8-iso-prostaglandin A2 (BioDeep_00000843911)
代谢物信息卡片
8-iso-prostaglandin A2
化学式: C20H30O4 (334.214398)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(C=CC1C=CC(=O)C1CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18-/m0/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ignacio De Las Heras-Gómez, Sonia Medina, Teresa Casas-Pina, Lidia Marín-Soler, Anna Tomás, Pedro Martínez-Hernández, Camille Oger, Jean-Marie Galano, Thierry Durand, Luisa Jimeno, Santiago Llorente, Elena Lozoya, Federico Ferreres, Ángel Gil-Izquierdo. Potential applications of lipid peroxidation products - F4-neuroprostanes, F3-neuroprostanesn-6 DPA, F2-dihomo-isoprostanes and F2-isoprostanes - in the evaluation of the allograft function in renal transplantation.
Free radical biology & medicine.
2017 03; 104(?):178-184. doi:
10.1016/j.freeradbiomed.2017.01.019. [PMID: 28089724] - Haiyan He, Yijiang Tao, Xiaoxiao Chen, Haiyan Qiu, Jie Zhu, Jianhui Zhang, Hang Ma. High levels of interleukin-6 and 8-iso-prostaglandin in the exhaled breath condensate and serum of patients with chronic obstructive pulmonary disease related pulmonary hypertension.
Chinese medical journal.
2014; 127(9):1608-12. doi:
NULL. [PMID: 24791862] - Amy C Butalla, Tracy E Crane, Bhimanagouda Patil, Betsy C Wertheim, Patricia Thompson, Cynthia A Thomson. Effects of a carrot juice intervention on plasma carotenoids, oxidative stress, and inflammation in overweight breast cancer survivors.
Nutrition and cancer.
2012; 64(2):331-41. doi:
10.1080/01635581.2012.650779. [PMID: 22292424] - Luca Puccetti, Francesca Santilli, Anna Laura Pasqui, Stefano Lattanzio, Rossella Liani, Federica Ciani, Elisabetta Ferrante, Giovanni Ciabattoni, Francesca Scarpini, Anna Ghezzi, Alberto Auteri, Giovanni Davì. Effects of atorvastatin and rosuvastatin on thromboxane-dependent platelet activation and oxidative stress in hypercholesterolemia.
Atherosclerosis.
2011 Jan; 214(1):122-8. doi:
10.1016/j.atherosclerosis.2010.10.006. [PMID: 21056418] - Stephanie L H Zeiger, Erik S Musiek, Giuseppe Zanoni, Giovanni Vidari, Jason D Morrow, Ginger J Milne, BethAnn McLaughlin. Neurotoxic lipid peroxidation species formed by ischemic stroke increase injury.
Free radical biology & medicine.
2009 Nov; 47(10):1422-31. doi:
10.1016/j.freeradbiomed.2009.08.011. [PMID: 19699297] - Maria Teresa Guagnano, Patrizia Ferroni, Francesca Santilli, Vincenzo Paoletti, Maria Rosaria Manigrasso, Lea Pescara, Chiara Cuccurullo, Giovanni Ciabattoni, Giovanni Davì. Determinants of platelet activation in hypertensives with microalbuminuria.
Free radical biology & medicine.
2009 Apr; 46(7):922-7. doi:
10.1016/j.freeradbiomed.2009.01.005. [PMID: 19280705] - Yee Ting Wong, Jan Gruber, Andrew M Jenner, Mary Pei-Ern Ng, Runsheng Ruan, Francis Eng Hock Tay. Elevation of oxidative-damage biomarkers during aging in F2 hybrid mice: protection by chronic oral intake of resveratrol.
Free radical biology & medicine.
2009 Mar; 46(6):799-809. doi:
10.1016/j.freeradbiomed.2008.12.016. [PMID: 19159678] - Jost Klawitter, Jamie Bendrick-Peart, Birgit Rudolph, Virginia Beckey, Jelena Klawitter, Manuel Haschke, Christopher Rivard, Laurence Chan, Dieter Leibfritz, Uwe Christians, Volker Schmitz. Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function.
Chemical research in toxicology.
2009 Jan; 22(1):118-28. doi:
10.1021/tx800253x. [PMID: 19099400] - Ralf A Benndorf, Edzard Schwedhelm, Anke Gnann, Raihana Taheri, Ghainsom Kom, Michael Didié, Anna Steenpass, Süleyman Ergün, Rainer H Böger. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis.
Circulation research.
2008 Oct; 103(9):1037-46. doi:
10.1161/circresaha.108.184036. [PMID: 18802021] - Kyoung-Ho Lee, Helmut Bartsch, Jagadeesan Nair, Dong-Ho Yoo, Yun-Chul Hong, Soo-Hun Cho, Daehee Kang. Effect of short-term fasting on urinary excretion of primary lipid peroxidation products and on markers of oxidative DNA damage in healthy women.
Carcinogenesis.
2006 Jul; 27(7):1398-403. doi:
10.1093/carcin/bgi337. [PMID: 16401636] - Erik S Musiek, Rebecca S Breeding, Ginger L Milne, Giuseppe Zanoni, Jason D Morrow, Bethann McLaughlin. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration.
Journal of neurochemistry.
2006 Jun; 97(5):1301-13. doi:
10.1111/j.1471-4159.2006.03797.x. [PMID: 16638022] - Nalan Ciçek Ozdöl, Aşkin Ateş, Olcay Tiryaki Aydintuğ, Mehmet Melli. Urinary 8-isoprostaglandin F(2alpha) level in Behçet's disease.
Prostaglandins & other lipid mediators.
2005 Dec; 78(1-4):96-106. doi:
10.1016/j.prostaglandins.2005.04.002. [PMID: 16303608] - Anna-Liisa Levonen, Aimee Landar, Anup Ramachandran, Erin K Ceaser, Dale A Dickinson, Giuseppe Zanoni, Jason D Morrow, Victor M Darley-Usmar. Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.
The Biochemical journal.
2004 Mar; 378(Pt 2):373-82. doi:
10.1042/bj20031049. [PMID: 14616092] - Ginger L Milne, Giuseppe Zanoni, Alessio Porta, Soumya Sasi, Giovanni Vidari, Erik S Musiek, Michael L Freeman, Jason D Morrow. The cyclopentenone product of lipid peroxidation, 15-A2t-isoprostane, is efficiently metabolized by HepG2 cells via conjugation with glutathione.
Chemical research in toxicology.
2004 Jan; 17(1):17-25. doi:
10.1021/tx034213o. [PMID: 14727915] - J Belik, R P Jankov, J Pan, M Yi, C R Pace-Asciak, A K Tanswell. Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium.
Journal of applied physiology (Bethesda, Md. : 1985).
2003 Nov; 95(5):1979-85. doi:
10.1152/japplphysiol.00420.2003. [PMID: 12857766] - Ina Hubatsch, Bengt Mannervik, Ling Gao, L Jackson Roberts, Yan Chen, Jason D Morrow. The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4.
Chemical research in toxicology.
2002 Sep; 15(9):1114-8. doi:
10.1021/tx020027r. [PMID: 12230403] - S Basu, M Eriksson. Lipid peroxidation induced by an early inflammatory response in endotoxaemia.
Acta anaesthesiologica Scandinavica.
2000 Jan; 44(1):17-23. doi:
10.1034/j.1399-6576.2000.440104.x. [PMID: 10669266]