Ceftaroline (BioDeep_00000844409)
代谢物信息卡片
Ceftaroline
化学式: C22H20N8O5S4 (604.043947)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCON=C(C1=NSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C=C5)C)C(=O)[O-]
InChI: InChI=1S/C22H20N8O5S4/c1-3-35-27-13(16-26-21(23)39-28-16)17(31)25-14-18(32)30-15(20(33)34)12(9-36-19(14)30)38-22-24-11(8-37-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H3-,23,25,26,28,31,33,34)/b27-13-/t14-,19-/m1/s1
描述信息
A cephalosporin that is the active metabolite of the prodrug ceftaroline fosamil. Used for the treatment of adults with acute bacterial skin and skin structure infections.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:70729
- PubChem: 9938701
- ChEMBL: CHEMBL4594371
- CAS: 189345-04-8
- MetaboLights: MTBLC70729
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Victória Etges Helfer, Bruna Bernar Dias, Graziela de Araújo Lock, Caroline Andrade Tomaszewski, Lucas Suchecki Barnet, Fabiano Barreto, Alexandre P Zavascki, Bibiana Verlindo de Araújo, Teresa Dalla Costa. Population Pharmacokinetic Modeling of Free Plasma and Free Brain Concentrations of Ceftaroline in Healthy and Methicillin-Resistant Staphylococcus aureus-Infected Wistar Rats.
Antimicrobial agents and chemotherapy.
2023 07; 67(7):e0038223. doi:
10.1128/aac.00382-23. [PMID: 37367389] - Alexander R Cain, Lauren M Finoli, Anthony Guarascio, Osakpolor Ogbebor, Nathan R Shively, Tyler Andrea, Derek N Bremmer. Ceftaroline Pharmacokinetics in a Critically Ill Adult Receiving Continuous Venovenous Hemodiafiltration.
The Annals of pharmacotherapy.
2022 08; 56(8):965-966. doi:
10.1177/10600280211053868. [PMID: 34711073] - Marc D Esquivel, Marguerite L Monogue, Greg S Smith, James D Finklea, James M Sanders. Ceftaroline versus vancomycin for treatment of acute pulmonary exacerbations of cystic fibrosis in adults.
Journal of global antimicrobial resistance.
2022 03; 28(?):67-70. doi:
10.1016/j.jgar.2021.12.008. [PMID: 34936925] - Raj Kumar, Vikas Kumar, Keun Woo Lee. A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatment.
Computers in biology and medicine.
2021 03; 130(?):104186. doi:
10.1016/j.compbiomed.2020.104186. [PMID: 33360831] - Shamir Kalaria, Sarah Williford, Dong Guo, Yan Shu, Christopher Medlin, Matthew Li, Siu Yan Amy Yeung, Farhan Ali, Wisna Jean, Mathangi Gopalakrishnan, Mojdeh Heavner. Optimizing ceftaroline dosing in critically ill patients undergoing continuous renal replacement therapy.
Pharmacotherapy.
2021 02; 41(2):205-211. doi:
10.1002/phar.2502. [PMID: 33438291] - Ariane Roujansky, Mathieu Martin, Camille Gomart, Anne Hulin, Roman Mounier. Multidrug-Resistant Staphylococcus epidermidis Ventriculostomy-Related Infection Successfully Treated by Intravenous Ceftaroline after Failure of Daptomycin Treatment.
World neurosurgery.
2020 Apr; 136(?):221-225. doi:
10.1016/j.wneu.2020.01.013. [PMID: 31931253] - Matthew Geriak, Fadi Haddad, Khulood Rizvi, Warren Rose, Ravina Kullar, Kerry LaPlante, Marie Yu, Logan Vasina, Krista Ouellette, Marcus Zervos, Victor Nizet, George Sakoulas. Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia.
Antimicrobial agents and chemotherapy.
2019 05; 63(5):. doi:
10.1128/aac.02483-18. [PMID: 30858203] - Alexia Chauzy, Abdelouaid Nadji, Jean-Christophe Combes, Nadine Defrance, Belaid Bouhemad, William Couet, Pascal Chavanet. Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with an external ventricular drain.
The Journal of antimicrobial chemotherapy.
2019 03; 74(3):675-681. doi:
10.1093/jac/dky489. [PMID: 30535190] - Federica Andreoni, Masanori Toyofuku, Carmen Menzi, Ratchara Kalawong, Srikanth Mairpady Shambat, Patrice François, Annelies S Zinkernagel, Leo Eberl. Antibiotics Stimulate Formation of Vesicles in Staphylococcus aureus in both Phage-Dependent and -Independent Fashions and via Different Routes.
Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
10.1128/aac.01439-18. [PMID: 30509943] - Melanie Roch, Maria Celeste Varela, Agustina Taglialegna, Warren E Rose, Adriana E Rosato. Activity of Telavancin against Staphylococcus aureus Isolates, Including Those with Decreased Susceptibility to Ceftaroline, from Cystic Fibrosis Patients.
Antimicrobial agents and chemotherapy.
2018 09; 62(9):. doi:
10.1128/aac.00956-18. [PMID: 29914961] - Richard R Watkins, George Yendewa, Steven D Burdette, Sophia Horattas, Nairmeen Awad Haller, Caroline Mangira, Robert A Salata, Robert A Bonomo. DISC: Describing Infections of the Spine treated with Ceftaroline.
Journal of global antimicrobial resistance.
2018 06; 13(?):146-151. doi:
10.1016/j.jgar.2018.01.001. [PMID: 29337085] - Emily E Barsky, Luis M Pereira, Keri J Sullivan, Alanna Wong, Alexander J McAdam, Gregory S Sawicki, Gregory P Priebe, Susan M Goobie. Ceftaroline pharmacokinetics and pharmacodynamics in patients with cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2018 05; 17(3):e25-e31. doi:
10.1016/j.jcf.2017.10.010. [PMID: 29103924] - Brian J Werth, Laura M Shireman. Pharmacodynamics of Ceftaroline plus Ampicillin against Enterococcus faecalis in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Simulated Endocardial Vegetations.
Antimicrobial agents and chemotherapy.
2017 04; 61(4):. doi:
10.1128/aac.02235-16. [PMID: 28096164] - Todd A Riccobene, Richard Pushkin, Alena Jandourek, William Knebel, Tatiana Khariton. Penetration of Ceftaroline into the Epithelial Lining Fluid of Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2016 10; 60(10):5849-57. doi:
10.1128/aac.02755-15. [PMID: 27431215] - M Grégoire, A G Leroy, R Bouquié, D Malandain, E Dailly, D Boutoille, C Renaud, P Jolliet, J Caillon, G Deslandes. Simultaneous determination of ceftaroline, daptomycin, linezolid and rifampicin concentrations in human plasma by on-line solid phase extraction coupled to high-performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2016 Jan; 118(?):17-26. doi:
10.1016/j.jpba.2015.10.008. [PMID: 26512995] - Elizabeth B Autry, Jeffrey M Rybak, Noelle R Leung, Brian M Gardner, Donna R Burgess, Michael I Anstead, Robert J Kuhn. Pharmacokinetic and Pharmacodynamic Analyses of Ceftaroline in Adults with Cystic Fibrosis.
Pharmacotherapy.
2016 Jan; 36(1):13-8. doi:
10.1002/phar.1681. [PMID: 26748559] - Shimin J Chung, Tze-Peng Lim, Andrea L Kwa. Intravenous ceftaroline 200 mg administered every 8 h is safe and adequate for meticillin-resistant Staphylococcus aureus bloodstream infections in end-stage renal failure patients on haemodialysis: a case study.
International journal of antimicrobial agents.
2015 Dec; 46(6):720-1. doi:
10.1016/j.ijantimicag.2015.09.012. [PMID: 26607339] - Tony K L Kiang, Kyle J Wilby, Mary H H Ensom. A critical review on the clinical pharmacokinetics, pharmacodynamics, and clinical trials of ceftaroline.
Clinical pharmacokinetics.
2015 Sep; 54(9):915-31. doi:
10.1007/s40262-015-0281-3. [PMID: 25940827] - Mamun-Ur Rashid, Staffan Rosenborg, Georgios Panagiotidis, Karin Söderberg-Löfdal, Andrej Weintraub, Carl Erik Nord. Ecological Effect of Ceftaroline-Avibactam on the Normal Human Intestinal Microbiota.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4504-9. doi:
10.1128/aac.00530-15. [PMID: 25987638] - Julie Ann Justo, Stockton M Mayer, Manjunath P Pai, Melinda M Soriano, Larry H Danziger, Richard M Novak, Keith A Rodvold. Pharmacokinetics of ceftaroline in normal body weight and obese (classes I, II, and III) healthy adult subjects.
Antimicrobial agents and chemotherapy.
2015 Jul; 59(7):3956-65. doi:
10.1128/aac.00498-15. [PMID: 25896707] - Gary E Stein, Fadi Yasin, Curtis Smith, Amy Scharmen, Daniel Havlichek, Charles Bill. A pharmacokinetic/pharmacodynamic analysis of ceftaroline prophylaxis in patients with external ventricular drains.
Surgical infections.
2015 Apr; 16(2):169-73. doi:
10.1089/sur.2014.098. [PMID: 25826463] - Safia S Kuriakose, Mohamed Rabbat, Jason C Gallagher. Ceftaroline CSF concentrations in a patient with ventriculoperitoneal shunt-related meningitis.
The Journal of antimicrobial chemotherapy.
2015 Mar; 70(3):953-4. doi:
10.1093/jac/dku464. [PMID: 25422288] - Charles E Edmiston, Candace J Krepel, David Leaper, Nathan A Ledeboer, Tami-Lea Mackey, Mary Beth Graham, Cheong Lee, Peter J Rossi, Kellie R Brown, Brian D Lewis, Gary R Seabrook. Antimicrobial activity of ceftaroline and other anti-infective agents against microbial pathogens recovered from the surgical intensive care patient population: a prevalence analysis.
Surgical infections.
2014 Dec; 15(6):745-51. doi:
10.1089/sur.2013.172. [PMID: 24896013] - Brian J Werth, Katie E Barber, Cortney E Ireland, Michael J Rybak. Evaluation of ceftaroline, vancomycin, daptomycin, or ceftaroline plus daptomycin against daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus in an in vitro pharmacokinetic/pharmacodynamic model of simulated endocardial vegetations.
Antimicrobial agents and chemotherapy.
2014 Jun; 58(6):3177-81. doi:
10.1128/aac.00088-14. [PMID: 24663016] - Santiago Grau, Luisa Sorlí, Sonia Luque. [Pharmacokinetics and pharmacodynamics of ceftaroline].
Enfermedades infecciosas y microbiologia clinica.
2014 Mar; 32 Suppl 2(?):15-20. doi:
10.1016/s0213-005x(14)70153-3. [PMID: 24702974] - Fırat Zafer Mengeloğlu, Tekin Taş, Esra Koçoğlu, Ayşegül Copur Çiçek, Keramettin Yanık, Hayati Güneş, Ihsan Hakkı Ciftci, Süleyman Durmaz, Ozlem Bucak, Rıdvan Güçkan, Hüseyin Agah Terzi, M Zeynep Yavuz. [In vitro activity of ceftaroline to MRSA isolates: a multicenter study].
Mikrobiyoloji bulteni.
2013 Oct; 47(4):677-83. doi:
10.5578/mb.5479. [PMID: 24237436] - Brian J Werth, George Sakoulas, Warren E Rose, Joseph Pogliano, Ryan Tewhey, Michael J Rybak. Ceftaroline increases membrane binding and enhances the activity of daptomycin against daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus in a pharmacokinetic/pharmacodynamic model.
Antimicrobial agents and chemotherapy.
2013 Jan; 57(1):66-73. doi:
10.1128/aac.01586-12. [PMID: 23070161] - George G Zhanel, Chris Yachison, Kim Nichol, Heather Adam, Ayman M Noreddin, Daryl J Hoban, James A Karlowsky. Assessment of the activity of ceftaroline against clinical isolates of penicillin-intermediate and penicillin-resistant Streptococcus pneumoniae with elevated MICs of ceftaroline using an in vitro pharmacodynamic model.
The Journal of antimicrobial chemotherapy.
2012 Jul; 67(7):1706-11. doi:
10.1093/jac/dks113. [PMID: 22467630] - Molly E Steed, Céline Vidaillac, Patricia Winterfield, Donald Biek, Michael J Rybak. Evaluation of ceftaroline activity versus ceftriaxone against clinical isolates of Streptococcus pneumoniae with various susceptibilities to cephalosporins in an in vitro pharmacokinetic/pharmacodynamic model.
Antimicrobial agents and chemotherapy.
2012 May; 56(5):2691-5. doi:
10.1128/aac.06185-11. [PMID: 22354289] - Molly Steed, Celine Vidaillac, Michael J Rybak. Evaluation of ceftaroline activity versus daptomycin (DAP) against DAP-nonsusceptible methicillin-resistant Staphylococcus aureus strains in an in vitro pharmacokinetic/pharmacodynamic model.
Antimicrobial agents and chemotherapy.
2011 Jul; 55(7):3522-6. doi:
10.1128/aac.00347-11. [PMID: 21576449] - Delphine Croisier-Bertin, Lionel Piroth, Pierre-Emmanuel Charles, Aurélie Larribeau, Donald Biek, Yigong Ge, Pascal Chavanet. Ceftaroline versus ceftriaxone in a highly penicillin-resistant pneumococcal pneumonia rabbit model using simulated human dosing.
Antimicrobial agents and chemotherapy.
2011 Jul; 55(7):3557-63. doi:
10.1128/aac.01773-09. [PMID: 21576444] - Darpan Kaushik, Sudeep Rathi, Ankit Jain. Ceftaroline: a comprehensive update.
International journal of antimicrobial agents.
2011 May; 37(5):389-95. doi:
10.1016/j.ijantimicag.2011.01.017. [PMID: 21420284] - Lauren Lim, Elizabeth Sutton, Jack Brown. Ceftaroline: a new broad-spectrum cephalosporin.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2011 Mar; 68(6):491-8. doi:
10.2146/ajhp100181. [PMID: 21378297] - Georgios Panagiotidis, Tobias Bäckström, Charlotte Asker-Hagelberg, Alena Jandourek, Andrej Weintraub, Carl Erik Nord. Effect of ceftaroline on normal human intestinal microflora.
Antimicrobial agents and chemotherapy.
2010 May; 54(5):1811-4. doi:
10.1128/aac.01716-09. [PMID: 20231399] - Yigong Ge, David Maynard, Douglas E Rickert. Comparative pharmacokinetics of ceftaroline in rats, rabbits, and monkeys following a single intravenous or intramuscular injection.
Antimicrobial agents and chemotherapy.
2010 Feb; 54(2):912-4. doi:
10.1128/aac.00645-09. [PMID: 19949051] - George G Zhanel, Grace Sniezek, Frank Schweizer, Sheryl Zelenitsky, Philippe R S Lagacé-Wiens, Ethan Rubinstein, Alfred S Gin, Daryl J Hoban, James A Karlowsky. Ceftaroline: a novel broad-spectrum cephalosporin with activity against meticillin-resistant Staphylococcus aureus.
Drugs.
2009; 69(7):809-31. doi:
10.2165/00003495-200969070-00003. [PMID: 19441869] - Ronald N Jones, Thomas R Fritsche, Yigong Ge, Koné Kaniga, Helio S Sader. Evaluation of PPI-0903M (T91825), a novel cephalosporin: bactericidal activity, effects of modifying in vitro testing parameters and optimization of disc diffusion tests.
The Journal of antimicrobial chemotherapy.
2005 Dec; 56(6):1047-52. doi:
10.1093/jac/dki362. [PMID: 16239290]