4-[[(2r,3s,4r,5r)-5-[6-Amino-8-[(3,4-Dichlorophenyl)methylamino]purin-9-Yl]-3,4-Dihydroxy-Oxolan-2-Yl]methoxymethyl]benzonitrile (BioDeep_00000844031)

   


代谢物信息卡片


4-[[(2r,3s,4r,5r)-5-[6-Amino-8-[(3,4-Dichlorophenyl)methylamino]purin-9-Yl]-3,4-Dihydroxy-Oxolan-2-Yl]methoxymethyl]benzonitrile

化学式: C25H23Cl2N7O4 (555.1188498)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1COCC2C(C(C(O2)N3C4=NC=NC(=C4N=C3NCC5=CC(=C(C=C5)Cl)Cl)N)O)O)C#N
InChI: InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1

描述信息

VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70.

同义名列表

2 个代谢物同义名

4-[[(2r,3s,4r,5r)-5-[6-Amino-8-[(3,4-Dichlorophenyl)methylamino]purin-9-Yl]-3,4-Dihydroxy-Oxolan-2-Yl]methoxymethyl]benzonitrile; VER-155008



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kosuke Sakai, Maya Inoue, Shintaro Mikami, Hiroaki Nishimura, Yoshiki Kuwabara, Akitoshi Kojima, Maiko Toda, Yumiko Ogawa-Kobayashi, Satoshi Kikuchi, Yusuke Hirata, Yuriko Mikami-Saito, Hiroyuki Kyoyama, Gaku Moriyama, Michio Shiibashi, Masahiro Seike, Akihiko Gemma, Kazutsugu Uematsu. Functional inhibition of heat shock protein 70 by VER-155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism. Thoracic cancer. 2021 02; 12(4):491-503. doi: 10.1111/1759-7714.13784. [PMID: 33319489]
  • Karolina Rogala-Koziarska, Łukasz Samluk, Katarzyna A Nałęcz. Amino acid transporter SLC6A14 depends on heat shock protein HSP90 in trafficking to the cell surface. Biochimica et biophysica acta. Molecular cell research. 2019 10; 1866(10):1544-1555. doi: 10.1016/j.bbamcr.2019.07.009. [PMID: 31326539]
  • Erina Matsuoka, Naoki Kato, Masakazu Hara. Induction of the heat shock response in Arabidopsis by heat shock protein 70 inhibitor VER-155008. Functional plant biology : FPB. 2019 09; 46(10):925-932. doi: 10.1071/fp18259. [PMID: 31217072]
  • Li-Peng Shan, Xiao-Hui Chen, Fei Ling, Bin Zhu, Gao-Xue Wang. Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection. Virus research. 2018 03; 247(?):1-9. doi: 10.1016/j.virusres.2018.01.005. [PMID: 29355582]
  • Wen-Fang Wang, Li Yan, Zhao Liu, Lan-Xuan Liu, Jian Lin, Zhi-Yin Liu, Xiong-Ping Chen, Wu Zhang, Zi-Zhen Xu, Ting Shi, Jun-Min Li, Yi-Lei Zhao, Guoyu Meng, Yi Xia, Jian-Yong Li, Jiang Zhu. HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells. Nature communications. 2017 08; 8(1):363. doi: 10.1038/s41467-017-00476-w. [PMID: 28842558]
  • Alice Cavanaugh, Brendon Juengst, Kathleen Sheridan, John F Danella, Heinric Williams. Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer. Oncotarget. 2015 Nov; 6(37):39821-38. doi: 10.18632/oncotarget.5496. [PMID: 26556859]