Abietane (BioDeep_00000844898)
代谢物信息卡片
Abietane
化学式: C20H36 (276.2816856)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1CCC2C(C1)CCC3C2(CCCC3(C)C)C
InChI: InChI=1S/C20H36/c1-14(2)15-7-9-17-16(13-15)8-10-18-19(3,4)11-6-12-20(17,18)5/h14-18H,6-13H2,1-5H3/t15-,16-,17-,18-,20+/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Monika Bielecka, Marta Stafiniak, Bartosz Pencakowski, Sylwester Ślusarczyk, Jan Paweł Jastrzębski, Łukasz Paukszto, Łukasz Łaczmański, Shima Gharibi, Adam Matkowski. Comparative transcriptomics of two Salvia subg. Perovskia species contribute towards molecular background of abietane-type diterpenoid biosynthesis.
Scientific reports.
2024 02; 14(1):3046. doi:
10.1038/s41598-024-53510-5. [PMID: 38321199] - Panagiotis Kallimanis, Prokopios Magiatis, Angeliki Panagiotopoulou, Kostas Ioannidis, Ioanna Chinou. Extraction Optimization and Qualitative/Quantitative Determination of Bioactive Abietane-Type Diterpenes from Three Salvia Species (Common Sage, Greek Sage and Rosemary) by 1H-qNMR.
Molecules (Basel, Switzerland).
2024 Jan; 29(3):. doi:
10.3390/molecules29030625. [PMID: 38338370] - Xing-Mei Ma, Liang-Yue Mo, Zhao-Peng Ren, Xiao-Na Fan, Ping-Hua Sun, Hai-Yan Tian, Ning Yang, Jia-Chen Zi. New abietane and tigliane diterpenoids from the roots of Euphorbia fischeriana and their cytotoxic activities.
Journal of Asian natural products research.
2023 Jun; 25(6):519-527. doi:
10.1080/10286020.2023.2197224. [PMID: 37229521] - Zuying Du, Ziqiu Peng, Hui Yang, Haisheng Wu, Jie Sun, Lili Huang. Identification and functional characterization of three cytochrome P450 genes for the abietane diterpenoid biosynthesis in Isodon lophanthoides.
Planta.
2023 Mar; 257(5):90. doi:
10.1007/s00425-023-04125-z. [PMID: 36991182] - Haixiu Li, Song Wu, Ruoxi Lin, Yiren Xiao, Ana Luisa Malaco Morotti, Ya Wang, Meytal Galilee, Haowen Qin, Tao Huang, Yong Zhao, Xun Zhou, Jun Yang, Qing Zhao, Angelos K Kanellis, Cathie Martin, Evangelos C Tatsis. The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae.
Molecular plant.
2023 03; 16(3):549-570. doi:
10.1016/j.molp.2023.01.006. [PMID: 36639870] - Stefania Sut, Erica Maccari, Gokhan Zengin, Irene Ferrarese, Francesca Loschi, Marta Faggian, Bertoni Paolo, Nicola De Zordi, Stefano Dall'Acqua. 'Smart Extraction Chain' with Green Solvents: Extraction of Bioactive Compounds from Picea abies Bark Waste for Pharmaceutical, Nutraceutical and Cosmetic Uses.
Molecules (Basel, Switzerland).
2022 Oct; 27(19):. doi:
10.3390/molecules27196719. [PMID: 36235255] - Manli Zhang, Meiying Chen, Yong Hou, Congzhao Fan, Hongyan Wei, Leiling Shi, Guoxu Ma, Jing Zhang. Inflammatory and Cytotoxic Activities of Abietane Terpenoids from Nepeta bracteata Benth.
Molecules (Basel, Switzerland).
2021 Sep; 26(18):. doi:
10.3390/molecules26185603. [PMID: 34577074] - Roméo Arago Dougué Kentsop, Valeria Iobbi, Giuliana Donadio, Barbara Ruffoni, Nunziatina De Tommasi, Angela Bisio. Abietane Diterpenoids from the Hairy Roots of Salvia corrugata.
Molecules (Basel, Switzerland).
2021 Aug; 26(17):. doi:
10.3390/molecules26175144. [PMID: 34500582] - Abdukriem Kadir, Guijuan Zheng, Xiaofeng Zheng, Pengfei Jin, Maitinuer Maiwulanjiang, Biao Gao, Haji Akber Aisa, Guangmin Yao. Structurally Diverse Diterpenoids from the Roots of Salvia deserta Based on Nine Different Skeletal Types.
Journal of natural products.
2021 05; 84(5):1442-1452. doi:
10.1021/acs.jnatprod.0c01180. [PMID: 33978415] - Núria Llurba Montesino, Marcel Kaiser, Pascal Mäser, Thomas J Schmidt. Salvia officinalis L.: Antitrypanosomal Activity and Active Constituents against Trypanosoma brucei rhodesiense.
Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
10.3390/molecules26113226. [PMID: 34072147] - Kai Guo, Yan Liu, Shi-Hong Luo, Yan-Chun Liu, De-Sen Li, Wen-Yuan Li, Sheng-Hong Li. Detoxification of Plant Aromatic Abietanoids via Cleavage of the Benzene Ring into 11,12-Seco-diterpene Polyenes by a Specialist Insect of Leucosceptrum canum.
Organic letters.
2020 01; 22(1):126-129. doi:
10.1021/acs.orglett.9b04044. [PMID: 31829019] - Francielle T G Sousa, Cristina Nunes, Camila Malta Romano, Ester Cerdeira Sabino, Miguel Angel González-Cardenete. Anti-Zika virus activity of several abietane-type ferruginol analogues.
Revista do Instituto de Medicina Tropical de Sao Paulo.
2020; 62(?):e97. doi:
10.1590/s1678-9946202062097. [PMID: 33295481] - Yang Liu, Jing Li, Dan Li, Xiao-Min Li, Dai Li, Gan Zhou, Kang-Ping Xu, Feng-Hua Kang, Zhen-Xing Zou, Ping-Sheng Xu, Gui-Shan Tan. Anti-cholinesterase activities of constituents isolated from Lycopodiastrum casuarinoides.
Fitoterapia.
2019 Nov; 139(?):104366. doi:
10.1016/j.fitote.2019.104366. [PMID: 31629868] - Jin-Long Liu, Min Yu, Hai-Bing Liao, Ting Liu, Yan-Hui Tan, Dong Liang, Gui-Jie Zhang. Sesquiterpenes and diterpenes from Euphorbia thymifolia.
Fitoterapia.
2019 Nov; 139(?):104408. doi:
10.1016/j.fitote.2019.104408. [PMID: 31698058] - Kostas Ioannidis, Eleni Melliou, Prokopios Magiatis. High-Throughput 1H-Nuclear Magnetic Resonance-Based Screening for the Identification and Quantification of Heartwood Diterpenic Acids in Four Black Pine (Pinus nigra Arn.) Marginal Provenances in Greece.
Molecules (Basel, Switzerland).
2019 Oct; 24(19):. doi:
10.3390/molecules24193603. [PMID: 31591296] - Carlos E S Bernardes, Catarina Garcia, Filipe Pereira, Joana Mota, P Pereira, Maria J Cebola, Catarina P Reis, Isabel Correia, M Fátima M Piedade, Manuel E Minas da Piedade, Patrícia Rijo. Extraction Optimization and Structural and Thermal Characterization of the Antimicrobial Abietane 7α-Acetoxy-6β-hydroxyroyleanone.
Molecular pharmaceutics.
2018 04; 15(4):1412-1419. doi:
10.1021/acs.molpharmaceut.7b00892. [PMID: 29494159] - Lara Morán, Sonia Andrés, Raúl Bodas, Nuria Prieto, F Javier Giráldez. Meat texture and antioxidant status are improved when carnosic acid is included in the diet of fattening lambs.
Meat science.
2012 Aug; 91(4):430-4. doi:
10.1016/j.meatsci.2012.02.027. [PMID: 22436658] - Pan Liu, Jin Li, Jianping Liu, Jikun Yang, Yongqing Fan. Release behavior of tanshinone IIA sustained-release pellets based on crack formation theory.
Journal of pharmaceutical sciences.
2012 Aug; 101(8):2811-20. doi:
10.1002/jps.23199. [PMID: 22610467] - Juan Zou, Lutai Pan, Qiji Li, Jianxin Pu, Ping Yao, Min Zhu, Jeffrey A Banas, Hongjie Zhang, Handong Sun. Rubesanolides C-E: abietane diterpenoids isolated from Isodon rubescens and evaluation of their anti-biofilm activity.
Organic & biomolecular chemistry.
2012 Jul; 10(26):5039-44. doi:
10.1039/c2ob25192b. [PMID: 22565549] - Yi He, Yumei Zhang, Jing Lu, Ruichao Lin. Isolation and structural elucidation of abietic acid as the main adulterant in an herbal drug for the treatment of psoriasis.
Journal of pharmaceutical and biomedical analysis.
2012 Jul; 66(?):345-8. doi:
10.1016/j.jpba.2012.03.007. [PMID: 22482903] - Yi-Hua Qian, Qingli Xiao, Jan Xu. The protective effects of tanshinone IIA on β-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron.
Brain research bulletin.
2012 Jul; 88(4):354-8. doi:
10.1016/j.brainresbull.2012.03.007. [PMID: 22498308] - Marcio Fronza, Evelyn Lamy, Stefan Günther, Berta Heinzmann, Stefan Laufer, Irmgard Merfort. Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action.
Phytochemistry.
2012 Jun; 78(?):107-19. doi:
10.1016/j.phytochem.2012.02.015. [PMID: 22436445] - Ying-Hong Xiao, Long-Fei Yang, Xue-Chao Feng, Hong Yang, Tong-Hui Ma. Tanshinones increase fibrinolysis through inhibition of plasminogen activator inhibitor-1.
CNS neuroscience & therapeutics.
2012 May; 18(5):436-8. doi:
10.1111/j.1755-5949.2012.00307.x. [PMID: 22533728] - Zong-Suo Liang, Dong-Feng Yang, Xiao Liang, Yue-Jin Zhang, Yan Liu, Feng-Hua Liu. Roles of reactive oxygen species in methyl jasmonate and nitric oxide-induced tanshinone production in Salvia miltiorrhiza hairy roots.
Plant cell reports.
2012 May; 31(5):873-83. doi:
10.1007/s00299-011-1208-6. [PMID: 22189441] - Masumi Okuda, Noriyasu Yamamoto, Nobuhisa Fukuda, Kohei Maekawa, Takeshi Kusaka, Manabu Hashimoto, Junichiro Kotake, Hiromasa Koizuka, Yoshihiro Fukuda. Effect of ecabet sodium treatment on urea breath test and stool antigen tests in volunteers with Helicobacter pylori infection.
Journal of gastroenterology and hepatology.
2012 Apr; 27 Suppl 3(?):100-2. doi:
10.1111/j.1440-1746.2012.07080.x. [PMID: 22486880] - Yongqing Wang, Nana Tang, Ling Meng, Peipei Zhang, Kun Xu, Ningling Jiang, Haibo Zhang, Ning Ou, Deqin Wu, Anjiu Chen, Xiyong Zhang, Ruihua Shi. Safety and tolerability of bismuthyl ecabet suspension, a novel anti-ulcer agent, following single and multiple oral dose administration in healthy Chinese subjects.
Clinical drug investigation.
2012 Apr; 32(4):247-52. doi:
10.2165/11599110-000000000-00000. [PMID: 22299715] - Wenli Zhang, Jin Li, Jianping Liu, Zimei Wu, Yiming Xu, Ji Wang. Tanshinone IIA-loaded reconstituted high density lipoproteins: Atherosclerotic plaque targeting mechanism in a foam cell model and pharmacokinetics in rabbits.
Die Pharmazie.
2012 Apr; 67(4):324-30. doi:
NULL. [PMID: 22570939] - M V Barni, M J Carlini, E G Cafferata, L Puricelli, S Moreno. Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells.
Oncology reports.
2012 Apr; 27(4):1041-8. doi:
10.3892/or.2012.1630. [PMID: 22246562] - Evelyne H A Doolaege, Els Vossen, Katleen Raes, Bruno De Meulenaer, Roland Verhé, Hubert Paelinck, Stefaan De Smet. Effect of rosemary extract dose on lipid oxidation, colour stability and antioxidant concentrations, in reduced nitrite liver pâtés.
Meat science.
2012 Apr; 90(4):925-31. doi:
10.1016/j.meatsci.2011.11.034. [PMID: 22196091] - Arash Mohebati, Joseph B Guttenplan, Amit Kochhar, Zhong-Lin Zhao, Wieslawa Kosinska, Kotha Subbaramaiah, Andrew J Dannenberg. Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis.
Cancer prevention research (Philadelphia, Pa.).
2012 Apr; 5(4):593-602. doi:
10.1158/1940-6207.capr-12-0002. [PMID: 22374940] - Sawangjitt Wittayalai, Supaporn Sathalalai, Sakornrat Thorroad, Prateep Worawittayanon, Somsak Ruchirawat, Nopporn Thasana. Lycophlegmariols A-D: cytotoxic serratene triterpenoids from the club moss Lycopodium phlegmaria L.
Phytochemistry.
2012 Apr; 76(?):117-23. doi:
10.1016/j.phytochem.2012.01.006. [PMID: 22281380] - Shihua Wu, Dingfang Wu, Junling Liang, Alain Berthod. Modeling gradient elution in countercurrent chromatography: efficient separation of tanshinones from Salvia miltiorrhiza Bunge.
Journal of separation science.
2012 Apr; 35(8):964-76. doi:
10.1002/jssc.201100993. [PMID: 22589157] - Ting Chu, Qing Zhang, Hui Li, Wei-cong Ma, Na Zhang, Hui Jin, Sheng-jun Mao. Development of intravenous lipid emulsion of tanshinone IIA and evaluation of its anti-hepatoma activity in vitro.
International journal of pharmaceutics.
2012 Mar; 424(1-2):76-88. doi:
10.1016/j.ijpharm.2011.12.049. [PMID: 22226873] - L Morán, J M Rodríguez-Calleja, R Bodas, N Prieto, F J Giráldez, S Andrés. Carnosic acid dietary supplementation at 0.12\% rates slows down meat discoloration in gluteus medius of fattening lambs.
Meat science.
2012 Mar; 90(3):789-95. doi:
10.1016/j.meatsci.2011.11.016. [PMID: 22133590] - Tae-Su Jang, HaiYan Zhang, GeumJin Kim, Dong Woo Kim, Byung-Sun Min, Wonku Kang, Kun Ho Son, MinKyun Na, Seung Ho Lee. Bioassay-guided isolation of fatty acid synthase inhibitory diterpenoids from the roots of Salvia miltiorrhiza Bunge.
Archives of pharmacal research.
2012 Mar; 35(3):481-6. doi:
10.1007/s12272-012-0311-8. [PMID: 22477195] - Xiao-Bing Li, Wei Wang, Guo-Jun Zhou, Yan Li, Xiao-Mei Xie, Tong-Shui Zhou. Production of salvianolic acid B in roots of Salvia miltiorrhiza (Danshen) during the post-harvest drying process.
Molecules (Basel, Switzerland).
2012 Feb; 17(3):2388-407. doi:
10.3390/molecules17032388. [PMID: 22370525] - Marc de la Roche, Trevor J Rutherford, Deepti Gupta, Dmitry B Veprintsev, Barbara Saxty, Stefan M Freund, Mariann Bienz. An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.
Nature communications.
2012 Feb; 3(?):680. doi:
10.1038/ncomms1680. [PMID: 22353711] - Chia-Chun Yu, Ching-Ruey Hsieh, George Hsiao, Pi-Yu Chen, Meng-Lun Chang, Hwa-Wen Yin, Tzong-Huei Lee, Ching-Kuo Lee. Regulated expressions of MMP-2, -9 by diterpenoids from Euphorbia formosana Hayata.
Molecules (Basel, Switzerland).
2012 Feb; 17(2):2082-90. doi:
10.3390/molecules17022082. [PMID: 22354186] - Qianliang Ming, Ting Han, Wenchao Li, Qiaoyan Zhang, Hong Zhang, Chengjian Zheng, Fang Huang, Khalid Rahman, Luping Qin. Tanshinone IIA and tanshinone I production by Trichoderma atroviride D16, an endophytic fungus in Salvia miltiorrhiza.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Feb; 19(3-4):330-3. doi:
10.1016/j.phymed.2011.09.076. [PMID: 22035769] - Alejandro F Barrero, M Mar Herrador, Pilar Arteaga, Jesús F Arteaga, Alejandro F Arteaga. Communic acids: occurrence, properties and use as chirons for the synthesis of bioactive compounds.
Molecules (Basel, Switzerland).
2012 Feb; 17(2):1448-67. doi:
10.3390/molecules17021448. [PMID: 22310167] - Mika Yanagitai, Sayaka Itoh, Tomomi Kitagawa, Takato Takenouchi, Hiroshi Kitani, Takumi Satoh. Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia.
Biochemical and biophysical research communications.
2012 Feb; 418(1):22-6. doi:
10.1016/j.bbrc.2011.12.087. [PMID: 22214931] - Xiaoming Zhang, Daqiang He, Linhao Xu, Shucai Ling. Protective effect of tanshinone IIA on rat kidneys during hypothermic preservation.
Molecular medicine reports.
2012 02; 5(2):405-9. doi:
10.3892/mmr.2011.639. [PMID: 22012069] - Yi Zhang, Ren-Xiong Wei, Xiao-Bin Zhu, Lin Cai, Wei Jin, Hao Hu. Tanshinone IIA induces apoptosis and inhibits the proliferation, migration, and invasion of the osteosarcoma MG-63 cell line in vitro.
Anti-cancer drugs.
2012 Feb; 23(2):212-9. doi:
10.1097/cad.0b013e32834e5592. [PMID: 22126901] - Melissa Raboni Alves Rodrigues, Luiz Kae Sales Kanazawa, Thiago Louback Machado das Neves, Carla Francielle da Silva, Heros Horst, Moacir Geraldo Pizzolatti, Adair Roberto Soares Santos, Cristiane Hatsuko Baggio, Maria Fernanda de Paula Werner. Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice.
Journal of ethnopharmacology.
2012 Jan; 139(2):519-26. doi:
10.1016/j.jep.2011.11.042. [PMID: 22154965] - Suvi T Häkkinen, Petri Lackman, Heli Nygrén, Kirsi-Marja Oksman-Caldentey, Hannu Maaheimo, Heiko Rischer. Differential patterns of dehydroabietic acid biotransformation by Nicotiana tabacum and Catharanthus roseus cells.
Journal of biotechnology.
2012 Jan; 157(2):287-94. doi:
10.1016/j.jbiotec.2011.11.008. [PMID: 22178236] - Chang Liu, Jianqin Li, Liangjie Wang, Fuqun Wu, Linfang Huang, Yue Xu, Jieyu Ye, Bin Xiao, Fanyi Meng, Shilin Chen, Mo Yang. Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling.
BMC complementary and alternative medicine.
2012 Jan; 12(?):5. doi:
10.1186/1472-6882-12-5. [PMID: 22248096] - Wenying Chen, Futian Tang, Bailu Xie, Shaorui Chen, Heqing Huang, Peiqing Liu. Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress.
European journal of pharmacology.
2012 Jan; 674(2-3):359-64. doi:
10.1016/j.ejphar.2011.10.040. [PMID: 22088276] - Dongfeng Yang, Pengda Ma, Xiao Liang, Zongsuo Liang, Meixiang Zhang, Shuang Shen, Hongyun Liu, Yan Liu. Metabolic profiles and cDNA-AFLP analysis of Salvia miltiorrhiza and Salvia castanea Diel f. tomentosa Stib.
PloS one.
2012; 7(1):e29678. doi:
10.1371/journal.pone.0029678. [PMID: 22303439] - Chao-Zhan Lin, Chen-Chen Zhu, Zhong-Xiang Zhao, Xiao-Hui Li, Tian-Qin Xiong, Yu-Ying Xia, Yu Ning. Two new abietane diterpenoids from the caulis and leaves of Callicarpa kochiana.
Fitoterapia.
2012 Jan; 83(1):1-5. doi:
10.1016/j.fitote.2011.09.013. [PMID: 21983345] - Hong-Jye Hong, Feng-Lin Hsu, Shih-Chang Tsai, Cheng-Hsin Lin, Ju-Chi Liu, Jin-Jer Chen, Tzu-Hurng Cheng, Paul Chan. Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.
Clinical and experimental pharmacology & physiology.
2012 Jan; 39(1):63-8. doi:
10.1111/j.1440-1681.2011.05637.x. [PMID: 22032308] - Jueun Oh, Tao Yu, Soo Jeong Choi, Yanyan Yang, Heung Soo Baek, Soon Ae An, Lee Kyoung Kwon, Jinsol Kim, Ho Sik Rho, Song Seok Shin, Wahn Soo Choi, Sungyoul Hong, Jae Youl Cho. Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid.
Mediators of inflammation.
2012; 2012(?):781375. doi:
10.1155/2012/781375. [PMID: 22577255] - Yan-yan Qi, Liang Xiao, Lu-ding Zhang, Shao-hua Song, Yi Mei, Teng Chen, Jian-ming Tang, Fang Liu, Guo-shan Ding, Yong-zhao Shi, Quan-xing Wang. Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion.
Frontiers in bioscience (Elite edition).
2012 01; 4(4):1303-13. doi:
10.2741/461. [PMID: 22201956] - Tomoko Kayashima, Kiminori Matsubara. Antiangiogenic effect of carnosic acid and carnosol, neuroprotective compounds in rosemary leaves.
Bioscience, biotechnology, and biochemistry.
2012; 76(1):115-9. doi:
10.1271/bbb.110584. [PMID: 22232247] - Yanlin Chen, Xuemei Wu, Shanshan Yu, Nilufer Jasmine Selimah Fauzee, Jingxian Wu, Lan Li, Jing Zhao, Yong Zhao. Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats.
Biological & pharmaceutical bulletin.
2012; 35(2):164-70. doi:
10.1248/bpb.35.164. [PMID: 22293345] - Han Wang, Ge Zu, Lei Yang, Yuan-gang Zu, Hua Wang, Zhong-hua Zhang, Ying Zhang, Lin Zhang, Hong-zheng Wang. Effects of heat and ultraviolet radiation on the oxidative stability of pine nut oil supplemented with carnosic acid.
Journal of agricultural and food chemistry.
2011 Dec; 59(24):13018-25. doi:
10.1021/jf203454v. [PMID: 22070203] - Verónica Rachel Olate, Olatz Goikoetxeaundia Usandizaga, Guillermo Schmeda-Hirschmann. Resin diterpenes from Austrocedrus chilensis.
Molecules (Basel, Switzerland).
2011 Dec; 16(12):10653-67. doi:
10.3390/molecules161210653. [PMID: 22186953] - Chia-Wen Tsai, Chia-Yuan Lin, Hui-Hsuan Lin, Jing-Hsien Chen. Carnosic acid, a rosemary phenolic compound, induces apoptosis through reactive oxygen species-mediated p38 activation in human neuroblastoma IMR-32 cells.
Neurochemical research.
2011 Dec; 36(12):2442-51. doi:
10.1007/s11064-011-0573-4. [PMID: 21833842] - Bidya Dhar Sahu, Kiran Kumar Reddy Rentam, Uday Kumar Putcha, Madhusudana Kuncha, Ganga Modi Naidu Vegi, Ramakrishna Sistla. Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Dec; 49(12):3090-7. doi:
10.1016/j.fct.2011.08.018. [PMID: 21930180] - Tingting Liu, Xiaoyu Sui, Rongrui Zhang, Lei Yang, Yuangang Zu, Lin Zhang, Ying Zhang, Zhonghua Zhang. Application of ionic liquids based microwave-assisted simultaneous extraction of carnosic acid, rosmarinic acid and essential oil from Rosmarinus officinalis.
Journal of chromatography. A.
2011 Nov; 1218(47):8480-9. doi:
10.1016/j.chroma.2011.09.073. [PMID: 21999917] - Sangeetha Sukumari-Ramesh, J Nicole Bentley, Melissa D Laird, Nagendra Singh, John R Vender, Krishnan M Dhandapani. Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2011 Nov; 29(7):701-10. doi:
10.1016/j.ijdevneu.2011.06.002. [PMID: 21704149] - Hiroki Maruoka, Harue Sasaya, Kensuke Sugihara, Koji Shimoke, Toshihiko Ikeuchi. Low-molecular-weight compounds having neurotrophic activity in cultured PC12 cells and neurons.
Journal of biochemistry.
2011 Nov; 150(5):473-5. doi:
10.1093/jb/mvr113. [PMID: 21908547] - Lei Chen, Xiao-ying Bi, Li-xun Zhu, Yi-qing Qiu, Su-ju Ding, Ben-qiang Deng. [Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2011 Nov; 9(11):1215-20. doi:
10.3736/jcim20111109. [PMID: 22088587] - Ł Kuźma, W Kisiel, A Królicka, H Wysokińska. Genetic transformation of Salvia austriaca by Agrobacterium rhizogenes and diterpenoid isolation.
Die Pharmazie.
2011 Nov; 66(11):904-7. doi:
. [PMID: 22204139] - Guan-Jhong Huang, Jeng-Shyan Deng, Shyh-Shyun Huang, Chi-I Chang, Tien-Ning Chang, Pei-Hsin Shie, Yueh-Hsiung Kuo. Anti-inflammatory activities of 6β-acetoxy-7α-hydroxyroyleanone from Taiwania cryptomerioides Hayata ex vivo and in vivo.
Journal of agricultural and food chemistry.
2011 Oct; 59(20):11211-8. doi:
10.1021/jf200576f. [PMID: 21830830] - Taïeb Tounekti, Iker Hernández, Maren Müller, Habib Khemira, Sergi Munné-Bosch. Kinetin applications alleviate salt stress and improve the antioxidant composition of leaf extracts in Salvia officinalis.
Plant physiology and biochemistry : PPB.
2011 Oct; 49(10):1165-76. doi:
10.1016/j.plaphy.2011.07.011. [PMID: 21856165] - Alvin Ibarra, Julien Cases, Marc Roller, Amparo Chiralt-Boix, Aurélie Coussaert, Christophe Ripoll. Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet.
The British journal of nutrition.
2011 Oct; 106(8):1182-9. doi:
10.1017/s0007114511001620. [PMID: 21676274] - Min Zhang, Svetlana Ignatova, Ping Hu, Qionglin Liang, Yiming Wang, Guoan Luo, Frank Wu Jun, Ian Sutherland. Development of a strategy and process parameters for a green process in counter-current chromatography: purification of tanshinone IIA and cryptotanshinone from Salvia miltiorrhiza Bunge as a case study.
Journal of chromatography. A.
2011 Sep; 1218(36):6031-7. doi:
10.1016/j.chroma.2010.12.118. [PMID: 21277581] - Yan Wang, Nian-Ping Feng, Yi-Lei Nan, Li-Hong Zhong, Hong-Yu Chen, Zhong-Zhe Fan, Qi Li. [Study on the pharmacokinetics of tashinone II(A) -loaded polylactic acid nanoparticles in rabbit].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2011 Sep; 34(9):1392-5. doi:
NULL. [PMID: 22260008] - Si-Yang Fan, Yue-Hu Pei, Hua-Wu Zeng, Shou-De Zhang, Yong-Li Li, Li Li, Ji Ye, Yue-Xin Pan, Hong-Lin Li, Wei-Dong Zhang. Compounds from Platycladus orientalis and their inhibitory effects on nitric oxide and TNF-α production.
Planta medica.
2011 Sep; 77(14):1623-30. doi:
10.1055/s-0030-1270905. [PMID: 21412696] - Kwang-Hyun Hwang, Ji-Yun Ahn, Suna Kim, Jae-Ho Park, Tae-Youl Ha. Abietic acid has an anti-obesity effect in mice fed a high-fat diet.
Journal of medicinal food.
2011 Sep; 14(9):1052-6. doi:
10.1089/jmf.2010.1471. [PMID: 21812648] - Jiang-Qin Liu, Tze-Fun Lee, Margaret Miedzyblocki, Godfrey C F Chan, David L Bigam, Po-Yin Cheung. Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets.
Journal of ethnopharmacology.
2011 Sep; 137(1):44-9. doi:
10.1016/j.jep.2011.03.047. [PMID: 21453766] - M Fronza, R Murillo, S Ślusarczyk, M Adams, M Hamburger, B Heinzmann, S Laufer, I Merfort. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
Bioorganic & medicinal chemistry.
2011 Aug; 19(16):4876-81. doi:
10.1016/j.bmc.2011.06.067. [PMID: 21775156] - Jinzhong Xu, Juan Lu, Fang Sun, Huanzhang Zhu, Lijun Wang, Xiaoyu Zhang, Zhongjun Ma. Terpenoids from Tripterygium wilfordii.
Phytochemistry.
2011 Aug; 72(11-12):1482-7. doi:
10.1016/j.phytochem.2011.03.018. [PMID: 21514608] - Li-Ching Chang, Chi-Lien Wu, Ching-Wen Liu, Wen-Ho Chuo, Ping-Chia Li, Tong-Rong Tsai. Preparation, characterization and cytotoxicity evaluation of tanshinone IIA nanoemulsions.
Journal of biomedical nanotechnology.
2011 Aug; 7(4):558-67. doi:
10.1166/jbn.2011.1315. [PMID: 21870460] - Siva Ram Kiran Vaka, S Narasimha Murthy, Michael A Repka, Tamas Nagy. Upregulation of endogenous neurotrophin levels in the brain by intranasal administration of carnosic acid.
Journal of pharmaceutical sciences.
2011 Aug; 100(8):3139-3145. doi:
10.1002/jps.22528. [PMID: 21360710] - Junsei Mimura, Kunio Kosaka, Atsushi Maruyama, Takumi Satoh, Nobuhiko Harada, Hidemi Yoshida, Kei Satoh, Masayuki Yamamoto, Ken Itoh. Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes.
Journal of biochemistry.
2011 Aug; 150(2):209-17. doi:
10.1093/jb/mvr065. [PMID: 21596795] - N Mulinacci, M Innocenti, M Bellumori, C Giaccherini, V Martini, M Michelozzi. Storage method, drying processes and extraction procedures strongly affect the phenolic fraction of rosemary leaves: an HPLC/DAD/MS study.
Talanta.
2011 Jul; 85(1):167-76. doi:
10.1016/j.talanta.2011.03.050. [PMID: 21645686] - Wentao Bi, Minglei Tian, Kyung Ho Row. Ultrasonication-assisted extraction and preconcentration of medicinal products from herb by ionic liquids.
Talanta.
2011 Jul; 85(1):701-6. doi:
10.1016/j.talanta.2011.04.054. [PMID: 21645761] - Lian-qun Jia, Jun-yi Feng, Guan-lin Yang, Wen-na Chen, Yang Chen. [Effect of tanshinone II A on TLR4 and TNF-α of endothelial cells induced by LPS].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2011 Jul; 27(7):733-5. doi:
". [PMID: 21722522] - M Alcaraz, D Armero, Y Martínez-Beneyto, J Castillo, O Benavente-García, H Fernandez, M Alcaraz-Saura, M Canteras. Chemical genoprotection: reducing biological damage to as low as reasonably achievable levels.
Dento maxillo facial radiology.
2011 Jul; 40(5):310-4. doi:
10.1259/dmfr/95408354. [PMID: 21697157] - Ping Wang, Xiaoqian Wu, Yingxia Bao, Jian Fang, Sigui Zhou, Jie Gao, Rongbiao Pi, Yong-Gao Mou, Peiqing Liu. Tanshinone IIA prevents cardiac remodeling through attenuating NAD (P)H oxidase-derived reactive oxygen species production in hypertensive rats.
Die Pharmazie.
2011 Jul; 66(7):517-24. doi:
NULL. [PMID: 21812327] - Christopher I Keeling, Lina L Madilao, Philipp Zerbe, Harpreet K Dullat, Jörg Bohlmann. The primary diterpene synthase products of Picea abies levopimaradiene/abietadiene synthase (PaLAS) are epimers of a thermally unstable diterpenol.
The Journal of biological chemistry.
2011 Jun; 286(24):21145-53. doi:
10.1074/jbc.m111.245951. [PMID: 21518766] - Xiaohui Xu, Wei Zhang, Changhong Yao, Xupeng Cao, Song Xue. [Quantitative analysis of hinokiol from cell suspension cultures of Cephalotaxus fortunei].
Se pu = Chinese journal of chromatography.
2011 Jun; 29(6):567-70. doi:
10.3724/sp.j.1123.2011.00567. [PMID: 22032171] - Li Mei Li, Jian Xin Pu, Wei Lie Xiao, Han Dong Sun. ent-Abietane diterpenoids from Isodon xerophilus.
Archives of pharmacal research.
2011 Jun; 34(6):875-9. doi:
10.1007/s12272-011-0602-5. [PMID: 21725806] - Evelyne H A Doolaege, Katleen Raes, Filip De Vos, Roland Verhé, Stefaan De Smet. Absorption, distribution and elimination of carnosic acid, a natural antioxidant from Rosmarinus officinalis, in rats.
Plant foods for human nutrition (Dordrecht, Netherlands).
2011 Jun; 66(2):196-202. doi:
10.1007/s11130-011-0233-5. [PMID: 21751091] - Xiaoying Wang, Yi Wang, Min Jiang, Yan Zhu, Limin Hu, Guanwei Fan, Yu Wang, Xiaojia Li, Xiumei Gao. Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways.
Journal of ethnopharmacology.
2011 Jun; 135(3):662-71. doi:
10.1016/j.jep.2011.03.070. [PMID: 21497648] - Matthew R Siebert, Jiaxu Zhang, Srirangam V Addepalli, Dean J Tantillo, William L Hase. The need for enzymatic steering in abietic acid biosynthesis: gas-phase chemical dynamics simulations of carbocation rearrangements on a bifurcating potential energy surface.
Journal of the American Chemical Society.
2011 Jun; 133(21):8335-43. doi:
10.1021/ja201730y. [PMID: 21548620] - Guoyin Kai, Hui Xu, Congcong Zhou, Pan Liao, Jianbo Xiao, Xiuqin Luo, Lijia You, Lin Zhang. Metabolic engineering tanshinone biosynthetic pathway in Salvia miltiorrhiza hairy root cultures.
Metabolic engineering.
2011 May; 13(3):319-27. doi:
10.1016/j.ymben.2011.02.003. [PMID: 21335099] - Cui-Ping Fang, Wei-Ting Wang, Zhi-Fen Wang, Cheng-Gang Shan, Da-Peng Ni, Yu-Qiong Zhang. [Effects of phytohormones on hairy root growth and tanshinone biosynthesis of Salvia miltiorrhiza].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2011 May; 34(5):661-4. doi:
". [PMID: 21954549] - Yongqiang Zhou, Weize Li, Lei Xu, Lvyi Chen. In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors.
Environmental toxicology and pharmacology.
2011 May; 31(3):443-52. doi:
10.1016/j.etap.2011.02.006. [PMID: 21787715] - Shuncang Zhang, Yan Liu, Shuang Shen, Zongsuo Liang, Dongfeng Yang. [Effects of elicitors on accumulation of phenolic acids and tanshinones in Salvia miltiorrhiza hairy root].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 May; 36(10):1269-74. doi:
10.4268/cjcmm20111004. [PMID: 21837963] - Chia-Feng Kuo, Jeng-De Su, Chun-Hung Chiu, Chiung-Chi Peng, Chi-Huang Chang, Tzu-Ying Sung, Shiau-Huei Huang, Wen-Chin Lee, Charng-Cherng Chyau. Anti-inflammatory effects of supercritical carbon dioxide extract and its isolated carnosic acid from Rosmarinus officinalis leaves.
Journal of agricultural and food chemistry.
2011 Apr; 59(8):3674-85. doi:
10.1021/jf104837w. [PMID: 21375325] - Xueying Tan, Jianping Li, Xinyue Wang, Nan Chen, Benzhi Cai, Gang Wang, Hongli Shan, Deli Dong, Yanju Liu, Xingda Li, Fan Yang, Xin Li, Peng Zhang, Xueqi Li, Baofeng Yang, Yanjie Lu. Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway.
International journal of biological sciences.
2011 Apr; 7(3):383-9. doi:
10.7150/ijbs.7.383. [PMID: 21494433] - Chun Guang Li, Shu Jun Sheng, Edwin C K Pang, Brian May, Charlie Chang Li Xue. Plant density-dependent variations in bioactive markers and root yield in Australian-grown Salvia miltiorrhiza Bunge.
Chemistry & biodiversity.
2011 Apr; 8(4):699-709. doi:
10.1002/cbdv.201000192. [PMID: 21480516] - Marvin J Núñez, Carolina P Reyes, Ignacio A Jiménez, Hirotaka Hayashi, Harukuni Tokuda, Isabel L Bazzocchi. ent-Rosane and abietane diterpenoids as cancer chemopreventive agents.
Phytochemistry.
2011 Apr; 72(4-5):385-90. doi:
10.1016/j.phytochem.2011.01.017. [PMID: 21315389] - Hidemi Yoshida, Junsei Mimura, Tadaatsu Imaizumi, Tomoh Matsumiya, Akira Ishikawa, Norifumi Metoki, Kunikazu Tanji, Ken Ota, Ryo Hayakari, Kunio Kosaka, Ken Itoh, Kei Satoh. Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation.
Neuroscience research.
2011 Apr; 69(4):291-8. doi:
10.1016/j.neures.2010.12.016. [PMID: 21241747] - Qiong Yan, JianYong Wu, Rui Liu. Modeling of tanshinone synthesis and phase distribution under the combined effect of elicitation and in situ adsorption in Salvia miltiorrhiza hairy root cultures.
Biotechnology letters.
2011 Apr; 33(4):813-9. doi:
10.1007/s10529-010-0484-5. [PMID: 21120586] - F Pop. Chemical stabilization of oils rich in long-chain polyunsaturated fatty acids during storage.
Food science and technology international = Ciencia y tecnologia de los alimentos internacional.
2011 Apr; 17(2):111-7. doi:
10.1177/1082013210368738. [PMID: 21447601] - Eleonora S Mengoni, Gabriel Vichera, Luciano A Rigano, Marcelo L Rodriguez-Puebla, Silvia R Galliano, Eduardo E Cafferata, Omar H Pivetta, Sivia Moreno, Adrián A Vojnov. Suppression of COX-2, IL-1β and TNF-α expression and leukocyte infiltration in inflamed skin by bioactive compounds from Rosmarinus officinalis L.
Fitoterapia.
2011 Apr; 82(3):414-21. doi:
10.1016/j.fitote.2010.11.023. [PMID: 21129455]