N-(2-(3,4-Dichlorophenyl)ethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamine (BioDeep_00000844354)
代谢物信息卡片
化学式: C15H22Cl2N2 (300.116)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CCC1=CC(=C(C=C1)Cl)Cl)CCN2CCCC2
InChI: InChI=1S/C15H22Cl2N2/c1-18(10-11-19-7-2-3-8-19)9-6-13-4-5-14(16)15(17)12-13/h4-5,12H,2-3,6-11H2,1H3
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Linda Garcés-Ramírez, Jennifer L Green, Takato Hiranita, Theresa A Kopajtic, Maddalena Mereu, Alexandra M Thomas, Christophe Mesangeau, Sanju Narayanan, Christopher R McCurdy, Jonathan L Katz, Gianluigi Tanda. Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.
Biological psychiatry.
2011 Feb; 69(3):208-17. doi:
10.1016/j.biopsych.2010.07.026. [PMID: 20950794] - R R Matsumoto, K L Hewett, B Pouw, W D Bowen, S M Husbands, J J Cao, A H Newman. Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters.
Neuropharmacology.
2001 Dec; 41(7):878-86. doi:
10.1016/s0028-3908(01)00116-2. [PMID: 11684152] - B R de Costa, X S He, C Dominguez, J Cutts, W Williams, W D Bowen. A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes.
Journal of medicinal chemistry.
1994 Jan; 37(2):314-21. doi:
10.1021/jm00028a016. [PMID: 8295220] - B R de Costa, X S He, J T Linders, C Dominguez, Z Q Gu, W Williams, W D Bowen. Synthesis and evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamines at sigma receptors. 2. Piperazines, bicyclic amines, bridged bicyclic amines, and miscellaneous compounds.
Journal of medicinal chemistry.
1993 Aug; 36(16):2311-20. doi:
10.1021/jm00068a007. [PMID: 8360875] - X S He, W D Bowen, K S Lee, W Williams, D R Weinberger, B R de Costa. Synthesis and binding characteristics of potential SPECT imaging agents for sigma-1 and sigma-2 binding sites.
Journal of medicinal chemistry.
1993 Mar; 36(5):566-71. doi:
10.1021/jm00057a006. [PMID: 8496936] - B R de Costa, C Dominguez, X S He, W Williams, L Radesca, W Bowen. Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes.
Journal of medicinal chemistry.
1992 Nov; 35(23):4334-43. doi:
10.1021/jm00101a011. [PMID: 1447735] - B de Costa, L Radesca, C Dominguez, L Di Paolo, W D Bowen. Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.
Journal of medicinal chemistry.
1992 Jun; 35(12):2221-30. doi:
10.1021/jm00090a012. [PMID: 1319493] - B R de Costa, L Radesca, L Di Paolo, W D Bowen. Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor.
Journal of medicinal chemistry.
1992 Jan; 35(1):38-47. doi:
10.1021/jm00079a004. [PMID: 1310114] - . .
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. [PMID: 32353859]
