(r)-Oxybutynin (BioDeep_00000844917)

   


代谢物信息卡片


(r)-Oxybutynin

化学式: C22H31NO3 (357.2303816)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CC#CCOC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
InChI: InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3/t22-/m0/s1

描述信息

C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent

同义名列表

1 个代谢物同义名

(r)-Oxybutynin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nicola Robinson, Ava Lorenc, Xing Liao. The evidence for Shiatsu: a systematic review of Shiatsu and acupressure. BMC complementary and alternative medicine. 2011 Oct; 11(?):88. doi: 10.1186/1472-6882-11-88. [PMID: 21982157]
  • Naoya Masumori, Shintaro Miyamoto, Taiji Tsukamoto, Seiji Furuya, Akihiko Iwasawa, Takashi Sato, Naoki Itoh, Akihiko Shibuya, Toshiro Oda. The efficacy and safety of propiverine hydrochloride in patients with overactive bladder symptoms who poorly responded to previous anticholinergic agents. Advances in urology. 2011; 2011(?):714978. doi: 10.1155/2011/714978. [PMID: 21747845]
  • D Aubert, E Berard, J-P Blanc, G Lenoir, F Liard, H Lottmann. [Isolated primary nocturnal enuresis: international evidence based management. Consensus recommendations by French expert group]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2010 May; 20(5):343-9. doi: 10.1016/j.purol.2009.12.007. [PMID: 20471578]
  • Taxiarchis Felekis, Konstantinos Katsanos, Dimitrios Christodoulou, Ioannis Asproudis, Epameinondas V Tsianos. Reversible bilateral optic neuritis after Infliximab discontinuation in a patient with Crohn's disease. Journal of Crohn's & colitis. 2009 Sep; 3(3):212-4. doi: 10.1016/j.crohns.2009.04.001. [PMID: 21172274]
  • Mohamed Heba, Nesrin Ramadan, Moustafa El-Laithy. Polymeric matrix membrane sensors for stability-indicating potentiometric determination of oxybutynin hydrochloride and flavoxate hydrochloride urogenital system drugs. Journal of AOAC International. 2008 Nov; 91(6):1318-30. doi: NULL. [PMID: 19202792]
  • T E Dawson, J Jamison. Intravesical treatments for painful bladder syndrome/ interstitial cystitis. The Cochrane database of systematic reviews. 2007 Oct; ?(4):CD006113. doi: 10.1002/14651858.cd006113.pub2. [PMID: 17943887]
  • H B Lottmann, I Alova. Primary monosymptomatic nocturnal enuresis in children and adolescents. International journal of clinical practice. Supplement. 2007 Sep; ?(155):8-16. doi: 10.1111/j.1742-1241.2007.01464.x. [PMID: 17727574]
  • Pritam Kanagale, Braj Bhushan Lohray, Ambikanandan Misra, Prakash Davadra, Rajesh Kini. Formulation and optimization of porous osmotic pump-based controlled release system of oxybutynin. AAPS PharmSciTech. 2007 Jul; 8(3):E53. doi: 10.1208/pt0803053. [PMID: 17915803]
  • Haruhi Mizushima, Kazuya Kinoshita, Koji Abe, Hitoshi Ishizuka, Yasuhiko Yamada. Pharmacokinetics/pharmacodynamics analysis of the relationship between the in vivo micturition pressure and receptor occupancy of (R)-oxybutynin and its metabolite in rats. Biological & pharmaceutical bulletin. 2007 May; 30(5):955-62. doi: 10.1248/bpb.30.955. [PMID: 17473442]
  • Kyle J Van Arendonk, Matthew J Knudson, J Christopher Austin, Christopher S Cooper. Improved efficacy of extended release oxybutynin in children with persistent daytime urinary incontinence converted from regular oxybutynin. Urology. 2006 Oct; 68(4):862-5. doi: 10.1016/j.urology.2006.04.034. [PMID: 17070368]
  • Osamu Maruyama, Yoshio Kawachi, Kisaburo Hanazawa, Kazuo Koizumi, Ryo Yamashita, Sosuke Sugimura, Shin-ichi Honda, Yoshiki Sugiyama, Toshihiko Saitoh, Kensho Noto. Naftopidil monotherapy vs naftopidil and an anticholinergic agent combined therapy for storage symptoms associated with benign prostatic hyperplasia: A prospective randomized controlled study. International journal of urology : official journal of the Japanese Urological Association. 2006 Oct; 13(10):1280-5. doi: 10.1111/j.1442-2042.2006.01538.x. [PMID: 17010005]
  • Michael Preik, Detlef Albrecht, Martin O'Connell, Christian Hampel, Rodney Anderson. Effect of controlled-release delivery on the pharmacokinetics of oxybutynin at different dosages: severity-dependent treatment of the overactive bladder. BJU international. 2004 Oct; 94(6):821-7. doi: 10.1111/j.1464-410x.2004.05040.x. [PMID: 15476516]
  • M Asif A Siddiqui, Caroline M Perry, Lesley J Scott. Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs. 2004; 64(8):885-912. doi: 10.2165/00003495-200464080-00011. [PMID: 15059046]
  • M V Zunzunegui Pastor, A Rodríguez-Laso, M J García de Yébenes, M D Aguilar Conesa, P Lázaro y de Mercado, A Otero Puime. [Prevalence of urinary incontinence and linked factors in men and women over 65]. Atencion primaria. 2003 Oct; 32(6):337-42. doi: 10.1016/s0212-6567(03)79293-2. [PMID: 14572396]
  • R Martín-Crespo Izquierdo, R Luque Mialdea. [Non-coordinated micturition syndrome mimicking posterior urethral valves in a male neonate]. Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica. 2003 Jul; 16(3):134-8. doi: NULL. [PMID: 14565094]
  • Rodney A Appell, Michael B Chancellor, R Howard Zobrist, Heather Thomas, Steven W Sanders. Pharmacokinetics, metabolism, and saliva output during transdermal and extended-release oral oxybutynin administration in healthy subjects. Mayo Clinic proceedings. 2003 Jun; 78(6):696-702. doi: 10.4065/78.6.696. [PMID: 12934778]
  • G Sathyan, M B Chancellor, S K Gupta. Effect of OROS controlled-release delivery on the pharmacokinetics and pharmacodynamics of oxybutynin chloride. British journal of clinical pharmacology. 2001 Oct; 52(4):409-17. doi: 10.1046/j.0306-5251.2001.01463.x. [PMID: 11678784]