3-Pyridinecarboxylic acid, 1-(2-(((diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro- (BioDeep_00000843921)

   


代谢物信息卡片


3-Pyridinecarboxylic acid, 1-(2-(((diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-

化学式: C21H22N2O3 (350.16303419999997)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CC(=C1)C(=O)O)CCON=C(C2=CC=CC=C2)C3=CC=CC=C3
InChI: InChI=1S/C21H22N2O3/c24-21(25)19-12-7-13-23(16-19)14-15-26-22-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-6,8-12H,7,13-16H2,(H,24,25)

描述信息

D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018756 - GABA Antagonists
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
D049990 - Membrane Transport Modulators

同义名列表

1 个代谢物同义名

3-Pyridinecarboxylic acid, 1-(2-(((diphenylmethylene)amino)oxy)ethyl)-1,2,5,6-tetrahydro-



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Shuxuan Lyu, Yuan Guo, Li Zhang, Yong Wang, Guoyi Tang, Ruotong Li, Jie Yang, Shasha Gao, Borui Ma, Jian Liu. Blockade of GABA transporter-1 and GABA transporter-3 in the lateral habenula improves depressive-like behaviors in a rat model of Parkinson's disease. Neuropharmacology. 2020 12; 181(?):108369. doi: 10.1016/j.neuropharm.2020.108369. [PMID: 33096108]
  • Paula Zaręba, Beata Gryzło, Katarzyna Malawska, Kinga Sałat, Georg C Höfner, Alicja Nowaczyk, Łukasz Fijałkowski, Anna Rapacz, Adrian Podkowa, Anna Furgała, Paweł Żmudzki, Klaus T Wanner, Barbara Malawska, Katarzyna Kulig. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. European journal of medicinal chemistry. 2020 Feb; 188(?):111920. doi: 10.1016/j.ejmech.2019.111920. [PMID: 31901745]
  • Simone K Huber, Georg Höfner, Klaus T Wanner. Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of γ-aminobutyric acid transporter 1 (GAT1). Bioorganic & medicinal chemistry. 2019 07; 27(13):2753-2763. doi: 10.1016/j.bmc.2019.05.001. [PMID: 31097402]
  • Felix Kern, Klaus T Wanner. Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1. Bioorganic & medicinal chemistry. 2019 04; 27(7):1232-1245. doi: 10.1016/j.bmc.2019.02.015. [PMID: 30777661]
  • Tobias J Hauke, Thomas Wein, Georg Höfner, Klaus T Wanner. Novel Allosteric Ligands of γ-Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries. Journal of medicinal chemistry. 2018 11; 61(22):10310-10332. doi: 10.1021/acs.jmedchem.8b01602. [PMID: 30376325]
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  • Xiaofeng Ma, Hodney Lubin, Enikő Ioja, Orsolya Kékesi, Ágnes Simon, Ágota Apáti, Tamás I Orbán, László Héja, Julianna Kardos, István E Markó. Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes. Bioorganic & medicinal chemistry letters. 2016 Jan; 26(2):417-423. doi: 10.1016/j.bmcl.2015.11.100. [PMID: 26706177]
  • Jonathan Stephan, Eckhard Friauf. Functional analysis of the inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in astrocytes of the lateral superior olive. Glia. 2014 Dec; 62(12):1992-2003. doi: 10.1002/glia.22720. [PMID: 25103283]
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  • Hong-Yan Liu, Yu-Xiang Li, Yin-Ju Hao, Hai-Yan Wang, Xiu-Ying Dai, Tao Sun, Jian-Qiang Yu. Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice. CNS neuroscience & therapeutics. 2012 Dec; 18(12):1030-2. doi: 10.1111/cns.12026. [PMID: 23164255]
  • Norio Sogawa, Yuri Hazehara, Muneyoshi Kunitomo, Yuya Morita, Bupsang Yoo, Kazumi Ohyama, Chiharu Sogawa, Shigeo Kitayama. Age-dependent changes in the susceptibility to thiopental anesthesia in mice: analysis of the relationship to the functional expression of GABA transporter. Pharmacology, biochemistry, and behavior. 2012 Dec; 103(2):267-72. doi: 10.1016/j.pbb.2012.08.027. [PMID: 22963929]
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  • Anton Dvorzhak, Olga Myakhar, Petr Unichenko, Knut Kirmse, Sergei Kirischuk. Estimation of ambient GABA levels in layer I of the mouse neonatal cortex in brain slices. The Journal of physiology. 2010 Jul; 588(Pt 13):2351-60. doi: 10.1113/jphysiol.2010.187054. [PMID: 20421290]
  • Georg Höfner, Klaus Theodor Wanner. Using short columns to speed up LC-MS quantification in MS binding assays. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 May; 878(17-18):1356-64. doi: 10.1016/j.jchromb.2009.12.006. [PMID: 20036623]
  • Guillermo Gonzalez-Burgos, Diana C Rotaru, Aleksey V Zaitsev, Nadezhda V Povysheva, David A Lewis. GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons. Journal of neurophysiology. 2009 Feb; 101(2):533-47. doi: 10.1152/jn.91161.2008. [PMID: 19073797]
  • Andrea Kragler, Georg Höfner, Klaus T Wanner. Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4. European journal of medicinal chemistry. 2008 Nov; 43(11):2404-11. doi: 10.1016/j.ejmech.2008.01.005. [PMID: 18395300]
  • Christine Zepperitz, Georg Höfner, Klaus T Wanner. Expanding the scope of MS binding assays to low-affinity markers as exemplified for mGAT1. Analytical and bioanalytical chemistry. 2008 May; 391(1):309-16. doi: 10.1007/s00216-008-1956-5. [PMID: 18345533]
  • Yin Fang Xu, You Qing Cai, Guo Qiang Cai, Jie Jiang, Zhe Jing Sheng, Zhu Gang Wang, Jian Fei. Hypoalgesia in mice lacking GABA transporter subtype 1. Journal of neuroscience research. 2008 Feb; 86(2):465-70. doi: 10.1002/jnr.21499. [PMID: 17918738]
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  • Ivan Marchionni, Azar Omrani, Enrico Cherubini. In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells. The Journal of physiology. 2007 Jun; 581(Pt 2):515-28. doi: 10.1113/jphysiol.2006.125609. [PMID: 17317750]
  • Sampsa T Sipilä, Juha Voipio, Kai Kaila. GAT-1 acts to limit a tonic GABA(A) current in rat CA3 pyramidal neurons at birth. The European journal of neuroscience. 2007 Feb; 25(3):717-22. doi: 10.1111/j.1460-9568.2007.05342.x. [PMID: 17298599]
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  • Sampsa Sipilä, Kristiina Huttu, Juha Voipio, Kai Kaila. GABA uptake via GABA transporter-1 modulates GABAergic transmission in the immature hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Jun; 24(26):5877-80. doi: 10.1523/jneurosci.1287-04.2004. [PMID: 15229234]
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  • J-H Hu, Y-H Ma, N Yang, Z-T Mei, M-H Zhang, J Fei, L-H Guo. Up-regulation of gamma-aminobutyric acid transporter I mediates ethanol sensitivity in mice. Neuroscience. 2004; 123(4):807-12. doi: 10.1016/j.neuroscience.2003.11.018. [PMID: 14751274]
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