(2S,3S)-Diepoxybutane (BioDeep_00000844407)
代谢物信息卡片
2,2-Bioxirane,(2R,2S)-rel-
化学式: C4H6O2 (86.0367776)
中文名称: 内消旋-1,2:3,4-二环氧丁烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(O1)C2CO2
InChI: InChI=1S/C4H6O2/c1-3(5-1)4-2-6-4/h3-4H,1-2H2/t3-,4-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gunnar Boysen, Nadia I Georgieva, Narisa K Bordeerat, Radim J Sram, Pamela Vacek, Richard J Albertini, James A Swenberg. Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Jan; 125(1):30-40. doi:
10.1093/toxsci/kfr272. [PMID: 22003190] - György András Csanády, Robert Steinhoff, Martin Bernhard Riester, Brigitte Semder, Christian Pütz, Qiang Li, Nadine Richter, Winfried Kessler, Dominik Klein, Johannes Georg Filser. 1,2:3,4-Diepoxybutane in blood of male B6C3F1 mice and male Sprague-Dawley rats exposed to 1,3-butadiene.
Toxicology letters.
2011 Dec; 207(3):286-90. doi:
10.1016/j.toxlet.2011.09.027. [PMID: 21983653] - Melissa Goggin, Dewakar Sangaraju, Vernon E Walker, Jeffrey Wickliffe, James A Swenberg, Natalia Tretyakova. Persistence and repair of bifunctional DNA adducts in tissues of laboratory animals exposed to 1,3-butadiene by inhalation.
Chemical research in toxicology.
2011 Jun; 24(6):809-17. doi:
10.1021/tx200009b. [PMID: 21452897] - Beatriz Porto, Raquel Vieira, Graça Porto. Increased capacity of lymphocytes from hereditary hemochromatosis patients homozygous for the C282Y HFE mutation to respond to the genotoxic effect of diepoxybutane.
Mutation research.
2009 Feb; 673(1):37-42. doi:
10.1016/j.mrgentox.2008.11.016. [PMID: 19146986] - Mohammad Al-Haggar, Zakaria Al-Morsy, Sohier Yahia, Nehad Chalaby, Amany Ragab, Abeer Mesbah. Correlation of thyroid and growth hormones to chromosomal instability in Egyptian Fanconi anemia patients.
Indian journal of pediatrics.
2008 Jul; 75(7):679-84. doi:
10.1007/s12098-008-0128-0. [PMID: 18716735] - Michael Schmiederer, Eugene Knutson, Perpetua Muganda, Thomas Albrecht. Acute exposure of human lung cells to 1,3-butadiene diepoxide results in G1 and G2 cell cycle arrest.
Environmental and molecular mutagenesis.
2005 May; 45(4):354-64. doi:
10.1002/em.20099. [PMID: 15688362] - Limen Chi, Everett Nixon, Fitzgerald Spencer. Uterine-ovarian biochemical and developmental interactions to the postimplantation treatment with a butadiene metabolite, diepoxybutane, in pregnant rats.
Journal of biochemical and molecular toxicology.
2002; 16(4):147-53. doi:
10.1002/jbt.10021. [PMID: 12242682] - R F Henderson, W E Bechtold, J R Thornton-Manning, A R Dahl. Urinary butadiene diepoxide: a potential biomarker of blood diepoxide.
Toxicology.
2001 Mar; 160(1-3):81-6. doi:
10.1016/s0300-483x(00)00438-8. [PMID: 11246127] - M C Kohn, R L Melnick. The privileged access model of 1,3-butadiene disposition.
Environmental health perspectives.
2000 Oct; 108 Suppl 5(?):911-7. doi:
10.1289/ehp.00108s5911. [PMID: 11036000] - S Landi, I Ponzanelli, G Cipollini, G Frenzilli, A Luccini, C P Milillo, I Sbrana, R Barale. Modulating factors of individual sensitivity to diepoxybutane: chromosome aberrations induced in vitro in human lymphocytes.
Mutagenesis.
1997 Jan; 12(1):17-22. doi:
10.1093/mutage/12.1.17. [PMID: 9025092] - Tretyakova NYu, Y P Lin, P B Upton, R Sangaiah, J A Swenberg. Macromolecular adducts of butadiene.
Toxicology.
1996 Oct; 113(1-3):70-6. doi:
10.1016/0300-483x(96)03429-4. [PMID: 8901884] - S J Kambouris, A K Chaudhary, I A Blair. Liquid chromatography/electrospray ionization tandem mass spectroscopy (LC/ESI MS/MS) analysis of 1,2-epoxybutene adducts of purine deoxynucleosides.
Toxicology.
1996 Oct; 113(1-3):331-5. doi:
10.1016/0300-483x(96)03468-3. [PMID: 8901920] - K T Kelsey, J K Wiencke, J Ward, W Bechtold, J Fajen. Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers.
Mutation research.
1995 Dec; 335(3):267-73. doi:
10.1016/0165-1161(95)00030-5. [PMID: 8524342] - S Landi, I Ponzanelli, R Barale. Effect of red cells and plasma blood in determining individual lymphocytes sensitivity to diepoxybutane assessed by in vitro induced sister chromatid exchanges.
Mutation research.
1995 Nov; 348(3):117-23. doi:
10.1016/0165-7992(95)00055-0. [PMID: 8524363] - L H Gildensoph, D P Briskin. Modification of an essential arginine residue associated with the plasma membrane ATPase of red beet (Beta vulgaris L.) storage tissue.
Archives of biochemistry and biophysics.
1989 May; 271(1):254-9. doi:
10.1016/0003-9861(89)90276-2. [PMID: 2523690] - M W Swaim, S V Pizzo. Modification of the tandem reactive centres of human inter-alpha-trypsin inhibitor with butanedione and cis-dichlorodiammineplatinum(II).
The Biochemical journal.
1988 Aug; 254(1):171-8. doi:
10.1042/bj2540171. [PMID: 2460086] - J J Chang, C F Scott, R W Colman. Role of arginine residues in the coagulant activity of high molecular weight kininogen.
Blood.
1986 Mar; 67(3):805-10. doi:
NULL. [PMID: 3633200]