epi-Cochlioquinone A (BioDeep_00000844235)
代谢物信息卡片
化学式: C30H44O8 (532.3036024)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(C)C1=CC(=O)C2=C(C1=O)OC3(CCC4C(C3C2O)(CCC(O4)C(C)(C)O)C)C)OC(=O)C
InChI: InChI=1S/C30H44O8/c1-9-15(2)25(36-17(4)31)16(3)18-14-19(32)22-24(34)27-29(7)12-10-20(28(5,6)35)37-21(29)11-13-30(27,8)38-26(22)23(18)33/h14-16,20-21,24-25,27,34-35H,9-13H2,1-8H3/t15-,16-,20+,21+,24+,25+,27+,29-,30-/m0/s1
描述信息
An organic heterotetracyclic that is 1,2,3,4a,5,6,6a,12,12a,12b-decahydropyrano[3,2-a]xanthene-8,11-dione substituted by a 2-hydroxypropan-2-yl group at position 3, hydroxy group at position 12, methyl groups at positions 6a and 12b and a 3-(acetyloxy)-4-methylhexan-2-yl moiety at position 9. Isolated from the fermentation broth of Stachybotrys bisbyi SANK 17777, it acts as an inhibitor of acyl-CoA:cholesterol acyltransferase.
同义名列表
1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pengcheng Zhu, Huimin Bu, Shirui Tan, Jinjuan Liu, Bo Yuan, Guokai Dong, Meng Wang, Yuji Jiang, Hong Zhu, Hui Li, Zhenjun Li, Jihong Jiang, Min Wu, Rongpeng Li. A Novel Cochlioquinone Derivative, CoB1, Regulates Autophagy in Pseudomonas aeruginosa Infection through the PAK1/Akt1/mTOR Signaling Pathway.
Journal of immunology (Baltimore, Md. : 1950).
2020 09; 205(5):1293-1305. doi:
10.4049/jimmunol.1901346. [PMID: 32747503] - Fernanda Fraga Campos, Luiz Henrique Rosa, Betania Barros Cota, Rachel Basques Caligiorne, Ana Lúcia Teles Rabello, Tânia Maria Almeida Alves, Carlos Augusto Rosa, Carlos Leomar Zani. Leishmanicidal metabolites from Cochliobolus sp., an endophytic fungus isolated from Piptadenia adiantoides (Fabaceae).
PLoS neglected tropical diseases.
2008; 2(12):e348. doi:
10.1371/journal.pntd.0000348. [PMID: 19079599] - Beatriz Bicalho, Regina A C Gonçalves, Ana Paula M Zibordi, Gilson P Manfio, Anita J Marsaioli. Antimicrobial compounds of fungi vectored by Clusia spp. (Clusiaceae) pollinating bees.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2003 Sep; 58(9-10):746-51. doi:
10.1515/znc-2003-9-1027. [PMID: 14577643] - T Fujioka. [Inhibitory action of natural compounds of microbial origin on cholesterol metabolism].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1997 Oct; 110 Suppl 1(?):75P-80P. doi:
10.1254/fpj.110.supplement_75. [PMID: 9503410] - T Fujioka, K Yao, K Hamano, T Hosoya, T Kagasaki, Y Furukawa, H Haruyama, S Sato, T Koga, Y Tsujita. Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi.
The Journal of antibiotics.
1996 May; 49(5):409-13. doi:
10.7164/antibiotics.49.409. [PMID: 8682715]