Methanone, (2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo(1,2,3-de)-1,4-benzoxazin-6-yl)-1-naphthalenyl-, (S)- (BioDeep_00000844597)
代谢物信息卡片
Methanone, (2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo(1,2,3-de)-1,4-benzoxazin-6-yl)-1-naphthalenyl-, (S)-
化学式: C27H26N2O3 (426.19433260000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C2=C3N1C(COC3=CC=C2)CN4CCOCC4)C(=O)C5=CC=CC6=CC=CC=C65
InChI: InChI=1S/C27H26N2O3/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28/h2-11,20H,12-17H2,1H3/t20-/m0/s1
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Abigail L Brewer, Claire E Felter, Anna R Sternitzky, Sade M Spencer. Somatic and anxiety-like behaviors in male and female rats during withdrawal from the non-selective cannabinoid agonist WIN 55,212-2.
Pharmacology, biochemistry, and behavior.
2024 Jan; ?(?):173707. doi:
10.1016/j.pbb.2024.173707. [PMID: 38244864] - S O Vanegas, A M Reck, C E Rodriguez, J A Marusich, O Yassin, G Sotzing, J L Wiley, S G Kinsey. Assessment of dependence potential and abuse liability of Δ8-tetrahydrocannabinol in mice.
Drug and alcohol dependence.
2022 11; 240(?):109640. doi:
10.1016/j.drugalcdep.2022.109640. [PMID: 36179506] - Alba Angelina, Rodrigo Jiménez-Saiz, Mario Pérez-Diego, Angel Maldonado, Beate Rückert, Mübeccel Akdis, Mar Martín-Fontecha, Cezmi A Akdis, Oscar Palomares. Cannabinoid WIN55212-2 impairs peanut-allergic sensitization and promotes the generation of allergen-specific regulatory T cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2022 04; 52(4):540-549. doi:
10.1111/cea.14092. [PMID: 34995385] - Zeynep Gizem Todurga Seven, Fatma Kubra Tombulturk, Selim Gokdemir, Sibel Ozyazgan. The Effects of the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin, Cannabinoid Agonist WIN 55,212-2, and Nitric Oxide Synthase Inhibitor Nω-Nitro-L-Arginine Methyl Ester Hydrochloride on the Serotonin and Dry Skin-Induced Itch.
International archives of allergy and immunology.
2022; 183(4):443-452. doi:
10.1159/000520509. [PMID: 34864727] - Laura L Erwin, Mark R Nilges, Ian B Denys, Jane C Sutphen, Ashton J Friend, Daniel R Kapusta, Peter J Winsauer. Interactive effects of (±)-trans-U50488 and its stereoisomers with cannabinoids.
Pharmacology, biochemistry, and behavior.
2021 08; 207(?):173218. doi:
10.1016/j.pbb.2021.173218. [PMID: 34118232] - Ferenc Zádor, Gábor Nagy-Grócz, Szabolcs Dvorácskó, Zsuzsanna Bohár, Edina Katalin Cseh, Dénes Zádori, Árpád Párdutz, Edina Szűcs, Csaba Tömböly, Anna Borsodi, Sándor Benyhe, László Vécsei. Long-term systemic administration of kynurenic acid brain region specifically elevates the abundance of functional CB1 receptors in rats.
Neurochemistry international.
2020 09; 138(?):104752. doi:
10.1016/j.neuint.2020.104752. [PMID: 32445659] - Qin Yang, Shunli Sun, Wei Liu, Qingguang Liu, Jibing Wang. Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice.
Biochemical and biophysical research communications.
2020 05; 525(3):639-645. doi:
10.1016/j.bbrc.2020.02.134. [PMID: 32122652] - Shivani Sachdev, Samuel D Banister, Marina Santiago, Chris Bladen, Michael Kassiou, Mark Connor. Differential activation of G protein-mediated signaling by synthetic cannabinoid receptor agonists.
Pharmacology research & perspectives.
2020 04; 8(2):e00566. doi:
10.1002/prp2.566. [PMID: 32101383] - Amanda Spring de Almeida, Flávia Karine Rigo, Samira Dal-Toé De Prá, Alessandra Marcone Milioli, Diéssica Padilha Dalenogare, Gabriele Cheiran Pereira, Camila Dos Santos Ritter, Diulle Spat Peres, Caren Tatiane de David Antoniazzi, Carolina Stein, Rafael Noal Moresco, Sara Marchesan Oliveira, Gabriela Trevisan. Characterization of Cancer-Induced Nociception in a Murine Model of Breast Carcinoma.
Cellular and molecular neurobiology.
2019 Jul; 39(5):605-617. doi:
10.1007/s10571-019-00666-8. [PMID: 30850915] - Robertta Silva Martins, Isis Grigorio de Freitas, Matheus Figueiredo Sathler, Vladimir Pedro Peralva Borges Martins, Clarissa de Sampaio Schitine, Luzia da Silva Sampaio, Hércules Rezende Freitas, Alex Christian Manhães, Maurício Dos Santos Pereira, Ricardo Augusto de Melo Reis, Regina Célia Cussa Kubrusly. Beta-adrenergic receptor activation increases GABA uptake in adolescent mice frontal cortex: Modulation by cannabinoid receptor agonist WIN55,212-2.
Neurochemistry international.
2018 11; 120(?):182-190. doi:
10.1016/j.neuint.2018.08.011. [PMID: 30170018] - Luzia S Sampaio, Fabio A Iannotti, Luciana Veneziani, Rosa T Borelli-Tôrres, Fabrizia De Maio, Fabiana Piscitelli, Ricardo A M Reis, Vincenzo Di Marzo, Marcelo Einicker-Lamas. Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells.
Biochemical pharmacology.
2018 08; 154(?):482-491. doi:
10.1016/j.bcp.2018.06.005. [PMID: 29890144] - Mohammed I Khan, Anna A Sobocińska, Klaudia K Brodaczewska, Katarzyna Zielniok, Malgorzata Gajewska, Claudine Kieda, Anna M Czarnecka, Cezary Szczylik. Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212-2 in renal cell carcinoma.
BMC cancer.
2018 May; 18(1):583. doi:
10.1186/s12885-018-4496-1. [PMID: 29792186] - Marisol Maya-López, María Verónica Mireles-García, Monserrat Ramírez-Toledo, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Abel Santamaría. Thallium-Induced Toxicity in Rat Brain Crude Synaptosomal/Mitochondrial Fractions is Sensitive to Anti-excitatory and Antioxidant Agents.
Neurotoxicity research.
2018 04; 33(3):634-640. doi:
10.1007/s12640-017-9863-1. [PMID: 29313218] - Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompres. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain.
Neuropharmacology.
2018 Feb; 129(?):1-15. doi:
10.1016/j.neuropharm.2017.11.005. [PMID: 29113897] - Angel Escamilla-Ramírez, Esperanza García, Guadalupe Palencia-Hernández, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Julio Sotelo, Abel Santamaría. URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors.
Neurotoxicity research.
2017 May; 31(4):532-544. doi:
10.1007/s12640-016-9698-1. [PMID: 28092019] - Erin K Kirschmann, Michael W Pollock, Vidhya Nagarajan, Mary M Torregrossa. Effects of Adolescent Cannabinoid Self-Administration in Rats on Addiction-Related Behaviors and Working Memory.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2017 Apr; 42(5):989-1000. doi:
10.1038/npp.2016.178. [PMID: 27582345] - Prusothman Yoganantharjah, Avinesh R Byreddy, Daniel Fraher, Munish Puri, Yann Gibert. Rapid quantification of neutral lipids and triglycerides during zebrafish embryogenesis.
The International journal of developmental biology.
2017; 61(1-2):105-111. doi:
10.1387/ijdb.160209yg. [PMID: 28287241] - Ya-Jing Feng, Yong-Yu Li, Xu-Hong Lin, Kun Li, Ming-Hua Cao. Anti-inflammatory effect of cannabinoid agonist WIN55, 212 on mouse experimental colitis is related to inhibition of p38MAPK.
World journal of gastroenterology.
2016 Nov; 22(43):9515-9524. doi:
10.3748/wjg.v22.i43.9515. [PMID: 27920472] - Rita Citraro, Emilio Russo, Antonio Leo, Roberto Russo, Carmen Avagliano, Michele Navarra, Antonio Calignano, Giovambattista De Sarro. Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2'-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice.
European journal of pharmacology.
2016 Nov; 791(?):523-534. doi:
10.1016/j.ejphar.2016.09.029. [PMID: 27663280] - Lawrence C Blume, Sandra Leone-Kabler, Deborah J Luessen, Glen S Marrs, Erica Lyons, Caroline E Bass, Rong Chen, Dana E Selley, Allyn C Howlett. Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner.
Journal of neurochemistry.
2016 11; 139(3):396-407. doi:
10.1111/jnc.13767. [PMID: 27513693] - Marie Mardal, Emma Gracia-Lor, Svenja Leibnitz, Sara Castiglioni, Markus R Meyer. Toxicokinetics of new psychoactive substances: plasma protein binding, metabolic stability, and human phase I metabolism of the synthetic cannabinoid WIN 55,212-2 studied using in vitro tools and LC-HR-MS/MS.
Drug testing and analysis.
2016 Oct; 8(10):1039-1048. doi:
10.1002/dta.1938. [PMID: 26810883] - Berhanu Geresu, Emmanuel Onaivi, Ephrem Engidawork. Behavioral evidence for the interaction between cannabinoids and Catha edulis F. (Khat) in mice.
Brain research.
2016 10; 1648(Pt A):333-338. doi:
10.1016/j.brainres.2016.08.006. [PMID: 27502029] - Chaela S Presley, Ammaar H Abidi, Bob M Moore. Cannabinoid receptor 1 ligands revisited: Pharmacological assessment in the ACTOne system.
Analytical biochemistry.
2016 Apr; 498(?):8-28. doi:
10.1016/j.ab.2015.12.019. [PMID: 26772161] - Antonietta Notaro, Selenia Sabella, Ornella Pellerito, Renza Vento, Giuseppe Calvaruso, Michela Giuliano. The secreted protein acidic and rich in cysteine is a critical mediator of cell death program induced by WIN/TRAIL combined treatment in osteosarcoma cells.
International journal of oncology.
2016 Mar; 48(3):1039-44. doi:
10.3892/ijo.2015.3307. [PMID: 26698404] - A L Colín-González, A L Paz-Loyola, I N Serratos, B Seminotti, C A J Ribeiro, G Leipnitz, D O Souza, M Wajner, A Santamaría. The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes.
Neuroscience.
2015 Dec; 310(?):578-88. doi:
10.1016/j.neuroscience.2015.09.043. [PMID: 26431622] - L S Sampaio, R Taveira Da Silva, D Lima, C L C Sampaio, F A Iannotti, E Mazzarella, V Di Marzo, A Vieyra, R A M Reis, M Einicker-Lamas. The endocannabinoid system in renal cells: regulation of Na(+) transport by CB1 receptors through distinct cell signalling pathways.
British journal of pharmacology.
2015 Oct; 172(19):4615-25. doi:
10.1111/bph.13050. [PMID: 25537261] - Susan Fung, Allison E Cherry, Cong Xu, Nephi Stella. Alkylindole-sensitive receptors modulate microglial cell migration and proliferation.
Glia.
2015 Oct; 63(10):1797-808. doi:
10.1002/glia.22845. [PMID: 25914169] - Kun Xu, Thomas Gilles, Bernhard Breit. Asymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines.
Nature communications.
2015 Jul; 6(?):7616. doi:
10.1038/ncomms8616. [PMID: 26137886] - Oliver Linsell, Philip W Brownjohn, Hayley Nehoff, Khaled Greish, John C Ashton. Effect of styrene maleic acid WIN55,212-2 micelles on neuropathic pain in a rat model.
Journal of drug targeting.
2015 May; 23(4):353-9. doi:
10.3109/1061186x.2014.997737. [PMID: 25541465] - Susanna Pietropaolo, Luigi Bellocchio, Andrea Ruiz-Calvo, Magali Cabanas, Zhuowei Du, Manuel Guzmán, Maurice Garret, Yoon H Cho. Chronic cannabinoid receptor stimulation selectively prevents motor impairments in a mouse model of Huntington's disease.
Neuropharmacology.
2015 Feb; 89(?):368-74. doi:
10.1016/j.neuropharm.2014.07.021. [PMID: 25123645] - Yung-Chien Hsu, Chen-Chou Lei, Ya-Hsueh Shih, Cheng Ho, Chun-Liang Lin. Induction of proteinuria by cannabinoid receptors 1 signaling activation in CB1 transgenic mice.
The American journal of the medical sciences.
2015 Feb; 349(2):162-8. doi:
10.1097/maj.0000000000000352. [PMID: 25474224] - E Rangel-López, A L Colín-González, A L Paz-Loyola, E Pinzón, I Torres, I N Serratos, P Castellanos, M Wajner, D O Souza, A Santamaría. Cannabinoid receptor agonists reduce the short-term mitochondrial dysfunction and oxidative stress linked to excitotoxicity in the rat brain.
Neuroscience.
2015 Jan; 285(?):97-106. doi:
10.1016/j.neuroscience.2014.11.016. [PMID: 25446347] - Eleni Fanarioti, Maria Mavrikaki, George Panagis, Ada Mitsacos, George G Nomikos, Panagiotis Giompres. Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.
The international journal of neuropsychopharmacology.
2014 Dec; 18(6):. doi:
10.1093/ijnp/pyu097. [PMID: 25522428] - David R Janero, Alexandros Makriyannis. Terpenes and lipids of the endocannabinoid and transient-receptor-potential-channel biosignaling systems.
ACS chemical neuroscience.
2014 Nov; 5(11):1097-106. doi:
10.1021/cn5000875. [PMID: 24866555] - Zdeněk Fišar, Namrata Singh, Jana Hroudová. Cannabinoid-induced changes in respiration of brain mitochondria.
Toxicology letters.
2014 Nov; 231(1):62-71. doi:
10.1016/j.toxlet.2014.09.002. [PMID: 25195527] - Jessica A Fawley, Mackenzie E Hofmann, Michael C Andresen. Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014 Jun; 34(24):8324-32. doi:
10.1523/jneurosci.0315-14.2014. [PMID: 24920635] - Fabiana C Vilela, Alexandre Giusti-Paiva. Cannabinoid receptor agonist disrupts behavioral and neuroendocrine responses during lactation.
Behavioural brain research.
2014 Apr; 263(?):190-7. doi:
10.1016/j.bbr.2014.01.037. [PMID: 24495659] - Eman Ilayan, Monika Feliszek, Barbara Malinowska, Eberhard Schlicker. Do cannabinoids exhibit a tyramine-like effect?.
Naunyn-Schmiedeberg's archives of pharmacology.
2013 Dec; 386(12):1041-6. doi:
10.1007/s00210-013-0903-y. [PMID: 23900610] - Fair M Vassoler, Nicole L Johnson, Elizabeth M Byrnes. Female adolescent exposure to cannabinoids causes transgenerational effects on morphine sensitization in female offspring in the absence of in utero exposure.
Journal of psychopharmacology (Oxford, England).
2013 Nov; 27(11):1015-22. doi:
10.1177/0269881113503504. [PMID: 24048098] - Carmen Walter, Nerea Ferreirós, Philipp Bishay, Gerd Geisslinger, Irmgard Tegeder, Jörn Lötsch. Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans.
Journal of clinical psychopharmacology.
2013 Oct; 33(5):699-705. doi:
10.1097/jcp.0b013e3182984015. [PMID: 23899642] - Muhammad T Akhtar, Shaukat Ali, Hassan Rashidi, Frank van der Kooy, Robert Verpoorte, Michael K Richardson. Developmental effects of cannabinoids on zebrafish larvae.
Zebrafish.
2013 Sep; 10(3):283-93. doi:
10.1089/zeb.2012.0785. [PMID: 23789728] - Patrizia Campolongo, Maria Morena, Sergio Scaccianoce, Viviana Trezza, Flavia Chiarotti, Gustav Schelling, Vincenzo Cuomo, Benno Roozendaal. Novelty-induced emotional arousal modulates cannabinoid effects on recognition memory and adrenocortical activity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2013 Jun; 38(7):1276-86. doi:
10.1038/npp.2013.26. [PMID: 23340520] - Yu Y Li, Birol Yuece, Hua M Cao, Hong X Lin, Shuai Lv, Jie C Chen, Stephanie Ochs, Andrej Sibaev, Elisabeth Deindl, Claus Schaefer, Martin Storr. Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis.
Laboratory investigation; a journal of technical methods and pathology.
2013 Mar; 93(3):322-33. doi:
10.1038/labinvest.2012.177. [PMID: 23381627] - Carol A Paronis, Ganesh A Thakur, Shama Bajaj, Spyros P Nikas, V Kiran Vemuri, Alexandros Makriyannis, Jack Bergman. Diuretic effects of cannabinoids.
The Journal of pharmacology and experimental therapeutics.
2013 Jan; 344(1):8-14. doi:
10.1124/jpet.112.199331. [PMID: 23019138] - Shuxian Hu, Wen S Sheng, R Bryan Rock. CB2 receptor agonists protect human dopaminergic neurons against damage from HIV-1 gp120.
PloS one.
2013; 8(10):e77577. doi:
10.1371/journal.pone.0077577. [PMID: 24147028] - Sanjay Mandhane, Prasanta Nayak, Durgesh Soni, Shakti Jain, John C Ashton, Thennati Rajamannar. Induction of glucose intolerance by acute administration of rimonabant.
Pharmacology.
2012; 89(5-6):339-47. doi:
10.1159/000337731. [PMID: 22678147] - Elodie L Plan, Guangli Ma, Mats Någård, Jörgen Jensen, Mats O Karlsson. Transient lower esophageal sphincter relaxation pharmacokinetic-pharmacodynamic modeling: count model and repeated time-to-event model.
The Journal of pharmacology and experimental therapeutics.
2011 Dec; 339(3):878-85. doi:
10.1124/jpet.111.181636. [PMID: 21890509] - Mariagrazia Rita Scuderi, Giuseppina Cantarella, Mimmo Scollo, Laurence Lempereur, Marco Palumbo, Gloria Saccani-Jotti, Renato Bernardini. The antimitogenic effect of the cannabinoid receptor agonist WIN55212-2 on human melanoma cells is mediated by the membrane lipid raft.
Cancer letters.
2011 Nov; 310(2):240-9. doi:
10.1016/j.canlet.2011.07.008. [PMID: 21807457] - A M Wasik, S Almestrand, X Wang, K Hultenby, Å-L Dackland, P Andersson, E Kimby, B Christensson, B Sander. WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells.
Cell death & disease.
2011 Nov; 2(?):e225. doi:
10.1038/cddis.2011.106. [PMID: 22048168] - Badr Mostafa Ibrahim, Abdel A Abdel-Rahman. Role of brainstem GABAergic signaling in central cannabinoid receptor evoked sympathoexcitation and pressor responses in conscious rats.
Brain research.
2011 Sep; 1414(?):1-9. doi:
10.1016/j.brainres.2011.07.046. [PMID: 21840505] - Xiaoyu Tian, Spiro Pavlopoulos, De-Ping Yang, Alexandros Makriyannis. The interaction of cannabinoid receptor agonists, CP55940 and WIN55212-2 with membranes using solid state 2H NMR.
Biochimica et biophysica acta.
2011 Sep; 1808(9):2095-101. doi:
10.1016/j.bbamem.2010.11.026. [PMID: 21129361] - América A Scopinho, Francisco S Guimarães, Fernando M A Corrêa, Leonardo B M Resstel. Cannabidiol inhibits the hyperphagia induced by cannabinoid-1 or serotonin-1A receptor agonists.
Pharmacology, biochemistry, and behavior.
2011 Apr; 98(2):268-72. doi:
10.1016/j.pbb.2011.01.007. [PMID: 21238476] - Shuangsong Hong, Gen Zheng, Xiaoyin Wu, Natasha T Snider, Chung Owyang, John W Wiley. Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat.
Gastroenterology.
2011 Feb; 140(2):627-637.e4. doi:
10.1053/j.gastro.2010.11.003. [PMID: 21070780] - Yan Zhao, Yan Liu, Weiping Zhang, Jiahong Xue, Yue Z Wu, Wei Xu, Xiao Liang, Tao Chen, Chiharu Kishimoto, Zuyi Yuan. WIN55212-2 ameliorates atherosclerosis associated with suppression of pro-inflammatory responses in ApoE-knockout mice.
European journal of pharmacology.
2010 Dec; 649(1-3):285-92. doi:
10.1016/j.ejphar.2010.09.027. [PMID: 20868672] - C Petrella, S Agostini, G S Alema', P Casolini, F Carpino, C Giuli, G Improta, G Linari, V Petrozza, M Broccardo. Cannabinoid agonist WIN55,212 in vitro inhibits interleukin-6 (IL-6) and monocyte chemo-attractant protein-1 (MCP-1) release by rat pancreatic acini and in vivo induces dual effects on the course of acute pancreatitis.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2010 Nov; 22(11):1248-56, e323. doi:
10.1111/j.1365-2982.2010.01569.x. [PMID: 20659297] - Ming-xiu Hao, Li-sheng Jiang, Ning-yuan Fang, Jun Pu, Liu-hua Hu, Ling-Hong Shen, Wei Song, Ben He. The cannabinoid WIN55,212-2 protects against oxidized LDL-induced inflammatory response in murine macrophages.
Journal of lipid research.
2010 Aug; 51(8):2181-90. doi:
10.1194/jlr.m001511. [PMID: 20305287] - M-H Son, H D Kim, Y N Chae, M-K Kim, C Y Shin, G J Ahn, S-H Choi, E K Yang, K-J Park, H W Chae, H-S Moon, S-H Kim, Y-G Shin, S-H Yoon. Peripherally acting CB1-receptor antagonist: the relative importance of central and peripheral CB1 receptors in adiposity control.
International journal of obesity (2005).
2010 Mar; 34(3):547-56. doi:
10.1038/ijo.2009.253. [PMID: 20029379] - Yan Zhao, Zuyi Yuan, Yan Liu, Jiahong Xue, Yuling Tian, Weimin Liu, Weiping Zhang, Yan Shen, Wei Xu, Xiao Liang, Tao Chen. Activation of cannabinoid CB2 receptor ameliorates atherosclerosis associated with suppression of adhesion molecules.
Journal of cardiovascular pharmacology.
2010 Mar; 55(3):292-8. doi:
10.1097/fjc.0b013e3181d2644d. [PMID: 20075743] - Alex Carrasquer, Nstang M Nebane, Walter M Williams, Zhao-Hui Song. Functional consequences of nonsynonymous single nucleotide polymorphisms in the CB2 cannabinoid receptor.
Pharmacogenetics and genomics.
2010 Mar; 20(3):157-66. doi:
10.1097/fpc.0b013e3283367c6b. [PMID: 20124950] - Pingwei Zhao, Dmitri Leonoudakis, Mary E Abood, Eric C Beattie. Cannabinoid receptor activation reduces TNFalpha-induced surface localization of AMPAR-type glutamate receptors and excitotoxicity.
Neuropharmacology.
2010 Feb; 58(2):551-8. doi:
10.1016/j.neuropharm.2009.07.035. [PMID: 19654014] - Hironobu Fukuda, Toshio Abe, Shigemi Yoshihara. The cannabinoid receptor agonist WIN 55,212-2 inhibits antigen-induced plasma extravasation in guinea pig airways.
International archives of allergy and immunology.
2010; 152(3):295-300. doi:
10.1159/000283042. [PMID: 20150748] - Ali Saber-Tehrani, Nima Naderi, Azadeh Hosseini Najarkolaei, Abbas Haghparast, Fereshteh Motamedi. Cannabinoids and their interactions with diazepam on modulation of serum corticosterone concentration in male mice.
Neurochemical research.
2010 Jan; 35(1):60-6. doi:
10.1007/s11064-009-0030-9. [PMID: 19590959] - B A S Reyes, J C Rosario, P M T Piana, E J Van Bockstaele. Cannabinoid modulation of cortical adrenergic receptors and transporters.
Journal of neuroscience research.
2009 Dec; 87(16):3671-8. doi:
10.1002/jnr.22158. [PMID: 19533736] - Amy Alexander, Paul F Smith, Rhonda J Rosengren. Cannabinoids in the treatment of cancer.
Cancer letters.
2009 Nov; 285(1):6-12. doi:
10.1016/j.canlet.2009.04.005. [PMID: 19442435] - Margaux M Salas, Kenneth M Hargreaves, Armen N Akopian. TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1.
The European journal of neuroscience.
2009 Apr; 29(8):1568-78. doi:
10.1111/j.1460-9568.2009.06702.x. [PMID: 19419422] - Li-sheng Jiang, Jun Pu, Zhi-hua Han, Liu-hua Hu, Ben He. Role of activated endocannabinoid system in regulation of cellular cholesterol metabolism in macrophages.
Cardiovascular research.
2009 Mar; 81(4):805-13. doi:
10.1093/cvr/cvn344. [PMID: 19074161] - Nico Wegener, Sybille Kuhnert, Annika Thüns, Rasmus Roese, Michael Koch. Effects of acute systemic and intra-cerebral stimulation of cannabinoid receptors on sensorimotor gating, locomotion and spatial memory in rats.
Psychopharmacology.
2008 Jun; 198(3):375-85. doi:
10.1007/s00213-008-1148-1. [PMID: 18446326] - M Dalle Carbonare, E Del Giudice, A Stecca, D Colavito, M Fabris, A D'Arrigo, D Bernardini, M Dam, A Leon. A saturated N-acylethanolamine other than N-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story...
Journal of neuroendocrinology.
2008 May; 20 Suppl 1(?):26-34. doi:
10.1111/j.1365-2826.2008.01689.x. [PMID: 18426496] - L Bellocchio, C Cervino, V Vicennati, R Pasquali, U Pagotto. Cannabinoid type 1 receptor: another arrow in the adipocytes' bow.
Journal of neuroendocrinology.
2008 May; 20 Suppl 1(?):130-8. doi:
10.1111/j.1365-2826.2008.01682.x. [PMID: 18426512] - Takahiro Shimizu, Kunihiko Yokotani. Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats.
European journal of pharmacology.
2008 Mar; 582(1-3):62-9. doi:
10.1016/j.ejphar.2007.12.020. [PMID: 18234185] - G La Rana, R Russo, G D'Agostino, O Sasso, G Mattace Raso, A Iacono, R Meli, D Piomelli, A Calignano. AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors.
Neuropharmacology.
2008 Mar; 54(3):521-9. doi:
10.1016/j.neuropharm.2007.10.021. [PMID: 18093621] - Teodora Georgieva, Savitha Devanathan, Dagmar Stropova, Chad K Park, Zdzislaw Salamon, Gordon Tollin, Victor J Hruby, William R Roeske, Henry I Yamamura, Eva Varga. Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling.
European journal of pharmacology.
2008 Feb; 581(1-2):19-29. doi:
10.1016/j.ejphar.2007.11.053. [PMID: 18162180] - Dai-Fei Wu, Li-Quan Yang, Andrea Goschke, Ralf Stumm, Lars-Ove Brandenburg, Ying-Jian Liang, Volker Höllt, Thomas Koch. Role of receptor internalization in the agonist-induced desensitization of cannabinoid type 1 receptors.
Journal of neurochemistry.
2008 Feb; 104(4):1132-43. doi:
10.1111/j.1471-4159.2007.05063.x. [PMID: 17986216] - Yong-Yao Cui, Bruno D'Agostino, Paul-André Risse, Guiseppina Marrocco, Emmanuel Naline, Yong Zhang, Hong-Zhuan Chen, Olivier Finance, Murielle Rinaldi-Carmona, Francesco Rossi, Charles Advenier. Cannabinoid CB(2) receptor activation prevents bronchoconstriction and airway oedema in a model of gastro-oesophageal reflux.
European journal of pharmacology.
2007 Nov; 573(1-3):206-13. doi:
10.1016/j.ejphar.2007.06.040. [PMID: 17643417] - Sharon Anavi-Goffer, Daniel Fleischer, Dow P Hurst, Diane L Lynch, Judy Barnett-Norris, Shanping Shi, Deborah L Lewis, Somnath Mukhopadhyay, Allyn C Howlett, Patricia H Reggio, Mary E Abood. Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.
The Journal of biological chemistry.
2007 Aug; 282(34):25100-13. doi:
10.1074/jbc.m703388200. [PMID: 17595161] - Marie Velenovská, Zdenek Fisar. Effect of cannabinoids on platelet serotonin uptake.
Addiction biology.
2007 Jun; 12(2):158-66. doi:
10.1111/j.1369-1600.2007.00065.x. [PMID: 17508987] - David A Price, William A Owens, Georgianna G Gould, Alan Frazer, James L Roberts, Lynette C Daws, Andrea Giuffrida. CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum.
Journal of neurochemistry.
2007 Apr; 101(2):389-96. doi:
10.1111/j.1471-4159.2006.04383.x. [PMID: 17250681] - R G Pertwee, A Thomas, L A Stevenson, R A Ross, S A Varvel, A H Lichtman, B R Martin, R K Razdan. The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo.
British journal of pharmacology.
2007 Mar; 150(5):586-94. doi:
10.1038/sj.bjp.0707124. [PMID: 17245367] - A Thomas, G L Baillie, A M Phillips, R K Razdan, R A Ross, R G Pertwee. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.
British journal of pharmacology.
2007 Mar; 150(5):613-23. doi:
10.1038/sj.bjp.0707133. [PMID: 17245363] - Moisés García-Arencibia, Sara González, Eva de Lago, José A Ramos, Raphael Mechoulam, Javier Fernández-Ruiz. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties.
Brain research.
2007 Feb; 1134(1):162-70. doi:
10.1016/j.brainres.2006.11.063. [PMID: 17196181] - Satyanarayana Valiveti, Remigius U Agu, Dana C Hammell, Kalpana S Paudel, D Caroline Earles, Daniel P Wermeling, Audra L Stinchcomb. Intranasal absorption of Delta(9)-tetrahydrocannabinol and WIN55,212-2 mesylate in rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2007 Feb; 65(2):247-52. doi:
10.1016/j.ejpb.2006.08.009. [PMID: 17014999] - Aaron M D'Antona, Kwang H Ahn, Debra A Kendall. Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization.
Biochemistry.
2006 May; 45(17):5606-17. doi:
10.1021/bi060067k. [PMID: 16634642] - Thomas Koch, Dai-Fei Wu, Li-Quan Yang, Lars-Ove Brandenburg, Volker Höllt. Role of phospholipase D2 in the agonist-induced and constitutive endocytosis of G-protein coupled receptors.
Journal of neurochemistry.
2006 Apr; 97(2):365-72. doi:
10.1111/j.1471-4159.2006.03736.x. [PMID: 16539674] - F Mátyás, Y Yanovsky, K Mackie, W Kelsch, U Misgeld, T F Freund. Subcellular localization of type 1 cannabinoid receptors in the rat basal ganglia.
Neuroscience.
2006; 137(1):337-61. doi:
10.1016/j.neuroscience.2005.09.005. [PMID: 16289348] - Ismael Galve-Roperh, Tania Aguado, Daniel Rueda, Guillermo Velasco, Manuel Guzmán. Endocannabinoids: a new family of lipid mediators involved in the regulation of neural cell development.
Current pharmaceutical design.
2006; 12(18):2319-25. doi:
10.2174/138161206777585139. [PMID: 16787257] - Jane E Lauckner, Bertil Hille, Ken Mackie. The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Proceedings of the National Academy of Sciences of the United States of America.
2005 Dec; 102(52):19144-9. doi:
10.1073/pnas.0509588102. [PMID: 16365309] - Jenny Flygare, Kristin Gustafsson, Eva Kimby, Birger Christensson, Birgitta Sander. Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma.
FEBS letters.
2005 Dec; 579(30):6885-9. doi:
10.1016/j.febslet.2005.11.020. [PMID: 16337199] - Adèle Thomas, Lesley A Stevenson, Kerrie N Wease, Martin R Price, Gemma Baillie, Ruth A Ross, Roger G Pertwee. Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.
British journal of pharmacology.
2005 Dec; 146(7):917-26. doi:
10.1038/sj.bjp.0706414. [PMID: 16205722] - Daniel J Lundberg, Andrea R Daniel, Stanley A Thayer. Delta(9)-Tetrahydrocannabinol-induced desensitization of cannabinoid-mediated inhibition of synaptic transmission between hippocampal neurons in culture.
Neuropharmacology.
2005 Dec; 49(8):1170-7. doi:
10.1016/j.neuropharm.2005.07.012. [PMID: 16157354] - Sean D McAllister, Calvin Chan, Ryan J Taft, Tri Luu, Mary E Abood, Dan H Moore, Ken Aldape, Garret Yount. Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells.
Journal of neuro-oncology.
2005 Aug; 74(1):31-40. doi:
10.1007/s11060-004-5950-2. [PMID: 16078104] - Alex Dyson, Marcus Peacock, Alice Chen, Jean-Philippe Courade, Mohammed Yaqoob, Alex Groarke, Christopher Brain, Yvonne Loong, Alyson Fox. Antihyperalgesic properties of the cannabinoid CT-3 in chronic neuropathic and inflammatory pain states in the rat.
Pain.
2005 Jul; 116(1-2):129-37. doi:
10.1016/j.pain.2005.03.037. [PMID: 15936883] - Shigemi Yoshihara, Hiroshi Morimoto, Makoto Ohori, Yumi Yamada, Toshio Abe, Osamu Arisaka. The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues.
Journal of pharmacological sciences.
2005 May; 98(1):77-82. doi:
10.1254/jphs.fp0050171. [PMID: 15888960] - Kenneth J Valenzano, Laykea Tafesse, Gary Lee, James E Harrison, Jamie M Boulet, Susan L Gottshall, Lilly Mark, Michelle S Pearson, Wendy Miller, Shen Shan, Leyana Rabadi, Yakov Rotshteyn, Suzanne M Chaffer, Paul I Turchin, David A Elsemore, Mathew Toth, Lee Koetzner, Garth T Whiteside. Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Neuropharmacology.
2005 Apr; 48(5):658-72. doi:
10.1016/j.neuropharm.2004.12.008. [PMID: 15814101] - Torsten Pfitzer, Nathalie Niederhoffer, Bela Szabo. Search for an endogenous cannabinoid-mediated effect in the sympathetic nervous system.
Naunyn-Schmiedeberg's archives of pharmacology.
2005 Jan; 371(1):9-17. doi:
10.1007/s00210-004-1003-9. [PMID: 15660243] - I Barna, D Zelena, A C Arszovszki, C Ledent. The role of endogenous cannabinoids in the hypothalamo-pituitary-adrenal axis regulation: in vivo and in vitro studies in CB1 receptor knockout mice.
Life sciences.
2004 Oct; 75(24):2959-70. doi:
10.1016/j.lfs.2004.06.006. [PMID: 15454346] - Satyanarayana Valiveti, Dana C Hammell, D Caroline Earles, Audra L Stinchcomb. Transdermal delivery of the synthetic cannabinoid WIN 55,212-2: in vitro/in vivo correlation.
Pharmaceutical research.
2004 Jul; 21(7):1137-45. doi:
10.1023/b:pham.0000032999.31948.2e. [PMID: 15290852] - Torsten Pfitzer, Nathalie Niederhoffer, Bela Szabo. Central effects of the cannabinoid receptor agonist WIN55212-2 on respiratory and cardiovascular regulation in anaesthetised rats.
British journal of pharmacology.
2004 Jul; 142(6):943-52. doi:
10.1038/sj.bjp.0705874. [PMID: 15226190] - Satyanarayana Valiveti, Paul K Kiptoo, Dana C Hammell, Audra L Stinchcomb. Transdermal permeation of WIN 55,212-2 and CP 55,940 in human skin in vitro.
International journal of pharmaceutics.
2004 Jun; 278(1):173-80. doi:
10.1016/j.ijpharm.2004.03.009. [PMID: 15158959] - Yuko Fukudome, Takako Ohno-Shosaku, Minoru Matsui, Yuko Omori, Masahiro Fukaya, Hiroshi Tsubokawa, Makoto M Taketo, Masahiko Watanabe, Toshiya Manabe, Masanobu Kano. Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling.
The European journal of neuroscience.
2004 May; 19(10):2682-92. doi:
10.1111/j.0953-816x.2004.03384.x. [PMID: 15147302]