N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine (BioDeep_00000843965)

   


代谢物信息卡片


N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine

化学式: C7H9Cl2NO3S (256.9680184)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(CSC(=CCl)Cl)C(=O)O
InChI: InChI=1S/C7H9Cl2NO3S/c1-4(11)10-5(7(12)13)3-14-6(9)2-8/h2,5H,3H2,1H3,(H,10,11)(H,12,13)/b6-2-/t5-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Yu-Syuan Luo, Shinji Furuya, Weihsueh Chiu, Ivan Rusyn. Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. Journal of toxicology and environmental health. Part A. 2018; 81(1-3):37-52. doi: 10.1080/15287394.2017.1408512. [PMID: 29190187]
  • Roy M Irving, Marie E Pinkerton, Adnan A Elfarra. Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene. Toxicology and applied pharmacology. 2013 Feb; 267(1):1-10. doi: 10.1016/j.taap.2012.12.002. [PMID: 23253325]
  • Roy M Irving, Adnan A Elfarra. Role of reactive metabolites in the circulation in extrahepatic toxicity. Expert opinion on drug metabolism & toxicology. 2012 Sep; 8(9):1157-72. doi: 10.1517/17425255.2012.695347. [PMID: 22681489]
  • Kirill Tsirulnikov, Natalia Abuladze, Myong-Chul Koag, Debra Newman, Karoline Scholz, Galyna Bondar, Quansheng Zhu, Nuraly K Avliyakulov, Wolfgang Dekant, Kym Faull, Ira Kurtz, Alexander Pushkin. Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2). Toxicology and applied pharmacology. 2010 Apr; 244(2):218-25. doi: 10.1016/j.taap.2009.12.035. [PMID: 20060011]
  • Edward A Lock, Jeremy L Barth, Scott W Argraves, Rick G Schnellmann. Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene. Toxicology and applied pharmacology. 2006 Oct; 216(2):319-30. doi: 10.1016/j.taap.2006.06.002. [PMID: 16844155]
  • Ankur V Dnyanmote, Sharmilee P Sawant, Edward A Lock, John R Latendresse, Alan A Warbritton, Harihara M Mehendale. Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes. Toxicology and applied pharmacology. 2006 Sep; 215(2):146-57. doi: 10.1016/j.taap.2006.01.018. [PMID: 16546232]
  • Midhun C Korrapati, Jaya Chilakapati, Edward A Lock, John R Latendresse, Alan Warbritton, Harihara M Mehendale. Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice. American journal of physiology. Renal physiology. 2006 Aug; 291(2):F439-55. doi: 10.1152/ajprenal.00384.2005. [PMID: 16495211]
  • J M Pombrio, A Giangreco, L Li, M F Wempe, M W Anders, D H Sweet, J B Pritchard, N Ballatori. Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1. Molecular pharmacology. 2001 Nov; 60(5):1091-9. doi: 10.1124/mol.60.5.1091. [PMID: 11641438]
  • E Rosner, W Dekant. Stereoselective formation of glutathione S-conjugates from halovinylmercapturate sulphoxides. Xenobiotica; the fate of foreign compounds in biological systems. 1999 Apr; 29(4):327-40. doi: 10.1080/004982599238533. [PMID: 10375004]
  • E A Lock, Y Sani, R B Moore, M B Finkelstein, M W Anders, A A Seawright. Bone marrow and renal injury associated with haloalkene cysteine conjugates in calves. Archives of toxicology. 1996; 70(10):607-19. doi: 10.1007/s002040050319. [PMID: 8870953]
  • W H Dantzler, K K Evans, S H Wright. Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules. The Journal of pharmacology and experimental therapeutics. 1995 Feb; 272(2):663-72. doi: NULL. [PMID: 7853180]
  • G Birner, S Vamvakas, W Dekant, D Henschler. Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure. Environmental health perspectives. 1993 Mar; 99(?):281-4. doi: 10.1289/ehp.9399281. [PMID: 8319644]
  • J N Commandeur, P J Boogaard, G J Mulder, N P Vermeulen. Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene. Archives of toxicology. 1991; 65(5):373-80. doi: 10.1007/bf02284259. [PMID: 1929851]
  • J N Commandeur, N P Vermeulen. Identification of N-acetyl(2,2-dichlorovinyl)- and N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in the rat. Chemical research in toxicology. 1990 May; 3(3):212-8. doi: 10.1021/tx00015a005. [PMID: 1966701]
  • W Dekant, M Koob, D Henschler. Metabolism of trichloroethene--in vivo and in vitro evidence for activation by glutathione conjugation. Chemico-biological interactions. 1990; 73(1):89-101. doi: 10.1016/0009-2797(90)90110-9. [PMID: 2302745]
  • G H Zhang, J L Stevens. Transport and activation of S-(1,2-dichlorovinyl)-L-cysteine and N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine in rat kidney proximal tubules. Toxicology and applied pharmacology. 1989 Aug; 100(1):51-61. doi: 10.1016/0041-008x(89)90091-4. [PMID: 2763302]
  • W Kanhai, W Dekant, D Henschler. Metabolism of the nephrotoxin dichloroacetylene by glutathione conjugation. Chemical research in toxicology. 1989 Jan; 2(1):51-6. doi: 10.1021/tx00007a009. [PMID: 2519231]
  • S Vamvakas, A A Elfarra, W Dekant, D Henschler, M W Anders. Mutagenicity of amino acid and glutathione S-conjugates in the Ames test. Mutation research. 1988 Sep; 206(1):83-90. doi: 10.1016/0165-1218(88)90144-9. [PMID: 2901035]
  • S Vamvakas, W Dekant, K Berthold, S Schmidt, D Wild, D Henschler. Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates. Biochemical pharmacology. 1987 Sep; 36(17):2741-8. doi: 10.1016/0006-2952(87)90258-9. [PMID: 3307787]
  • W Dekant, M Metzler, D Henschler. Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats. Biochemical pharmacology. 1986 Aug; 35(15):2455-8. doi: 10.1016/0006-2952(86)90039-0. [PMID: 3741453]