Bohemine (BioDeep_00000843982)

   


代谢物信息卡片


Bohemine

化学式: C18H24N6O (340.20114939999996)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)N1C=NC2=C(N=C(N=C21)NCCCO)NCC3=CC=CC=C3
InChI: InChI=1S/C18H24N6O/c1-13(2)24-12-21-15-16(20-11-14-7-4-3-5-8-14)22-18(23-17(15)24)19-9-6-10-25/h3-5,7-8,12-13,25H,6,9-11H2,1-2H3,(H2,19,20,22,23)

描述信息

Bohemine is a purine analogue and is a synthetic and selective CDK inhibitor with IC50s of 4.6 μM, 83 μM, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively. Bohemine also inhibits ERK2 with an IC50 of 52 μM and has less inhibitory effect on CDK1, CDK4 and CDK6. Bohemine has a broad spectrum anti-cancer activities[1][2].

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Bohemine



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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
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文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ran An, Yuichiro Hagiya, Ai Tamura, Shanshan Li, Hikaru Saito, Daisuke Tokushima, Toshihisa Ishikawa. Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro. Pharmaceutical research. 2009 Feb; 26(2):449-58. doi: 10.1007/s11095-008-9738-5. [PMID: 18841444]
  • Hana Pospísilová, Marek Sebela, Ondrej Novák, Ivo Frébort. Hydrolytic cleavage of N6-substituted adenine derivatives by eukaryotic adenine and adenosine deaminases. Bioscience reports. 2008 Dec; 28(6):335-47. doi: 10.1042/bsr20080081. [PMID: 18673302]
  • Florence I Raynaud, Steven R Whittaker, Peter M Fischer, Steven McClue, Michael I Walton, S Elaine Barrie, Michelle D Garrett, Paul Rogers, Simon J Clarke, Lloyd R Kelland, Melanie Valenti, Lisa Brunton, Suzanne Eccles, David P Lane, Paul Workman. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Jul; 11(13):4875-87. doi: 10.1158/1078-0432.ccr-04-2264. [PMID: 16000586]
  • K Vermeulen, M Strnad, V Krystof, L Havlícek, A Van der Aa, M Lenjou, G Nijs, I Rodrigus, B Stockman, H van Onckelen, D R Van Bockstaele, Z N Berneman. Antiproliferative effect of plant cytokinin analogues with an inhibitory activity on cyclin-dependent kinases. Leukemia. 2002 Mar; 16(3):299-305. doi: 10.1038/sj.leu.2402378. [PMID: 11896531]
  • Z Chmela, J Veselý, K Lemr, M Rypka, J Hanus, L Havlícek, V Krystof, L Michnová, K Fuksová, J Lukes. In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route. Drug metabolism and disposition: the biological fate of chemicals. 2001 Mar; 29(3):326-34. doi: . [PMID: 11181503]
  • P Binarová, J Dolezel, P Draber, E Heberle-Bors, M Strnad, L Bögre. Treatment of Vicia faba root tip cells with specific inhibitors to cyclin-dependent kinases leads to abnormal spindle formation. The Plant journal : for cell and molecular biology. 1998 Dec; 16(6):697-707. doi: 10.1046/j.1365-313x.1998.00340.x. [PMID: 10069076]