3-(Glutathion-S-yl)acetaminophen (BioDeep_00000843880)
代谢物信息卡片
化学式: C18H24N4O8S (456.1315)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1=CC(=C(C=C1)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
InChI: InChI=1S/C18H24N4O8S/c1-9(23)21-10-2-4-13(24)14(6-10)31-8-12(17(28)20-7-16(26)27)22-15(25)5-3-11(19)18(29)30/h2,4,6,11-12,24H,3,5,7-8,19H2,1H3,(H,20,28)(H,21,23)(H,22,25)(H,26,27)(H,29,30)/t11-,12-/m0/s1
相关代谢途径
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Nida Sohail, Maria Azam, Hafiza Farhat, Khan Hira, Faizah Urooj, Shamim A Qureshi, Jehan Ara, Muhammad Shaiq Ali, Syed Ehteshamul-Haque. Ulva fasciata, a green alga, attenuates the kidney and liver dysfunctions in rats induced by acetaminophen.
Drug and chemical toxicology.
2022 Dec; ?(?):1-14. doi:
10.1080/01480545.2022.2150206. [PMID: 36476192] - Xiqian Zhang, Ruina Li, Wenya Hu, Jin Zeng, Xuehua Jiang, Ling Wang. A reliable LC-MS/MS method for the quantification of N-acetyl-p-benzoquinoneimine, acetaminophen glutathione and acetaminophen glucuronide in mouse plasma, liver and kidney: Method validation and application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2018 Nov; 32(11):e4331. doi:
10.1002/bmc.4331. [PMID: 29978489] - Scott A Reisman, Iván L Csanaky, Lauren M Aleksunes, Curtis D Klaassen. Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 May; 109(1):31-40. doi:
10.1093/toxsci/kfp047. [PMID: 19246624] - Ja Yong Lee, Da Woon Jung, Hyun Ah Park, Soo Jeong Kim, Jin Ho Chung, Chang Kiu Moon, Young Chul Kim. Effect of taurine on biliary excretion and metabolism of acetaminophen in male hamsters.
Biological & pharmaceutical bulletin.
2004 Nov; 27(11):1792-6. doi:
10.1248/bpb.27.1792. [PMID: 15516725] - A E Mutlib, J Shockcor, R Espina, N Graciani, A Du, L S Gan. Disposition of glutathione conjugates in rats by a novel glutamic acid pathway: characterization of unique peptide conjugates by liquid chromatography/mass spectrometry and liquid chromatography/NMR.
The Journal of pharmacology and experimental therapeutics.
2000 Aug; 294(2):735-45. doi:
NULL. [PMID: 10900255] - K J Hoffmann, D B Axworthy, T A Baillie. Mechanistic studies on the metabolic activation of acetaminophen in vivo.
Chemical research in toxicology.
1990 May; 3(3):204-11. doi:
10.1021/tx00015a004. [PMID: 2131832] - L J Fischer, M D Green, A W Harman. Studies on the fate of the glutathione and cysteine conjugates of acetaminophen in mice.
Drug metabolism and disposition: the biological fate of chemicals.
1985 Mar; 13(2):121-6. doi:
NULL. [PMID: 2859156] - C P Siegers, C D Klaassen. Biliary excretion of acetaminophen in ureter-ligated rats.
Pharmacology.
1984; 28(3):177-80. doi:
10.1159/000137959. [PMID: 6718484]
