Tilidine, (-)- (BioDeep_00000843946)

   

Volatile Flavor Compounds


代谢物信息卡片


Tilidine, (-)-

化学式: C17H23NO2 (273.1728698)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C1(CCC=CC1N(C)C)C2=CC=CC=C2
InChI: InChI=1S/C17H23NO2/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3/h5-8,10-12,15H,4,9,13H2,1-3H3/t15-,17+/m0/s1

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
N - Nervous system > N02 - Analgesics > N02A - Opioids

同义名列表

2 个代谢物同义名

Tilidine, (-)-; Dextilidine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • C Wolfert, M Merbach, G Stammler, O Emrich, A D Meid, J Burhenne, A Blank, G Mikus. [Management of chronic pain using extended release tilidine : Quality of life and implication of comedication on tilidine metabolism]. Schmerz (Berlin, Germany). 2017 10; 31(5):516-523. doi: 10.1007/s00482-017-0228-8. [PMID: 28597312]
  • Christine Eichbaum, Kristin Mathes, Jürgen Burhenne, Christoph Markert, Antje Blank, Gerd Mikus. Pre-systemic elimination of tilidine: localization and consequences for the formation of the active metabolite nortilidine. Basic & clinical pharmacology & toxicology. 2015 Feb; 116(2):129-33. doi: 10.1111/bcpt.12328. [PMID: 25223231]
  • Barbara Grün, Ulrike Merkel, Klaus-Dieter Riedel, Johanna Weiss, Gerd Mikus. Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine. British journal of clinical pharmacology. 2012 Nov; 74(5):854-63. doi: 10.1111/j.1365-2125.2012.04261.x. [PMID: 22381043]
  • Justin J J van der Hooft, Ric C H de Vos, Velitchka Mihaleva, Raoul J Bino, Lars Ridder, Niels de Roo, Doris M Jacobs, John P M van Duynhoven, Jacques Vervoort. Structural elucidation and quantification of phenolic conjugates present in human urine after tea intake. Analytical chemistry. 2012 Aug; 84(16):7263-71. doi: 10.1021/ac3017339. [PMID: 22827565]
  • Ruth Verplaetse, Jan Tytgat. Development and validation of a sensitive UPLC-MS/MS method for the analysis of narcotic analgesics in urine and whole blood in forensic context. Forensic science international. 2012 Feb; 215(1-3):136-45. doi: 10.1016/j.forsciint.2011.01.047. [PMID: 21356580]
  • Canli Zhang, Ruichao Zhang, Na Na, Joris R Delanghe, Jin Ouyang. Direct monitoring changes of salbutamol concentration in serum by chemiluminescent imaging. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jul; 879(22):2089-94. doi: 10.1016/j.jchromb.2011.05.040. [PMID: 21684222]
  • Christoph Köhler, Thomas Grobosch, Torsten Binscheck. Rapid quantification of tilidine, nortilidine, and bisnortilidine in urine by automated online SPE-LC-MS/MS. Analytical and bioanalytical chemistry. 2011 Apr; 400(1):17-23. doi: 10.1007/s00216-010-4466-1. [PMID: 21140136]
  • Barbara Grün, Stefanie Krautter, Klaus-Dieter Riedel, Gerd Mikus. Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole. British journal of clinical pharmacology. 2009 Nov; 68(5):712-20. doi: 10.1111/j.1365-2125.2009.03498.x. [PMID: 19916995]
  • Annette Thierauf, Reinhard Dettmeyer, Heike Wollersen, Burkhard Madea. Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman. Forensic science international. 2007 Dec; 173(2-3):178-81. doi: 10.1016/j.forsciint.2007.01.001. [PMID: 17317059]
  • Ulrich Brennscheidt, Ulrike Brunnmüller, Dietfried Proppe, Peter Thomann, Klaus-Ulrich Seiler. Pharmacokinetics of tilidine and naloxone in patients with severe hepatic impairment. Arzneimittel-Forschung. 2007; 57(2):106-11. doi: 10.1055/s-0031-1296591. [PMID: 17396621]
  • F Musshoff, J Trafkowski, U Kuepper, B Madea. An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites. Journal of mass spectrometry : JMS. 2006 May; 41(5):633-40. doi: 10.1002/jms.1021. [PMID: 16541404]
  • Jacek Piotr Hajda, Eberhard Jähnchen, Svein Oie, Dietmar Trenk. Sequential first-pass metabolism of nortilidine: the active metabolite of the synthetic opioid drug tilidine. Journal of clinical pharmacology. 2002 Nov; 42(11):1257-61. doi: 10.1177/009127002762491352. [PMID: 12412825]
  • K U Seiler, E Jähnchen, D Trenk, U Brennscheidt, B Heintz. Pharmacokinetics of tilidine in terminal renal failure. Journal of clinical pharmacology. 2001 Jan; 41(1):79-84. doi: 10.1177/00912700122009863. [PMID: 11144998]
  • P Högger. Adverse effects of opioid analgesic treatment are correlated with a significant elevation in plasma epinephrine in healthy humans. European journal of clinical pharmacology. 2000 Sep; 56(6-7):463-8. doi: 10.1007/s002280000175. [PMID: 11049008]
  • P Högger, P Rohdewald. Comparison of tilidine/naloxone, tramadol and bromfenac in experimental pain: a double-blind randomized crossover study in healthy human volunteers. International journal of clinical pharmacology and therapeutics. 1999 Aug; 37(8):377-85. doi: NULL. [PMID: 10475140]
  • W Martin, J Ring, M Gaupp, P Arnold, R Sennewald, K Doser. Bioavailability investigation of a new tilidine/naloxone liquid formulation compared to a reference formulation. Arzneimittel-Forschung. 1999 Jul; 49(7):599-607. doi: 10.1055/s-0031-1300469. [PMID: 10442208]
  • R Regenthal, M Krüger, M Richter, R Preiss. Poisoning with tilidine and naloxone: toxicokinetic and clinical observations. Human & experimental toxicology. 1998 Nov; 17(11):593-7. doi: 10.1177/096032719801701101. [PMID: 9865414]
  • S Bolze, R Boulieu. HPLC determination of ketamine, norketamine, and dehydronorketamine in plasma with a high-purity reversed-phase sorbent. Clinical chemistry. 1998 Mar; 44(3):560-4. doi: 10.1093/clinchem/44.3.560. [PMID: 9510862]
  • K O Vollmer, P Thomann, H Hengy. Pharmacokinetics of tilidine and metabolites in man. Arzneimittel-Forschung. 1989 Oct; 39(10):1283-8. doi: NULL. [PMID: 2610722]
  • J Cordonnier, A Wauters, A Heyndrickx. Comparison of a GLC-NPD method with a GLC-MS-SIM procedure for the determination of tilidine and its metabolites in plasma. Journal of analytical toxicology. 1987 Jul; 11(4):144-8. doi: 10.1093/jat/11.4.144. [PMID: 3626526]
  • E J McGuire, C J DiFonzo, R A Martin, F A de la Iglesia. Evaluation of chronic toxicity and carcinogenesis in rodents with the synthetic analgesic, tilidine fumarate. Toxicology. 1986 May; 39(2):149-63. doi: 10.1016/0300-483x(86)90132-0. [PMID: 3705081]
  • H Hengy, K O Vollmer, V Gladigau. GLC determination of tilidine, nortilidine, and bisnortilidine in biological fluids with a nitrogen-sensitive detector. Journal of pharmaceutical sciences. 1978 Dec; 67(12):1765-8. doi: 10.1002/jps.2600671237. [PMID: 722500]
  • H Hengy, K O Vollmer, V Gladigau. Gas-chromatographic determination of nanogram amounts of enantiomers of nortilidine, a main metabolite of tilidine, in biological specimens. Clinical chemistry. 1978 Apr; 24(4):692-7. doi: 10.1093/clinchem/24.4.692. [PMID: 639277]
  • I Jurna, W Ehrenthal, K Pfleger. Tolerance to morphine induced by chronic treatment with tilidine. Naunyn-Schmiedeberg's archives of pharmacology. 1977 Jun; 298(2):193-5. doi: 10.1007/bf00508629. [PMID: 882158]
  • K O Vollmer, A V Hodenberg. [Metabolism of DL-trans-2-dimethylamino-1-phenyl-cyclohex-3-ene-trans-1-carboxylic acid ester hydrochloride (Tilidine HC1). 3. Renal elimination of metabolites in the rat, dog and man]. Arzneimittel-Forschung. 1977; 27(9):1707-13. doi: NULL. [PMID: 21670]
  • M Van Boven, P Daenens, N Bruneel. A death case involving tilidine. Archives of toxicology. 1976 Oct; 36(2):121-5. doi: 10.1007/bf00351971. [PMID: 1036886]
  • K O Vollmer, A Poisson. [ On the metabolism of ethyl-DL-trans-2-dimethylamino-1-phenyl-cyclohex-3-ene-trans-1-carboxylate-hydrochloride (Tilidine-HCl). 2nd Communication: Studies with 14C-labelled substance on rats and dogs]. Arzneimittel-Forschung. 1976; 26(10):1827-36. doi: NULL. [PMID: 1037201]
  • L Ringwelski. [Analog computer analysis of radioactivity kinetics in man following oral administration of tilidine HCl-14C]. International journal of clinical pharmacology and biopharmacy. 1975 Mar; 11(2):177-84. doi: NULL. [PMID: 1140877]
  • G Holzmann, P H Kreutzer, K Roth. [Metabolism of trans-tilidine: isolation and identification of the metabolite from human urine (author's transl)]. Archiv der Pharmazie. 1975 Mar; 308(3):169-78. doi: 10.1002/ardp.19753080303. [PMID: 1130954]