S-(1,2-Dichlorovinyl)-L-cysteine (BioDeep_00000843902)
代谢物信息卡片
S-(1,2-Dichlorovinyl)-L-cysteine
化学式: C5H7Cl2NO2S (214.9574542)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(=O)O)N)SC(=CCl)Cl
InChI: InChI=1S/C5H7Cl2NO2S/c6-1-4(7)11-2-3(8)5(9)10/h1,3H,2,8H2,(H,9,10)/t3-/m0/s1
描述信息
An L-alpha-amino acid that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a 1,2-dichlorovinyl group.
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:46650
- ChEBI: CHEBI:46654
- PubChem: 6433207
- ChEMBL: CHEMBL2311075
- CAS: 1932786-76-9
- CAS: 13419-46-0
- CAS: 1948-28-3
- CAS: 627-72-5
- MetaboLights: MTBLC46650
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Elana R Elkin, Kelly M Bakulski, Justin A Colacino, Dave Bridges, Brian A Kilburn, D Randall Armant, Rita Loch-Caruso. Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models.
Archives of toxicology.
2021 05; 95(5):1595-1619. doi:
10.1007/s00204-021-03011-5. [PMID: 33725128] - Elana R Elkin, Dave Bridges, Sean M Harris, Rita Karen Loch-Caruso. Exposure to Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells.
Chemical research in toxicology.
2020 06; 33(6):1339-1355. doi:
10.1021/acs.chemrestox.9b00356. [PMID: 31951115] - Chiara Formica, Tareq Malas, Judit Balog, Lotte Verburg, Peter A C 't Hoen, Dorien J M Peters. Characterisation of transcription factor profiles in polycystic kidney disease (PKD): identification and validation of STAT3 and RUNX1 in the injury/repair response and PKD progression.
Journal of molecular medicine (Berlin, Germany).
2019 12; 97(12):1643-1656. doi:
10.1007/s00109-019-01852-3. [PMID: 31773180] - Elana R Elkin, Dave Bridges, Rita Loch-Caruso. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts.
Toxicology.
2019 11; 427(?):152283. doi:
10.1016/j.tox.2019.152283. [PMID: 31476333] - Chiara Formica, Hester Happé, Kimberley Am Veraar, Andrea Vortkamp, Marion Scharpfenecker, Helen McNeill, Dorien Jm Peters. Four-jointed knock-out delays renal failure in an ADPKD model with kidney injury.
The Journal of pathology.
2019 09; 249(1):114-125. doi:
10.1002/path.5286. [PMID: 31038742] - Yu-Syuan Luo, Shinji Furuya, Weihsueh Chiu, Ivan Rusyn. Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.
Journal of toxicology and environmental health. Part A.
2018; 81(1-3):37-52. doi:
10.1080/15287394.2017.1408512. [PMID: 29190187] - Elana R Elkin, Sean M Harris, Rita Loch-Caruso. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line.
Toxicology and applied pharmacology.
2018 01; 338(?):30-42. doi:
10.1016/j.taap.2017.11.006. [PMID: 29129777] - Iman Hassan, Anjana M Kumar, Hae-Ryung Park, Lawrence H Lash, Rita Loch-Caruso. Reactive Oxygen Stimulation of Interleukin-6 Release in the Human Trophoblast Cell Line HTR-8/SVneo by the Trichlorethylene Metabolite S-(1,2-Dichloro)-l-Cysteine.
Biology of reproduction.
2016 09; 95(3):66. doi:
10.1095/biolreprod.116.139261. [PMID: 27488030] - Hong Sik Yoo, Blair U Bradford, Oksana Kosyk, Takeki Uehara, Svitlana Shymonyak, Leonard B Collins, Wanda M Bodnar, Louise M Ball, Avram Gold, Ivan Rusyn. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.
Journal of toxicology and environmental health. Part A.
2015; 78(1):32-49. doi:
10.1080/15287394.2015.958418. [PMID: 25424545] - Hong Sik Yoo, Blair U Bradford, Oksana Kosyk, Svitlana Shymonyak, Takeki Uehara, Leonard B Collins, Wanda M Bodnar, Louise M Ball, Avram Gold, Ivan Rusyn. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.
Journal of toxicology and environmental health. Part A.
2015; 78(1):15-31. doi:
10.1080/15287394.2015.958417. [PMID: 25424544] - Roy M Irving, Adnan A Elfarra. Role of reactive metabolites in the circulation in extrahepatic toxicity.
Expert opinion on drug metabolism & toxicology.
2012 Sep; 8(9):1157-72. doi:
10.1517/17425255.2012.695347. [PMID: 22681489] - Nobuaki Shirai, Mareki Ohtsuji, Keitaro Hagiwara, Hiroki Tomisawa, Naomi Ohtsuji, Sachiko Hirose, Hiromi Hagiwara. Nephrotoxic effect of subchronic exposure to S-(1,2-dichlorovinyl)-L-cysteine in mice.
The Journal of toxicological sciences.
2012; 37(5):871-8. doi:
10.2131/jts.37.871. [PMID: 23037997] - Roy M Irving, Mark S Brownfield, Adnan A Elfarra. N-biotinyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide as a potential model for S-(1,2-dichlorovinyl)-L-cysteine sulfoxide: characterization of stability and reactivity with glutathione and kidney proteins in vitro.
Chemical research in toxicology.
2011 Nov; 24(11):1915-23. doi:
10.1021/tx200263n. [PMID: 21988407] - Hester Happé, Annemieke M van der Wal, Wouter N Leonhard, Steven J Kunnen, Martijn H Breuning, Emile de Heer, Dorien J M Peters. Altered Hippo signalling in polycystic kidney disease.
The Journal of pathology.
2011 May; 224(1):133-42. doi:
10.1002/path.2856. [PMID: 21381034] - Sungkyoon Kim, Leonard B Collins, Gunnar Boysen, James A Swenberg, Avram Gold, Louise M Ball, Blair U Bradford, Ivan Rusyn. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine.
Toxicology.
2009 Aug; 262(3):230-8. doi:
10.1016/j.tox.2009.06.013. [PMID: 19549554] - Feng Xu, Irene Papanayotou, David A Putt, Jian Wang, Lawrence H Lash. Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Biochemical pharmacology.
2008 Aug; 76(4):552-67. doi:
10.1016/j.bcp.2008.05.016. [PMID: 18602084] - Zabeena P Shaik, E Kim Fifer, Grazyna Nowak. Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury.
American journal of physiology. Renal physiology.
2008 Feb; 294(2):F423-32. doi:
10.1152/ajprenal.00463.2007. [PMID: 18077599] - Philip Clay. Assessment of the genotoxicity of trichloroethylene and its metabolite, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), in the comet assay in rat kidney.
Mutagenesis.
2008 Jan; 23(1):27-33. doi:
10.1093/mutage/gem034. [PMID: 18003627] - Nella Barshteyn, Adnan A Elfarra. Formation of three N-acetyl-L-cysteine monoadducts and one diadduct by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with N-acetyl-L-cysteine at physiological conditions: chemical mechanisms and toxicological implications.
Chemical research in toxicology.
2007 Oct; 20(10):1563-9. doi:
10.1021/tx700263w. [PMID: 17892265] - Midhun C Korrapati, Jaya Chilakapati, Frank A Witzmann, Chundury Rao, Edward A Lock, Harihara M Mehendale. Proteomics of S-(1, 2-dichlorovinyl)-L-cysteine-induced acute renal failure and autoprotection in mice.
American journal of physiology. Renal physiology.
2007 Oct; 293(4):F994-F1006. doi:
10.1152/ajprenal.00114.2007. [PMID: 17581926] - Marjo de Graauw, Sylvia Le Dévédec, Ine Tijdens, Mirjam B Smeets, André M Deelder, Bob van de Water. Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells.
The Journal of pharmacology and experimental therapeutics.
2007 Jul; 322(1):89-100. doi:
10.1124/jpet.106.117689. [PMID: 17442843] - Lawrence H Lash, David A Putt, Sarah E Hueni, Scott G Payton, Joshua Zwickl. Interactive toxicity of inorganic mercury and trichloroethylene in rat and human proximal tubules: effects on apoptosis, necrosis, and glutathione status.
Toxicology and applied pharmacology.
2007 Jun; 221(3):349-62. doi:
10.1016/j.taap.2007.03.023. [PMID: 17481684] - Zabeena P Shaik, E Kim Fifer, Grazyna Nowak. Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells.
American journal of physiology. Renal physiology.
2007 Jan; 292(1):F292-303. doi:
10.1152/ajprenal.00082.2006. [PMID: 16940564] - Edward A Lock, Jeremy L Barth, Scott W Argraves, Rick G Schnellmann. Changes in gene expression in human renal proximal tubule cells exposed to low concentrations of S-(1,2-dichlorovinyl)-l-cysteine, a metabolite of trichloroethylene.
Toxicology and applied pharmacology.
2006 Oct; 216(2):319-30. doi:
10.1016/j.taap.2006.06.002. [PMID: 16844155] - Jane C Caldwell, Nagalakshmi Keshava. Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Environmental health perspectives.
2006 Sep; 114(9):1457-63. doi:
10.1289/ehp.8692. [PMID: 16966105] - Midhun C Korrapati, Jaya Chilakapati, Edward A Lock, John R Latendresse, Alan Warbritton, Harihara M Mehendale. Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice.
American journal of physiology. Renal physiology.
2006 Aug; 291(2):F439-55. doi:
10.1152/ajprenal.00384.2005. [PMID: 16495211] - Angela Mally, Cheryl L Walker, Jeffrey I Everitt, Wolfgang Dekant, Spiros Vamvakas. Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichlorovinyl)-L-cysteine in vitro.
Toxicology.
2006 Jul; 224(1-2):108-18. doi:
10.1016/j.tox.2006.04.036. [PMID: 16730402] - Ramesh N Reddy, John R Latendresse, Harihara M Mehendale. Colchicine antimitosis causes progression of S-(1,2-dichlorovinyl)-L-cysteine-induced injury leading to acute renal failure and death in mice.
Toxicology.
2006 Mar; 220(2-3):147-59. doi:
10.1016/j.tox.2005.12.012. [PMID: 16457931] - Ankur V Dnyanmote, Sharmilee P Sawant, Edward A Lock, John R Latendresse, Alan A Warbritton, Harihara M Mehendale. Diabetic mice are protected from normally lethal nephrotoxicity of S-1,2-dichlorovinyl-L-cysteine (DCVC): role of nephrogenic tissue repair.
Toxicology and applied pharmacology.
2006 Mar; 211(2):133-47. doi:
10.1016/j.taap.2005.07.015. [PMID: 16125744] - Marjo de Graauw, Ine Tijdens, Rainer Cramer, Steve Corless, John F Timms, Bob van de Water. Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis.
The Journal of biological chemistry.
2005 Aug; 280(33):29885-98. doi:
10.1074/jbc.m412708200. [PMID: 15944157] - Lawrence H Lash, David A Putt, Sarah E Hueni, Beth P Horwitz. Molecular markers of trichloroethylene-induced toxicity in human kidney cells.
Toxicology and applied pharmacology.
2005 Aug; 206(2):157-68. doi:
10.1016/j.taap.2004.09.023. [PMID: 15967204] - Midhun C Korrapati, Edward A Lock, Harihara M Mehendale. Molecular mechanisms of enhanced renal cell division in protection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death.
American journal of physiology. Renal physiology.
2005 Jul; 289(1):F175-85. doi:
10.1152/ajprenal.00418.2004. [PMID: 15741605] - Xiuli Liu, Malinda L Godwin, Grazyna Nowak. Protein kinase C-alpha inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-L-cysteine injury in renal cells.
American journal of physiology. Renal physiology.
2004 Jul; 287(1):F64-73. doi:
10.1152/ajprenal.00216.2003. [PMID: 14996667] - Vishal S Vaidya, Kartik Shankar, Edward A Lock, Darlene Dixon, Harihara M Mehendale. Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway.
Toxicologic pathology.
2003 Nov; 31(6):604-18. doi:
10.1080/01926230390241945. [PMID: 14585728] - Shelley Brown DuTeaux, Matt J Hengel, Danica E DeGroot, Karen A Jelks, Marion G Miller. Evidence for trichloroethylene bioactivation and adduct formation in the rat epididymis and efferent ducts.
Biology of reproduction.
2003 Sep; 69(3):771-9. doi:
10.1095/biolreprod.102.014845. [PMID: 12724279] - Trevor A McGoldrick, Edward A Lock, Vicente Rodilla, Gabrielle M Hawksworth. Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells.
Archives of toxicology.
2003 Jul; 77(7):365-70. doi:
10.1007/s00204-003-0459-6. [PMID: 12700887] - Vishal S Vaidya, Kartik Shankar, Edward A Lock, Thomas J Bucci, Harihara M Mehendale. Role of tissue repair in survival from s-(1,2-dichlorovinyl)-L-cysteine-induced acute renal tubular necrosis in the mouse.
Toxicological sciences : an official journal of the Society of Toxicology.
2003 Jul; 74(1):215-27. doi:
10.1093/toxsci/kfg111. [PMID: 12730612] - Grazyna Nowak. Protein kinase C mediates repair of mitochondrial and transport functions after toxicant-induced injury in renal cells.
The Journal of pharmacology and experimental therapeutics.
2003 Jul; 306(1):157-65. doi:
10.1124/jpet.103.050336. [PMID: 12665543] - Lawrence H Lash, David A Putt, Sarah E Hueni, Renee J Krause, Adnan A Elfarra. Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells.
The Journal of pharmacology and experimental therapeutics.
2003 Jun; 305(3):1163-72. doi:
10.1124/jpet.102.046185. [PMID: 12626654] - Vishal S Vaidya, Kartik Shankar, Edward A Lock, Thomas J Bucci, Harihara M Mehendale. Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice.
Toxicology and applied pharmacology.
2003 Apr; 188(2):110-21. doi:
10.1016/s0041-008x(02)00080-7. [PMID: 12691729] - Renee J Krause, Lawrence H Lash, Adnan A Elfarra. Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity.
The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):185-91. doi:
10.1124/jpet.102.042911. [PMID: 12490590] - Lawrence H Lash, David A Putt, Larry H Matherly. Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter.
The Journal of pharmacology and experimental therapeutics.
2002 Nov; 303(2):476-86. doi:
10.1124/jpet.102.040220. [PMID: 12388626] - L H Lash, S E Hueni, D A Putt. Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells.
Toxicology and applied pharmacology.
2001 Nov; 177(1):1-16. doi:
10.1006/taap.2001.9295. [PMID: 11708895] - P A Nony, G Nowak, R G Schnellmann. Collagen IV promotes repair of renal cell physiological functions after toxicant injury.
American journal of physiology. Renal physiology.
2001 Sep; 281(3):F443-53. doi:
10.1152/ajprenal.2001.281.3.f443. [PMID: 11502594] - Y Chen, J Cai, M W Anders, J L Stevens, D P Jones. Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis.
Toxicology and applied pharmacology.
2001 Feb; 170(3):172-80. doi:
10.1006/taap.2000.9107. [PMID: 11162782] - B S Cummings, R C Zangar, R F Novak, L H Lash. Cytotoxicity of trichloroethylene and S-(1, 2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells.
Toxicology.
2000 Sep; 150(1-3):83-98. doi:
10.1016/s0300-483x(00)00252-3. [PMID: 10996665] - G Nowak, C A Carter, R G Schnellmann. Ascorbic acid promotes recovery of cellular functions following toxicant-induced injury.
Toxicology and applied pharmacology.
2000 Aug; 167(1):37-45. doi:
10.1006/taap.2000.8986. [PMID: 10936077] - B S Cummings, L H Lash. Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2000 Feb; 53(2):458-66. doi:
10.1093/toxsci/53.2.458. [PMID: 10696794] - B van de Water, J F Nagelkerke, J L Stevens. Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells.
The Journal of biological chemistry.
1999 May; 274(19):13328-37. doi:
10.1074/jbc.274.19.13328. [PMID: 10224094] - G Nowak, K B Keasler, D E McKeller, R G Schnellmann. Differential effects of EGF on repair of cellular functions after dichlorovinyl-L-cysteine-induced injury.
The American journal of physiology.
1999 02; 276(2):F228-36. doi:
10.1152/ajprenal.1999.276.2.f228. [PMID: 9950953] - W H Dantzler, K K Evans, C E Groves, J R Welborn, J North, J L Stevens, S H Wright. Relation of cysteine conjugate nephrotoxicity to transport by the basolateral organic anion transport system in isolated S2 segments of rabbit proximal renal tubules.
The Journal of pharmacology and experimental therapeutics.
1998 Jul; 286(1):52-60. doi:
NULL. [PMID: 9655841] - S H Wright, T M Wunz, J North, J L Stevens. Na-dependent transport of S-(1,2-dichlorovinyl)-L-cysteine by renal brush-border membrane vesicles.
The Journal of pharmacology and experimental therapeutics.
1998 Apr; 285(1):162-9. doi:
NULL. [PMID: 9536006] - H Richter, S Vamvakas. S-(1,2-dichlorovinyl)-L-cysteine-induced dedifferentiation and p53 gene mutations in LLC-PK1 cells: a comparative investigation with S-(2-chloroethyl)cysteine, potassium bromate, cis-platinum and styrene oxide.
Toxicology letters.
1998 Jan; 94(2):145-57. doi:
10.1016/s0378-4274(98)00006-x. [PMID: 9574811] - Y Zhan, J L Cleveland, J L Stevens. A role for c-myc in chemically induced renal-cell death.
Molecular and cellular biology.
1997 Nov; 17(11):6755-64. doi:
10.1128/mcb.17.11.6755. [PMID: 9343440] - C M Walsh Clang, M D Aleo. Mechanistic analysis of S-(1,2-dichlorovinyl)-L-cysteine-induced cataractogenesis in vitro.
Toxicology and applied pharmacology.
1997 Sep; 146(1):144-55. doi:
10.1006/taap.1997.8236. [PMID: 9299606] - T Green, J Dow, M K Ellis, J R Foster, J Odum. The role of glutathione conjugation in the development of kidney tumours in rats exposed to trichloroethylene.
Chemico-biological interactions.
1997 Jul; 105(2):99-117. doi:
10.1016/s0009-2797(97)00040-9. [PMID: 9251723] - M A Otieno, M W Anders. Cysteine S-conjugates activate transcription factor NF-kappa B in cultured renal epithelial cells.
The American journal of physiology.
1997 Jul; 273(1 Pt 2):F136-43. doi:
10.1152/ajprenal.1997.273.1.f136. [PMID: 9249601] - G Birner, U Bernauer, M Werner, W Dekant. Biotransformation, excretion and nephrotoxicity of haloalkene-derived cysteine S-conjugates.
Archives of toxicology.
1997; 72(1):1-8. doi:
10.1007/s002040050461. [PMID: 9458184] - S Vamvakas, H Richter, D Bittner. Poly(ADP-ribosyl)ation and nuclear matrix/intermediate filament proteins in renal carcinogenesis.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.
1997; 143(?):195-208. doi:
10.1007/978-3-642-60393-8_13. [PMID: 8912420] - L Bouthillier, M Charbonneau, J Brodeur. Assessment of the role of glutathione conjugation in the protection afforded by anethol dithiolthione against hexachloro-1,3-butadiene-induced nephrotoxicity.
Toxicology and applied pharmacology.
1996 Jul; 139(1):177-85. doi:
10.1006/taap.1996.0156. [PMID: 8685901] - P Goldfarb, S Perry, H Harries, C Scholfield, T Lock, L King, G Gibson. Molecular cloning and expression of cDNAs for rat and human kidney cysteine conjugate beta-lyase.
Biochemical Society transactions.
1996 May; 24(2):330S. doi:
10.1042/bst024330s. [PMID: 8736988] - B Van de Water, M Kruidering, J F Nagelkerke. F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells.
The American journal of physiology.
1996 Apr; 270(4 Pt 2):F593-603. doi:
10.1152/ajprenal.1996.270.4.f593. [PMID: 8967337] - B van de Water, J P Zoeteweij, J F Nagelkerke. Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition.
Archives of biochemistry and biophysics.
1996 Mar; 327(1):71-80. doi:
10.1006/abbi.1996.0094. [PMID: 8615698] - S Vamvakas, H Richter, D Bittner. Induction of dedifferentiated clones of LLC-PK1 cells upon long-term exposure to dichlorovinylcysteine.
Toxicology.
1996 Jan; 106(1-3):65-74. doi:
10.1016/0300-483x(95)03166-d. [PMID: 8571403] - U Bernauer, G Birner, W Dekant, D Henschler. Biotransformation of trichloroethene: dose-dependent excretion of 2,2,2-trichloro-metabolites and mercapturic acids in rats and humans after inhalation.
Archives of toxicology.
1996; 70(6):338-46. doi:
10.1007/s002040050283. [PMID: 8975632] - Y Kato, Y Asano, A J Cooper. Inactivation of brain and kidney aspartate aminotransferases by S-(1,2,-dichlorovinyl)-L-cysteine and by S-(1,1,2,2,-tetrafluoroethyl)-L-cysteine.
Developmental neuroscience.
1996; 18(5-6):505-14. doi:
10.1159/000111447. [PMID: 8940625] - E A Lock, Y Sani, R B Moore, M B Finkelstein, M W Anders, A A Seawright. Bone marrow and renal injury associated with haloalkene cysteine conjugates in calves.
Archives of toxicology.
1996; 70(10):607-19. doi:
10.1007/s002040050319. [PMID: 8870953] - O Ilinskaja, S Vamvakas. Alterations of the renal function in the isolated perfused rat kidney system after in vivo and in vitro application of S-(1,2-dichlorovinyl)-L-cysteine and S-(2,2-dichlorovinyl)-L-cysteine.
Archives of toxicology.
1996; 70(3-4):224-9. doi:
10.1007/s002040050264. [PMID: 8825681] - R J Eyre, D K Stevens, J C Parker, R J Bull. Renal activation of trichloroethene and S-(1,2-dichlorovinyl)-L-cysteine and cell proliferative responses in the kidneys of F344 rats and B6C3F1 mice.
Journal of toxicology and environmental health.
1995 Dec; 46(4):465-81. doi:
10.1080/15287399509532049. [PMID: 8523472] - R J Eyre, D K Stevens, J C Parker, R J Bull. Acid-labile adducts to protein can be used as indicators of the cysteine S-conjugate pathway of trichloroethene metabolism.
Journal of toxicology and environmental health.
1995 Dec; 46(4):443-64. doi:
10.1080/15287399509532048. [PMID: 8523471] - B van de Water, J P Zoeteweij, H J de Bont, J F Nagelkerke. Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury.
Molecular pharmacology.
1995 Nov; 48(5):928-37. doi:
. [PMID: 7476924] - J W Davis, D P Blakeman, R A Jolly, W H Packwood, G J Kolaja, T W Petry. S-(1,2-dichlorovinyl)-L-cysteine-induced nephrotoxicity in the New Zealand white rabbit: characterization of proteinuria and examination of the potential role of oxidative injury.
Toxicologic pathology.
1995 Jul; 23(4):487-97. doi:
10.1177/019262339502300405. [PMID: 7501960] - S E Kays, R G Schnellmann. Regeneration of renal proximal tubule cells in primary culture following toxicant injury: response to growth factors.
Toxicology and applied pharmacology.
1995 Jun; 132(2):273-80. doi:
10.1006/taap.1995.1108. [PMID: 7785054] - W H Dantzler, K K Evans, S H Wright. Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.
The Journal of pharmacology and experimental therapeutics.
1995 Feb; 272(2):663-72. doi:
NULL. [PMID: 7853180] - M B Finkelstein, N J Patel, M W Anders. Metabolism of [14C]- and [35S]S-(1,2-dichlorovinyl)-L-cysteine in the male Fischer 344 rat.
Drug metabolism and disposition: the biological fate of chemicals.
1995 Jan; 23(1):124-8. doi:
NULL. [PMID: 7720515] - Q Chen, T W Jones, J L Stevens. Early cellular events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates.
Journal of cellular physiology.
1994 Nov; 161(2):293-302. doi:
10.1002/jcp.1041610214. [PMID: 7525611] - B Van de Water, J J Jaspers, D H Maasdam, G J Mulder, J F Nagelkerke. In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function.
The American journal of physiology.
1994 Nov; 267(5 Pt 2):F888-99. doi:
10.1152/ajprenal.1994.267.5.f888. [PMID: 7977793] - K Yu, Q Chen, H Liu, Y Zhan, J L Stevens. Signalling the molecular stress response to nephrotoxic and mutagenic cysteine conjugates: differential roles for protein synthesis and calcium in the induction of c-fos and c-myc mRNA in LLC-PK1 cells.
Journal of cellular physiology.
1994 Nov; 161(2):303-11. doi:
10.1002/jcp.1041610215. [PMID: 7962114] - J W Davis, T W Petry. Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity.
Journal of biochemical toxicology.
1994 Jun; 9(3):121-30. doi:
10.1002/jbt.2570090303. [PMID: 7983677] - B van de Water, J P Zoeteweij, H J de Bont, G J Mulder, J F Nagelkerke. Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine.
The Journal of biological chemistry.
1994 May; 269(20):14546-52. doi:
10.1016/s0021-9258(17)36658-9. [PMID: 8182062] - L H Lash, P J Sausen, R J Duescher, A J Cooley, A A Elfarra. Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide.
The Journal of pharmacology and experimental therapeutics.
1994 Apr; 269(1):374-83. doi:
NULL. [PMID: 8169843] - G W Miller, E A Lock, R G Schnellmann. Strychnine and glycine protect renal proximal tubules from various nephrotoxicants and act in the late phase of necrotic cell injury.
Toxicology and applied pharmacology.
1994 Apr; 125(2):192-7. doi:
10.1006/taap.1994.1064. [PMID: 8171427] - N Patel, G Birner, W Dekant, M W Anders. Glutathione-dependent biosynthesis and bioactivation of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of dichloroacetylene, in rat tissues and subcellular fractions.
Drug metabolism and disposition: the biological fate of chemicals.
1994 Jan; 22(1):143-7. doi:
. [PMID: 8149874] - L Dong, J L Stevens, D Fabbro, S Jaken. Regulation of protein kinase C isozymes in kidney regeneration.
Cancer research.
1993 Oct; 53(19):4542-9. doi:
NULL. [PMID: 8402625] - S E Kays, C D Berdanier, A R Swagler, E A Lock, R G Schnellmann. An in vitro model of renal proximal tubule cell regeneration.
Journal of pharmacological and toxicological methods.
1993 Aug; 29(4):211-5. doi:
10.1016/1056-8719(93)90027-c. [PMID: 8400416] - B van de Water, J P Zoetewey, H J de Bont, G J Mulder, J F Nagelkerke. The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine.
Biochemical pharmacology.
1993 Jun; 45(11):2259-67. doi:
10.1016/0006-2952(93)90197-5. [PMID: 8517866] - C E Groves, P J Hayden, E A Lock, R G Schnellmann. Differential cellular effects in the toxicity of haloalkene and haloalkane cysteine conjugates to rabbit renal proximal tubules.
Journal of biochemical toxicology.
1993 Mar; 8(1):49-56. doi:
10.1002/jbt.2570080108. [PMID: 8492303] - S Vamvakas, U Köster. The nephrotoxin dichlorovinylcysteine induces expression of the protooncogenes c-fos and c-myc in LLC-PK1 cells--a comparative investigation with growth factors and 12-O-tetradecanoylphorbolacetate.
Cell biology and toxicology.
1993 Jan; 9(1):1-13. doi:
10.1007/bf00755136. [PMID: 7686084] - Q Chen, K Yu, J L Stevens. Regulation of the cellular stress response by reactive electrophiles. The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock protein gene by nephrotoxic cysteine conjugates.
The Journal of biological chemistry.
1992 Dec; 267(34):24322-7. doi:
NULL. [PMID: 1447182] - G J Stijntjes, J M te Koppele, N P Vermeulen. High-performance liquid chromatography-fluorescence assay of pyruvic acid to determine cysteine conjugate beta-lyase activity: application to S-1,2-dichlorovinyl-L-cysteine and S-2-benzothiazolyl-L-cysteine.
Analytical biochemistry.
1992 Nov; 206(2):334-43. doi:
10.1016/0003-2697(92)90375-h. [PMID: 1443603] - S Vamvakas, D Bittner, W Dekant, M W Anders. Events that precede and that follow S-(1,2-dichlorovinyl)-L-cysteine-induced release of mitochondrial Ca2+ and their association with cytotoxicity to renal cells.
Biochemical pharmacology.
1992 Sep; 44(6):1131-8. doi:
10.1016/0006-2952(92)90377-u. [PMID: 1417936] - T W Simmons, M W Anders, N Ballatori. L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine transport in rat liver canalicular membrane vesicles: potential reabsorption mechanisms for biliary metabolites of glutathione and its S-conjugates.
The Journal of pharmacology and experimental therapeutics.
1992 Sep; 262(3):1182-8. doi:
NULL. [PMID: 1527723] - Q Chen, K Yu, N J Holbrook, J L Stevens. Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol.
The Journal of biological chemistry.
1992 Apr; 267(12):8207-12. doi:
NULL. [PMID: 1569075] - A Wallin, G Zhang, T W Jones, S Jaken, J L Stevens. Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1,2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells.
Laboratory investigation; a journal of technical methods and pathology.
1992 Apr; 66(4):474-84. doi:
NULL. [PMID: 1374823] - P J Hayden, C J Welsh, Y Yang, W H Schaefer, A J Ward, J L Stevens. Formation of mitochondrial phospholipid adducts by nephrotoxic cysteine conjugate metabolites.
Chemical research in toxicology.
1992 Mar; 5(2):232-7. doi:
10.1021/tx00026a013. [PMID: 1643252] - P J Sausen, A A Elfarra, A J Cooley. Methimazole protection of rats against chemically induced kidney damage in vivo.
The Journal of pharmacology and experimental therapeutics.
1992 Jan; 260(1):393-401. doi:
NULL. [PMID: 1731048] - P J Sausen, A A Elfarra. Reactivity of cysteine S-conjugate sulfoxides: formation of S-[1-chloro-2-(S-glutathionyl)vinyl]-L-cysteine sulfoxide by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with glutathione.
Chemical research in toxicology.
1991 Nov; 4(6):655-60. doi:
10.1021/tx00024a010. [PMID: 1807449] - D G Abraham, A J Cooper. Glutamine transaminase K and cysteine S-conjugate beta-lyase activity stains.
Analytical biochemistry.
1991 Sep; 197(2):421-7. doi:
10.1016/0003-2697(91)90414-o. [PMID: 1723851] - D A Koechel, M E Krejci, R E Ridgewell. The acute effects of S-(1,2-dichlorovinyl)-L-cysteine and related chemicals on renal function and ultrastructure in the pentobarbital-anesthetized dog: structure-activity relationships, biotransformation, and unique site-specific nephrotoxicity.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1991 Jul; 17(1):17-33. doi:
10.1016/0272-0590(91)90235-v. [PMID: 1916074]