S-Ethyl glutathione (BioDeep_00000844080)
代谢物信息卡片
S-Ethyl glutathione
化学式: C12H21N3O6S (335.1151006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCSCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
InChI: InChI=1S/C12H21N3O6S/c1-2-22-6-8(11(19)14-5-10(17)18)15-9(16)4-3-7(13)12(20)21/h7-8H,2-6,13H2,1H3,(H,14,19)(H,15,16)(H,17,18)(H,20,21)/t7-,8-/m0/s1
描述信息
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Luiza L Knittel, Huaying Zhao, Ai Nguyen, Antônio Miranda, Peter Schuck, Alioscka A Sousa. Ultrasmall Gold Nanoparticles Coated with Zwitterionic Glutathione Monoethyl Ester: A Model Platform for the Incorporation of Functional Peptides.
The journal of physical chemistry. B.
2020 05; 124(19):3892-3902. doi:
10.1021/acs.jpcb.0c01444. [PMID: 32352799] - Daniela Giustarini, Federico Galvagni, Isabella Dalle Donne, Aldo Milzani, Filiberto Maria Severi, Annalisa Santucci, Ranieri Rossi. N-acetylcysteine ethyl ester as GSH enhancer in human primary endothelial cells: A comparative study with other drugs.
Free radical biology & medicine.
2018 10; 126(?):202-209. doi:
10.1016/j.freeradbiomed.2018.08.013. [PMID: 30114478] - Md Sarwar Jahan, Mohd Nozulaidi, Mohd Khairi, Nashriyah Mat. Light-harvesting complexes in photosystem II regulate glutathione-induced sensitivity of Arabidopsis guard cells to abscisic acid.
Journal of plant physiology.
2016 May; 195(?):1-8. doi:
10.1016/j.jplph.2016.03.002. [PMID: 26970687] - Min Ae Han, Seon Min Woo, Kyoung-jin Min, Shin Kim, Jong-Wook Park, Dong Eun Kim, Sang Hyun Kim, Yung Hyun Choi, Taeg Kyu Kwon. 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression.
Chemico-biological interactions.
2015 Feb; 228(?):69-78. doi:
10.1016/j.cbi.2015.01.020. [PMID: 25619640] - Muhammad Abdus Sobahan, Nasima Akter, Eiji Okuma, Misugi Uraji, Wenxiu Ye, Izumi C Mori, Yoshimasa Nakamura, Yoshiyuki Murata. Allyl isothiocyanate induces stomatal closure in Vicia faba.
Bioscience, biotechnology, and biochemistry.
2015; 79(10):1737-42. doi:
10.1080/09168451.2015.1045827. [PMID: 26027691] - Elena Giordano, Alberto Davalos, Nathalie Nicod, Francesco Visioli. Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells.
Molecular nutrition & food research.
2014 May; 58(5):954-62. doi:
10.1002/mnfr.201300465. [PMID: 24347345] - Raquel Urtasun, Francisco Javier Cubero, Natalia Nieto. Oxidative stress modulates KLF6Full and its splice variants.
Alcoholism, clinical and experimental research.
2012 Nov; 36(11):1851-62. doi:
10.1111/j.1530-0277.2012.01798.x. [PMID: 22486562] - Petr Benes, Petra Alexova, Lucia Knopfova, Alena Spanova, Jan Smarda. Redox state alters anti-cancer effects of wedelolactone.
Environmental and molecular mutagenesis.
2012 Aug; 53(7):515-24. doi:
10.1002/em.21712. [PMID: 22733624] - Eiji Okuma, Md Sarwar Jahan, Shintaro Munemasa, Mohammad Anowar Hossain, Daichi Muroyama, Mohammad Mahbub Islam, Ken'ichi Ogawa, Megumi Watanabe-Sugimoto, Yoshimasa Nakamura, Yasuaki Shimoishi, Izumi C Mori, Yoshiyuki Murata. Negative regulation of abscisic acid-induced stomatal closure by glutathione in Arabidopsis.
Journal of plant physiology.
2011 Nov; 168(17):2048-55. doi:
10.1016/j.jplph.2011.06.002. [PMID: 21764168] - Paola Vigilanza, Katia Aquilano, Sara Baldelli, Giuseppe Rotilio, Maria Rosa Ciriolo. Modulation of intracellular glutathione affects adipogenesis in 3T3-L1 cells.
Journal of cellular physiology.
2011 Aug; 226(8):2016-24. doi:
10.1002/jcp.22542. [PMID: 21520053] - Nicole Schütze, Irina Lehmann, Ulrike Bönisch, Jan C Simon, Tobias Polte. Exposure to mycotoxins increases the allergic immune response in a murine asthma model.
American journal of respiratory and critical care medicine.
2010 Jun; 181(11):1188-99. doi:
10.1164/rccm.200909-1350oc. [PMID: 20194814] - Rajat Singh, Yongjun Wang, Jörn M Schattenberg, Youqing Xiang, Mark J Czaja. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Nov; 297(5):G907-17. doi:
10.1152/ajpgi.00151.2009. [PMID: 20501438] - Jamie J O'Brien, Sherry L Spinelli, Joanna Tober, Neil Blumberg, Charles W Francis, Mark B Taubman, James Palis, Kathryn E Seweryniak, Jacqueline M Gertz, Richard P Phipps. 15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes.
Blood.
2008 Nov; 112(10):4051-60. doi:
10.1182/blood-2008-05-158535. [PMID: 18755987] - Ganesan Murali, Chinnakkannu Panneerselvam. Modulatory role of glutathione monoester in augmenting age-associated neuronal antioxidant system.
Experimental aging research.
2008 Oct; 34(4):419-36. doi:
10.1080/03610730802271906. [PMID: 18726753] - Simone Holtgrefe, Jochen Gohlke, Julia Starmann, Samantha Druce, Susanne Klocke, Bianca Altmann, Joanna Wojtera, Christian Lindermayr, Renate Scheibe. Regulation of plant cytosolic glyceraldehyde 3-phosphate dehydrogenase isoforms by thiol modifications.
Physiologia plantarum.
2008 Jun; 133(2):211-28. doi:
10.1111/j.1399-3054.2008.01066.x. [PMID: 18298409] - Shu Zhang, Fei-Yan Chai, Hong Yan, Yong Guo, J J Harding. Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats.
Molecular vision.
2008 May; 14(?):862-70. doi:
NULL. [PMID: 18490958] - E C Curnow, J Ryan, D Saunders, E S Hayes. Bovine in vitro oocyte maturation as a model for manipulation of the gamma-glutamyl cycle and intraoocyte glutathione.
Reproduction, fertility, and development.
2008; 20(5):579-88. doi:
10.1071/rd08041. [PMID: 18577355] - Y Unahara, A Kojima-Yuasa, M Higashida, D O Kennedy, A Murakami, H Ohigashi, I Matsui-Yuasa. Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27(kip1) translocation and retinoblastoma protein phosphorylation by 1'-acetoxychavicol acetate.
Amino acids.
2007 Sep; 33(3):469-76. doi:
10.1007/s00726-006-0437-4. [PMID: 17031475] - Ganesan Murali, Chinnakkannu Panneerselvam. Age-associated oxidative macromolecular damages in rat brain regions: role of glutathione monoester.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2007 Aug; 62(8):824-30. doi:
10.1093/gerona/62.8.824. [PMID: 17702872] - Namakkal Surappan Rajasekaran, Niranjali S Devaraj, Halagowder Devaraj. Modulation of rat erythrocyte antioxidant defense system by buthionine sulfoximine and its reversal by glutathione monoester therapy.
Biochimica et biophysica acta.
2004 Mar; 1688(2):121-9. doi:
10.1016/j.bbadis.2003.11.004. [PMID: 14990342] - Behrouz Jafari, Bin Ouyang, Li-Fu Li, Charles A Hales, Deborah A Quinn. Intracellular glutathione in stretch-induced cytokine release from alveolar type-2 like cells.
Respirology (Carlton, Vic.).
2004 Mar; 9(1):43-53. doi:
10.1111/j.1440-1843.2003.00527.x. [PMID: 14982601] - Robert C Carlisle, Tomas Etrych, Simon S Briggs, Jon A Preece, Karel Ulbrich, Leonard W Seymour. Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction.
The journal of gene medicine.
2004 Mar; 6(3):337-44. doi:
10.1002/jgm.525. [PMID: 15026995] - Kian Hong Ng, Beng Gek Lim, Kim Ping Wong. Sulfate conjugating and transport functions of MDCK distal tubular cells.
Kidney international.
2003 Mar; 63(3):976-86. doi:
10.1046/j.1523-1755.2003.00818.x. [PMID: 12631078] - Jolanda M Rijnkels, Ralf M W Moison, Elena Podda, Gerard M J Beijersbergen van Henegouwen. Photoprotection by antioxidants against UVB-radiation-induced damage in pig skin organ culture.
Radiation research.
2003 Feb; 159(2):210-7. doi:
10.1667/0033-7587(2003)159[0210:pbaaur]2.0.co;2. [PMID: 12537526] - Jun Xu, Daisuke Maki, Susan R Stapleton. Mediation of cadmium-induced oxidative damage and glucose-6-phosphate dehydrogenase expression through glutathione depletion.
Journal of biochemical and molecular toxicology.
2003; 17(2):67-75. doi:
10.1002/jbt.10062. [PMID: 12717738] - Amir M Abushamaa, Thomas A Sporn, Rodney J Folz. Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen.
American journal of physiology. Lung cellular and molecular physiology.
2002 Aug; 283(2):L336-45. doi:
10.1152/ajplung.00012.2002. [PMID: 12114195] - H Sudo, Y Hashimoto, T Niikura, Z Shao, T Yasukawa, Y Ito, M Yamada, M Hata, T Hiraki, M Kawasumi, K Kouyama, I Nishimoto. Secreted Abeta does not mediate neurotoxicity by antibody-stimulated amyloid precursor protein.
Biochemical and biophysical research communications.
2001 Mar; 282(2):548-56. doi:
10.1006/bbrc.2001.4604. [PMID: 11401495] - T S Chen, J P Richie, H T Nagasawa, C A Lang. Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice.
Mechanisms of ageing and development.
2000 Dec; 120(1-3):127-39. doi:
10.1016/s0047-6374(00)00214-1. [PMID: 11087910] - G Piwien-Pilipuk, M D Galigniana. Oxidative stress induced by L-buthionine-(S,R)-sulfoximine, a selective inhibitor of glutathione metabolism, abrogates mouse kidney mineralocorticoid receptor function.
Biochimica et biophysica acta.
2000 Feb; 1495(3):263-80. doi:
10.1016/s0167-4889(99)00166-4. [PMID: 10699465] - I Grattagliano, G Vendemiale, B H Lauterburg. Reperfusion injury of the liver: role of mitochondria and protection by glutathione ester.
The Journal of surgical research.
1999 Sep; 86(1):2-8. doi:
10.1006/jsre.1999.5620. [PMID: 10452861] - J M Esteve, J Mompo, J Garcia de la Asuncion, J Sastre, M Asensi, J Boix, J R Vina, J Vina, F V Pallardo. Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitro.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1999 Jun; 13(9):1055-64. doi:
10.1096/fasebj.13.9.1055. [PMID: 10336888] - C Leeuwenburgh, L L Ji. Glutathone and glutathione ethyl ester supplementation of mice alter glutathione homeostasis during exercise.
The Journal of nutrition.
1998 Dec; 128(12):2420-6. doi:
10.1093/jn/128.12.2420. [PMID: 9868190] - J F Rebbeor, G C Connolly, M E Dumont, N Ballatori. ATP-dependent transport of reduced glutathione in yeast secretory vesicles.
The Biochemical journal.
1998 Sep; 334 ( Pt 3)(?):723-9. doi:
10.1042/bj3340723. [PMID: 9729482] - K Nishida, Y Ohta, I Ishiguro. Glycine facilitates gamma-glutamylcysteinylethyl ester-mediated increase in liver glutathione level.
European journal of pharmacology.
1997 Aug; 333(2-3):289-92. doi:
10.1016/s0014-2999(97)01130-8. [PMID: 9314046] - P Aukrust, A M Svardal, F Müller, B Lunden, R K Berge, S S Frøland. Decreased levels of total and reduced glutathione in CD4+ lymphocytes in common variable immunodeficiency are associated with activation of the tumor necrosis factor system: possible immunopathogenic role of oxidative stress.
Blood.
1995 Aug; 86(4):1383-91. doi:
NULL. [PMID: 7632946] - I Grattagliano, P Wieland, C Schranz, B H Lauterburg. Disposition of glutathione monoethyl ester in the rat: glutathione ester is a slow release form of extracellular glutathione.
The Journal of pharmacology and experimental therapeutics.
1995 Feb; 272(2):484-8. doi:
. [PMID: 7853160] - I Grattagliano, P Wieland, C Schranz, B H Lauterburg. Effect of oral glutathione monoethyl ester and glutathione on circulating and hepatic sulfhydrils in the rat.
Pharmacology & toxicology.
1994 Dec; 75(6):343-7. doi:
10.1111/j.1600-0773.1994.tb00372.x. [PMID: 7899255] - J Mårtensson, J Han, O W Griffith, A Meister. Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs.
Proceedings of the National Academy of Sciences of the United States of America.
1993 Jan; 90(1):317-21. doi:
10.1073/pnas.90.1.317. [PMID: 8419936] - N Ballatori, A T Truong. Glutathione as a primary osmotic driving force in hepatic bile formation.
The American journal of physiology.
1992 Nov; 263(5 Pt 1):G617-24. doi:
10.1152/ajpgi.1992.263.5.g617. [PMID: 1443136] - M K Robinson, M S Ahn, J D Rounds, J A Cook, D O Jacobs, D W Wilmore. Parenteral glutathione monoester enhances tissue antioxidant stores.
JPEN. Journal of parenteral and enteral nutrition.
1992 Sep; 16(5):413-8. doi:
10.1177/0148607192016005413. [PMID: 1433773] - L S Milner, S H Wei, S J Stohs, Z M Eldeen, M T Houser. Role of glutathione metabolism in the reduction of proteinuria by dimethylthiourea in adriamycin nephrosis.
Nephron.
1992; 62(2):192-7. doi:
10.1159/000187032. [PMID: 1436313] - B A Neuschwander-Tetri, L D Ferrell, R J Sukhabote, J H Grendell. Glutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse.
The Journal of clinical investigation.
1992 Jan; 89(1):109-16. doi:
10.1172/jci115550. [PMID: 1370292] - M T Houser, L S Milner, P C Kolbeck, S H Wei, S J Stohs. Glutathione monoethyl ester moderates mercuric chloride-induced acute renal failure.
Nephron.
1992; 61(4):449-55. doi:
10.1159/000186965. [PMID: 1501744] - R A Ansari, R S Thakran, W O Berndt. Effects of mercuric chloride on renal plasma membrane function after depletion or elevation of renal glutathione.
Toxicology and applied pharmacology.
1991 Nov; 111(2):364-72. doi:
10.1016/0041-008x(91)90037-f. [PMID: 1957319] - M T Vincenzini, F Favilli, M Stio, T Iantomasi. Intestinal glutathione transport system: a possible detoxication role.
Biochimica et biophysica acta.
1991 Apr; 1073(3):571-9. doi:
10.1016/0304-4165(91)90232-6. [PMID: 2015281] - S J Hermansky, S J Stohs, Z M Eldeen, V F Roche, K A Mereish. Evaluation of potential chemoprotectants against microcystin-LR hepatotoxicity in mice.
Journal of applied toxicology : JAT.
1991 Feb; 11(1):65-73. doi:
10.1002/jat.2550110112. [PMID: 1902496] - T Mizutani, K Ito, H Nomura, K Nakanishi. Nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with DL-buthionine sulphoximine.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1990 Mar; 28(3):169-77. doi:
10.1016/0278-6915(90)90005-8. [PMID: 2344991] - M E Anderson, M Underwood, R J Bridges, A Meister. Glutathione metabolism at the blood-cerebrospinal fluid barrier.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1989 Nov; 3(13):2527-31. doi:
10.1096/fasebj.3.13.2572501. [PMID: 2572501] - R C Scaduto, V H Gattone, L W Grotyohann, J Wertz, L F Martin. Effect of an altered glutathione content on renal ischemic injury.
The American journal of physiology.
1988 Nov; 255(5 Pt 2):F911-21. doi:
10.1152/ajprenal.1988.255.5.f911. [PMID: 3189564] - M E Anderson, F Powrie, R N Puri, A Meister. Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.
Archives of biochemistry and biophysics.
1985 Jun; 239(2):538-48. doi:
10.1016/0003-9861(85)90723-4. [PMID: 4004275]