3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine (BioDeep_00000844490)
代谢物信息卡片
3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine
化学式: C9H11IN2O (289.9916106)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CNC1COC2=CC(=CN=C2)I
InChI: InChI=1S/C9H11IN2O/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8/h3-5,8,12H,1-2,6H2/t8-/m0/s1
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Irina Esterlis, Jonas O Hannestad, Evgenia Perkins, Frederic Bois, D Cyril D'Souza, Rachel F Tyndale, John P Seibyl, Dorothy M Hatsukami, Kelly P Cosgrove, Stephanie S O'Malley. Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers.
The American journal of psychiatry.
2013 Apr; 170(4):399-407. doi:
10.1176/appi.ajp.2012.12060793. [PMID: 23429725] - Irina Esterlis, Jonas O Hannestad, Frederic Bois, R Andrew Sewell, Rachel F Tyndale, John P Seibyl, Marina R Picciotto, Marc Laruelle, Richard E Carson, Kelly P Cosgrove. Imaging changes in synaptic acetylcholine availability in living human subjects.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2013 Jan; 54(1):78-82. doi:
10.2967/jnumed.112.111922. [PMID: 23160789] - Chih-Liang Chin, Robert A Carr, Daniel A Llano, Olivier Barret, Hongyu Xu, Jeffrey Batis, Andrei O Koren, John P Seibyl, Kennan C Marsh, Gilles Tamagnan, Michael W Decker, Mark Day, Gerard B Fox. Pharmacokinetic modeling and [¹²³]5-IA-85380 single photon emission computed tomography imaging in baboons: optimization of dosing regimen for ABT-089.
The Journal of pharmacology and experimental therapeutics.
2011 Mar; 336(3):716-23. doi:
10.1124/jpet.110.173609. [PMID: 21172907] - Irina Esterlis, Kelly P Cosgrove, Jeffery C Batis, Frederic Bois, Stephanie M Stiklus, Evgenia Perkins, John P Seibyl, Richard E Carson, Julie K Staley. Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2010 Aug; 51(8):1226-33. doi:
10.2967/jnumed.109.072447. [PMID: 20660383] - Effie M Mitsis, Kelly P Cosgrove, Julie K Staley, Frederic Bois, Erin B Frohlich, Gilles D Tamagnan, Kristina M Estok, John P Seibyl, Christopher H van Dyck. Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT.
Neurobiology of aging.
2009 Sep; 30(9):1490-7. doi:
10.1016/j.neurobiolaging.2007.12.008. [PMID: 18242781] - Effie M Mitsis, Kristina M Reech, Frederic Bois, Gilles D Tamagnan, Martha G Macavoy, John P Seibyl, Julie K Staley, Christopher H van Dyck. 123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2009 Sep; 50(9):1455-63. doi:
10.2967/jnumed.109.064030. [PMID: 19690024] - James Robert Brasić, Yun Zhou, John L Musachio, John Hilton, Hong Fan, Andrew Crabb, Christopher J Endres, Melvin J Reinhardt, Ahmet S Dogan, Mohab Alexander, Olivier Rousset, Marika A Maris, Jeffrey Galecki, Ayon Nandi, Dean F Wong. Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers.
Synapse (New York, N.Y.).
2009 Apr; 63(4):339-58. doi:
10.1002/syn.20611. [PMID: 19140167] - Kelly P Cosgrove, Effie M Mitsis, Frederic Bois, Erin Frohlich, Gilles D Tamagnan, Erica Krantzler, Edward Perry, Paul K Maciejewski, C Neill Epperson, Sharon Allen, Stephanie O'malley, Carolyn M Mazure, John P Seibyl, Christopher H van Dyck, Julie K Staley. 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Oct; 48(10):1633-40. doi:
10.2967/jnumed.107.042317. [PMID: 17873128] - Ronald M Baldwin, Sami S Zoghbi, Julie K Staley, Eric Brenner, Mohammed S Al-Tikriti, Louis Amici, Masahiro Fujita, Robert B Innis, Gilles Tamagnan. Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasma.
Nuclear medicine and biology.
2006 May; 33(4):549-54. doi:
10.1016/j.nucmedbio.2006.03.002. [PMID: 16720248] - Julie K Staley, Christopher H van Dyck, David Weinzimmer, Eric Brenner, Ronald M Baldwin, Gilles D Tamagnan, Patrizia Riccardi, Effie Mitsis, John P Seibyl. 123I-5-IA-85380 SPECT measurement of nicotinic acetylcholine receptors in human brain by the constant infusion paradigm: feasibility and reproducibility.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2005 Sep; 46(9):1466-72. doi:
NULL. [PMID: 16157529] - Marcelo Mamede, Koichi Ishizu, Masashi Ueda, Takahiro Mukai, Yasuhiko Iida, Hidenao Fukuyama, Tsuneo Saga, Hideo Saji. Quantification of human nicotinic acetylcholine receptors with 123I-5IA SPECT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2004 Sep; 45(9):1458-70. doi:
NULL. [PMID: 15347712] - Masashi Ueda, Yasuhiko Iida, Takahiro Mukai, Marcelo Mamede, Koichi Ishizu, Mikako Ogawa, Yasuhiro Magata, Junji Konishi, Hideo Saji. 5-[123I]Iodo-A-85380: assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects.
Annals of nuclear medicine.
2004 Jun; 18(4):337-44. doi:
10.1007/bf02984473. [PMID: 15359928] - Masahiro Fujita, John P Seibyl, D Bruce Vaupel, Gilles Tamagnan, Michele Early, Sami S Zoghbi, Ronald M Baldwin, Andrew G Horti, Andrei O KoreN, Alexey G Mukhin, Shaukat Khan, Ali Bozkurt, Alane S Kimes, Edythe D London, Robert B Innis. Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects.
European journal of nuclear medicine and molecular imaging.
2002 Feb; 29(2):183-90. doi:
10.1007/s00259-001-0695-z. [PMID: 11926380] - M Kassiou, S Eberl, S R Meikle, A Birrell, C Constable, M J Fulham, D F Wong, J L Musachio. In vivo imaging of nicotinic receptor upregulation following chronic (-)-nicotine treatment in baboon using SPECT.
Nuclear medicine and biology.
2001 Feb; 28(2):165-75. doi:
10.1016/s0969-8051(00)00206-7. [PMID: 11295427] - Sami S Zoghbi, Gilles Tamagnan, Masahiro Fujita, Ronald M Baldwin, Mohammed S Al-Tikriti, Louis Amici, John P Seibyl, Robert B Innis. Measurement of plasma metabolites of (S)-5-[123I]iodo-3-(2-azetidinylmethoxy)pyridine (5-IA-85380), a nicotinic acetylcholine receptor imaging agent, in nonhuman primates.
Nuclear medicine and biology.
2001 Jan; 28(1):91-96. doi:
10.1016/s0969-8051(00)00188-8. [PMID: 11182569]