: 7793660] - H H Korsten, E W Ackerman, R J Grouls, A A van Zundert, W F Boon, F Bal, M A Crommelin, J G Ribot, F Hoefsloot, J L Slooff. Long-lasting epidural sensory blockade by n-butyl-p-aminobenzoate in the terminally ill intractable cancer pain patient.
Anesthesiology.
1991 Dec; 75(6):950-60. doi:
10.1097/00000542-199112000-00005. [PMID: 1741516] - B Mazumdar, A A Tomlinson, G C Faulder. Preliminary study to assay plasma amethocaine concentrations after topical application of a new local anaesthetic cream containing amethocaine.
British journal of anaesthesia.
1991 Oct; 67(4):432-6. doi:
10.1093/bja/67.4.432. [PMID: 1931400] - H H Korsten, L J Hellebrekers, R J Grouls, E W Ackerman, A A van Zundert, H van Herpen, E Gruys. Long-lasting epidural sensory blockade by n-butyl p-aminobenzoate in the dog: neurotoxic or local anesthetic effect?.
Anesthesiology.
1990 Sep; 73(3):491-8. doi:
10.1097/00000542-199009000-00020. [PMID: 2393134]
