(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (BioDeep_00000844209)

   


代谢物信息卡片


(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid

化学式: C7H9NO5 (187.0480704)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C2C(C2O1)C(=O)O)(C(=O)O)N
InChI: InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1

描述信息

LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects[1][2].

同义名列表

2 个代谢物同义名

(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; LY379268



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rudy Toneatti, Jong M Shin, Urjita H Shah, Carl R Mayer, Justin M Saunders, Miguel Fribourg, Paul T Arsenovic, William G Janssen, Stuart C Sealfon, Juan F López-Giménez, Deanna L Benson, Daniel E Conway, Javier González-Maeso. Interclass GPCR heteromerization affects localization and trafficking. Science signaling. 2020 10; 13(654):. doi: 10.1126/scisignal.aaw3122. [PMID: 33082287]
  • Krish Chandrasekaran, Muragundla Anjaneyulu, Joungil Choi, Pranith Kumar, Mohammad Salimian, Cheng-Ying Ho, James W Russell. Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1-PGC-1α-TFAM pathway. International review of neurobiology. 2019; 145(?):177-209. doi: 10.1016/bs.irn.2019.04.002. [PMID: 31208524]
  • Yulia Benitex, Fu-Ni Luan, Eric Shields, Colleen A McNaney, Daniel G Morgan, Timothy V Olah, Dieter M Drexler. Bioanalysis of (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) in rat plasma using derivatization liquid chromatography/mass spectrometry. Bioanalysis. 2014; 6(14):1901-5. doi: 10.4155/bio.14.103. [PMID: 25158962]
  • Hwei-Hsien Chen, Astrid Stoker, Athina Markou. The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice. Psychopharmacology. 2010 May; 209(4):343-50. doi: 10.1007/s00213-010-1802-2. [PMID: 20217053]
  • F Matrisciano, M Zusso, I Panaccione, B Turriziani, A Caruso, L Iacovelli, L Noviello, G Togna, D Melchiorri, P Debetto, R Tatarelli, G Battaglia, F Nicoletti, P Giusti, P Girardi. Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis. Neuropharmacology. 2008 Feb; 54(2):428-37. doi: 10.1016/j.neuropharm.2007.10.020. [PMID: 18082849]
  • Mara D'Onofrio, Antonietta Arcella, Valeria Bruno, Richard T Ngomba, Giuseppe Battaglia, Vincenza Lombari, Giuseppe Ragona, Antonella Calogero, Ferdinando Nicoletti. Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells. Journal of neurochemistry. 2003 Mar; 84(6):1288-95. doi: 10.1046/j.1471-4159.2003.01633.x. [PMID: 12614329]
  • M P Johnson, M Chamberlain. Modulation of stress-induced and stimulated hyperprolactinemia with the group II metabotropic glutamate receptor selective agonist, LY379268. Neuropharmacology. 2002 Oct; 43(5):799-808. doi: 10.1016/s0028-3908(02)00142-9. [PMID: 12384165]