Bopindolol malonate (BioDeep_00000844018)
代谢物信息卡片
Bopindolol malonate
化学式: C26H32N2O7 (484.2209402)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)OC(=O)C3=CC=CC=C3.C(C(=O)O)C(=O)O
InChI: 1H2,(H,4,5)(H,6,7)
描述信息
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- F Belal, M Sharaf El-Din, F Aly, M Hefnawy, M El-Awady. Fluorometric determination of bopindolol and celiprolol in pharmaceutical preparations and biological fluids.
Journal of fluorescence.
2012 Jul; 22(4):1141-50. doi:
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Hypertension (Dallas, Tex. : 1979).
1999 Jan; 33(1 Pt 2):467-71. doi:
10.1161/01.hyp.33.1.467. [PMID: 9931149] - J Bagatin, S Sardelić, N Pivac, S Polić, D Ljutic, D Rakic, M Naranca, L Bojić, Z Kovacić, Z Rumboldt. Comparison of chlorthalidone, propranolol and bopindolol in six-month treatment of arterial hypertension.
International journal of clinical pharmacology research.
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1997 Jan; 109(1):1-12. doi:
10.1254/fpj.109.1. [PMID: 9067994] - J Widimský, V Lánská, V Hulínský, I Balazovjech, V Havlík, P Havránek, E Kroupa, L Nikodýmová, F Pátek, F Svítil, P Svihovcová. [Treatment of hypertension with a fixed combination of bopindolol and chlorthalidone (Sandoretic)].
Vnitrni lekarstvi.
1996 Apr; 42(4):223-8. doi:
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Japanese journal of pharmacology.
1995 Jul; 68(3):323-9. doi:
10.1254/jjp.68.323. [PMID: 7474556] - C Farsang, J Kapocsi, I Kiss, E Török, G Kerkovits, J Holló, T Jávor. Hungarian Isradipine Study (HIS): long-term (3-year) effects on blood pressure and plasma lipids.
American journal of hypertension.
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European journal of clinical pharmacology.
1992; 43(1):11-5. doi:
10.1007/bf02280747. [PMID: 1354617] - A Zsáry, N Káldi, K Kállay. [The effect of the blood pressure lowering effect of bopindolol (Sandonorm) in patients with mild and moderate hypertension].
Orvosi hetilap.
1991 Sep; 132(39):2149-51. doi:
NULL. [PMID: 1681490] - N J MacDonald, A C Grant, R S Rodger, P A Meredith, H L Elliott. The effect of renal impairment on the pharmacokinetics and metabolism of bopindolol.
British journal of clinical pharmacology.
1991 Jun; 31(6):697-700. doi:
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The American journal of cardiology.
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Drugs.
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British journal of clinical pharmacology.
1990 Oct; 30(4):547-56. doi:
10.1111/j.1365-2125.1990.tb03812.x. [PMID: 1981317] - I Virgolini, P Fitscha, F Rauscha, H Sinzinger. Effects of bopindolol on platelet function in hypertension at rest and during exercise.
Prostaglandins, leukotrienes, and essential fatty acids.
1990 Jun; 40(2):125-30. doi:
10.1016/0952-3278(90)90154-d. [PMID: 2143586] - A H van den Meiracker, A J Man in 't Veld, F Boomsma, P J Blankestijn, M A Schalekamp. Epinephrine-induced enhancement of sympathetic activity in humans: inhibition by nonselective as well as beta 1-selective beta-adrenoceptor blockade.
Journal of cardiovascular pharmacology.
1990 Apr; 15(4):610-7. doi:
10.1097/00005344-199004000-00014. [PMID: 1691392] - G Wensing, R A Branch, H Humbert, E E Ohnhaus, W Kirch. Pharmacokinetics after a single oral dose of bopindolol in patients with cirrhosis.
European journal of clinical pharmacology.
1990; 39(6):569-72. doi:
10.1007/bf00316097. [PMID: 1982762] - T Ishihara, W P Chin, Y Yoshida, H T Sun, A Mitomi, T Ishibashi, K Tamura, S Imai. Effects of chronic oral administration of a new beta-blocker, bopindolol, on serum lipoprotein concentrations and blood pressure of spontaneously hypertensive rats.
Archives internationales de pharmacodynamie et de therapie.
1989 Nov; 302(?):145-57. doi:
NULL. [PMID: 2576891] - V Fedelesová, V Spustová, M Hucková, G Kovác. [Bopindolol does not affect normal glucose and lipid metabolism in hypertensive patients].
Vnitrni lekarstvi.
1989 Sep; 35(9):873-9. doi:
NULL. [PMID: 2573194] - X Z Jin, G D Liu. Prevention of postischemic reperfusion damage on isolated working rat hearts by bopindolol and propranolol.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1989 Sep; 10(5):394-8. doi:
". [PMID: 2575837] - A G Proakis, R J Barrett, L A Anderson, K F Wright, D R Taylor. Effect of bopindolol on renin secretion and renal excretory function in rats.
Journal of cardiovascular pharmacology.
1989 Jun; 13(6):862-9. doi:
10.1097/00005344-198906000-00008. [PMID: 2484080] - K Yamashita, K Shigematsu, T Maeda, Y Ishida, M Niwa, M Ozaki. [Antihypertensive effect of bopindolol on stroke-prone spontaneously hypertensive rats (SHRSP)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1989 Jan; 93(1):7-15. doi:
10.1254/fpj.93.7. [PMID: 2565861] - J Shohat, M Modan, J B Rosenfeld. Bopindolol: long-term effects on blood pressure, renal function, plasma renin activity, and plasma aldosterone in mild-to-moderate essential hypertension.
Fundamental & clinical pharmacology.
1989; 3(1):53-8. doi:
10.1111/j.1472-8206.1989.tb00030.x. [PMID: 2565862] - A H van den Meiracker, A J Man in't Veld, F Boomsma, P J Blankestijn, M A Schalekamp. Adrenaline-induced amplification of sympathetic activity during rest and stress: inhibition by non-selective and beta 1-selective beta-adrenoceptor blockade.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1988 Dec; 6(4):S558-61. doi:
10.1097/00004872-198812040-00175. [PMID: 2907349] - S L Perkins, B Tattrie, P M Johnson, E Z Rabin. Analytical problems encountered during high-performance liquid chromatographic separation and coulometric detection of bopindolol metabolites in human plasma.
Therapeutic drug monitoring.
1988; 10(4):480-5. doi:
10.1097/00007691-198804000-00019. [PMID: 2904713] - E Pintérová, J Kacerovský, Z Zadák, J Malý, V Pidrman. The effect of bopindolol on lipids and platelet aggregation.
Cor et vasa.
1988; 30(5):352-60. doi:
NULL. [PMID: 3229118] - H Humbert, J Denouel, H P Keller. Column liquid chromatographic determination of hydrolysed bopindolol, in the picogram per millilitre range in plasma, using cartridge extraction and dual electrochemical detection.
Journal of chromatography.
1987 Nov; 422(?):205-15. doi:
10.1016/0378-4347(87)80453-x. [PMID: 2893803] - R Colnago, M Meregalli, D Turri, M Nazzari, G Fiorella, E E Guffanti, C Mazzola. Double-blind comparison of once-daily bopindolol and atenolol for mild-to-moderate hypertension.
International journal of clinical pharmacology, therapy, and toxicology.
1987 Jun; 25(6):347-52. doi:
NULL. [PMID: 2887520] - J Fabre, J Wintsch, R Peter-Contesse, C Bouchardy, C Liniger, L Favre, A Donath. Effects of bopindolol on renal function.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 6(?):S45-50. doi:
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Journal of cardiovascular pharmacology.
1986; 8 Suppl 6(?):S39-41. doi:
10.1097/00005344-198608006-00009. [PMID: 2439817] - P Dayer, G Mérier, J J Perrenoud, A Marmy, T Leemann. Interindividual pharmacokinetic and pharmacodynamic variability of different beta blockers.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 6(?):S20-4. doi:
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Journal of cardiovascular pharmacology.
1986; 8 Suppl 6(?):S16-9. doi:
NULL. [PMID: 2439812] - P Bolli, F W Amann, F B Müller, B Meyer, D Burckhardt, F R Bühler. Withdrawal of the long-acting beta blocker bopindolol is not associated with beta-adrenoceptor supersensitivity.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 6(?):S64-9. doi:
10.1097/00005344-198608006-00015. [PMID: 2439824] - P van Brummelen, P Bolli, M I Koolen, H B Staehelin, F R Bühler. Plasma lipid fractions during bopindolol treatment in hypertensive patients.
Journal of cardiovascular pharmacology.
1986; 8 Suppl 6(?):S42-4. doi:
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British journal of clinical pharmacology.
1986 Jan; 21(1):45-51. doi:
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1985; 28(2):149-53. doi:
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1984 Jul; 36(1):5-13. doi:
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1983 May; 5(3):426-9. doi:
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