Remdesivir triphosphate (BioDeep_00000843853)
代谢物信息卡片
化学式: C12H16N5O13P3 (530.9957476)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)C#N)N
InChI: InChI=1S/C12H16N5O13P3/c13-4-12(8-2-1-6-11(14)15-5-16-17(6)8)10(19)9(18)7(28-12)3-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-2,5,7,9-10,18-19H,3H2,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t7-,9-,10-,12+/m1/s1
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alexander P Walker, Haitian Fan, Jeremy R Keown, Michael L Knight, Jonathan M Grimes, Ervin Fodor. The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme.
Nucleic acids research.
2021 12; 49(22):13019-13030. doi:
10.1093/nar/gkab1160. [PMID: 34850141] - Bing Wang, Vladimir Svetlov, Yuri I Wolf, Eugene V Koonin, Evgeny Nudler, Irina Artsimovitch. Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides.
mBio.
2021 06; 12(3):e0142321. doi:
10.1128/mbio.01423-21. [PMID: 34154407] - Massimo Tempestilli, Priscilla Caputi, Valeria Avataneo, Stefania Notari, Olindo Forini, Laura Scorzolini, Luisa Marchioni, Tommaso Ascoli Bartoli, Concetta Castilletti, Eleonora Lalle, Maria R Capobianchi, Emanuele Nicastri, Antonio D'Avolio, Giuseppe Ippolito, Chiara Agrati. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19.
The Journal of antimicrobial chemotherapy.
2020 10; 75(10):2977-2980. doi:
10.1093/jac/dkaa239. [PMID: 32607555] - Eva Konkolova, Milan Dejmek, Hubert Hřebabecký, Michal Šála, Jiří Böserle, Radim Nencka, Evzen Boura. Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses.
Antiviral research.
2020 10; 182(?):104899. doi:
10.1016/j.antiviral.2020.104899. [PMID: 32763313] - Victoria C Yan, Florian L Muller. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.
ACS medicinal chemistry letters.
2020 Jul; 11(7):1361-1366. doi:
10.1021/acsmedchemlett.0c00316. [PMID: 32665809] - Valeria Avataneo, Amedeo de Nicolò, Jessica Cusato, Miriam Antonucci, Alessandra Manca, Alice Palermiti, Catriona Waitt, Stephen Walimbwa, Mohammed Lamorde, Giovanni di Perri, Antonio D'Avolio. Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease.
The Journal of antimicrobial chemotherapy.
2020 07; 75(7):1772-1777. doi:
10.1093/jac/dkaa152. [PMID: 32361744] - Mark Olsen, Sarah E Cook, Vanthida Huang, Niels Pedersen, Brian G Murphy. Perspectives: potential therapeutic options for SARS-CoV-2 patients based on feline infectious peritonitis strategies: central nervous system invasion and drug coverage.
International journal of antimicrobial agents.
2020 Jun; 55(6):105964. doi:
10.1016/j.ijantimicag.2020.105964. [PMID: 32251732] - Maria L Agostini, Erica L Andres, Amy C Sims, Rachel L Graham, Timothy P Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y Feng, Robert Jordan, Adrian S Ray, Tomas Cihlar, Dustin Siegel, Richard L Mackman, Michael O Clarke, Ralph S Baric, Mark R Denison. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.
mBio.
2018 03; 9(2):. doi:
10.1128/mbio.00221-18. [PMID: 29511076]