GW1929 (BioDeep_00000844699)
Volatile Flavor Compounds
代谢物信息卡片
(S)-2-(2-benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid
化学式: C30H29N3O4 (495.21579540000005)
中文名称: N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CCOC1=CC=C(C=C1)CC(C(=O)O)NC2=CC=CC=C2C(=O)C3=CC=CC=C3)C4=CC=CC=N4
InChI: InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
描述信息
GW 1929 is an orally active peroxisome proliferator-activated receptor-γ (PPARγ) agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW 1929 (hydrochloride) has antidiabetic efficacy and neuroprotective potential[1][2].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:79992
- PubChem: 6518171
- ChEMBL: CHEMBL434063
- CAS: 196808-23-8
- CAS: 196808-24-9
- medchemexpress: HY-15655
- KEGG: C15626
- PubChem: 17396616
- KNApSAcK: 79992
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zeyu Li, Tong Liu, Yang Feng, Yingmu Tong, Yifan Jia, Cong Wang, Ruixia Cui, Kai Qu, Chang Liu, Jingyao Zhang. PPARγ Alleviates Sepsis-Induced Liver Injury by Inhibiting Hepatocyte Pyroptosis via Inhibition of the ROS/TXNIP/NLRP3 Signaling Pathway.
Oxidative medicine and cellular longevity.
2022; 2022(?):1269747. doi:
10.1155/2022/1269747. [PMID: 35136484] - Seungchan An, Gyudong Kim, Hyun Jin Kim, Sungjin Ahn, Hyun Young Kim, Hyejin Ko, Young Eum Hyun, Mai Nguyen, Juri Jeong, Zijing Liu, Jinhe Han, Hongseok Choi, Jinha Yu, Ji Won Kim, Hyuk Woo Lee, Kenneth A Jacobson, Won Jea Cho, Young-Mi Kim, Keon Wook Kang, Minsoo Noh, Lak Shin Jeong. Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.
Journal of medicinal chemistry.
2020 12; 63(24):16012-16027. doi:
10.1021/acs.jmedchem.0c01874. [PMID: 33325691] - Siwen Li, Mei Shi, Ying Wan, Yanling Wang, Mei Zhu, Boya Wang, Yangmei Zhan, Bing Ran, Chunling Wu. Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity.
Ecotoxicology and environmental safety.
2020 Sep; 201(?):110801. doi:
10.1016/j.ecoenv.2020.110801. [PMID: 32502906] - Hao Fan, Jing-Wen Yang, Jin Huang, Lu Wang, Na-Na Yang, Jian-Feng Tu, Cun-Zhi Liu. Peroxisome proliferator-activated receptor-γ mediates the antihypertensive effects of acupuncture in spontaneously hypertensive rats.
Neuroreport.
2020 09; 31(13):952-958. doi:
10.1097/wnr.0000000000001496. [PMID: 32568773] - Jeayoung C Shin, Eunyoung Lee, Seungchan An, Sun Hee Jin, Jaehyoun Ha, Won Jun Choi, Minsoo Noh. Benzophenone-3 and benzophenone-8 exhibit obesogenic activity via peroxisome proliferator-activated receptor γ pathway.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Sep; 67(?):104886. doi:
10.1016/j.tiv.2020.104886. [PMID: 32407875] - Ying Qin, Haoyan Jia, Guizhu Zhao, Zhihong Li, Hongqin Wang, Baiqing Gao. Characterization of the metabolites of GW1929 in rat by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2020 Jan; 34(2):e8585. doi:
10.1002/rcm.8585. [PMID: 31515879] - Daniela Passeri, Andrea Carotti, Jose M Ramos Pittol, Gianmario Ciaccioli, Roberto Pellicciari, Saskia W C van Mil, Antimo Gioiello. Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool.
MedChemComm.
2019 Aug; 10(8):1412-1419. doi:
10.1039/c9md00264b. [PMID: 31673308] - Sungjin Ahn, Seungchan An, Moonyoung Lee, Eunyoung Lee, Jeong Joo Pyo, Jeong Hyeon Kim, Min Won Ki, Sun Hee Jin, Jaehyoun Ha, Minsoo Noh. A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells.
Archives of toxicology.
2019 07; 93(7):1903-1915. doi:
10.1007/s00204-019-02462-1. [PMID: 31016361] - Yong Seok Han, Sang Min Kim, Jun Hee Lee, Sang Hun Lee. Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression.
International journal of molecular sciences.
2018 May; 19(5):. doi:
10.3390/ijms19051367. [PMID: 29734669] - Narcy Arizmendi, Chenjie Hou, Fujiang Guo, Yiming Li, Marianna Kulka. Bicyclic eremophilane-type petasite sesquiterpenes potentiate peroxisome proliferator-activated receptor γ activator-mediated inhibition of dendritic cells.
International journal of immunopathology and pharmacology.
2018 Jan; 32(?):2058738418787739. doi:
10.1177/2058738418787739. [PMID: 30014756] - Jinha Yu, Seyeon Ahn, Hee Jin Kim, Moonyoung Lee, Sungjin Ahn, Jungmin Kim, Sun Hee Jin, Eunyoung Lee, Gyudong Kim, Jae Hoon Cheong, Kenneth A Jacobson, Lak Shin Jeong, Minsoo Noh. Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential.
Journal of medicinal chemistry.
2017 09; 60(17):7459-7475. doi:
10.1021/acs.jmedchem.7b00805. [PMID: 28799755] - Vladimir S Shavva, Denis A Mogilenko, Alexandra M Bogomolova, Artemy A Nikitin, Ella B Dizhe, Alexander M Efremov, Galina N Oleinikova, Andrej P Perevozchikov, Sergey V Orlov. PPARγ Represses Apolipoprotein A-I Gene but Impedes TNFα-Mediated ApoA-I Downregulation in HepG2 Cells.
Journal of cellular biochemistry.
2016 09; 117(9):2010-22. doi:
10.1002/jcb.25498. [PMID: 26813964] - Sandra Barbosa-da-Silva, Vanessa Souza-Mello, D'Angelo Carlo Magliano, Thatiany de Souza Marinho, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda. Singular effects of PPAR agonists on nonalcoholic fatty liver disease of diet-induced obese mice.
Life sciences.
2015 Apr; 127(?):73-81. doi:
10.1016/j.lfs.2015.02.003. [PMID: 25748419] - Swei Sunny Hahn, Qing Tang, Fang Zheng, Shunyu Zhao, Jingjing Wu. GW1929 inhibits α7 nAChR expression through PPARγ-independent activation of p38 MAPK and inactivation of PI3-K/mTOR: The role of Egr-1.
Cellular signalling.
2014 Apr; 26(4):730-9. doi:
10.1016/j.cellsig.2013.12.019. [PMID: 24412748] - Mesfin Yimam, Jifu Zhao, Brandon Corneliusen, Mandee Pantier, Lidia Alfaro Brownell, Qi Jia. UP780, a chromone-enriched aloe composition improves insulin sensitivity.
Metabolic syndrome and related disorders.
2013 Aug; 11(4):267-75. doi:
10.1089/met.2012.0135. [PMID: 23573999] - Manju S Devi, Perumana R Sudhakaran. Angiogenic response of advanced glycation end products (AGEs) involves PPARgamma.
Indian journal of biochemistry & biophysics.
2012 Feb; 49(1):18-24. doi:
. [PMID: 22435140] - Shuichiro Hara, Toshifumi Takahashi, Mitsuyoshi Amita, Hideki Igarashi, Seiji Tsutsumi, Hirohisa Kurachi. Bezafibrate restores the inhibition of FSH-induced follicular development and steroidogenesis by tumor necrosis factor-alpha through peroxisome proliferator-activated receptor-gamma pathway in an in vitro mouse preantral follicle culture.
Biology of reproduction.
2011 Nov; 85(5):895-906. doi:
10.1095/biolreprod.111.090738. [PMID: 21734263] - Yoshikane Izawa, Shinichi Takahashi, Norihiro Suzuki. Pioglitazone enhances pyruvate and lactate oxidation in cultured neurons but not in cultured astroglia.
Brain research.
2009 Dec; 1305(?):64-73. doi:
10.1016/j.brainres.2009.09.098. [PMID: 19800324] - Zivar Yousefipour, Adebayo Oyekan, Mohammad Newaz. Role of G protein-coupled receptor kinase-2 in peroxisome proliferator-activated receptor gamma-mediated modulation of blood pressure and renal vascular reactivity in SHR.
American journal of nephrology.
2009; 30(3):201-8. doi:
10.1159/000218061. [PMID: 19420904] - C Nugent, J B Prins, J P Whitehead, D Savage, J M Wentworth, V K Chatterjee, S O'Rahilly. Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR gamma activation.
Molecular endocrinology (Baltimore, Md.).
2001 Oct; 15(10):1729-38. doi:
10.1210/mend.15.10.0715. [PMID: 11579205] - J M Way, W W Harrington, K K Brown, W K Gottschalk, S S Sundseth, T A Mansfield, R K Ramachandran, T M Willson, S A Kliewer. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues.
Endocrinology.
2001 Mar; 142(3):1269-77. doi:
10.1210/endo.142.3.8037. [PMID: 11181544] - K K Brown, B R Henke, S G Blanchard, J E Cobb, R Mook, I Kaldor, S A Kliewer, J M Lehmann, J M Lenhard, W W Harrington, P J Novak, W Faison, J G Binz, M A Hashim, W O Oliver, H R Brown, D J Parks, K D Plunket, W Q Tong, J A Menius, K Adkison, S A Noble, T M Willson. A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Diabetes.
1999 Jul; 48(7):1415-24. doi:
10.2337/diabetes.48.7.1415. [PMID: 10389847]