N-(4,4-Diphenyl-3-butenyl)nipecotic acid (BioDeep_00000843932)

   


代谢物信息卡片


N-(4,4-Diphenyl-3-butenyl)nipecotic acid

化学式: C22H25NO2 (335.1885)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(CN(C1)CCC=C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O
InChI: InChI=1S/C22H25NO2/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25)

描述信息

D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D018377 - Neurotransmitter Agents > D018682 - GABA Agents

同义名列表

1 个代谢物同义名

N-(4,4-Diphenyl-3-butenyl)nipecotic acid



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Felix Kern, Klaus T Wanner. Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1. Bioorganic & medicinal chemistry. 2019 04; 27(7):1232-1245. doi: 10.1016/j.bmc.2019.02.015. [PMID: 30777661]
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  • Norio Sogawa, Yuri Hazehara, Muneyoshi Kunitomo, Yuya Morita, Bupsang Yoo, Kazumi Ohyama, Chiharu Sogawa, Shigeo Kitayama. Age-dependent changes in the susceptibility to thiopental anesthesia in mice: analysis of the relationship to the functional expression of GABA transporter. Pharmacology, biochemistry, and behavior. 2012 Dec; 103(2):267-72. doi: 10.1016/j.pbb.2012.08.027. [PMID: 22963929]
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  • Mark R Faust, Georg Höfner, Jörg Pabel, Klaus T Wanner. Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. European journal of medicinal chemistry. 2010 Jun; 45(6):2453-66. doi: 10.1016/j.ejmech.2010.02.029. [PMID: 20219271]
  • Adriana Galvan, Xing Hu, Yoland Smith, Thomas Wichmann. Localization and function of GABA transporters in the globus pallidus of parkinsonian monkeys. Experimental neurology. 2010 Jun; 223(2):505-15. doi: 10.1016/j.expneurol.2010.01.018. [PMID: 20138865]
  • Marco Milanese, Simona Zappettini, Emanuela Jacchetti, Tiziana Bonifacino, Chiara Cervetto, Cesare Usai, Giambattista Bonanno. In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis. Journal of neurochemistry. 2010 Apr; 113(2):489-501. doi: 10.1111/j.1471-4159.2010.06628.x. [PMID: 20132478]
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  • Andrea Kragler, Georg Höfner, Klaus T Wanner. Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4. European journal of medicinal chemistry. 2008 Nov; 43(11):2404-11. doi: 10.1016/j.ejmech.2008.01.005. [PMID: 18395300]
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