Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- (BioDeep_00000844203)

   


代谢物信息卡片


Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-

化学式: C14H17ClN2O (264.1029342)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN2CCC1C(C2)NC(=O)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C14H17ClN2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17/h1-4,10,13H,5-9H2,(H,16,18)/t13-/m0/s1

描述信息

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1 个代谢物同义名

Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-



数据库引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Jian Yin, Xin Zhao, Lijuan Wang, Xiaojuan Xie, Hemei Geng, Xiandong Zhan, Jinliang Teng. Sevoflurane-induced inflammation development: involvement of cholinergic anti-inflammatory pathway. Behavioural pharmacology. 2019 12; 30(8):730-737. doi: 10.1097/fbp.0000000000000507. [PMID: 31625977]
  • Dong-Jie Li, Jian Liu, Xia Hua, Hui Fu, Fang Huang, Yi-Bo Fei, Wen-Jie Lu, Fu-Ming Shen, Pei Wang. Nicotinic acetylcholine receptor α7 subunit improves energy homeostasis and inhibits inflammation in nonalcoholic fatty liver disease. Metabolism: clinical and experimental. 2018 02; 79(?):52-63. doi: 10.1016/j.metabol.2017.11.002. [PMID: 29129819]
  • Ping Ke, Bo-Zong Shao, Zhe-Qi Xu, Xiong-Wen Chen, Wei Wei, Chong Liu. Activating α7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of β-arrestin-1. CNS neuroscience & therapeutics. 2017 Nov; 23(11):875-884. doi: 10.1111/cns.12758. [PMID: 28941191]
  • Mendi A Higgins, Lawrence R Marcin, F Christopher Zusi, Robert Gentles, Min Ding, Bradley C Pearce, Amy Easton, Walter A Kostich, Matthew A Seager, Clotilde Bourin, Linda J Bristow, Kim A Johnson, Regina Miller, John Hogan, Valerie Whiterock, Michael Gulianello, Meredith Ferrante, Yanling Huang, Adam Hendricson, Andrew Alt, John E Macor, Joanne J Bronson. Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia. Bioorganic & medicinal chemistry. 2017 01; 25(2):496-513. doi: 10.1016/j.bmc.2016.11.018. [PMID: 27914948]
  • David Mata, David M Linn, Cindy L Linn. Retinal ganglion cell neuroprotection induced by activation of alpha7 nicotinic acetylcholine receptors. Neuropharmacology. 2015 Dec; 99(?):337-46. doi: 10.1016/j.neuropharm.2015.07.036. [PMID: 26239818]
  • Olena Lykhmus, Galyna Gergalova, Marios Zouridakis, Socrates Tzartos, Sergiy Komisarenko, Maryna Skok. Inflammation decreases the level of alpha7 nicotinic acetylcholine receptors in the brain mitochondria and makes them more susceptible to apoptosis induction. International immunopharmacology. 2015 Nov; 29(1):148-51. doi: 10.1016/j.intimp.2015.04.007. [PMID: 25887272]
  • Feng Ma, Fan Gong, Jinhan Lv, Jun Gao, Jingzu Ma. Effects of a7nAChR agonist on the tissue estrogen receptor expression of castrated rats. International journal of clinical and experimental pathology. 2015; 8(10):13421-5. doi: . [PMID: 26722551]
  • Zong-Zhuang Li, Zhen-Zhen Guo, Zhi Zhang, Qun-An Cao, Ya-Juan Zhu, Hua-Li Yao, Li-Li Wu, Qiu-Yan Dai. Nicotine-induced upregulation of VCAM-1, MMP-2, and MMP-9 through the α7-nAChR-JNK pathway in RAW264.7 and MOVAS cells. Molecular and cellular biochemistry. 2015 Jan; 399(1-2):49-58. doi: 10.1007/s11010-014-2231-z. [PMID: 25381636]
  • Quan Hu, Ming-Hua Du, Sen Hu, Jia-ke Chai, Hong-Min Luo, Xiao-Han Hu, Lin Zhang, Zhi-Long Lin, Li Ma, Huan Wang, Zhi-Yong Sheng. PNU-282987 improves the hemodynamic parameters by alleviating vasopermeability and tissue edema in dogs subjected to a lethal burns shock. Journal of burn care & research : official publication of the American Burn Association. 2014 Jul; 35(4):e197-204. doi: 10.1097/bcr.0b013e31829afe46. [PMID: 23877136]
  • Galyna Gergalova, Olena Lykhmus, Sergiy Komisarenko, Maryna Skok. α7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways. The international journal of biochemistry & cell biology. 2014 Apr; 49(?):26-31. doi: 10.1016/j.biocel.2014.01.001. [PMID: 24412630]
  • Ming-hua Du, Quan Hu, Hong-min Luo, Zhi-long Lin, Li Ma, Huan Wang, Sen Hu. [Effects of PNU282987 on organ function and survival in dogs with lethal burn shock]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. 2012 Nov; 24(11):651-4. doi: NULL. [PMID: 23131281]
  • Jun Xiong, Yu-Jing Yuan, Fu-Shan Xue, Qiang Wang, Yi Cheng, Rui-Ping Li, Xu Liao, Jian-Hua Liu. Postconditioning with α7nAChR agonist attenuates systemic inflammatory response to myocardial ischemia--reperfusion injury in rats. Inflammation. 2012 Aug; 35(4):1357-64. doi: 10.1007/s10753-012-9449-2. [PMID: 22391744]
  • Ramakrishna Nirogi, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Ramanatha Saralaya, Nageswararao Muddana, Prashanth Komarneni. Methyllycaconitine: a non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - in vivo target localization and biodistribution in rat brain. Journal of pharmacological and toxicological methods. 2012 Jul; 66(1):22-8. doi: 10.1016/j.vascn.2012.05.003. [PMID: 22609758]
  • Jesper T Andreasen, John P Redrobe, Elsebet Ø Nielsen. Combined α7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: a comparison of SSR180711 and PNU-282987. Pharmacology, biochemistry, and behavior. 2012 Jan; 100(3):624-9. doi: 10.1016/j.pbb.2011.11.004. [PMID: 22108649]
  • Dong-Jie Li, Roger G Evans, Zhong-Wei Yang, Shu-Wei Song, Pei Wang, Xiu-Juan Ma, Chong Liu, Tao Xi, Ding-Feng Su, Fu-Ming Shen. Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension. Hypertension (Dallas, Tex. : 1979). 2011 Feb; 57(2):298-307. doi: 10.1161/hypertensionaha.110.160077. [PMID: 21173343]
  • C Chipana, I Torres, J Camarasa, D Pubill, E Escubedo. Memantine protects against amphetamine derivatives-induced neurotoxic damage in rodents. Neuropharmacology. 2008 Jun; 54(8):1254-63. doi: 10.1016/j.neuropharm.2008.04.003. [PMID: 18455739]
  • Jens Halvard Grønlien, Monika Håkerud, Hilde Ween, Kirsten Thorin-Hagene, Clark A Briggs, Murali Gopalakrishnan, John Malysz. Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Molecular pharmacology. 2007 Sep; 72(3):715-24. doi: 10.1124/mol.107.035410. [PMID: 17565004]