(3R)-1-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4-bipiperidine (BioDeep_00000844889)
代谢物信息卡片
化学式: C30H35N3O3 (485.267828)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(CN(C1)C2CCN(CC2)C(=O)C3=C4C=CC=CC4=CC5=CC=CC=C53)C(=O)N6CCOCC6
InChI: InChI=1S/C30H35N3O3/c34-29(32-16-18-36-19-17-32)24-8-5-13-33(21-24)25-11-14-31(15-12-25)30(35)28-26-9-3-1-6-22(26)20-23-7-2-4-10-27(23)28/h1-4,6-7,9-10,20,24-25H,5,8,11-19,21H2/t24-/m1/s1
描述信息
CP-640186 is an orally active and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism that enables the synthesis of malonyl-CoA. CP-640186 can also stimulate muscle fatty acid oxidation[1][2].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:45293
- PubChem: 449097
- ChEMBL: CHEMBL208943
- CAS: 591778-68-6
- CAS: 630111-13-6
- medchemexpress: HY-15259
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Yuning Pang, Xiang Xu, Xiaojun Xiang, Yongnan Li, Zengqi Zhao, Jiamin Li, Shengnan Gao, Qiangde Liu, Kangsen Mai, Qinghui Ai. High Fat Activates O-GlcNAcylation and Affects AMPK/ACC Pathway to Regulate Lipid Metabolism.
Nutrients.
2021 May; 13(6):. doi:
10.3390/nu13061740. [PMID: 34063748] - Stefanie Keil, Marco Müller, Gerhard Zoller, Guido Haschke, Katrin Schroeter, Maike Glien, Sven Ruf, Ingo Focken, Andreas W Herling, Dieter Schmoll. Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.
Journal of medicinal chemistry.
2010 Dec; 53(24):8679-87. doi:
10.1021/jm101179e. [PMID: 21082864] - Tomomichi Chonan, Takahiro Oi, Daisuke Yamamoto, Miyoko Yashiro, Daisuke Wakasugi, Hiroaki Tanaka, Ayumi Ohoka-Sugita, Fusayo Io, Hiroko Koretsune, Akira Hiratate. (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
Bioorganic & medicinal chemistry letters.
2009 Dec; 19(23):6645-8. doi:
10.1016/j.bmcl.2009.10.012. [PMID: 19853443] - Hailong Zhang, Benjamin Tweel, Jiang Li, Liang Tong. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186.
Structure (London, England : 1993).
2004 Sep; 12(9):1683-91. doi:
10.1016/j.str.2004.07.009. [PMID: 15341732]