Microcystin (BioDeep_00000844365)
代谢物信息卡片
Microcystin
化学式: C49H74N10O12 (994.5487)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(N(C1=O)C)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)O)C
InChI: InChI=1S/C49H74N10O12/c1-26(2)23-36-45(66)57-40(48(70)71)30(6)41(62)55-35(17-14-22-52-49(50)51)44(65)54-34(19-18-27(3)24-28(4)38(60)25-33-15-12-11-13-16-33)29(5)46(67)59(10)37(47(68)69)20-21-39(61)58(9)32(8)43(64)53-31(7)42(63)56-36/h11-13,15-16,18-19,24,26,28-31,34-38,40,60H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,63)(H,57,66)(H,68,69)(H,70,71)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31-,34-,35-,36-,37+,38-,40+/m0/s1
描述信息
D009676 - Noxae > D002273 - Carcinogens > D052998 - Microcystins
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jia H Shi, Nicole E Olson, Johnna A Birbeck, Jin Pan, Nicholas J Peraino, Andrew L Holen, Isabel R Ledsky, Stephen J Jacquemin, Linsey C Marr, David G Schmale, Judy A Westrick, Andrew P Ault. Aerosolized Cyanobacterial Harmful Algal Bloom Toxins: Microcystin Congeners Quantified in the Atmosphere.
Environmental science & technology.
2023 Dec; 57(51):21801-21814. doi:
10.1021/acs.est.3c03297. [PMID: 38078756] - Halima Abdullahi, Yahuza Tanimu, Suwebat Ayanronke Akinyemi, Maria do Carmo Bittencourt-Oliveira, Mathias Ahii Chia. Assessment of microcystins in surface water and irrigated vegetables in Kwaru stream, Hayin Danmani, Kaduna-Nigeria.
Environmental science and pollution research international.
2022 Nov; 29(52):78303-78313. doi:
10.1007/s11356-022-21381-w. [PMID: 35689773] - Mohammed Haida, Fatima El Khalloufi, Richard Mugani, El Mahdi Redouane, Alexandre Campos, Vitor Vasconcelos, Brahim Oudra. Effects of Irrigation with Microcystin-Containing Water on Growth, Physiology, and Antioxidant Defense in Strawberry Fragaria vulgaris under Hydroponic Culture.
Toxins.
2022 03; 14(3):. doi:
10.3390/toxins14030198. [PMID: 35324694] - Yanyan Zhang, Sung Vo Duy, Gabriel Munoz, Sébastien Sauvé. Phytotoxic effects of microcystins, anatoxin-a and cylindrospermopsin to aquatic plants: A meta-analysis.
The Science of the total environment.
2022 Mar; 810(?):152104. doi:
10.1016/j.scitotenv.2021.152104. [PMID: 34863769] - Molly C Mills, Morgan V Evans, Seungjun Lee, Thomas Knobloch, Christopher Weghorst, Jiyoung Lee. Acute cyanotoxin poisoning reveals a marginal effect on mouse gut microbiome composition but indicates metabolic shifts related to liver and gut inflammation.
Ecotoxicology and environmental safety.
2021 Jun; 215(?):112126. doi:
10.1016/j.ecoenv.2021.112126. [PMID: 33721663] - Hui Zeng, Yao Tan, Lingqiao Wang, Menglong Xiang, Ziyuan Zhou, Ji-An Chen, Jia Wang, Renping Zhang, Yingqiao Tian, Jiaohua Luo, Yujing Huang, Chen Lv, Weiqun Shu, Zhiqun Qiu. Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study.
Ecotoxicology and environmental safety.
2021 Apr; 212(?):111990. doi:
10.1016/j.ecoenv.2021.111990. [PMID: 33524912] - Hehua Lei, Yuchen Song, Manyuan Dong, Gui Chen, Zheng Cao, Fang Wu, Chuan Chen, Ce Zhang, Caixiang Liu, Zunji Shi, Limin Zhang. Metabolomics safety assessments of microcystin exposure via drinking water in rats.
Ecotoxicology and environmental safety.
2021 Apr; 212(?):111989. doi:
10.1016/j.ecoenv.2021.111989. [PMID: 33524913] - Seungjun Lee, Jinnam Kim, Jiyoung Lee. Colonization of toxic cyanobacteria on the surface and inside of leafy green: A hidden source of cyanotoxin production and exposure.
Food microbiology.
2021 Apr; 94(?):103655. doi:
10.1016/j.fm.2020.103655. [PMID: 33279080] - Yanyan Zhang, Joann K Whalen, Sébastien Sauvé. Phytotoxicity and bioconcentration of microcystins in agricultural plants: Meta-analysis and risk assessment.
Environmental pollution (Barking, Essex : 1987).
2021 Mar; 272(?):115966. doi:
10.1016/j.envpol.2020.115966. [PMID: 33168379] - Haibo Jin, Jiwei Hou, Xiannan Meng, Tan Ma, Bo Wang, Zhenyu Liu, Xiaoxuan Sha, Jie Ding, Xiaodong Han. Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice.
Ecotoxicology and environmental safety.
2021 Jan; 208(?):111748. doi:
10.1016/j.ecoenv.2020.111748. [PMID: 33396074] - Jiyoung Lee, Seungjun Lee, Alba Mayta, Igor Mrdjen, Christopher Weghorst, Thomas Knobloch. Microcystis toxin-mediated tumor promotion and toxicity lead to shifts in mouse gut microbiome.
Ecotoxicology and environmental safety.
2020 Dec; 206(?):111204. doi:
10.1016/j.ecoenv.2020.111204. [PMID: 32871519] - Maria Fernanda Falcone-Dias, Marianna Vaz Rodrigues, Jeppe Lund Nielsen, Nadieh de Jonge, Niels O G Jørgensen, Diego Peres Alonso, Gianmarco S David, Reinaldo José da Silva, João Pessoa Araújo Júnior. Occurrence of Cyanobacteria and microcystins in hydroelectric reservoirs used for fish farming.
Journal of water and health.
2020 Dec; 18(6):983-994. doi:
10.2166/wh.2020.089. [PMID: 33328369] - Chanjuan Liang, Hongyue Liu. Response of hormone in rice seedlings to irrigation contaminated with cyanobacterial extract containing microcystins.
Chemosphere.
2020 Oct; 256(?):127157. doi:
10.1016/j.chemosphere.2020.127157. [PMID: 32470740] - Medina O Kadiri, Solomon Isagba, Jeffrey U Ogbebor, Osasere A Omoruyi, Timothy E Unusiotame-Owolagba, Adriana Sturion Lorenzi, Maria do Carmo Bittencourt-Oliveira, Mathias Ahii Chia. The presence of microcystins in the coastal waters of Nigeria, from the Bights of Bonny and Benin, Gulf of Guinea.
Environmental science and pollution research international.
2020 Oct; 27(28):35284-35293. doi:
10.1007/s11356-020-09740-x. [PMID: 32592053] - Donna S Francy, Amie M G Brady, Erin A Stelzer, Jessica R Cicale, Courtney Hackney, Harrison D Dalby, Pamela Struffolino, Daryl F Dwyer. Predicting microcystin concentration action-level exceedances resulting from cyanobacterial blooms in selected lake sites in Ohio.
Environmental monitoring and assessment.
2020 Jul; 192(8):513. doi:
10.1007/s10661-020-08407-x. [PMID: 32666330] - Marcelo Gustavo Paulino, Driele Tavares, Ana Paula Terezan, Marise Margareth Sakuragui, Emanuele Pesenti, Alessandra Giani, Marta Margareth Cestari, João Batista Fernandes, Marisa Narciso Fernandes. Biotransformations, Antioxidant System Responses, and Histopathological Indexes in the Liver of Fish Exposed to Cyanobacterial Extract.
Environmental toxicology and chemistry.
2020 05; 39(5):1041-1051. doi:
10.1002/etc.4696. [PMID: 32102115] - Nataliia Khomutovska, Małgorzata Sandzewicz, Łukasz Łach, Małgorzata Suska-Malawska, Monika Chmielewska, Hanna Mazur-Marzec, Marta Cegłowska, Toirbek Niyatbekov, Susanna A Wood, Jonathan Puddick, Jan Kwiatowski, Iwona Jasser. Limited Microcystin, Anatoxin and Cylindrospermopsin Production by Cyanobacteria from Microbial Mats in Cold Deserts.
Toxins.
2020 04; 12(4):. doi:
10.3390/toxins12040244. [PMID: 32290390] - Rebekah E Wharton, Brady R Cunningham, Adam M Schaefer, Sophia M Guldberg, Elizabeth I Hamelin, Rudolph C Johnson. Measurement of Microcystin and Nodularin Activity in Human Urine by Immunocapture-Protein Phosphatase 2A Assay.
Toxins.
2019 12; 11(12):. doi:
10.3390/toxins11120729. [PMID: 31847123] - Dariusz Dziga, Nada Tokodi, Damjana Drobac Backović, Mikołaj Kokociński, Adam Antosiak, Jakub Puchalski, Wojciech Strzałka, Mariusz Madej, Jussi Meriluoto, Zorica Svirčev. The Effect of a Combined Hydrogen Peroxide-MlrA Treatment on the Phytoplankton Community and Microcystin Concentrations in a Mesocosm Experiment in Lake Ludoš.
Toxins.
2019 12; 11(12):. doi:
10.3390/toxins11120725. [PMID: 31835838] - Tino Barchewitz, Arthur Guljamow, Sven Meissner, Stefan Timm, Manja Henneberg, Otto Baumann, Martin Hagemann, Elke Dittmann. Non-canonical localization of RubisCO under high-light conditions in the toxic cyanobacterium Microcystis aeruginosa PCC7806.
Environmental microbiology.
2019 12; 21(12):4836-4851. doi:
10.1111/1462-2920.14837. [PMID: 31637830] - Jinyu Liu, Caiyun Yang, Yuxin Chi, Donghao Wu, Xianzhu Dai, Xiaohui Zhang, Yasuo Igarashi, Feng Luo. Algicidal characterization and mechanism of Bacillus licheniformis Sp34 against Microcystis aeruginosa in Dianchi Lake.
Journal of basic microbiology.
2019 Nov; 59(11):1112-1124. doi:
10.1002/jobm.201900112. [PMID: 31502316] - Marisa O D Silva, Jakob Pernthaler. Priming of microcystin degradation in carbon-amended membrane biofilm communities is promoted by oxygen-limited conditions.
FEMS microbiology ecology.
2019 11; 95(11):. doi:
10.1093/femsec/fiz157. [PMID: 31589311] - Dariusz Dziga, Mikołaj Kokociński, Jakub Barylski, Grzegorz Nowicki, Anna Maksylewicz, Adam Antosiak, Agnieszka Katarzyna Banaś, Wojciech Strzałka. Correlation between specific groups of heterotrophic bacteria and microcystin biodegradation in freshwater bodies of central Europe.
FEMS microbiology ecology.
2019 11; 95(11):. doi:
10.1093/femsec/fiz162. [PMID: 31609415] - Shumiao Yu, Chao Li, Caicai Xu, Kokoette Effiong, Xi Xiao. Understanding the inhibitory mechanism of antialgal allelochemical flavonoids from genetic variations: Photosynthesis, toxin synthesis and nutrient utility.
Ecotoxicology and environmental safety.
2019 Aug; 177(?):18-24. doi:
10.1016/j.ecoenv.2019.03.097. [PMID: 30954008] - Gustavo Franciscatti Mecina, Mathias Ahii Chia, Micheline Kézia Cordeiro-Araújo, Maria do Carmo Bittencourt-Oliveira, Rosa Maria Varela, Ascensión Torres, José María González Molinillo, Francisco Antonio Macías, Regildo Márcio Gonçalves da Silva. Effect of flavonoids isolated from Tridax procumbens on the growth and toxin production of Microcystis aeruginos.
Aquatic toxicology (Amsterdam, Netherlands).
2019 Jun; 211(?):81-91. doi:
10.1016/j.aquatox.2019.03.011. [PMID: 30954847] - Yan Yu, Yudie Zeng, Jing Li, Caiyun Yang, Xiaohui Zhang, Feng Luo, Xianzhu Dai. An algicidal Streptomyces amritsarensis strain against Microcystis aeruginosa strongly inhibits microcystin synthesis simultaneously.
The Science of the total environment.
2019 Feb; 650(Pt 1):34-43. doi:
10.1016/j.scitotenv.2018.08.433. [PMID: 30195130] - Chenlin Hu, Jiyoung Lee. A Novel Proof-of-Concept Sandwich Immunoassay for Screening Microcystin in Cyanobacteria Based on Michael Addition Reaction.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2019 Jan; 35(1):107-111. doi:
10.2116/analsci.18sdn03. [PMID: 30298821] - Cliff Ross, B Christopher Warhurst, Amber Brown, Chase Huff, Judith D Ochrietor. Mesohaline conditions represent the threshold for oxidative stress, cell death and toxin release in the cyanobacterium Microcystis aeruginosa.
Aquatic toxicology (Amsterdam, Netherlands).
2019 Jan; 206(?):203-211. doi:
10.1016/j.aquatox.2018.11.019. [PMID: 30500607] - Jing Wang, Yabing Chen, Zhangpeng Chen, Zou Xiang, Jie Ding, Xiaodong Han. Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus.
Ecotoxicology and environmental safety.
2018 Nov; 163(?):391-399. doi:
10.1016/j.ecoenv.2018.07.094. [PMID: 30064084] - Pratik Kumar, Krishnamoorthy Hegde, Satinder Kaur Brar, Maximiliano Cledon, Azadeh Kermanshahi-Pour, Audrey Roy-Lachapelle, Rosa Galvez-Cloutier. Biodegradation of microcystin-LR using acclimatized bacteria isolated from different units of the drinking water treatment plant.
Environmental pollution (Barking, Essex : 1987).
2018 Nov; 242(Pt A):407-416. doi:
10.1016/j.envpol.2018.07.008. [PMID: 30005254] - Rui Wang, Yiping Tai, Xiang Wan, Weifeng Ruan, Ying Man, Jiaxi Wang, Yufen Yang, Yang Yang. Enhanced removal of Microcystis bloom and microcystin-LR using microcosm constructed wetlands with bioaugmentation of degrading bacteria.
Chemosphere.
2018 Nov; 210(?):29-37. doi:
10.1016/j.chemosphere.2018.06.140. [PMID: 29980069] - Qing Cao, Alan D Steinman, Xiang Wan, Liqiang Xie. Bioaccumulation of microcystin congeners in soil-plant system and human health risk assessment: A field study from Lake Taihu region of China.
Environmental pollution (Barking, Essex : 1987).
2018 Sep; 240(?):44-50. doi:
10.1016/j.envpol.2018.04.067. [PMID: 29729568] - Xiaofen Wang, Lizhi Xu, Xinxiu Li, Jingwen Chen, Wei Zhou, Jiapeng Sun, Yaping Wang. The differential effects of microcystin-LR on mitochondrial DNA in the hippocampus and cerebral cortex.
Environmental pollution (Barking, Essex : 1987).
2018 Sep; 240(?):68-76. doi:
10.1016/j.envpol.2018.04.103. [PMID: 29729571] - Qing Cao, Alan D Steinman, Xiang Wan, Liqiang Xie. Combined toxicity of microcystin-LR and copper on lettuce (Lactuca sativa L.).
Chemosphere.
2018 Sep; 206(?):474-482. doi:
10.1016/j.chemosphere.2018.05.051. [PMID: 29775940] - Min Zhang, Xiucui Wang, Jiayu Tao, Shuang Li, Shupeng Hao, Xuezhu Zhu, Yajun Hong. PAHs would alter cyanobacterial blooms by affecting the microcystin production and physiological characteristics of Microcystis aeruginosa.
Ecotoxicology and environmental safety.
2018 Aug; 157(?):134-142. doi:
10.1016/j.ecoenv.2018.03.052. [PMID: 29621704] - Yabing Chen, Jing Wang, Xiang Chen, Dongmei Li, Xiaodong Han. Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels.
Aquatic toxicology (Amsterdam, Netherlands).
2018 Jun; 199(?):116-126. doi:
10.1016/j.aquatox.2018.03.018. [PMID: 29621671] - Marisa O D Silva, Judith F Blom, Yana Yankova, Jörg Villiger, Jakob Pernthaler. Priming of microbial microcystin degradation in biomass-fed gravity driven membrane filtration biofilms.
Systematic and applied microbiology.
2018 May; 41(3):221-231. doi:
10.1016/j.syapm.2017.11.009. [PMID: 29358063] - Guangfu Liu, Mingjing Ke, Xiaoji Fan, Meng Zhang, Youchao Zhu, Tao Lu, Liwei Sun, Haifeng Qian. Reproductive and endocrine-disrupting toxicity of Microcystis aeruginosa in female zebrafish.
Chemosphere.
2018 Feb; 192(?):289-296. doi:
10.1016/j.chemosphere.2017.10.167. [PMID: 29112878] - Jeong-Ann Park, Sung-Mok Jung, Jae-Woo Choi, Jae-Hyun Kim, Seungkwan Hong, Sang-Hyup Lee. Mesoporous carbon for efficient removal of microcystin-LR in drinking water sources, Nak-Dong River, South Korea: Application to a field-scale drinking water treatment plant.
Chemosphere.
2018 Feb; 193(?):883-891. doi:
10.1016/j.chemosphere.2017.11.092. [PMID: 29874763] - Haibing Cong, Feng Sun, Wenjing Chen, Yajun Xu, Wei Wang. Study on the method and mechanism of pre-pressure coagulation and sedimentation for Microcystis removal from drinking-water sources.
Environmental technology.
2018 Feb; 39(4):433-449. doi:
10.1080/09593330.2017.1302002. [PMID: 28278099] - Stanislav Melnik, Anna-Cathrine Neumann, Ryan Karongo, Sebastian Dirndorfer, Martin Stübler, Verena Ibl, Reinhard Niessner, Dietmar Knopp, Eva Stoger. Cloning and plant-based production of antibody MC10E7 for a lateral flow immunoassay to detect [4-arginine]microcystin in freshwater.
Plant biotechnology journal.
2018 01; 16(1):27-38. doi:
10.1111/pbi.12746. [PMID: 28421663] - Seungjun Lee, Xuewen Jiang, Manjunath Manubolu, Ken Riedl, Stuart A Ludsin, Jay F Martin, Jiyoung Lee. Fresh produce and their soils accumulate cyanotoxins from irrigation water: Implications for public health and food security.
Food research international (Ottawa, Ont.).
2017 12; 102(?):234-245. doi:
10.1016/j.foodres.2017.09.079. [PMID: 29195944] - Cihelio A Amorim, Cláudia Ulisses, Ariadne Nascimento Moura. Biometric and physiological responses of Egeria densa Planch. cultivated with toxic and non-toxic strains of Microcystis.
Aquatic toxicology (Amsterdam, Netherlands).
2017 Oct; 191(?):201-208. doi:
10.1016/j.aquatox.2017.08.012. [PMID: 28846860] - Wang Lin, Jie Hou, Honghui Guo, Yuming Qiu, Li Li, Dapeng Li, Rong Tang. Dualistic immunomodulation of sub-chronic microcystin-LR exposure on the innate-immune defense system in male zebrafish.
Chemosphere.
2017 Sep; 183(?):315-322. doi:
10.1016/j.chemosphere.2017.05.079. [PMID: 28551208] - Aleksandra Bukowska, Tomasz Kaliński, Michał Koper, Iwona Kostrzewska-Szlakowska, Jan Kwiatowski, Hanna Mazur-Marzec, Iwona Jasser. Predicting blooms of toxic cyanobacteria in eutrophic lakes with diverse cyanobacterial communities.
Scientific reports.
2017 08; 7(1):8342. doi:
10.1038/s41598-017-08701-8. [PMID: 28827675] - Sebastian Dirren, Gianna Pitsch, Marisa O D Silva, Thomas Posch. Grazing of Nuclearia thermophila and Nuclearia delicatula (Nucleariidae, Opisthokonta) on the toxic cyanobacterium Planktothrix rubescens.
European journal of protistology.
2017 Aug; 60(?):87-101. doi:
10.1016/j.ejop.2017.05.009. [PMID: 28675820] - Amel Saoudi, Luc Brient, Sabrine Boucetta, Rachid Ouzrout, Myriam Bormans, Mourad Bensouilah. Management of toxic cyanobacteria for drinking water production of Ain Zada Dam.
Environmental monitoring and assessment.
2017 Jul; 189(7):361. doi:
10.1007/s10661-017-6058-4. [PMID: 28667413] - Xuewen Jiang, Seungjun Lee, Chulkyoon Mok, Jiyoung Lee. Sustainable Methods for Decontamination of Microcystin in Water Using Cold Plasma and UV with Reusable TiO₂ Nanoparticle Coating.
International journal of environmental research and public health.
2017 05; 14(5):. doi:
10.3390/ijerph14050480. [PMID: 28475156] - M G Paulino, D Tavares, F Bieczynski, P G Pedrão, N E S Souza, M M Sakuragui, C M Luquet, A P Terezan, J B Fernandes, A Giani, M N Fernandes. Crude extract of cyanobacteria (Radiocystis fernandoi, strain R28) induces liver impairments in fish.
Aquatic toxicology (Amsterdam, Netherlands).
2017 Jan; 182(?):91-101. doi:
10.1016/j.aquatox.2016.11.012. [PMID: 27886582] - J Machado, J Azevedo, M Freitas, E Pinto, A Almeida, V Vasconcelos, A Campos. Analysis of the use of microcystin-contaminated water in the growth and nutritional quality of the root-vegetable, Daucus carota.
Environmental science and pollution research international.
2017 Jan; 24(1):752-764. doi:
10.1007/s11356-016-7822-7. [PMID: 27752954] - Qin Qiao, Séverine Le Manach, Hélène Huet, Evelyne Duvernois-Berthet, Soraya Chaouch, Charlotte Duval, Benoit Sotton, Loïc Ponger, Arul Marie, Lucrèce Mathéron, Sarah Lennon, Gérard Bolbach, Chakib Djediat, Cécile Bernard, Marc Edery, Benjamin Marie. An integrated omic analysis of hepatic alteration in medaka fish chronically exposed to cyanotoxins with possible mechanisms of reproductive toxicity.
Environmental pollution (Barking, Essex : 1987).
2016 Dec; 219(?):119-131. doi:
10.1016/j.envpol.2016.10.029. [PMID: 27814527] - Maranda Esterhuizen-Londt, Marie von Schnehen, Sandra Kühn, Stephan Pflugmacher. Oxidative stress responses in the animal model, Daphnia pulex exposed to a natural bloom extract versus artificial cyanotoxin mixtures.
Aquatic toxicology (Amsterdam, Netherlands).
2016 Oct; 179(?):151-7. doi:
10.1016/j.aquatox.2016.09.003. [PMID: 27614285] - Carolyn L McCarty, Leigh Nelson, Samantha Eitniear, Eric Zgodzinski, Amanda Zabala, Laurie Billing, Mary DiOrio. Community Needs Assessment After Microcystin Toxin Contamination of a Municipal Water Supply - Lucas County, Ohio, September 2014.
MMWR. Morbidity and mortality weekly report.
2016 Sep; 65(35):925-9. doi:
10.15585/mmwr.mm6535a1. [PMID: 27607896] - Xiaoyu Li, Junguo Ma, Yuanyuan Li. Molecular Cloning and Expression Determination of p38 MAPK from the Liver and Kidney of Silver Carp.
Journal of biochemical and molecular toxicology.
2016 May; 30(5):224-31. doi:
10.1002/jbt.21781. [PMID: 26866509] - Sylvain Corbel, Christian Mougin, Sylvie Nélieu, Ghislaine Delarue, Noureddine Bouaïcha. Evaluation of the transfer and the accumulation of microcystins in tomato (Solanum lycopersicum cultivar MicroTom) tissues using a cyanobacterial extract containing microcystins and the radiolabeled microcystin-LR ((14)C-MC-LR).
The Science of the total environment.
2016 Jan; 541(?):1052-1058. doi:
10.1016/j.scitotenv.2015.10.004. [PMID: 26473707] - Matthew J Harke, Christopher J Gobler. Daily transcriptome changes reveal the role of nitrogen in controlling microcystin synthesis and nutrient transport in the toxic cyanobacterium, Microcystis aeruginosa.
BMC genomics.
2015 Dec; 16(?):1068. doi:
10.1186/s12864-015-2275-9. [PMID: 26673568] - Panpan Meng, Haiyan Pei, Wenrong Hu, Zhongde Liu, Xiuqing Li, Hangzhou Xu. Allelopathic effects of Ailanthus altissima extracts on Microcystis aeruginosa growth, physiological changes and microcystins release.
Chemosphere.
2015 Dec; 141(?):219-26. doi:
10.1016/j.chemosphere.2015.07.057. [PMID: 26246191] - Sebastián E Sabatini, Beatríz M Brena, Macarena Pirez, María Del Carmen Ríos de Molina, Carlos M Luquet. Oxidative effects and toxin bioaccumulation after dietary microcystin intoxication in the hepatopancreas of the crab Neohelice (Chasmagnathus) granulata.
Ecotoxicology and environmental safety.
2015 Oct; 120(?):136-41. doi:
10.1016/j.ecoenv.2015.05.041. [PMID: 26070043] - Xiao Huang, Liang Chen, Wanjing Liu, Qin Qiao, Kang Wu, Jing Wen, Cuihong Huang, Rong Tang, Xuezhen Zhang. Involvement of oxidative stress and cytoskeletal disruption in microcystin-induced apoptosis in CIK cells.
Aquatic toxicology (Amsterdam, Netherlands).
2015 Aug; 165(?):41-50. doi:
10.1016/j.aquatox.2015.05.009. [PMID: 26022555] - Ewelina Chrapusta, Michał Węgrzyn, Kornelia Zabaglo, Ariel Kaminski, Michal Adamski, Paulina Wietrzyk, Jan Bialczyk. Microcystins and anatoxin-a in Arctic biocrust cyanobacterial communities.
Toxicon : official journal of the International Society on Toxinology.
2015 Jul; 101(?):35-40. doi:
10.1016/j.toxicon.2015.04.016. [PMID: 25937338] - Sylvain Corbel, Christian Mougin, Fabrice Martin-Laurent, Olivier Crouzet, David Bru, Sylvie Nélieu, Noureddine Bouaïcha. Evaluation of phytotoxicity and ecotoxicity potentials of a cyanobacterial extract containing microcystins under realistic environmental concentrations and in a soil-plant system.
Chemosphere.
2015 Jun; 128(?):332-40. doi:
10.1016/j.chemosphere.2015.02.008. [PMID: 25754013] - Rainer Kurmayer, Judith F Blom, Li Deng, Jakob Pernthaler. Integrating phylogeny, geographic niche partitioning and secondary metabolite synthesis in bloom-forming Planktothrix.
The ISME journal.
2015 Mar; 9(4):909-21. doi:
10.1038/ismej.2014.189. [PMID: 25325384] - YoonKyung Cha, Craig A Stow. Mining web-based data to assess public response to environmental events.
Environmental pollution (Barking, Essex : 1987).
2015 Mar; 198(?):97-9. doi:
10.1016/j.envpol.2014.12.027. [PMID: 25577650] - Yan Huang, Rong Li, Hongjun Liu, Beibei Wang, Chenmin Zhang, Qirong Shen. Novel resource utilization of refloated algal sludge to improve the quality of organic fertilizer.
Environmental technology.
2014 Aug; 35(13-16):1658-67. doi:
10.1080/09593330.2013.878397. [PMID: 24956756] - Ingunn A Samdal, Andreas Ballot, Kjersti E Løvberg, Christopher O Miles. Multihapten approach leading to a sensitive ELISA with broad cross-reactivity to microcystins and nodularin.
Environmental science & technology.
2014 Jul; 48(14):8035-43. doi:
10.1021/es5012675. [PMID: 24941031] - Junmei Jia, Wei Luo, Yonglong Lu, John P Giesy. Bioaccumulation of microcystins (MCs) in four fish species from Lake Taihu, China: assessment of risks to humans.
The Science of the total environment.
2014 Jul; 487(?):224-32. doi:
10.1016/j.scitotenv.2014.04.037. [PMID: 24784747] - Shweta Singh, Ravi Kumar Asthana. Assessment of microcystin concentration in carp and catfish: a case study from Lakshmikund pond, Varanasi, India.
Bulletin of environmental contamination and toxicology.
2014 Jun; 92(6):687-92. doi:
10.1007/s00128-014-1277-7. [PMID: 24771133] - Yun Kong, Pei Zou, Li-Ming Song, Zi Wang, Jiao-Qin Qi, Liang Zhu, Xiang-Yang Xu. [Effects of iron on the algae growth and microcystin synthesis: a review].
Ying yong sheng tai xue bao = The journal of applied ecology.
2014 May; 25(5):1533-40. doi:
". [PMID: 25129959] - Wei-Min Wang, Yu Deng, Hua Zou, Chan-Juan Liang. [Effects of microcystins on growth and antioxidant system of rice roots].
Huan jing ke xue= Huanjing kexue.
2014 Apr; 35(4):1468-72. doi:
". [PMID: 24946604] - Wei Li, Jun Chen, Ping Xie, Jun He, Xiaochun Guo, Xun Tuo, Wei Zhang, Laiyan Wu. Rapid conversion and reversible conjugation of glutathione detoxification of microcystins in bighead carp (Aristichthys nobilis).
Aquatic toxicology (Amsterdam, Netherlands).
2014 Feb; 147(?):18-25. doi:
10.1016/j.aquatox.2013.12.001. [PMID: 24362245] - Yuan-Fu Lu, Jie Liu, Kai Connie Wu, Qiang Qu, Fang Fan, Curtis D Klaassen. Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice.
PloS one.
2014; 9(3):e93013. doi:
10.1371/journal.pone.0093013. [PMID: 24667526] - Benoît Lévesque, Marie-Christine Gervais, Pierre Chevalier, Denis Gauvin, Elhadji Anassour-Laouan-Sidi, Suzanne Gingras, Nathalie Fortin, Geneviève Brisson, Charles Greer, David Bird. Prospective study of acute health effects in relation to exposure to cyanobacteria.
The Science of the total environment.
2014 Jan; 466-467(?):397-403. doi:
10.1016/j.scitotenv.2013.07.045. [PMID: 23927933] - Esther Kohler, Jörg Villiger, Thomas Posch, Nicolas Derlon, Tanja Shabarova, Eberhard Morgenroth, Jakob Pernthaler, Judith F Blom. Biodegradation of microcystins during gravity-driven membrane (GDM) ultrafiltration.
PloS one.
2014; 9(11):e111794. doi:
10.1371/journal.pone.0111794. [PMID: 25369266] - Csaba Máthé, Márta M-Hamvas, Gábor Vasas. Microcystin-LR and cylindrospermopsin induced alterations in chromatin organization of plant cells.
Marine drugs.
2013 Sep; 11(10):3689-717. doi:
10.3390/md11103689. [PMID: 24084787] - Lionel Sebbag, Nicole Smee, Deon van der Merwe, Dustin Schmid. Liver failure in a dog following suspected ingestion of blue-green algae (Microcystis spp.): a case report and review of the toxin.
Journal of the American Animal Hospital Association.
2013 Sep; 49(5):342-6. doi:
10.5326/jaaha-ms-5913. [PMID: 23861261] - Shawn Acuña, Dolores Baxa, Swee Teh. Sublethal dietary effects of microcystin producing Microcystis on threadfin shad, Dorosoma petenense.
Toxicon : official journal of the International Society on Toxinology.
2012 Nov; 60(6):1191-202. doi:
10.1016/j.toxicon.2012.08.004. [PMID: 22925841] - Hue T Tran, Mhairi Nimick, R Glen Uhrig, George Templeton, Nick Morrice, Robert Gourlay, Alison DeLong, Greg B G Moorhead. Arabidopsis thaliana histone deacetylase 14 (HDA14) is an α-tubulin deacetylase that associates with PP2A and enriches in the microtubule fraction with the putative histone acetyltransferase ELP3.
The Plant journal : for cell and molecular biology.
2012 Jul; 71(2):263-72. doi:
10.1111/j.1365-313x.2012.04984.x. [PMID: 22404109] - Arash Zamyadi, Sherri L MacLeod, Yan Fan, Natasha McQuaid, Sarah Dorner, Sébastien Sauvé, Michèle Prévost. Toxic cyanobacterial breakthrough and accumulation in a drinking water plant: a monitoring and treatment challenge.
Water research.
2012 Apr; 46(5):1511-23. doi:
10.1016/j.watres.2011.11.012. [PMID: 22137293] - Thomas Krüger, Nadine Hölzel, Bernd Luckas. Influence of cultivation parameters on growth and microcystin production of Microcystis aeruginosa (Cyanophyceae) isolated from Lake Chao (China).
Microbial ecology.
2012 Jan; 63(1):199-209. doi:
10.1007/s00248-011-9899-3. [PMID: 21710225] - R Glen Uhrig, Greg B Moorhead. Two ancient bacterial-like PPP family phosphatases from Arabidopsis are highly conserved plant proteins that possess unique properties.
Plant physiology.
2011 Dec; 157(4):1778-92. doi:
10.1104/pp.111.182493. [PMID: 21976480] - Yan Li, Ji-an Chen, Qing Zhao, Chaowen Pu, Zhiqun Qiu, Renping Zhang, Weiqun Shu. A cross-sectional investigation of chronic exposure to microcystin in relationship to childhood liver damage in the Three Gorges Reservoir Region, China.
Environmental health perspectives.
2011 Oct; 119(10):1483-8. doi:
10.1289/ehp.1002412. [PMID: 21561830] - Emilie Lance, Frederic Alonzo, Marion Tanguy, Claudia Gérard, Myriam Bormans. Impact of microcystin-producing cyanobacteria on reproductive success of Lymnaea stagnalis (Gastropoda, Pulmonata) and predicted consequences at the population level.
Ecotoxicology (London, England).
2011 Jun; 20(4):719-30. doi:
10.1007/s10646-011-0613-5. [PMID: 21340554] - Ondrej Adamovsky, Radovan Kopp, Andrea Zikova, Ludek Blaha, Jiri Kohoutek, Petra Ondrackova, Hana Paskerova, Jan Mares, Miloslava Palikova. The effect of peroral administration of toxic cyanobacteria on laboratory rats (Rattus norvegicus var. alba).
Neuro endocrinology letters.
2011; 32 Suppl 1(?):35-45. doi:
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Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2011; 46(10):1102-12. doi:
10.1080/10934529.2011.590721. [PMID: 21806454] - A Fischer, S J Hoeger, K Stemmer, D J Feurstein, D Knobeloch, A Nussler, D R Dietrich. The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells.
Toxicology and applied pharmacology.
2010 May; 245(1):9-20. doi:
10.1016/j.taap.2010.02.006. [PMID: 20171238] - Jianzhong Chen, Jian Dai, Haiyang Zhang, Chenyi Wang, Guoqing Zhou, Zhiping Han, Zhili Liu. Bioaccumulation of microcystin and its oxidative stress in the apple (Malus pumila).
Ecotoxicology (London, England).
2010 Apr; 19(4):796-803. doi:
10.1007/s10646-009-0456-5. [PMID: 20052542] - Ana Isabel Prieto, Angeles Jos, Silvia Pichardo, Isabel Moreno, María Alvarez de Sotomayor, Rosario Moyano, Alfonso Blanco, Ana María Cameán. Time-dependent protective efficacy of Trolox (vitamin E analog) against microcystin-induced toxicity in tilapia (Oreochromis niloticus).
Environmental toxicology.
2009 Dec; 24(6):563-79. doi:
10.1002/tox.20458. [PMID: 19051281] - Daniel Hoefel, Caroline M M Adriansen, Magali A C Bouyssou, Christopher P Saint, Gayle Newcombe, Lionel Ho. Development of an mlrA gene-directed TaqMan PCR assay for quantitative assessment of microcystin-degrading bacteria within water treatment plant sand filter biofilms.
Applied and environmental microbiology.
2009 Aug; 75(15):5167-9. doi:
10.1128/aem.00036-09. [PMID: 19502429] - Ulla Kaasalainen, Jouni Jokela, David P Fewer, Kaarina Sivonen, Jouko Rikkinen. Microcystin production in the tripartite cyanolichen Peltigera leucophlebia.
Molecular plant-microbe interactions : MPMI.
2009 Jun; 22(6):695-702. doi:
10.1094/mpmi-22-6-0695. [PMID: 19445594] - Paul J Oberholster, Jan G Myburgh, Danny Govender, Roy Bengis, Anna-Maria Botha. Identification of toxigenic Microcystis strains after incidents of wild animal mortalities in the Kruger National Park, South Africa.
Ecotoxicology and environmental safety.
2009 May; 72(4):1177-82. doi:
10.1016/j.ecoenv.2008.12.014. [PMID: 19232725] - Tong Qiu, Ping Xie, Ying Liu, Guangyu Li, Qian Xiong, Le Hao, Huiying Li. The profound effects of microcystin on cardiac antioxidant enzymes, mitochondrial function and cardiac toxicity in rat.
Toxicology.
2009 Mar; 257(1-2):86-94. doi:
10.1016/j.tox.2008.12.012. [PMID: 19135122] - S Saqrane, I El Ghazali, B Oudra, L Bouarab, S Dekayir, L Mandi, N Ouazzani, V M Vasconcelos. Detection of microcystin contamination by the measurement of the variability of the in vivo chlorophyll fluorescence in aquatic plant Lemna gibba.
Toxicon : official journal of the International Society on Toxinology.
2009 Jan; 53(1):9-14. doi:
10.1016/j.toxicon.2008.10.004. [PMID: 18977237] - Xiaojie Pan, Fengyi Chang, Lijuan Kang, Yongding Liu, Genbao Li, Dunhai Li. Effects of gibberellin A(3) on growth and microcystin production in Microcystis aeruginosa (cyanophyta).
Journal of plant physiology.
2008 Nov; 165(16):1691-7. doi:
10.1016/j.jplph.2007.08.012. [PMID: 18395293] - Guangyu Li, Ping Xie, Juan Fu, Le Hao, Qian Xiong, Huiying Li. Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish.
Aquatic toxicology (Amsterdam, Netherlands).
2008 Jun; 88(1):75-80. doi:
10.1016/j.aquatox.2008.03.007. [PMID: 18455246] - Ana I Prieto, Angeles Jos, Silvia Pichardo, Isabel Moreno, Ana M Cameán. Protective role of vitamin E on the microcystin-induced oxidative stress in tilapia fish (Oreochromis niloticus).
Environmental toxicology and chemistry.
2008 May; 27(5):1152-9. doi:
10.1897/07-496.1. [PMID: 18419199] - Li Li, Ping Xie, Longgen Guo, Zhixin Ke, Qiong Zhou, Yaqin Liu, Tong Qiu. Field and laboratory studies on pathological and biochemical characterization of microcystin-induced liver and kidney damage in the phytoplanktivorous bighead carp.
TheScientificWorldJournal.
2008 Feb; 8(?):121-37. doi:
10.1100/tsw.2008.32. [PMID: 18264629] - E D Hilborn, W W Carmichael, R M Soares, M Yuan, J C Servaites, H A Barton, S M F O Azevedo. Serologic evaluation of human microcystin exposure.
Environmental toxicology.
2007 Oct; 22(5):459-63. doi:
10.1002/tox.20281. [PMID: 17696142] - Sana Saqrane, Issam El Ghazali, Youness Ouahid, Majida El Hassni, Ismaïl El Hadrami, Lahcen Bouarab, Franscica F del Campo, Brahim Oudra, Vitor Vasconcelos. Phytotoxic effects of cyanobacteria extract on the aquatic plant Lemna gibba: microcystin accumulation, detoxication and oxidative stress induction.
Aquatic toxicology (Amsterdam, Netherlands).
2007 Aug; 83(4):284-94. doi:
10.1016/j.aquatox.2007.05.004. [PMID: 17582520] - Min-Ho Jang, Kyong Ha, Noriko Takamura. Reciprocal allelopathic responses between toxic cyanobacteria (Microcystis aeruginosa) and duckweed (Lemna japonica).
Toxicon : official journal of the International Society on Toxinology.
2007 Apr; 49(5):727-33. doi:
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