Liproxstatin-1 (BioDeep_00000844665)
代谢物信息卡片
Liproxstatin-1
化学式: C19H21ClN4 (340.1455)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CNCCC12C(=NCC3=CC(=CC=C3)Cl)NC4=CC=CC=C4N2
InChI: InChI=1S/C19H21ClN4/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18/h1-7,12,21,24H,8-11,13H2,(H,22,23)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jinshuai Lan, Li Liu, Wenjun Zhao, Zhe Li, Ruifeng Zeng, Shiyuan Fang, Lixia Chen, Yi Shen, Hai Wei, Tong Zhang, Yue Ding. Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system.
Free radical biology & medicine.
2024 Jun; 218(?):26-40. doi:
10.1016/j.freeradbiomed.2024.03.023. [PMID: 38570172] - Zachary P Rokop, Wenjun Zhang, Nandini Ghosh, Nirupam Biswas, Amitava Das, Jingmei Lin, Chandan K Sen, Chandrashekhar Kubal. Exacerbated ischemia-reperfusion injury in fatty livers is mediated by lipid peroxidation stress and ferroptosis.
Surgery.
2024 Jun; 175(6):1539-1546. doi:
10.1016/j.surg.2024.02.001. [PMID: 38508920] - Xuelian Xiang, Mengtao Xu, Li Liu, Nuo Meng, Yu Lei, Yong Feng, Guodu Tang. Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats.
Scientific reports.
2024 04; 14(1):9548. doi:
10.1038/s41598-024-60159-7. [PMID: 38664508] - Bei Cheng, Jun Zhang, Qinhao Shen, Zheyi Sun, Yingwei Luo, Yu Hu. Liproxstatin-1 alleviates cartilage degradation by inhibiting chondrocyte ferroptosis in the temporomandibular joint.
Biology of the cell.
2024 Jan; 116(1):e202300042. doi:
10.1111/boc.202300042. [PMID: 37919852] - Jin Zhao, Jiawei Li, Dong Wei, Fei Gao, Xiucheng Yang, Bingqing Yue, Dian Xiong, Mingzhao Liu, Hongyang Xu, Chunxiao Hu, Jingyu Chen. Liproxstatin-1 Alleviates Lung Transplantation-induced Cold Ischemia-Reperfusion Injury by Inhibiting Ferroptosis.
Transplantation.
2023 10; 107(10):2190-2202. doi:
10.1097/tp.0000000000004638. [PMID: 37202851] - Qiqi Cai, Qunhe Shen, Weimin Zhu, Sheng Zhang, Jingjing Ke, Zhongqiu Lu. Paraquat-induced ferroptosis suppression via NRF2 expression regulation.
Toxicology in vitro : an international journal published in association with BIBRA.
2023 Jul; ?(?):105655. doi:
10.1016/j.tiv.2023.105655. [PMID: 37507096] - Jiaojiao Fan, Xinyue Xu, Yuting Li, Lingge Zhang, Mengqiu Miao, Yujia Niu, Yue Zhang, Aihua Zhang, Zhanjun Jia, Mengqiu Wu. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis.
Free radical biology & medicine.
2023 01; 194(?):84-98. doi:
10.1016/j.freeradbiomed.2022.11.029. [PMID: 36403736] - Jie Tong, Xiu-Ting Lan, Zhen Zhang, Yi Liu, Di-Yang Sun, Xu-Jie Wang, Shen-Xi Ou-Yang, Chun-Lin Zhuang, Fu-Ming Shen, Pei Wang, Dong-Jie Li. Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis.
Acta pharmacologica Sinica.
2022 Nov; ?(?):. doi:
10.1038/s41401-022-01010-5. [PMID: 36323829] - Yang Li, Miao Sun, Fuyang Cao, Yu Chen, Linlin Zhang, Hao Li, Jiangbei Cao, Jie Song, Yulong Ma, Weidong Mi, Xiaoying Zhang. The Ferroptosis Inhibitor Liproxstatin-1 Ameliorates LPS-Induced Cognitive Impairment in Mice.
Nutrients.
2022 Nov; 14(21):. doi:
10.3390/nu14214599. [PMID: 36364859] - Jacob L Brown, Fredrick F Peelor, Constantin Georgescu, Jonathan D Wren, Michael Kinter, Victoria J Tyrrell, Valerie B O'Donnell, Benjamin F Miller, Holly Van Remmen. Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy.
Redox biology.
2022 Oct; 57(?):102518. doi:
10.1016/j.redox.2022.102518. [PMID: 36283174] - Kailin Yang, Liuting Zeng, Xiao Yuan, Shanshan Wang, Anqi Ge, Hao Xu, Jinsong Zeng, Jinwen Ge. The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113611. doi:
10.1016/j.biopha.2022.113611. [PMID: 36081288] - Chen Bao, Chao Liu, Qian Liu, Lijuan Hua, Jiannan Hu, Ziling Li, Shuyun Xu. Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis.
International immunopharmacology.
2022 Aug; 109(?):108770. doi:
10.1016/j.intimp.2022.108770. [PMID: 35483233] - Lei Wang, An Wang, Qian Fu, Zhongyu Shi, Xiaoying Chen, Yan Wang, Wenhui Xu, Tieshan Wang, Shujing Zhang, Sumin Hu. Ferroptosis plays an important role in promoting ionizing radiation-induced intestinal injuries.
Biochemical and biophysical research communications.
2022 03; 595(?):7-13. doi:
10.1016/j.bbrc.2022.01.068. [PMID: 35091109] - Bo Zhang, Xiang Chen, Feng Ru, Yu Gan, Bingsheng Li, Weiping Xia, Guoyu Dai, Yao He, Zhi Chen. Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis.
Cell death & disease.
2021 09; 12(9):843. doi:
10.1038/s41419-021-04137-1. [PMID: 34511597] - Jingjing Du, Lishuang Wang, Xiaoming Huang, Na Zhang, Ze Long, You Yang, Fangfang Zhong, Bowen Zheng, Wenjian Lan, Wanjun Lin, Wenzhe Ma. Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 May; 85(?):153551. doi:
10.1016/j.phymed.2021.153551. [PMID: 33827043] - Ningning Tao, Kang Li, Jingjing Liu, Guoqing Fan, Tieying Sun. Liproxstatin-1 alleviates bleomycin-induced alveolar epithelial cells injury and mice pulmonary fibrosis via attenuating inflammation, reshaping redox equilibrium, and suppressing ROS/p53/α-SMA pathway.
Biochemical and biophysical research communications.
2021 04; 551(?):133-139. doi:
10.1016/j.bbrc.2021.02.127. [PMID: 33735625] - Yang Cao, Yin Li, Chao He, Feng Yan, Jian-Ru Li, Hang-Zhe Xu, Jian-Feng Zhuang, Hang Zhou, Yu-Cong Peng, Xiong-Jie Fu, Xiao-Yang Lu, Yuan Yao, Yu-Yu Wei, Yun Tong, Yi-Fu Zhou, Lin Wang. Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage.
Neuroscience bulletin.
2021 Apr; 37(4):535-549. doi:
10.1007/s12264-020-00620-5. [PMID: 33421025] - Deliang Ma, Chang Li, Pengling Jiang, Yingjian Jiang, Jiang Wang, Dianliang Zhang. Inhibition of Ferroptosis Attenuates Acute Kidney Injury in Rats with Severe Acute Pancreatitis.
Digestive diseases and sciences.
2021 02; 66(2):483-492. doi:
10.1007/s10620-020-06225-2. [PMID: 32219613] - Kyu Min Kim, Sam Seok Cho, Sung Hwan Ki. Emerging roles of ferroptosis in liver pathophysiology.
Archives of pharmacal research.
2020 Oct; 43(10):985-996. doi:
10.1007/s12272-020-01273-8. [PMID: 33079307] - Martina Maria Capelletti, Hana Manceau, Hervé Puy, Katell Peoc'h. Ferroptosis in Liver Diseases: An Overview.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21144908. [PMID: 32664576] - Ariunaa Sampilvanjil, Tadayoshi Karasawa, Naoya Yamada, Takanori Komada, Tsunehito Higashi, Chintogtokh Baatarjav, Sachiko Watanabe, Ryo Kamata, Nobuhiko Ohno, Masafumi Takahashi. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells.
American journal of physiology. Heart and circulatory physiology.
2020 03; 318(3):H508-H518. doi:
10.1152/ajpheart.00559.2019. [PMID: 31975626] - Zhiwei Zheng, Dongmei Tang, Liping Zhao, Wen Li, Jinghong Han, Bing Hu, Guohui Nie, Yingzi He. Liproxstatin-1 Protects Hair Cell-Like HEI-OC1 Cells and Cochlear Hair Cells against Neomycin Ototoxicity.
Oxidative medicine and cellular longevity.
2020; 2020(?):1782659. doi:
10.1155/2020/1782659. [PMID: 33343803] - Xuhui Chen, Bo Zhang, Tongtong Liu, Miaomiao Feng, Yue Zhang, Chuanhan Zhang, Wenlong Yao, Li Wan. Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death.
ACS chemical neuroscience.
2019 12; 10(12):4824-4833. doi:
10.1021/acschemneuro.9b00539. [PMID: 31682397] - Yang Li, Dongcheng Feng, Zhanyu Wang, Yan Zhao, Ruimin Sun, Donghai Tian, Deshun Liu, Feng Zhang, Shili Ning, Jihong Yao, Xiaofeng Tian. Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion.
Cell death and differentiation.
2019 Nov; 26(11):2284-2299. doi:
10.1038/s41418-019-0299-4. [PMID: 30737476] - Yuki Yamaguchi, Takashi Kasukabe, Shunichi Kumakura. Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis.
International journal of oncology.
2018 Mar; 52(3):1011-1022. doi:
10.3892/ijo.2018.4259. [PMID: 29393418] - Christine Wenz, Dagmar Faust, Berenike Linz, Christian Turmann, Teodora Nikolova, John Bertin, Peter Gough, Peter Wipf, Anna Sophia Schröder, Stefan Krautwald, Cornelia Dietrich. t-BuOOH induces ferroptosis in human and murine cell lines.
Archives of toxicology.
2018 Feb; 92(2):759-775. doi:
10.1007/s00204-017-2066-y. [PMID: 28975372] - Sebastian Doll, Marcus Conrad. Iron and ferroptosis: A still ill-defined liaison.
IUBMB life.
2017 06; 69(6):423-434. doi:
10.1002/iub.1616. [PMID: 28276141] - Xiehuang Sheng, Chao Shan, Jianbiao Liu, Jintong Yang, Bin Sun, Dezhan Chen. Theoretical insights into the mechanism of ferroptosis suppression via inactivation of a lipid peroxide radical by liproxstatin-1.
Physical chemistry chemical physics : PCCP.
2017 May; 19(20):13153-13159. doi:
10.1039/c7cp00804j. [PMID: 28489094] - Jennifer Yinuo Cao, Scott J Dixon. Mechanisms of ferroptosis.
Cellular and molecular life sciences : CMLS.
2016 06; 73(11-12):2195-209. doi:
10.1007/s00018-016-2194-1. [PMID: 27048822] - Jose Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth, Yulia Y Tyurina, Vladimir A Tyurin, Victoria J Hammond, Nadja Herbach, Michaela Aichler, Axel Walch, Elke Eggenhofer, Devaraj Basavarajappa, Olof Rådmark, Sho Kobayashi, Tobias Seibt, Heike Beck, Frauke Neff, Irene Esposito, Rüdiger Wanke, Heidi Förster, Olena Yefremova, Marc Heinrichmeyer, Georg W Bornkamm, Edward K Geissler, Stephen B Thomas, Brent R Stockwell, Valerie B O'Donnell, Valerian E Kagan, Joel A Schick, Marcus Conrad. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Nature cell biology.
2014 Dec; 16(12):1180-91. doi:
10.1038/ncb3064. [PMID: 25402683]
