Taltirelin hydrate (BioDeep_00000844924)
代谢物信息卡片
化学式: C17H31N7O9 (477.2183156)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=O)CC(NC1=O)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)N.O.O.O.O
InChI: /m0..../s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C76367 - Thyrotropin-Releasing Hormone Analogue
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- John P Dougherty, Danielle A Springer, Mary J Cullen, Marvin C Gershengorn. Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays.
Behavioural brain research.
2019 03; 360(?):255-261. doi:
10.1016/j.bbr.2018.12.011. [PMID: 30529403] - John P Dougherty, Brian S Wolff, Mary J Cullen, Leorey N Saligan, Marvin C Gershengorn. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.
Pharmacological research.
2017 Oct; 124(?):1-8. doi:
10.1016/j.phrs.2017.07.012. [PMID: 28720519] - Nanthakumar Thirunarayanan, Eshel A Nir, Bruce M Raaka, Marvin C Gershengorn. Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2013 May; 38(6):950-6. doi:
10.1038/npp.2012.256. [PMID: 23303050] - Akihiko Urayama, Shizuo Yamada, Ryohei Kimura, Jun Zhang, Yasuo Watanabe. Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice.
Life sciences.
2002 Dec; 72(4-5):601-7. doi:
10.1016/s0024-3205(02)02268-3. [PMID: 12467901] - Shingo Horimoto, Tsuyoshi Mayumi, Kozo Tagawa, Hirokazu Yamakita, Masayoshi Yoshikawa. Determination of taltirelin, a new stable thyrotropin-releasing hormone analogue, in human plasma by high-performance liquid chromatography turbo-ionspray ionization tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2002 Nov; 30(4):1361-9. doi:
10.1016/s0731-7085(02)00396-5. [PMID: 12408927] - A Urayama, S Yamada, K Hirano, Y Deguchi, R Kimura. Brain receptor binding characteristics and pharmacokinetic-pharmacodynamic analysis of thyrotropin-releasing hormone analogues.
Life sciences.
2001 Dec; 70(6):647-57. doi:
10.1016/s0024-3205(01)01445-x. [PMID: 11833715] - S Morikawa, T Sakai, K Murata, K Banno, T Sato, T Takai, T Suzuki. Radioimmunoassay for TA-0910, a new stable thyrotropin releasing hormone analogue and its metabolite, TA-0910 acid-type, in human plasma and urine.
Journal of pharmaceutical and biomedical analysis.
1998 Apr; 16(8):1267-74. doi:
10.1016/s0731-7085(97)00145-3. [PMID: 9777599] - T Inui, T Fujiwara, M Susami, N Hishida, Y Kuwamura, H Kuse, Y Kawai, S Kudow. [Repeated dose toxicity studies of taltirelin tetrahydrate(TA-0910) by oral administration to rats].
The Journal of toxicological sciences.
1997 Nov; 22 Suppl 2(?):335-56. doi:
10.2131/jts.22.supplementii_335. [PMID: 9430093] - N Hishida, H Kuse, T Yamamura, M Noguchi, Y Kawai, M Hori. [Acute toxicity studies of taltirelin tetrahydrate in mice, rats, and dogs].
The Journal of toxicological sciences.
1997 Nov; 22 Suppl 2(?):327-34. doi:
10.2131/jts.22.supplementii_327. [PMID: 9430092] - S Nishino, J Arrigoni, J Shelton, T Kanbayashi, W C Dement, E Mignot. Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1997 Aug; 17(16):6401-8. doi:
10.1523/jneurosci.17-16-06401.1997. [PMID: 9236248] - M Moriyasu, M Nasu, H Honda, T Sakamoto, M Yamamura, Y Matsuoka. [Effect of (-)-N-[(S)-hexahydro-l-methyl-2, 6-dioxo-4-pyrimidinylcarbonyl]-L-histidyl-L-prolinamide (TA-0910), a new TRH analog, on plasma levels of TSH and thyroid hormones in rats].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1996 Jun; 107(6):285-97. doi:
10.1254/fpj.107.285. [PMID: 8690309] - S Chishima. A radioimmunoassay for TA-0910, a new metabolically stable thyrotrophin-releasing hormone analogue.
Journal of pharmaceutical and biomedical analysis.
1994 Jun; 12(6):795-804. doi:
10.1016/0731-7085(94)e0007-n. [PMID: 7918782] - K Miyashita, M Murakami, T Satoh, T Monden, M Yamada, T Iriuchijima, A Kazihara, M Mori. Alteration by prolonged oral administration of a thyrotropin-releasing hormone analog, TA-0910, of the pituitary-thyroid axis in subjects with brain stroke.
Internal medicine (Tokyo, Japan).
1993 Sep; 32(9):681-5. doi:
10.2169/internalmedicine.32.681. [PMID: 8142670]